β-Cell inflammation in human type 2 diabetes and the role of autophagy

Inflammaging: disturbed interplay between autophagy and inflammasomes

(2016) Antero Salminen et al.   Aging-US

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Revisiting the notion of type 1 diabetes being a T-cell-mediated autoimmune disease

(2013) Oskar Skog et al.   Current Opinion in Endocrinology Diabetes and Obesity

Autophagy and the Immune System

(2012) Petric Kuballa et al.   Annual Review of Immunology

Autophagy in immunity

(2012) Xu-Jie Zhou et al.   Autophagy

Secreted Frizzled-Related Protein 4 Reduces Insulin Secretion and Is Overexpressed in Type 2 Diabetes

(2012) Taman Mahdi et al.   Cell Metabolism

A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets

(2012) Jalal Taneera et al.   Cell Metabolism

Interleukin-1 (IL-1) family of cytokines: Role in Type 2 Diabetes

(2012) Monisha Banerjee et al.   CLINICA CHIMICA ACTA

Does the small tyrosine kinase inhibitor imatinib mesylate counteract diabetes by affecting pancreatic islet amyloidosis and fibrosis?

(2012) Nils Welsh   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Tyrosine-kinase inhibitors and patient-reported outcomes in chronic myeloid leukemia: A systematic review

(2012) Fabio Efficace et al.   LEUKEMIA RESEARCH

Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin–proteasome system in pancreatic beta cell dysfunction

(2012) Marco Bugliani et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Analysis of Beta-Cell Gene Expression Reveals Inflammatory Signaling and Evidence of Dedifferentiation following Human Islet Isolation and Culture

(2012) Sarita Negi et al.   PLoS One

Quantification of islet size and architecture

(2012) German Kilimnik et al.   Islets

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

(2011) Qingyuan Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autophagy and apoptosis: what is the connection?

(2011) Jacob M. Gump et al.   TRENDS IN CELL BIOLOGY

The emerging role of autophagy in the pathophysiology of diabetes mellitus

(2010) Claudio D. Gonzalez et al.   Autophagy

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes

(2010) M. Igoillo-Esteve et al.   DIABETOLOGIA

The BCL-2 Family Reunion

(2010) Jerry E. Chipuk et al.   MOLECULAR CELL

Gene Expression Profiles of Beta-Cell Enriched Tissue Obtained by Laser Capture Microdissection from Subjects with Type 2 Diabetes

(2010) Lorella Marselli et al.   PLoS One

The pancreas in human type 1 diabetes

(2010) Patrick A. Rowe et al.   Seminars in Immunopathology

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

(2009) S Luo et al.   CELL DEATH AND DIFFERENTIATION

Goals of Treatment for Type 2 Diabetes:  -Cell preservation for glycemic control

(2009) P. Marchetti et al.   DIABETES CARE

Towards better understanding of the contributions of overwork and glucotoxicity to the β-cell inadequacy of type 2 diabetes

(2009) G. C. Weir et al.   DIABETES OBESITY & METABOLISM

Autophagy in human type 2 diabetes pancreatic beta cells

(2009) M. Masini et al.   DIABETOLOGIA

Islet-associated macrophages in type 2 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Prolonged Culture of Human Islets Induces ER Stress

(2009) S. Erbel et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

The role of inflammation in insulitis and β-cell loss in type 1 diabetes

(2009) Décio L. Eizirik et al.   Nature Reviews Endocrinology

Islet Inflammation Impairs the Pancreatic β-Cell in Type 2 Diabetes

(2009) Marc Y. Donath et al.   PHYSIOLOGY

Autophagy: Principles and significance in health and disease

(2008) Virginia Todde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Resolving the Conundrum of Islet Transplantation by Linking Metabolic Dysregulation, Inflammation, and Immune Regulation

(2008) Xiaolun Huang et al.   ENDOCRINE REVIEWS

Increased Interleukin (IL)-1β Messenger Ribonucleic Acid Expression in β-Cells of Individuals with Type 2 Diabetes and Regulation of IL-1β in Human Islets by Glucose and Autostimulation

(2008) Marianne Böni-Schnetzler et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE