Journal
DIABETES OBESITY & METABOLISM
Volume 16, Issue 2, Pages 170-178Publisher
WILEY
DOI: 10.1111/dom.12192
Keywords
incretin therapy; insulin resistance; insulin secretion; type 2 diabetes
Categories
Funding
- F. Hoffmann-La Roche
- Eli-Lilly
- Amylin Pharmaceuticals
- GlaxoSmithKline
- Novo Nordisk
- Sanofi-Aventis
- Boehringer Ingelheim
- Pfizer
- MannKind
- Takeda
- Daiichi Sankyo
- Forest
- Johnson Johnson
- Novartis
- Roche
- Merck
- Bristol-Myers Squibb
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AimsT-emerge 2 was a randomized, open-label, 24-week trial comparing subcutaneous taspoglutide 10mg weekly (Taspo10), taspoglutide 20mg weekly (Taspo20; titrated after 4weeks of Taspo10), with exenatide 10 mcg BID (Exe; after 4weeks of Exe 5 mcg) in patients inadequately controlled on metformin, a thiazolidinedione, or both. T-emerge 2 showed that once-weekly Taspo provided better glycaemic control than Exe. This report focuses on a subset of T-emerge 2 participants undergoing a standardized liquid meal comparing Taspo to Exe, which has been previously shown to lower postprandial glucose. MethodsMeal tolerance tests (MTT) were performed at baseline and at week 24 in a subset of Taspo10, Taspo20 and Exe patients (n=42, 39 and 67, respectively). Blood samples for glucose, insulin, glucagon and C-peptide were obtained before and after (30, 60, 90, 120 and 180min) ingestion of a standardized liquid meal. ResultsThe 2-h postprandial, mean 0-3h and iAUC0-3h glucose during the MTT was reduced to a similar extent in all groups and the time profile of the postprandial glucose showed a similar pattern. Taspo10 and Taspo20, but not Exe, significantly increased insulin from baseline (both mean and iAUC0-3h). Although changes from baseline in C-peptide were not significant within any treatment group, the mean change from baseline (both mean 0-3h and iAUC0-3h) was significantly increased in Taspo10 vs. Exe. Mean glucagon showed significant decreases in all groups. ConclusionTaspoglutide and Exe improved postprandial glucose tolerance to a similar extent but possibly with different intimate mechanisms.
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