Journal
DIABETES OBESITY & METABOLISM
Volume 12, Issue 11, Pages 976-982Publisher
WILEY
DOI: 10.1111/j.1463-1326.2010.01288.x
Keywords
beta-cell; body composition; glycaemic control
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Funding
- Lund University
- Swedish Research Council [11284, 4499]
- Swedish Diabetes Association
- Novo Nordisk Foundation
- Dir. Albert Pahlsson's Foundation
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Aim: Clinical studies have suggested a role for dietary glycaemic index (GI) in body weight regulation and diabetes risk. Here, we investigated the long-term metabolic effects of low and high glycaemic diets using the C57BL/6J mouse model. Methods: Female C57BL/6J mice were fed low or high glycaemic starch in either low-fat or medium-fat diets for 22 weeks. Oral and intravenous glucose tolerance tests were performed to investigate the effect of the experimental diets on glucose tolerance and insulin resistance. Results: In this study, a high glycaemic diet resulted in impaired oral glucose tolerance compared to a low glycaemic diet. This effect was more pronounced in the group fed a medium-fat diet, suggesting that a lower dietary fat content ameliorates the negative effect of a high glycaemic diet. No effect on body weight or body fat content was observed in either a low-fat diet or a medium-fat diet. Static incubation of isolated islets did not show any differences in basal (3.3 mM glucose) or glucose-stimulated (8.6 and 16.7 mM glucose) insulin secretion between mice fed a low or high glycaemic diet. Conclusion: Together, our data suggest that the impaired glucose tolerance seen after a high glycaemic diet is not explained by altered beta-cell function.
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