Article
Endocrinology & Metabolism
Anita M. Nucci, Suvi M. Virtanen, David Cuthbertson, Johnny Ludvigsson, Ulle Einberg, Celine Huot, Luis Castano, Baerbel Aschemeier, Dorothy J. Becker, Mikael Knip, Jeffrey P. Krischer
Summary: In children at genetic risk of type 1 diabetes, being overweight at 2-10 years of age is associated with an increased risk of progression from multiple IA to type 1 diabetes and with the development of type 1 diabetes, but not with the development of IA. Future studies should assess the impact of weight management strategies on these outcomes.
Article
Microbiology
Patrick G. G. Gavin, Ki Wook Kim, Maria E. E. Craig, Michelle M. M. Hill, Emma E. Hamilton-Williams
Summary: The study demonstrates the interconnectedness of the gut microbiota, metaproteome, and virome in young children. A functional remodeling of the gut microbiota accompanies both islet autoimmunity and viral infection, with a switch in function in Faecalibacterium occurring at the onset of islet autoimmunity.
Article
Endocrinology & Metabolism
Kenney Ng, Harry Stavropoulos, Vibha Anand, Riitta Veijola, Jorma Toppari, Marlena Maziarz, Markus Lundgren, Kathy Waugh, Brigitte Frohnert, Frank Martin, William Hagopian, Peter Achenbach
Summary: This study defined islet autoantibody type-specific titer thresholds that significantly improved type 1 diabetes risk stratification in children.
Article
Immunology
Sulafa Elhassan, Fran Dong, Teresa Buckner, Randi K. Johnson, Jennifer A. Seifert, Patrick M. Carry, Lauren Vanderlinden, Kathleen Waugh, Marian Rewers, Jill M. Norris
Summary: Studies have shown that iron intake may be associated with the risk of developing type 1 diabetes. This study found that individuals with high iron intake had a lower risk of developing type 1 diabetes compared to those with moderate iron intake.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, General & Internal
Anna-Maria Lampousi, Sofia Carlsson, Josefin E. Lofvenborg
Summary: Breastfeeding and late introduction of gluten, fruit, and cow's milk may reduce the risk of T1D, while high childhood intake of cow's milk may increase it.
Review
Endocrinology & Metabolism
Michelle So, Cate Speake, Andrea K. Steck, Markus Lundgren, Peter G. Colman, Jerry P. Palmer, Kevan C. Herold, Carla J. Greenbaum
Summary: Islet autoantibodies are key markers for diagnosing type 1 diabetes and identifying at-risk individuals pre-symptomatically. Prediction of disease progression based on autoantibody count has been shown to be effective, but heterogeneous. Characteristics such as molecular specifics and sequence-dependent risk profiles have emerged as predictive features. Studying these features can improve trial design aimed at predicting and preventing disease.
Article
Endocrinology & Metabolism
Bum Chul Kwon, Peter Achenbach, Vibha Anand, Brigitte I. Frohnert, William Hagopian, Jianying Hu, Eileen Koski, Ake Lernmark, Olivia Lou, Frank Martin, Kenney Ng, Jorma Toppari, Riitta Veijola
Summary: Analyzing the levels of autoantibodies can better differentiate children who progress to type 1 diabetes from those who do not.
Review
Nutrition & Dietetics
Valdemar Brimnes Ingemann Johansen, Knud Josefsen, Julie Christine Antvorskov
Summary: This study systematically reviewed the association between maternal dietary factors during gestation and the risk of developing type 1 diabetes and/or islet autoimmunity (IA) in offspring. The most investigated dietary factors were gluten, dietary advanced glycosylated end products (dAGEs), vitamin D, fatty acids, and iron. The results showed that prenatal exposure to a gluten-free environment and certain fatty acids and vitamin D had protective effects against IA development, while in utero exposure to iron and fat correlated with increased risks of IA.
Article
Public, Environmental & Occupational Health
Qiong Wu, Yiwen Huang, Michelle Helena van Velthoven, Wei Wang, Yanfeng Zhang
Summary: The study revealed improvements in complementary feeding practices among children in Huzhu County, Qinghai Province from 2012 to 2014, but a decline was observed from 2014 to 2018. Caregivers' feeding knowledge also showed an increase during the same period.
JOURNAL OF GLOBAL HEALTH
(2021)
Review
Medicine, General & Internal
Ake Lernmark, Beena Akolkar, William Hagopian, Jeffrey Krischer, Richard McIndoe, Marian Rewers, Jorma Toppari, Kendra Vehik, Anette-G. Ziegler, TEDDY Study Grp
Summary: The etiology of type 1 diabetes involves pancreatic islet beta-cell autoimmune pathogenesis that leads to the clinical onset of the disease. By testing autoantibodies against insulin, glutamic acid decarboxylase, islet antigen-2, and ZnT8 transporter, children can be monitored from birth until the appearance of the first islet autoantibody. The incidence rate of the first-appearing autoantibody follows two different patterns, and an innate immune reaction may precede the adaptive response.
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Randi K. Johnson, Roy Tamura, Nicole Frank, Ulla Uusitalo, Jimin Yang, Sari Niinisto, Carin Andren Aronsson, Anette-G. Ziegler, William Hagopian, Marian Rewers, Jorma Toppari, Beena Akolkar, Jeffrey Krischer, Suvi M. Virtanen, Jill M. Norris
Summary: The study found that maternal food consumption during late pregnancy was not significantly associated with offspring risk for IA or type 1 diabetes.
Article
Nutrition & Dietetics
Markus Mattila, Leena Hakola, Sari Niinisto, Heli Tapanainen, Hanna-Mari Takkinen, Suvi Ahonen, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Suvi M. Virtanen
Summary: The study found no association between maternal intake of vitamin C or iron during pregnancy and the risk of offspring developing islet autoimmunity or type 1 diabetes.
Article
Endocrinology & Metabolism
Janet Snell-Bergeon, Kathleen Waugh, Fran Dong, Andrea Steck, Jill Norris, Marian Rewers
Summary: The study aimed to investigate the relationship between physical activity and the progression of type 1 diabetes. By using an accelerometer to assess physical activity among children and youth at high-genetics risk for type 1 diabetes with islet autoimmunity, it was found that low-physical activity is not a risk factor for progressing from islet autoimmunity to diabetes.
PEDIATRIC DIABETES
(2022)
Article
Endocrinology & Metabolism
Fabio Russo, Antonio Citro, Giorgia Squeri, Francesca Sanvito, Paolo Monti, Silvia Gregori, Maria Grazia Roncarolo, Andrea Annoni
Summary: The study demonstrated that a combination therapy using a lentiviral vector and a suboptimal dose of anti-CD3 monoclonal antibody could effectively control autoimmune diabetes and prevent recurrence of autoimmunity post-islet transplantation in NOD mice. Optimized therapeutic conditioning before alloislet transplantation resulted in normoglycemia and reduced insulitis in diabetic NOD mice, showing a potential for resolving autoimmune diabetes in the presence of residual endogenous beta-cell mass.
Article
Gastroenterology & Hepatology
Shuai Yuan, Susanna C. Larsson
Summary: This study provides further evidence for the causal associations of higher body mass index, type 2 diabetes, and smoking with an increased risk of diverticular disease. Coffee consumption was not found to be associated with diverticular disease. The potential impact of alcohol consumption on the risk of diverticular disease requires further investigation.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Food Science & Technology
Nicolai A. Lund-Blix, Kjersti S. Ronningen, Hakon Boas, German Tapia, Lene F. Andersen
FOOD & NUTRITION RESEARCH
(2016)
Article
Gastroenterology & Hepatology
Ketil Stordal, Karen M. Lundeby, Anne L. Brantsaeter, Margaretha Haugen, Britt Nakstad, Nicolai A. Lund-Blix, Lars C. Stene
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2017)
Article
Nutrition & Dietetics
Christine L. Parr, Maria C. Magnus, Oystein Karlstad, Kristin Holvik, Nicolai A. Lund-Blix, Margareta Haugen, Christian M. Page, Per Nafstad, Per M. Ueland, Stephanie J. London, Siri E. Haberg, Wenche Nystad
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2018)
Article
Public, Environmental & Occupational Health
Maria C. Magnus, Sjurdur F. Olsen, Charlotta Granstrom, Nicolai A. Lund-Blix, Jannet Svensson, Jesper Johannesen, Abigail Fraser, Torild Skrivarhaug, Geir Joner, Pal R. Njolstad, Ketil Stordal, Lars C. Stene
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2018)
Article
Multidisciplinary Sciences
Ketil Stordal, Harry J. McArdle, Helen Hayes, German Tapia, Marte K. Viken, Nicolai A. Lund-Blix, Margaretha Haugen, Geir Joner, Torild Skrivarhaug, Karl Marild, Pal R. Njolstad, Merete Eggesbo, Siddhartha Mandal, Christian M. Page, Stephanie J. London, Benedicte A. Lie, Lars C. Stene
SCIENTIFIC REPORTS
(2018)
Article
Endocrinology & Metabolism
Nicolai A. Lund-Blix, Fran Dong, Karl Marild, Jennifer Seifert, Anna E. Baron, Kathleen C. Waugh, Geir Joner, Ketil Stordal, German Tapia, Lars C. Stene, Randi K. Johnson, Marian J. Rewers, Jill M. Norris
Article
Endocrinology & Metabolism
German Tapia, Karl Marild, Sandra R. Dahl, Nicolai A. Lund-Blix, Marte K. Viken, Benedicte A. Lie, Pal R. Njolstad, Geir Joner, Torild Skrivarhaug, Arieh S. Cohen, Ketil Stordal, Lars C. Stene
Article
Gastroenterology & Hepatology
Karl Marild, Fran Dong, Nicolai A. Lund-Blix, Jennifer Seifert, Anna E. Baron, Kathleen C. Waugh, Iman Taki, Ketil Stordal, German Tapia, Lars C. Stene, Randi K. Johnson, Edwin Liu, Marian J. Rewers, Jill M. Norris
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Gastroenterology & Hepatology
Nicolai A. Lund-Blix, Karl Marild, German Tapia, Jill M. Norris, Lars C. Stene, Ketil Stordal
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2019)
Article
Medicine, General & Internal
Nicolai A. Lund-Blix, German Tapia, Karl Marild, Anne Lise Brantsaeter, Pal R. Njolstad, Geir Joner, Torild Skrivarhaug, Ketil Stordal, Lars C. Stene
Article
Multidisciplinary Sciences
Nicolai A. Lund-Blix, German Tapia, Karl Marild, Anne Lise Brantsaeter, Merete Eggesbo, Siddhartha Mandal, Lars C. Stene, Ketil Stordal
SCIENTIFIC REPORTS
(2020)
Article
Endocrinology & Metabolism
Jaakko Tuomilehto, Graham D. Ogle, Nicolai A. Lund-Blix, Lars C. Stene
PEDIATRIC ENDOCRINOLOGY REVIEWS PER
(2020)
Article
Endocrinology & Metabolism
Nicolai A. Lund-Blix, Stine Dydensborg Sander, Ketil Stordal, Anne-Marie Nybo Andersen, Kjersti S. Ronningen, Geir Joner, Torild Skrivarhaug, Pal R. Njolstad, Steffen Husby, Lars C. Stene