Article
Urology & Nephrology
Charat Thongprayoon, Yeshwanter Radhakrishnan, Wisit Cheungpasitporn, Tananchai Petnak, Jose Zabala Genovez, Api Chewcharat, Fawad Qureshi, Michael A. Mao, Kianoush B. Kashani
Summary: This study found that hypochloremia during CRRT treatment is associated with higher mortality rates, while hyperchloremia is not. The increase in serum chloride range is also associated with increased mortality rates.
JOURNAL OF NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Young Rok Ham, Eu Jin Lee, Hae Ri Kim, Jae Wan Jeon, Ki Ryang Na, Kang Wook Lee, Dae Eun Choi
Summary: This study aimed to identify the differences in renal ultrasonographic findings between patients with and without DM, and to evaluate the relationship between renal ultrasound findings and renal prognosis in patients with DM. The results showed that patients with DM had thicker renal cortical thickness/parenchymal thickness than those without, despite having lower eGFRs. In the progression group, the renal scores were significantly higher than those from the non-progression group.
Article
Critical Care Medicine
Thummaporn Naorungroj, Ary Serpa Neto, Amanda Wang, Martin Gallagher, Rinaldo Bellomo
Summary: This study investigated the impact of renal replacement therapy (RRT) modality and treatment protocol on RRT dependence in critically ill patients with acute kidney injury. The results showed that there was no difference in RRT dependence at day 28 between continuous RRT (CRRT) and intermittent hemodialysis (IHD). However, among survivors, CRRT-first was associated with decreased 28-day RRT dependence and more RRT-free days. Additionally, the ATN treatment protocol in CRRT-first patients was associated with increased RRT dependence and mortality.
Article
Urology & Nephrology
Hsin-Hsiung Chang, Wen-Chih Liu, Tsung-Chang Tsai
Summary: This study investigated the association between statin use during hospitalization period after renal replacement therapy and reduced mortality in patients with dialysis-requiring acute kidney injury. The results showed that among 1035 patients, only 24.9% received statin therapy during hospitalization. During the 1-year follow-up, the mortality rates were significantly lower in statin users compared to non-users (49.2% vs 69.6% for 1-year mortality, and HR=0.46, P<0.001 for in-hospital mortality).
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Michael Boehm, Helmut Schumacher, Christian Werner, Koon K. Teo, Eva M. Lonn, Felix Mahfoud, Thimoteus Speer, Giuseppe Mancia, Josep Redon, Roland E. Schmieder, Karen Sliwa, Nikolaus Marx, Michael A. Weber, Ulrich Laufs, Bryan Williams, Salim Yusuf, Johannes F. E. Mann
Summary: This study analyzed the association between physical activity and renal and cardiovascular outcomes in high-risk patients aged >= 55 years. The results showed that moderate physical activity was associated with improved kidney outcomes, with a threshold of at least two sessions per week. The association between physical activity and renal outcomes did not differ significantly between those with and without diabetes, but the absolute benefit of activity was greater in people with diabetes.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lihua Guan, Lei Li, Yutong Zou, Jian Zhong, Ling Qiu
Summary: Diabetes is associated with cardiovascular disease and liver fibrosis, with FIB-4 being a crucial predictor for CVD in patients with liver diseases. A study using NHANES data from 1999-2008 found that FIB-4 is associated with all-cause and CVD mortality in the diabetic population, with age significantly affecting this association, but only affecting the incidence of myocardial infarction. Further research on the relationship between FIB-4 and CVD in diabetic populations is needed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Transplantation
Thummaporn Naorungroj, Ary Serpa Neto, Lara Zwakman-Hessels, Fumitaka Yanase, Glenn Eastwood, Raghavan Murugan, John A. Kellum, Rinaldo Bellomo
Summary: In patients undergoing CRRT, higher early NUF rates (>1.75 mL/kg/h) were associated with increased mortality rates compared to lower rates (<1.01 mL/kg/h). These findings highlight the need for further clinical trials to validate or refute these results.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Health Care Sciences & Services
Jose Manuel Munoz-Terol, Jose L. Rocha, Pablo Castro-de la Nuez, Juan Jose Egea-Guerrero, Luis Gil-Sacaluga, Emilio Garcia-Cabrera, Angel Vilches-Arenas
Summary: This study aimed to analyze the factors associated with survival in patients undergoing renal replacement therapy (RRT). The study found that renal transplantation (RT) was the most influential independent factor in patient survival, with the greatest protective effect. Based on the findings, it is recommended to consider both modifiable and nonmodifiable factors when evaluating the effectiveness of RRT.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Murielle Abou-Samra, Koen Venema, Carole Ayoub Moubareck, Mirey Karavetian
Summary: This cross-sectional analysis examined the association of peptide hormones with obesity markers, insulin resistance, and dyslipidemia. The study found that obese individuals had higher levels of leptin, insulin, insulin resistance, and triglycerides, while normal-weight individuals had higher levels of ghrelin.
Article
Medicine, General & Internal
I-Chieh Mao, Pei-Ru Lin, Shin-Hwar Wu, Hsin-Hui Hsu, Pei-Shan Hung, Chew-Teng Kor
Summary: This study investigated the association between serum potassium levels and variability and ICU mortality in critically ill patients with acute kidney injury undergoing continuous renal replacement therapy (CRRT). The findings showed that patients with mean serum potassium levels between 3.0 and 4.0 mmol/L had the lowest mortality. Additionally, patients with higher variability in serum potassium levels had a significantly increased risk of in-hospital death.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Charat Thongprayoon, Wisit Cheungpasitporn, Yeshwanter Radhakrishnan, Tananchai Petnak, Fawad Qureshi, Michael A. Mao, Kianoush B. Kashani
Summary: In critically ill patients requiring CRRT, three out of four patients had hypoalbuminemia (<3.5 g/dL) at CRRT initiation, but only severe hypoalbuminemia <2.5 g/dL was significantly associated with higher mortality.
JOURNAL OF CRITICAL CARE
(2022)
Article
Critical Care Medicine
Jong Min Lee, Seung Don Baek, Tae Hyun Kim, Hwa Ran Jeon, Jin Hee Han, Jai Won Chang
Summary: Studies have shown that the addition of PMX-HP to CRRT does not significantly improve the survival rate of patients with sepsis, and this remains the case even after matching for disease severity.
Article
Medicine, General & Internal
Jose Manuel Munoz-Terol, Jose L. Rocha, Pablo Castro-de La Nuez, Emilio Garcia-Cabrera, Angel Vilches-Arenas
Summary: Chronic kidney disease is a non-communicable disease that is growing rapidly in terms of morbidity and mortality. Renal transplantation is the first choice for end-stage kidney disease patients, while dialysis is an alternative. This study aims to assess the potential years of life lost by patients on renal replacement therapy. The average potential years of life lost for dialysis patients is 9.0 years, while this figure decreases to 2.2 years for kidney transplant recipients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Lei Zhong, Bo Xie, Xiao-Wei Ji, Xiang-Hong Yang
Summary: This study investigated the relationship between albumin corrected anion gap (ACAG) at CRRT initiation and all-cause mortality in AKI patients in the ICU, finding that higher ACAG levels were significantly correlated with ICU all-cause mortality, emphasizing the importance of monitoring patients with elevated ACAG values.
INTERNAL AND EMERGENCY MEDICINE
(2022)
Review
Medicine, General & Internal
Saikat Mitra, Ryan Ruiyang Ling, Chuen Seng Tan, Kiran Shekar, Graeme MacLaren, Kollengode Ramanathan
Summary: This systematic review and meta-analysis analyzed outcomes of patients receiving renal replacement therapy (RRT) on extracorporeal membrane oxygenation (ECMO) from January 2000 to September 2020. The study found that RRT on ECMO was associated with higher mortality rates and longer ICU/hospital stay compared to those without RRT. In the last five years, mortality decreased by 20% in patients receiving RRT, but there is still an increased risk of death. Future research should focus on minimizing renal dysfunction and determining the optimal timing for initiating RRT in ECMO patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Transplantation
Jennifer S. Lees, Stephen J. H. Dobbin, Benjamin M. P. Elyan, David F. Gilmour, Laurie P. Tomlinson, Ninian N. Lang, Patrick B. Mark
Summary: This study conducted a systematic review and meta-analysis of intravitreal VEGF inhibitor treatments for retinal diseases. The results showed that there was no increased risk of cardiorenal side effects, but VEGF inhibitor treatment was associated with higher all-cause mortality in patients with diabetic eye disease.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Michele Farisco, Irene Zecchino, Giovambattista Capasso, CONNECT Consortium
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
William J. Hulme, Elizabeth Williamson, Elsie M. F. Horne, Amelia Green, Helen I. I. McDonald, Alex J. J. Walker, Helen J. J. Curtis, Caroline E. Morton, Brian MacKenna, Richard Croker, Amir Mehrkar, Seb Bacon, David Evans, Peter Inglesby, Simon Davy, Krishnan Bhaskaran, Anna Schultze, Christopher T. Rentsch, Laurie Tomlinson, Ian J. Douglas, Stephen J. W. Evans, Liam Smeeth, Tom Palmer, Ben Goldacre, Miguel A. Hernan, Jonathan A. C. Sterne
Summary: The COVID-19 vaccines were developed and evaluated through randomized trials, but important questions remain unanswered. Observational studies and target trial emulation can provide valuable insights, although potential biases need to be managed. This article presents two approaches to emulate target trials using observational data.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Urology & Nephrology
Shalini Santhakumaran, Manuela Savino, Fran Benoy-Deeney, Retha Steenkamp, James Medcalf, Dorothea Nitsch
Summary: This study compared two methods of data collection for COVID-19 infections among patients on kidney replacement therapy in England. The results showed that direct submission of data by renal centers allowed real-time monitoring for patients undergoing in-center hemodialysis treatment. For other kidney replacement therapy modalities, using a national swab test dataset through frequent linkage may be the most effective method. Optimizing central surveillance can improve patient care by informing interventions and assisting planning at local, regional, and national levels.
Article
Urology & Nephrology
Esther Wong, Javeria Peracha, David Pitcher, Anna Casula, Retha Steenkamp, James F. Medcalf, Dorothea Nitsch
Summary: A study in the English National Health Service found that the mortality rate for patients with acute kidney injury is higher in winter compared to summer by 33%. Furthermore, the mortality rate varied across different NHS trusts, with 9 out of 90 centers being outliers. Despite adjusting for clinical and demographic factors, the reasons for increased mortality in winter remain unclear and warrant further investigation into other factors such as winter pressures.
Article
Medicine, General & Internal
Sarah Cook, Niklas Schmedt, Julie Broughton, Philip A. Kalra, Laurie A. Tomlinson, Jennifer K. Quint
Summary: This study investigated the prevalence of chronic kidney disease (CKD), demographic and clinical characteristics, treatment patterns, and rates of cardiovascular and renal complications in patients with type 2 diabetes (T2D) treated in routine clinical care. The results showed that the prevalence of CKD remained stable at approximately 30% in T2D patients, and CKD was associated with significantly increased rates of complications, especially in those with comorbid heart failure.
Article
Medicine, General & Internal
Emily Herrett, Keith Tomlin, Liang-Yu Lin, Laurie A. Tomlinson, Mark Jit, Andrew Briggs, Michael Marks, Frank Sandmann, John Parry, Christopher Bates, Jessica Morley, Seb Bacon, Benjamin Butler-Cole, Viyaasan Mahalingasivam, Alan Dennison, Deb Smith, Ethan Gabriel, Amir Mehrkar, Ben Goldacre, Liam Smeeth, Rosalind M. M. Eggo
Summary: This study aims to understand the impact of long COVID on health-related quality of life and productivity in English primary care patients. Participants will be asked to complete questionnaires through a smartphone app, covering aspects such as HRQoL, productivity, and symptoms of long COVID. Analysis will be conducted using the OpenSAFELY data platform to estimate the impact on HRQoL, productivity, and cost to the NHS.
Article
Medicine, General & Internal
Christopher Kintu, Opeyemi Soremekun, Abram B. Kamiza, Allan Kalungi, Richard Mayanja, Robert Kalyesubula, S. Bernard Bagaya, Daudi Jjingo, June Fabian, Dipender Gill, Moffat Nyirenda, Dorothea Nitsch, Tinashe Chikowore, Segun Fatumo
Summary: In individuals of African ancestry, genetically predicted lower LDL-C and TC are causally associated with higher eGFR levels in a U-shaped manner. Lowering LDL-C does not necessarily improve the risk of kidney disease. Further research is needed to confirm the potential association between lipid traits and the risk of kidney disease in individuals of African ancestry.
Article
Health Care Sciences & Services
Sophie V. Eastwood, Alun D. Hughes, Laurie Tomlinson, Rohini Mathur, Liam Smeeth, Krishnan Bhaskaran, Nishi Chaturvedi
Summary: This study found ethnic differences in hypertension management in the UK, with better management among South Asians and poorer management among African/African Caribbean individuals. These differences may be associated with medication adherence and treatment persistence. Therefore, a nationwide strategy is necessary to understand and address the ongoing management disparities among people on antihypertensive medications.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Urology & Nephrology
Winnie Magadi, Javeria Peracha, William S. McKane, Manuela Savino, Fiona Braddon, Retha Steenkamp, Dorothea Nitsch
Summary: In this study, differences in burden of hospital-acquired acute kidney injury (H-AKI) and mortality risk across different treatment specialties in the English National Health Service (NHS) were identified. It was found that patients in surgical specialties had a lower 30-day mortality risk compared to general medicine, while critical care and oncology patients had the highest mortality risk.
Article
Multidisciplinary Sciences
Sophie Graham, Elise Tessier, Julia Stowe, Jamie Lopez Bernal, Edward P. K. Parker, Dorothea Nitsch, Elizabeth Miller, Nick Andrews, Jemma L. Walker, Helen I. McDonald
Summary: National test-negative-case-control studies are conducted in the UK to monitor the effectiveness of COVID-19 vaccines. A questionnaire was sent to participants of the first published study to assess potential biases and changes in behavior related to vaccination. The findings showed a slight decrease in vaccine effectiveness after two doses of BNT162b2, but minimal evidence of riskier behavior after vaccination. These results provide reassurance to policymakers and clinicians.
NATURE COMMUNICATIONS
(2023)
Article
Psychiatry
Opeyemi Soremekun, Clarisse Musanabaganwa, Annette Uwineza, Maddalena Ardissino, Skanda Rajasundaram, Agaz H. Wani, Stefan Jansen, Jean Mutabaruka, Eugene Rutembesa, Chisom Soremekun, Cisse Cheickna, Mamadou Wele, Joseph Mugisha, Oyekanmi Nash, Eugene Kinyanda, Dorothea Nitsch, Myriam Fornage, Tinashe Chikowore, Dipender Gill, Derek E. Wildman, Leon Mutesa, Monica Uddin, Segun Fatumo
Summary: Observational studies have shown a link between PTSD and IS, but it is unclear if this association is causal. Using Mendelian randomization, the researchers found evidence that genetic liability to specific sub-phenotypes of PTSD, such as hyperarousal and avoidance, may have a causal effect on the risk of IS in individuals of European and African ancestry.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Medicine, General & Internal
Richard Mayanja, Tafadzwa Machipisa, Opeyemi Soremeku, Abram B. Kamiza, Christopher Kintu, Allan Kalungi, Robert Kalyesubula, Obondo J. Sande, Daudi Jjingo, June Fabian, Cassianne Robinson-Cohen, Nora Franceschini, Dorothea Nitsch, Moffat Nyirenda, Eleftheria Zeggini, Andrew P. Morris, Tinashe Chikowore, Segun Fatumo
Summary: Chronic kidney disease is on the rise in Africa, but the genetic factors behind it are not well understood. While creatinine-based estimated glomerular filtration rate (eGFR) is commonly used to estimate kidney function, it has been shown to be inadequate in detecting low kidney function in Sub-Saharan Africa. On the other hand, eGFR based on cystatin-C (eGFRcys) has shown significantly better performance. Therefore, this study aimed to conduct a GWAS for eGFRcys.
Article
Public, Environmental & Occupational Health
Linda Nab, Edward P. K. Parker, Colm D. Andrews, William J. Hulme, Louis Fisher, Jessica Morley, Amir Mehrkar, Brian MacKenna, Peter Inglesby, Caroline E. Morton, Sebastian C. J. Bacon, George Hickman, David Evans, Tom Ward, Rebecca M. Smith, Simon Davy, Iain Dillingham, Steven Maude, Ben F. C. Butler-Cole, Thomas O'Dwyer, Catherine L. Stables, Lucy Bridges, Christopher Bates, Jonathan Cockburn, John Parry, Frank Hester, Sam Harper, Bang Zheng, Elizabeth J. Williamson, Rosalind M. Eggo, Stephen J. W. Evans, Ben Goldacre, Laurie A. Tomlinson, Alex J. Walker
Summary: This study examined trends in COVID-19-related mortality risks among different demographic and clinical population subgroups during successive waves of the pandemic. The findings showed a decrease in absolute COVID-19-related death rates over time in the overall population, but the relative risk profiles for vulnerable subgroups with lower vaccination coverage or impaired immune response persisted and worsened.
LANCET PUBLIC HEALTH
(2023)
Letter
Medicine, General & Internal
Robert C. Speth
Summary: The article does not differentiate between ACE inhibitor therapy and ARB therapy in advanced CKD. The mechanisms of action of ACE inhibitors and ARBs differ substantially, with varying effects on renal function.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)