Article
Medicine, General & Internal
Anna Oliveras, Susana Vazquez, Maria Jose Soler, Isabel Galceran, Xavier Duran, Albert Goday, David Benaiges, Marta Crespo, Julio Pascual, Marta Riera
Summary: Obesity-related hyperfiltration causes an increase in GFR and hyperalbuminuria, which can be reversed after bariatric surgery. Body weight and aldosterone are the main factors mediating changes in eGFR in obesity and bariatric surgery, while albuminuria is associated with glucose homeostasis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Jeffrey L. Segar, Connie C. Grobe, Justin L. Grobe
Summary: The study found that extremely preterm infants born at 22-23 weeks of gestational age have high levels of sodium intake and urinary excretion in the early stages of life, only achieving positive sodium balance after 10 weeks of birth. Higher sodium intakes than those currently recommended by the American Academy of Pediatrics are needed to achieve significant positive sodium balance in this population.
PEDIATRIC NEPHROLOGY
(2021)
Article
Nutrition & Dietetics
Fuyuko Takahashi, Yoshitaka Hashimoto, Ayumi Kaji, Ryosuke Sakai, Akane Miki, Yuka Kawate, Takuro Okamura, Noriyuki Kitagawa, Hiroshi Okada, Naoko Nakanishi, Saori Majima, Takafumi Senmaru, Emi Ushigome, Masahide Hamaguchi, Mai Asano, Masahiro Yamazaki, Michiaki Fukui
Summary: This study investigated the relationship between obesity and high estimated salt intake with and without habitual miso consumption, showing that miso consumption promotes salt excretion and may lead to an apparently higher estimated salt intake than actual. High estimated salt intake was not significantly associated with obesity, indicating the need for clinicians to be aware of the effects of miso consumption on estimated salt intake.
Review
Endocrinology & Metabolism
Maria Anna Bantounou, Panagiotis Sardellis, Rosa Thuemmler, Daniel Black Boada, Justyna Kaczmarek, Ribeya Mahmood, Josip Plascevic, Sam Philip
Summary: This study investigated the renal safety profile of sotagliflozin, a new inhibitor of sodium-glucose co-transporter-1 and -2, in patients with type 1 and type 2 diabetes. The results showed that sotagliflozin did not adversely affect renal function and did not change the risk of key renal outcomes, even in patients with pre-existing renal impairment.
DIABETES OBESITY & METABOLISM
(2023)
Article
Physiology
Antonio G. Soares, Jorge Contreras, Crystal R. Archer, Elena Mironova, Rebecca Berdeaux, James D. Stockand, Tarek Mohamed Abd El-Aziz
Summary: The study demonstrates that targeted activation of Gs signaling exclusively in renal principal cells (PC) is sufficient to increase ENaC activity and decrease urinary sodium excretion in live animals.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Atsuo Tahara
Summary: Ipragliflozin, an SGLT2 inhibitor, demonstrates significant antihyperglycemic effects and increases urinary glucose excretion in a hyperglycemic state, but has weaker effects in non-hyperglycemic or hypoglycemic conditions. These effects are dependent on blood glucose levels.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Yang Yang, Gaosi Xu
Summary: This paper summarizes the mechanisms of hyperfiltration in early diabetic kidney disease (DKD), including the effect of glucose reabsorption, renal growth, nitric oxide, adenosine, atrial natriuretic peptide, cyclooxygenase, renin-angiotensin-aldosterone system, and endothelin. Potential treatments targeting these mechanisms may provide new therapeutic opportunities for reducing renal burden in DKD patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Suiyuan Hu, Chu Lin, Xiaoling Cai, Xingyun Zhu, Fang Lv, Lin Nie, Linong Ji
Summary: This study conducted a systematic review and meta-analysis to compare the urinary glucose excretion (UGE) mediated by SGLT2 inhibitors (SGLT2i) in individuals with different levels of renal function. The results showed that UGE decreased with the extent of renal function impairment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Ilhan Kurultak, Neslihan Sarigul, Nil Su Kodal, Filiz Korkmaz
Summary: In this study, ATR-FTIR spectroscopy was used to analyze urine samples and successfully differentiate individuals with renal hyperfiltration (RHf) from those with normal GFR. The spectral analysis showed significant differences in spectral features between hyperfiltrators and normofiltraters, indicating that RHf can simultaneously affect the excretion of multiple substances. This study demonstrates that urine spectroscopy can be used as a rapid and non-invasive pre-screening tool.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Yasuhiro Iijima, Masafumi Nakayama, Takashi Miwa, Fumiyoshi Yakou, Hirofumi Tomiyama, Junpei Shikuma, Rokuro Ito, Akihiko Tanaka, Naoki Manda, Masato Odawara
Summary: This study examined the effects of dapagliflozin as an add-on therapy for diabetes on estimated glomerular filtration rate (eGFRcys) and urinary sodium excretion. The results showed that dapagliflozin significantly increased eGFRcys and urinary sodium excretion, as well as decreased blood pressure. These findings suggest that dapagliflozin add-on therapy may have nephroprotective effects in individuals with type 2 diabetes mellitus.
Article
Pharmacology & Pharmacy
Osaze Edosuyi, Ayobami Adesuyi, Myung Choi, Ighodaro Igbe, Adebayo Oyekan
Summary: Malate regulates blood pressure via nitric oxide production and has effects on renal function in salt-sensitive rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Mao-Bing Chen, Hua Wang, Qi-Han Zheng, Hua-Lan Xu, Wei-Yan Cui
Summary: A meta-analysis of multiple studies showed that SGLT inhibitors have a significant effect in reducing HbA1c levels in patients with type 2 diabetes mellitus, but with heterogeneous outcomes. Subgroup analysis can help reduce this heterogeneity by dividing populations into different subgroups.
Article
Immunology
Anxiang Cai, Jianxiao Shen, Xiaoqian Yang, Xinghua Shao, Leyi Gu, Shan Mou, Xiajing Che
Summary: This study analyzed the kidneys of healthy mice, diabetic mice, and diabetic mice treated with dapagliflozin using ATAC and RNA sequencing, and identified Csf2rb, Btla, and Isg15 as key candidate genes associated with hyperglycemia, azotemia, and albuminuria in DKD. The study also demonstrated that dapagliflozin exhibited anti-inflammatory effects on renal cells and attenuated kidney injury and inflammation in mice.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Savitha Shenoy, Detlef Bockenhauer
Summary: In rare cases, hypernatraemia may be caused by salt poisoning instead of dehydration, making it difficult to diagnose. Currently, there is no accepted cut-off value to distinguish between dehydration and salt poisoning, resulting in differing opinions on the diagnosis. It is important to address this challenge and improve the assessment tools for hypernatraemia.
Article
Medicine, General & Internal
Alexandre T. Maciel, Daniel Vitorio, Eduardo A. Osawa
Summary: This article discusses the role of urine biochemistry in monitoring acute kidney injury (AKI) and proposes a novel perspective for interpreting widely recognized urine biochemical parameters. It highlights the usefulness of sequential assessment of these parameters in AKI monitoring, especially in critical care settings.
FRONTIERS IN MEDICINE
(2022)
Article
Virology
Xiaoxing Qiu, Lori Sokoll, Paul Yip, Debra J. Elliott, Renu Dua, Phaedre Mohr, Xiao Yan Wang, Megan Spencer, Priscilla Swanson, George J. Dawson, John Hackett
JOURNAL OF CLINICAL VIROLOGY
(2017)
Article
Medicine, General & Internal
Thomas E. MacMillan, Patrick Gudgeon, Paul M. Yip, Rodrigo B. Cavalcanti
AMERICAN JOURNAL OF MEDICINE
(2018)
Article
Medical Laboratory Technology
Jennifer Taher, Jake Cosme, Brian A. Renley, David J. Daghfal, Paul M. Yip
CLINICAL BIOCHEMISTRY
(2019)
Article
Medical Laboratory Technology
Dana Bailey, Danijela Konforte, Vilte E. Barakauskas, Paul M. Yip, Vathany Kulasingam, Mohamed Abou El Hassan, Lori A. Beach, Ivan M. Blasutig, Peter Catomeris, Kent C. Dooley, Yanping Gong, Peter Kavsak, Edward W. Randell, Jason L. Robinson, Julie Shaw, Jennifer Taher, Nicole White-Al Habeeb
CLINICAL BIOCHEMISTRY
(2020)
Article
Surgery
Kevin Quach, Monica Abdelmasih, Pei Xuan Chen, Yanhong Li, Olusegun Famure, Michelle Nash, Ramesh Prasad, Bruce A. Perkins, Paul M. Yip, S. Joseph Kim
Summary: The study found an association between 25-hydroxyvitamin D (25(OH)D) levels and posttransplant diabetes among kidney transplant recipients, with lower 25(OH)D levels being associated with a higher risk of diabetes. This suggests that serum 25(OH)D may be an independent predictor of posttransplant diabetes in this patient population.
PROGRESS IN TRANSPLANTATION
(2021)
Editorial Material
Medical Laboratory Technology
Jennifer Taher, Megan Spencer, Paul M. Yip
JOURNAL OF APPLIED LABORATORY MEDICINE
(2022)
Letter
Public, Environmental & Occupational Health
Alice Zhabokritsky, Samira Mubareka, Robert A. Kozak, Finlay Maguire, Lily Yip, Paul Yip, Jeff Powis
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Endocrinology & Metabolism
Vikas S. Sridhar, Hongyan Liu, Leif Erik Lovblom, Denice S. Feig, Elaine Herer, Michelle A. Hladunewich, Alexander Kiss, Radha P. Kohly, Lorraine L. Lipscombe, Paul M. Yip, David Z. Cherney, Baiju R. Shah
Summary: This study aimed to investigate the mechanistic pathways associated with microvascular complications in pregnant women with gestational diabetes mellitus (GDM) or microvascular disease. The results showed significant associations between GDM status and various biomarkers, including apolipoprotein A1, interleukin (IL)-6, IL-8, soluble tumour necrosis factor receptor-I and -II, vascular endothelial growth factor, and von Willebrand factor. Elevated levels of high-sensitivity C-reactive protein and soluble tumour necrosis factor receptor-II were associated with increased albuminuria, while high-sensitivity C-reactive protein and previous GDM were associated with retinopathy. These findings suggest that mechanistic pathways related to microvascular complications are active in pregnant women with GDM or microvascular disease.
CANADIAN JOURNAL OF DIABETES
(2023)
Article
Endocrinology & Metabolism
Jason Baek, Vamana Rajeswaran, Susan Tran, Lisa Alexander, Diana Jaskolka, Shirine Usmani, Paul Yip, Geetha Mukerji
Summary: This study aimed to reduce unnecessary repeat A1C testing through a quality improvement initiative. The results showed that after the intervention, unnecessary testing decreased by 84%. By using root-cause analysis and provider education, resource stewardship can be effectively promoted to reduce unnecessary A1C testing.
CANADIAN JOURNAL OF DIABETES
(2023)
Article
Medical Laboratory Technology
Agnes Chan, Jorge Martinez-Cajas, Paul M. Yip, Vathany Kulasingam, Jocelyn Garland, David Holland, M. Khaled Shamseddin, Yanping Gong
Summary: Four quantitative SARS-CoV-2 serological assays were compared in different patient cohorts, and results showed poor correlation quantitatively, semi-quantitatively, and qualitatively. Harmonization of these assays is needed to achieve comparable measurements.
CLINICAL BIOCHEMISTRY
(2023)
Article
Medical Laboratory Technology
Jessica J. Miller, Roy Augustin, Lusia Sepiashvili, Ravinder J. Singh, Eric Bro, Karen Weishuhn, Kirsten Kotsopoulos, Joan Brennan, Yenge Diambomba, Victoria Higgins, Matthew Nichols, Vathany Kulasingam, Daniel R. Beriault, Paul M. Yip, Jennifer Taher
Summary: Vitamin D supplementation is commonly given to neonates and infants due to limited vitamin D stores at birth, but over-supplementation can lead to toxicity. This study found fluctuations in 25-hydroxy vitamin D levels in pre-term neonates receiving supplementation, and discrepancies between different immunoassay platforms and LC-MS/MS measurements. It suggests that neonatal 25-hydroxy vitamin D measurements alone should not be used for nutritional monitoring and other clinical and laboratory parameters should be considered.
JOURNAL OF APPLIED LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Jessica J. Miller, Victoria Higgins, Nir Melamed, Michelle Hladunewich, Liyan Ma, Paul M. Yip, Lei Fu
Summary: Preeclampsia is a multisystem disorder characterized by hypertension and proteinuria after 20 weeks gestation. This study evaluated the clinical performance of the sFlt-1:PlGF ratio for predicting preeclampsia and found that a cutoff value of >38 had the highest diagnostic accuracy. sFlt-1:PlGF outperformed traditional markers of preeclampsia such as proteinuria and hypertension.
JOURNAL OF APPLIED LABORATORY MEDICINE
(2023)
Letter
Medical Laboratory Technology
Michelle L. Parker, Michelle Sholzberg, Paul M. Yip, Daniel R. Beriault
CLINICAL BIOCHEMISTRY
(2021)
Article
Health Care Sciences & Services
Sheharyar Raza, Andre C. Amaral, Jeffrey Pang, Fuad Moussa, Dominick Shelton, Lowyl Notario, Heather Harrington, Jeannie L. Callum, Paul M. Yip
Article
Physiology
Marko Skrtic, Yuliya Lytvyn, Petter Bjornstad, Heather N. Reich, James W. Scholey, Paul Yip, Etienne B. Sochett, Bruce Perkins, David Z. I. Cherney
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2017)