Article
Endocrinology & Metabolism
Chenjie Xu, Yabing Hou, Keyi Si, Zhi Cao
Summary: There is an interaction between cardiorespiratory fitness and genetic susceptibility and inflammation in relation to the risk of type 2 diabetes. Improving cardiorespiratory fitness can reduce the risk of type 2 diabetes caused by genetic susceptibility.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Endocrinology & Metabolism
Julia Carrasco-Zanini, Maik Pietzner, Eleanor Wheeler, Nicola D. Kerrison, Claudia Langenberg, Nicholas J. Wareham
Summary: By combining omics biomarkers with clinical models, the predictive performance for type 2 diabetes can be significantly improved.
Article
Environmental Sciences
Chengyong Jia, Shiyang Zhang, Xu Cheng, Peiwen Li, Jun An, Xin Zhang, Wending Li, Yali Xu, Handong Yang, Tao Jing, Huan Guo, Meian He
Summary: A study found that higher circulating levels of OCP were independently associated with an increased risk of type 2 diabetes, with beta-BHC possibly being the major contributor. Genetic predisposition to T2D-related morbidity, such as visceral adiposity, should be considered when assessing the risk of T2D conferred by OCPs.
ENVIRONMENTAL POLLUTION
(2023)
Article
Endocrinology & Metabolism
Richard A. Oram, Seth A. Sharp, Catherine Pihoker, Lauric Ferrat, Giuseppina Imperatore, Adrienne Williams, Maria J. Redondo, Lynne Wagenknecht, Lawrence M. Dolan, Jean M. Lawrence, Michael N. Weedon, Ralph D'Agostino, William A. Hagopian, Jasmin Divers, Dana Dabelea
Summary: This study assessed the utility of genetic risk scores (GRS) in classifying diabetes type among racially/ethnically diverse youth. The results showed that GRS for type 1 diabetes (T1D) and type 2 diabetes (T2D) were strong independent predictors of etiologic type. Discrimination was similar across all racial/ethnic groups but score distribution varied. Clustering by combined genetic risk improved the prediction of diabetes type.
Article
Endocrinology & Metabolism
Kan Wang, Fariba Ahmadizar, Sven Geurts, Banafsheh Arshi, Jan A. Kors, Dimitris Rizopoulos, Eric J. G. Sijbrands, M. Arfan Ikram, Maryam Kavousi
Summary: This study examined the association between the longitudinal evolution of heart rate variability (HRV) and the development of type 2 diabetes (T2D). The results showed that an increase in heart rate and a decrease in HRV were independently associated with the incidence of T2D, especially among younger individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Yuanjue Wu, Mengyun Luo, Xiao Tan, Liangkai Chen
Summary: This study aimed to assess the long-term association between stair climbing and the incidence of type 2 diabetes (T2D) and evaluate modifications by genetic predisposition to T2D. The results showed that participants who regularly climbed stairs had a lower risk of incident T2D compared to those who reported no stair climbing. Additionally, among individuals with low genetic predisposition, those who climbed 110-150 steps/day appeared to have the lowest overall T2D risk.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Article
Endocrinology & Metabolism
Jia Liu, Lu Wang, Yun Qian, Qian Shen, Man Yang, Yunqiu Dong, Hai Chen, Zhijie Yang, Yaqi Liu, Xuan Cui, Hongxia Ma, Guangfu Jin
Summary: This study aimed to identify novel metabolic markers for future type 2 diabetes (T2D) risk in Han Chinese individuals and determine if the combined effect of metabolic and genetic markers improves prediction accuracy. The researchers found that abnormal levels of 5 metabolites were associated with increased future T2D risk. The genetic risk score (GRS) based on 20 single nucleotide polymorphisms (SNPs) was also significantly associated with T2D risk and improved prediction models when combined with metabolites and clinical factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Environmental Sciences
Fei Wang, Ying Zhang, Shiyang Zhang, Xu Han, Yue Wei, Huan Guo, Xiaomin Zhang, Handong Yang, Tangchun Wu, Meian He
Summary: This study found a U-shaped association between serum BPA levels and the risk of type 2 diabetes. Additionally, individuals with higher serum BPA levels and a genetic risk for diabetes had higher fasting plasma glucose levels and a higher risk of type 2 diabetes.
ENVIRONMENTAL POLLUTION
(2022)
Article
Public, Environmental & Occupational Health
Gertraud Maskarinec, Phyllis Ash Raquinio, Veronica W. Setiawan, Thomas Ernst, Adrian A. Franke, Steven D. Buchthal, John A. Shepherd, Lynne R. Wilkens, Unhee Lim, Loic Le Marchand
Summary: The study indicates that VAT score plays an important role in the onset of T2D, especially among older adults of Japanese ancestry. The VAT score in Japanese Americans is significantly associated with the incidence of T2D.
ANNALS OF EPIDEMIOLOGY
(2021)
Article
Endocrinology & Metabolism
Zhi-Hao Li, Pei-Dong Zhang, Qing Chen, Xiang Gao, Vincent C. H. Chung, Dong Shen, Xi-Ru Zhang, Wen-Fang Zhong, Qing-Mei Huang, Dan Liu, Pei-Liang Chen, Wei-Qi Song, Xian-Bo Wu, Virginia Byers Kraus, Chen Mao
Summary: This study found that unfavorable sleep and circadian patterns, high genetic risk, and incident type 2 diabetes risk are associated independently. Adhering to a healthy sleep and circadian pattern can reduce the risk of developing diabetes, which provides important implications for public health strategies.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Xuan Wang, Hao Ma, Minghao Kou, Rui Tang, Qiaochu Xue, Xiang Li, Timothy S. Harlan, Yoriko Heianza, Lu Qi
Summary: The study found an association between higher frequency of adding salt to foods and increased risk of type 2 diabetes (T2D). This association was partly mediated by body mass index and C-reactive protein.
MAYO CLINIC PROCEEDINGS
(2023)
Article
Endocrinology & Metabolism
Zhenhuang Zhuang, Xue Dong, Jinzhu Jia, Zhonghua Liu, Tao Huang, Lu Qi
Summary: This study found that a healthy sleep pattern is associated with a lower risk of type 2 diabetes mellitus (T2DM). They constructed a metabolomic signature consisting of 153 metabolites, which was strongly correlated with sleep pattern and inversely associated with T2DM risk. Mendelian randomization analysis further indicated a causal relationship between the metabolomic signature and incident T2DM.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Health Care Sciences & Services
Sara Sokooti, Wendy A. Dam, Tamas Szili-Torok, Jolein Gloerich, Alain J. van Gool, Adrian Post, Martin H. de Borst, Ron T. Gansevoort, Hiddo J. L. Heerspink, Robin P. F. Dullaart, Stephan J. L. Bakker
Summary: Fasting proinsulin levels can serve as a marker of beta-cell dysfunction and predict the development of type 2 diabetes. Hypertension and kidney dysfunction are closely associated with this relationship.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
John T. Walker, Diane C. Saunders, Vivek Rai, Hung-Hsin Chen, Peter Orchard, Chunhua Dai, Yasminye D. Pettway, Alexander L. Hopkirk, Conrad V. Reihsmann, Yicheng Tao, Simin Fan, Shristi Shrestha, Arushi Varshney, Lauren E. Petty, Jordan J. Wright, Christa Ventresca, Samir Agarwala, Radhika Aramandla, Greg Poffenberger, Regina Jenkins, Shaojun Mei, Nathaniel J. Hart, Sharon Phillips, Hakmook Kang, Dale L. Greiner, Leonard D. Shultz, Rita Bottino, Jie Liu, Jennifer E. Below, Stephen C. J. Parker, Alvin C. Powers, Marcela Brissova
Summary: Integration of multiomics data with functional analysis of pancreatic tissues from individuals with early-stage type 2 diabetes indicates that the genetic risk converges on RFX6, which regulates chromatin architecture at multiple risk loci.
Article
Endocrinology & Metabolism
Yimin Zhao, Yueying Li, Zhenhuang Zhuang, Zimin Song, Wenxiu Wang, Ninghao Huang, Xue Dong, Wendi Xiao, Jinzhu Jia, Zhonghua Liu, Duo Li, Tao Huang
Summary: This study found an association between cumulative social risks and incident type 2 diabetes. Adherence to a healthy lifestyle can reduce the risk of diabetes caused by social vulnerability. Genetic susceptibility and disadvantaged social status may interact synergistically, leading to additional risks for type 2 diabetes.
Article
Cardiac & Cardiovascular Systems
Jaffar Al-Sheikhli, Ian Patchett, Ven Gee Lim, Leeann Marshall, Will Foster, Michael Kuehl, Shamil Yusuf, Sandeep Panikker, Kiran Patel, Faizel Osman, Prithwish Banerjee, Nicolas Lellouche, Tarvinder Dhanjal
Summary: The feasibility study of using the DiamondTemp ablation (DTA) catheter system for ventricular tachycardia (VT) ablation in ischaemic cardiomyopathy (ICM) patients showed significant improvements in patient condition and clinical outcomes.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Article
Nutrition & Dietetics
Mahshid Dehghan, Andrew Mente, Sumathy Rangarajan, Viswanathan Mohan, Sumathi Swaminathan, Alvaro Avezum, Scott A. Lear, Annika Rosengren, Paul Poirier, Fernando Lanas, Patricio Lopez-Jaramillo, Biju Soman, Chuangshi Wang, Andres Orlandini, Noushin Mohammadifard, Khalid F. AlHabib, Jephat Chifamba, Afzal Hussein Yusufali, Romaina Iqbal, Rasha Khatib, Karen Yeates, Thandi Puoane, Yuksel Altuntas, Homer Uy Co, Sidong Li, Weida Liu, Katarzyna Zatonska, Rita Yusuf, Noorhassim Ismail, Victoria Miller, Salim Yusuf
Summary: This study found that higher intake of ultra-processed foods (UPFs) is associated with increased risk of mortality and cardiovascular disease (CVD) in a diverse multinational cohort. The results showed that a diet high in UPFs is related to higher risk of total mortality, cardiovascular mortality, and non-cardiovascular mortality, but not major CVD events.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Jannie Nielsen, Roopa Shivashankar, Solveig A. Cunningham, Dorairaj Prabhakaran, Nikhil Tandon, Viswanathan Mohan, Romaina Iqbal, K. M. Venkat Narayan, Mohammed K. Ali, Shivani Anil Patel
Summary: Little is known about couple concordance in chronic diseases in urban India and Pakistan. This study found a high concordance of chronic conditions among couples in these regions, especially in couples with higher socioeconomic status.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Review
Nutrition & Dietetics
Viswanathan Mohan, Vasudevan Sudha, Shanmugam Shobana, Rajagopal Gayathri, Kamala Krishnaswamy
Summary: The prevalence of diabetes is increasing rapidly globally, especially in India, where the urbanization and globalization have led to changes in dietary patterns and lifestyle factors that contribute to the diabetes epidemic. The consumption of processed refined grain staples, inadequate nutrient intake, unhealthy fats, and sedentary lifestyles are the main drivers of diabetes in India. This review discusses the quality and quantity of Indian diets and proposes strategies to address the diabetes epidemic, with potential implications for other developing nations in the South East Asian region.
JOURNAL OF NUTRITION
(2023)
Editorial Material
Genetics & Heredity
Michael Chong, Guillaume Pare
Summary: Current assessment and treatment of VTE do not fully consider genetic factors. Recent research highlights the significant role of common genetic variants in VTE risk, leading to the development of genetic predictors that surpass and complement clinical risk factors and genetic testing for monogenic thrombophilia.
Review
Nutrition & Dietetics
Claudia Sikorski, Shuling Yang, Rosain Stennett, Victoria Miller, Koon Teo, Sonia S. Anand, Guillaume Pare, Salim Yusuf, Mahshid Dehghan, Andrew Mente
Summary: The study aimed to examine trends in dietary energy, macronutrient, and food consumption in different geographic regions. The findings revealed significant regional variations in dietary trends.
Article
Multidisciplinary Sciences
Younghun Y. Han, Jinyoung J. Byun, Catherine Zhu, Ryan R. Sun, Julia Y. Roh, Heather Cordell, Hyun-Sung A. Lee, Vikram R. Shaw, Sung Wook Kang, Javad Razjouyan, Matthew A. Cooley, Manal M. Hassan, Katherine A. Siminovitch, Trine Folseraas, David Ellinghaus, Annika Bergquist, Simon M. Rushbrook, Andre Franke, Tom H. Karlsen, Konstantinos N. Lazaridis, Katherine A. McGlynn, Lewis R. Roberts, Christopher Amos, Christoph Schramm, David Shapiro, Elizabeth Goode
Summary: This study used multitrait joint analyses to explore the genetic contribution and correlations between various clinical and epidemiological traits associated with PSC. Several new risk loci and potential susceptibility genes such as MANBA and IRF5 were identified, and in silico drug screening provided candidate agents for further investigation of pharmacological effects in PSC.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Rosain N. Stennett, Kristi B. Adamo, Sonia S. Anand, Harpreet S. Bajaj, Shrikant Bangdiwala, Dipika Desai, Hertzel C. Gerstein, Sujane Kandasamy, Farah Khan, Scott A. Lear, Sarah D. McDonald, Tayler Pocsai, Paul Ritvo, Andrea Rogge, Karleen M. Schulze, Diana Sherifali, Jennifer C. Stearns, Gita Wahi, Natalie C. Williams, Michael A. Zulyniak, Russell J. de Souza
Summary: This study aims to evaluate the effectiveness and participant acceptability of a culturally tailored, personalised nutrition intervention on the glucose area under the curve in pregnant women of South Asian ancestry with gestational diabetes risk factors. A total of 190 South Asian pregnant women will be enrolled and randomly assigned to two groups to observe the changes in their glucose levels. Findings will be disseminated through scientific publications and community-orientated strategies.
Article
Medicine, General & Internal
Amelie Bonnefond, Ranjit Unnikrishnan, Alessandro Doria, Martine Vaxillaire, Rohit N. Kulkarni, Viswanathan Mohan, Vincenzo Trischitta, Philippe Froguel
Summary: Monogenic diabetes encompasses several clinical conditions characterized by early-onset diabetes, including neonatal diabetes, maturity-onset diabetes of the young (MODY) and diabetes-associated syndromes. It can be misdiagnosed as type 2 diabetes, and different genetic variations can lead to different forms of diabetes. Precision medicine approaches and next-generation sequencing have improved diagnosis and treatment options.
NATURE REVIEWS DISEASE PRIMERS
(2023)
Article
Medicine, General & Internal
Padmapritha Thamotharan, Seshadhri Srinivasan, Jothydev Kesavadev, Gopika Krishnan, Viswanathan Mohan, Subathra Seshadhri, Korkut Bekiroglu, Chiara Toffanin
Summary: This paper presents a human digital twin (HDT) framework for managing elderly type 2 diabetes (E-T2D) by exploiting patient-specific data and building personalized models. The HDT virtualizes the patient and updates virtual models simultaneously from measurements, providing deeper insights about the patient. The HDT helps improve time-in-range and reduces insulin infusion in E-T2D management.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Abhishek Vyas, Sundaresan Raman, Sagnik Sen, Kim Ramasamy, Ramachandran Rajalakshmi, Viswanathan Mohan, Rajiv Raman
Summary: This paper discusses the importance of using machine learning to investigate diabetic retinopathy (DR) and rank its risk factors by importance using different machine learning models. The study uses a dataset from four large population-based studies in India and applies various machine learning models to identify the most important risk factors and predict DR. The results show that glycosylated hemoglobin and systolic blood pressure are consistently ranked among the top risk factors for DR in all models.
Review
Health Policy & Services
Anne Kumurenzi, Julie Richardson, Lehana Thabane, Jeanne Kagwiza, Gerard Urimubenshi, Leah Hamilton, Jackie Bosch, Tiago Jesus
Summary: This study aimed to synthesize evidence on the effectiveness of community-level rehabilitation interventions delivered by non-professional community-level workers or informal caregivers to improve health outcomes for persons with physical impairments or disabilities. The current evidence on the effectiveness of delivering rehabilitation interventions by non-professional community-level workers and informal caregivers is inconclusive.
HUMAN RESOURCES FOR HEALTH
(2023)
Article
Multidisciplinary Sciences
Ravi Retnakaran, Jiajie Pu, Alexandra Emery, Stewart B. Harris, Sonja M. Reichert, Hertzel C. Gerstein, Natalia McInnes, Caroline K. Kramer, Bernard Zinman
Summary: Induction with short-term insulin therapy followed by maintenance with metformin can stabilize beta-cell function in early type 2 diabetes. The study found that initial reversibility of beta-cell dysfunction and preserved hepatic insulin sensitivity are associated with sustained stabilization of beta-cell function.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Liam Mc Morrow, Frauke Becker, Ruth L. Coleman, Hertzel C. Gerstein, Lars Ryden, Stefan Schoeder, Alastair M. Gray, Jose Leal, Rury R. Holman, ACE Study Grp
Summary: This study analyzed the use of acarbose in Chinese coronary heart disease patients with impaired glucose tolerance. The results showed that patients using acarbose had higher costs compared to placebo, but there was no significant difference in QALYs.
JOURNAL OF DIABETES
(2023)
Article
Clinical Neurology
Aristeidis H. Katsanos, Shun Fu Lee, Tali Cukierman-Yaffe, Laura Sherlock, Graciela Muniz-Terrera, Michele Canavan, Raed Joundi, Mukul Sharma, Ashkan Shoamanesh, Andrea Derix, Hertzel C. Gerstein, Salim Yusuf, Martin J. O'Donnell, Jackie Bosch, William N. Whiteley
Summary: A global variation in cognitive function and global function in older adults has been observed in this study. The estimated average scores of cognition differed significantly among different global regions. The proportion of participants with cognitive or functional impairment also varied across regions.
CEREBRAL CIRCULATION - COGNITION AND BEHAVIOR
(2023)