Journal
DIABETES CARE
Volume 35, Issue 10, Pages 1981-1985Publisher
AMER DIABETES ASSOC
DOI: 10.2337/dc12-0250
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- Isfahan University of Medical Sciences, Isfahan, Iran
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OBJECTIVE-To determine the effects of soy milk consumption compared with cow's milk on inflammation, coagulation, and oxidative stress among patients with diabetic nephropathy. RESEARCH DESIGN AND METHODS-This randomized, crossover clinical trial was conducted on 25 type 2 diabetic patients with nephropathy. This study had two trial phases, each for 4 weeks and one washout period for 2 weeks. Patients were randomly assigned to consume a diet containing soy milk or a diet containing cow's milk. RESULTS-Soy milk consumption resulted in a significant reduction in D-dimer level (percent change: -3.77 vs. 16.13%; P < 0.05). This significant effect remained even after adjusting For confounding factor (carbohydrate intake). However, soy milk consumption had no significant effects on tumor necrosis factor-alpha, interleukin-6, high-sensitivity C-reactive protein (hs-CRP), and malondialdehyde levels. The result was near to significance regarding the effect of soy milk consumption on hs-CRP (percent change: -35.45 vs. 36.76%; P = 0.05). However, this effect was not significant after adjusting for the confounding variable (carbohydrate intake). CONCLUSIONS-Soy milk consumption could decrease serum D-dimer level among type 2 diabetic patients with nephropathy. However, markers of inflammation and oxidative stress did not change following soy milk intake among these patients.
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