Article
Medicine, General & Internal
Martin Berger, Alexander Dressel, Marcus E. E. Kleber, Winfried Maerz, Peter Hellstern, Nikolaus Marx, Katharina Schuett
Summary: This explorative study evaluates platelet reactivity and factors that may modify it. Both high and low platelet reactivity are strong predictors of cardiovascular and all-cause mortality, equivalent to the presence of coronary artery disease. Glucose control, kidney function improvement, and lower inflammation are associated with reduced mortality risk, regardless of platelet reactivity. However, only patients with high platelet reactivity benefit from aspirin treatment, resulting in lower mortality.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Angela P. Moissl, Graciela E. Delgado, Bernhard K. Kraemer, Christine Dawczynski, Tatjana Stojakovic, Winfried Maerz, Marcus E. Kleber, Stefan Lorkowski
Summary: The study found significantly increased mortality in patients with high alcohol consumption, and reduced risk in low-volume drinkers; however, after adjusting for cardiovascular risk factors, the risk difference between abstainers and low-volume drinkers was no longer significant.
Article
Cardiac & Cardiovascular Systems
Takashi Saito, Hiroyuki Arashi, Junichi Yamaguchi, Fumiaki Mori, Hiroshi Ogawa, Nobuhisa Hagiwara
Summary: This study investigated the association between serum cystatin-C (Cys-C) levels and cardiovascular events in patients with acute coronary syndrome (ACS). The results showed that elevated Cys-C levels were associated with increased all-cause mortality but not with other cardiovascular events in ACS patients.
CARDIORENAL MEDICINE
(2022)
Article
Surgery
Marie Bodilsen Nielsen, Jonathan Nortoft Dahl, Rasmus Laursen, Bente Jespersen, Per Ivarsen, Simon Winther, Henrik Birn
Summary: Kidney failure is linked to a higher risk of cardiovascular disease and death. This retrospective study examined the relationship between risk factors, coronary artery calcium score (CACS), coronary computed tomography angiography (CTA), major adverse cardiovascular events (MACE), and all-cause mortality in kidney transplant candidates. The presence of multiple risk factors, high CACS, and significant artery stenosis were found to predict MACE and mortality. In a subgroup undergoing both CACS and CTA, these imaging techniques provided additional information for predicting MACE.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Nutrition & Dietetics
Pollyanna Patriota, Idris Guessous, Serge Rezzi, Pedro Marques-Vidal
Summary: This prospective population-based study found that vitamin D levels were inversely associated with cardiovascular disease (CVD) events, but not with CVD or overall mortality.
Article
Medicine, General & Internal
Arno R. Bourgonje, Margery A. Connelly, Harry van Goor, Peter R. van Dijk, Robin P. F. Dullaart
Summary: This study found that higher plasma citrate levels are associated with an increased risk of cardiovascular (CV) mortality in patients with type 2 diabetes (T2D), particularly in males. These findings suggest that citrate may play an important role in the pathogenesis of T2D-related vascular complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Hamid Ahmadirad, Farshad Teymoori, Ebrahim Mokhtari, Mitra Kazemi Jahromi, Mostafa Norouzzadeh, Saeed Tavakkoli, Tahere Shahrokhtabar, Hossein Farhadnejad, Parvin Mirmiran
Summary: Recently, researchers have focused on the serum C-peptide as a possible predictor of mortality, but the association between serum C-peptide and cardiovascular diseases (CVDs) mortality and all-cause mortality has not been clearly identified. This meta-analysis aimed to assess the relationship between serum C-peptide and the risk of CVDs mortality and all-cause mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Geriatrics & Gerontology
Jack Paterson, Michelle Trevenen, Keith Hill, Osvaldo P. Almeida, Bu B. Yeap, Jonathan Golledge, Graeme J. Hankey, Leon Flicker
Summary: This study found that poorer balance and strength performance are associated with future all-cause and cardiovascular mortality, and balance is equal to strength as a modifiable risk factor for cause-specific mortality.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Peripheral Vascular Disease
Kenan Toprak
Summary: This study found that C-peptide level is an independent predictor of CIN in patients with diabetes. Low levels of C-peptide are associated with a greater risk of CIN.
Review
Medicine, General & Internal
Wei Luo, Dan Xu, Jin Zhang, Yao Zhou, Qin Yang, Qiuju Lv, Zhen Qu
Summary: This study found that a decreased level of serum 25-hydroxyvitamin D (25-OHD) is associated with an increased risk of cardiovascular disease (CVD).
POSTGRADUATE MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Duke Appiah, Sujata Luitel, Chike C. Nwabuo, Imo Ebong, Stephen J. Winters
Summary: This study found that low levels of total E2 or FE2 were associated with an increased risk of CVD mortality in young and middle-aged men, particularly among non-Hispanic White men.
Article
Biochemistry & Molecular Biology
Timothy E. O'Toole, Xiaohong Li, Daniel W. Riggs, David J. Hoetker, Shahid P. Baba, Aruni Bhatnagar
Summary: The study found significant associations between nonconjugated carnosine and cardiovascular risk factors like hypertension and heart failure, while carnosine conjugates were significantly associated with diabetes and HDL levels. This suggests that carnosine and its conjugates may be informative biomarkers for assessing CVD risk, especially in relation to diabetes and skeletal muscle injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Xiaoling Zhang, Tong Tong, Andrew Chang, Ting Fang Alvin Ang, Qiushan Tao, Sanford Auerbach, Sherral Devine, Wei Qiao Qiu, Jesse Mez, Joseph Massaro, Kathryn L. Lunetta, Rhoda Au, Lindsay A. Farrer
Summary: This study found that an increase in high density lipoprotein (HDL) cholesterol levels was associated with a decreased risk of Alzheimer's disease (AD) in early and middle adulthood, while an increase in glucose levels in middle adulthood was associated with an increased risk of AD. These findings suggest that managing cholesterol and glucose from early adulthood can lower the risk of AD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Moritz Mirna, Alexander Lauten, Peter Jirak, Richard Rezar, Bernhard Wernly, Vera Paar, Thomas K. Felder, Uta C. Hoppe, Lukas J. Motloch, Christian Jung, Brunilda Alushi, Michael Lichtenauer, Hermann Salmhofer
Summary: The study found that serum levels of cFGF23 and iFGF23 were positively correlated with serum creatinine and inversely correlated with estimated glomerular filtration rate. cFGF23 was significantly associated with 1-year mortality in patients with eGFR >= 45ml/min/1.73m(2), suggesting it could be an individual risk factor for mortality in patients undergoing TAVR.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Biology
Nicholay Teodorovich, Gera Gandelman, Michael Jonas, Yakov Fabrikant, Michael Sraia Swissa, Sara Shimoni, Jacob George, Moshe Swissa
Summary: The CHA(2)DS(2)-VAS(C) score can be used to predict mortality in patients undergoing coronary angiography, and it has predictive value.
Article
Pharmacology & Pharmacy
Jorn F. Dopheide, Luise Adam, Sebastian Wiedmer, Mathias Kaspar, Gunther Silbernagel, Iris Baumgartner, Heinz Drexel
Summary: This study analyzed lipid-lowering therapy (LLT) in symptomatic PAD patients, finding that the majority of patients were on statin therapy, but there is still room for improvement. Patients with additional vascular region affected received more intensive treatment and had lower LDL-C levels.
CURRENT VASCULAR PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Vasiliki Lagou, Reedik Maegi, Jouke- Jan Hottenga, Harald Grallert, John R. B. Perry, Nabila Bouatia-Naji, Letizia Marullo, Denis Rybin, Rick Jansen, Josine L. Min, Antigone S. Dimas, Anna Ulrich, Liudmila Zudina, Jesper R. Gadin, Longda Jiang, Alessia Faggian, Amelie Bonnefond, Joao Fadista, Maria G. Stathopoulou, Aaron Isaacs, Sara M. Willems, Pau Navarro, Toshiko Tanaka, Anne U. Jackson, May E. Montasser, Jeff R. O'Connell, Lawrence F. Bielak, Rebecca J. Webster, Richa Saxena, Jeanette M. Stafford, Beate St Pourcain, Nicholas J. Timpson, Perttu Salo, So-Youn Shin, Najaf Amin, Albert V. Smith, Guo Li, Niek Verweij, Anuj Goel, Ian Ford, Paul C. D. Johnson, Toby Johnson, Karen Kapur, Gudmar Thorleifsson, Rona J. Strawbridge, Laura J. Rasmussen-Torvik, Tonu Esko, Evelin Mihailov, Tove Fall, Ross M. Fraser, Anubha Mahajan, Stavroula Kanoni, Vilmantas Giedraitis, Marcus E. Kleber, Guenther Silbernagel, Julia Meyer, Martina Mueller-Nurasyid, Andrea Ganna, Antti-Pekka Sarin, Loic Yengo, Dmitry Shungin, Jian'an Luan, Momoko Horikoshi, Ping An, Serena Sanna, Yvonne Boettcher, N. William Rayner, Ilja M. Nolte, Tatijana Zemunik, Erik van Iperen, Peter Kovacs, Nicholas D. Hastie, Sarah H. Wild, Stela McLachlan, Susan Campbell, Ozren Polasek, Olga Carlson, Josephine Egan, Wieland Kiess, Gonneke Willemsen, Johanna Kuusisto, Markku Laakso, Maria Dimitriou, Andrew A. Hicks, Rainer Rauramaa, Stefania Bandinelli, Barbara Thorand, Yongmei Liu, Iva Miljkovic, Lars Lind, Alex Doney, Markus Perola, Aroon Hingorani, Mika Kivimaki, Meena Kumari, Amanda J. Bennett, Christopher J. Groves, Christian Herder, Heikki A. Koistinen, Leena Kinnunen, Ulf de Faire, Stephan J. L. Bakker, Matti Uusitupa, Colin N. A. Palmer, J. Wouter Jukema, Naveed Sattar, Anneli Pouta, Harold Snieder, Eric Boerwinkle, James S. Pankow, Patrik K. Magnusson, Ulrika Krus, Chiara Scapoli, Eco J. C. N. de Geus, Matthias Blueher, Bruce H. R. Wolffenbuttel, Michael A. Province, Goncalo R. Abecasis, James B. Meigs, G. Kees Hovingh, Jaana Lindstroem, James F. Wilson, Alan F. Wright, George V. Dedoussis, Stefan R. Bornstein, Peter E. H. Schwarz, Anke Toenjes, Bernhard R. Winkelmann, Bernhard O. Boehm, Winfried Maerz, Andres Metspalu, Jackie F. Price, Panos Deloukas, Antje Koerner, Timo A. Lakka, Sirkka M. Keinanen-Kiukaanniemi, Timo E. Saaristo, Richard N. Bergman, Jaakko Tuomilehto, Nicholas J. Wareham, Claudia Langenberg, Satu Maennistoe, Paul W. Franks, Caroline Hayward, Veronique Vitart, Jaakko Kaprio, Sophie Visvikis-Siest, Beverley Balkau, David Altshuler, Igor Rudan, Michael Stumvoll, Harry Campbell, Cornelia M. van Duijn, Christian Gieger, Thomas Illig, Luigi Ferrucci, Nancy L. Pedersen, Peter P. Pramstaller, Michael Boehnke, Timothy M. Frayling, Alan R. Shuldiner, Patricia A. Peyser, Sharon L. R. Kardia, Lyle J. Palmer, Brenda W. Penninx, Pierre Meneton, Tamara B. Harris, Gerjan Navis, Pim van der Harst, George Davey Smith, Nita G. Forouhi, Ruth J. F. Loos, Veikko Salomaa, Nicole Soranzo, Dorret I. Boomsma, Leif Groop, Tiinamaija Tuomi, Albert Hofman, Patricia B. Munroe, Vilmundur Gudnason, David S. Siscovick, Hugh Watkins, Cecile Lecoeur, Peter Vollenweider, Anders Franco-Cereceda, Per Eriksson, Marjo-Riitta Jarvelin, Kari Stefansson, Anders Hamsten, George Nicholson, Fredrik Karpe, Emmanouil T. Dermitzakis, Cecilia M. Lindgren, Mark I. McCarthy, Philippe Froguel, Marika A. Kaakinen, Valeriya Lyssenko, Richard M. Watanabe, Erik Ingelsson, Jose C. Florez, Josee Dupuis, Ines Barroso, Andrew P. Morris, Inga Prokopenko
Summary: Sex differences play a role in genetic effects on fasting glucose and insulin levels, with a sex dimorphism in allelic effects on fasting insulin and sex-homogeneous effects on fasting glucose. In addition, there are stronger genetic correlations between fasting insulin and waist-to-hip ratio/anorexia nervosa in women, and waist-to-hip ratio is causally related to insulin resistance in women but not in men. These findings highlight the importance of understanding metabolic and glycemic health sex dimorphism in exploring genetic effects in related phenotypes between women and men.
NATURE COMMUNICATIONS
(2021)
Review
Ophthalmology
Laura Posch-Pertl, Monja Michelitsch, Gernot Wagner, Brigitte Wildner, Guenther Silbernagel, Gudrun Pregartner, Andreas Wedrich
Summary: The study indicated that patients with glaucoma showed significantly higher total cholesterol levels and lower HDL levels compared to those without glaucoma. Although LDL levels were slightly higher in patients with glaucoma, the difference was not significant.
ACTA OPHTHALMOLOGICA
(2022)
Correction
Multidisciplinary Sciences
Vasiliki Lagou, Reedik Magi, Jouke-Jan Hottenga, Harald Grallert, John R. B. Perry, Nabila Bouatia-Naji, Letizia Marullo, Denis Rybin, Rick Jansen, Josine L. Min, Antigone S. Dimas, Anna Ulrich, Liudmila Zudina, Jesper R. Gadin, Longda Jiang, Alessia Faggian, Amelie Bonnefond, Joao Fadista, Maria G. Stathopoulou, Aaron Isaacs, Sara M. Willems, Pau Navarro, Toshiko Tanaka, Anne U. Jackson, May E. Montasser, Jeff R. O'Connell, Lawrence F. Bielak, Rebecca J. Webster, Richa Saxena, Jeanette M. Stafford, Beate St Pourcain, Nicholas J. Timpson, Perttu Salo, So-Youn Shin, Najaf Amin, Albert V. Smith, Guo Li, Niek Verweij, Anuj Goel, Ian Ford, Paul C. D. Johnson, Toby Johnson, Karen Kapur, Gudmar Thorleifsson, Rona J. Strawbridge, Laura J. Rasmussen-Torvik, Tonu Esko, Evelin Mihailov, Tove Fall, Ross M. Fraser, Anubha Mahajan, Stavroula Kanoni, Vilmantas Giedraitis, Marcus E. Kleber, Guenther Silbernagel, Julia Meyer, Martina Mueller-Nurasyid, Andrea Ganna, Antti-Pekka Sarin, Loic Yengo, Dmitry Shungin, Jian'an Luan, Momoko Horikoshi, Ping An, Serena Sanna, Yvonne Boettcher, N. William Rayner, Ilja M. Nolte, Tatijana Zemunik, Erik van Iperen, Peter Kovacs, Nicholas D. Hastie, Sarah H. Wild, Stela McLachlan, Susan Campbell, Ozren Polasek, Olga Carlson, Josephine Egan, Wieland Kiess, Gonneke Willemsen, Johanna Kuusisto, Markku Laakso, Maria Dimitriou, Andrew A. Hicks, Rainer Rauramaa, Stefania Bandinelli, Barbara Thorand, Yongmei Liu, Iva Miljkovic, Lars Lind, Alex Doney, Markus Perola, Aroon Hingorani, Mika Kivimaki, Meena Kumari, Amanda J. Bennett, Christopher J. Groves, Christian Herder, Heikki A. Koistinen, Leena Kinnunen, Ulf de Faire, Stephan J. L. Bakker, Matti Uusitupa, Colin N. A. Palmer, J. Wouter Jukema, Naveed Sattar, Anneli Pouta, Harold Snieder, Eric Boerwinkle, James S. Pankow, Patrik K. Magnusson, Ulrika Krus, Chiara Scapoli, Eco J. C. N. de Geus, Matthias Blueher, Bruce H. R. Wolffenbuttel, Michael A. Province, Goncalo R. Abecasis, James B. Meigs, G. Kees Hovingh, Jaana Lindstroem, James F. Wilson, Alan F. Wright, George V. Dedoussis, Stefan R. Bornstein, Peter E. H. Schwarz, Anke Toenjes, Bernhard R. Winkelmann, Bernhard O. Boehm, Winfried Maerz, Andres Metspalu, Jackie F. Price, Panos Deloukas, Antje Koerner, Timo A. Lakka, Sirkka M. Keinanen-Kiukaanniemi, Timo E. Saaristo, Richard N. Bergman, Jaakko Tuomilehto, Nicholas J. Wareham, Claudia Langenberg, Satu Mannisto, Paul W. Franks, Caroline Hayward, Veronique Vitart, Jaakko Kaprio, Sophie Visvikis-Siest, Beverley Balkau, David Altshuler, Igor Rudan, Michael Stumvoll, Harry Campbell, Cornelia M. van Duijn, Christian Gieger, Thomas Illig, Luigi Ferrucci, Nancy L. Pedersen, Peter P. Pramstaller, Michael Boehnke, Timothy M. Frayling, Alan R. Shuldiner, Patricia A. Peyser, Sharon L. R. Kardia, Lyle J. Palmer, Brenda W. Penninx, Pierre Meneton, Tamara B. Harris, Gerjan Navis, Pim van der Harst, George Davey Smith, Nita G. Forouhi, Ruth J. F. Loos, Veikko Salomaa, Nicole Soranzo, Dorret I. Boomsma, Leif Groop, Tiinamaija Tuomi, Albert Hofman, Patricia B. Munroe, Vilmundur Gudnason, David S. Siscovick, Hugh Watkins, Cecile Lecoeur, Peter Vollenweider, Anders Franco-Cereceda, Per Eriksson, Marjo-Riitta Jarvelin, Kari Stefansson, Anders Hamsten, George Nicholson, Fredrik Karpe, Emmanouil T. Dermitzakis, Cecilia M. Lindgren, Mark I. McCarthy, Philippe Froguel, Marika A. Kaakinen, Valeriya Lyssenko, Richard M. Watanabe, Erik Ingelsson, Jose C. Florez, Josee Dupuis, Ines Barroso, Andrew P. Morris, Inga Prokopenko
Summary: The translation article points out an error in this paper and provides a correction link.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Lingyao Zeng, Sylvain Moser, Nazanin Mirza-Schreiber, Claudia Lamina, Stefan Coassin, Christopher P. Nelson, Tarmo Annilo, Oscar Franzen, Marcus E. Kleber, Salome Mack, Till F. M. Andlauer, Beibei Jiang, Barbara Stiller, Ling Li, Christina Willenborg, Matthias Munz, Thorsten Kessler, Adnan Kastrati, Karl-Ludwig Laugwitz, Jeanette Erdmann, Susanne Moebus, Markus M. Noethen, Annette Peters, Konstantin Strauch, Martina Mueller-Nurasyid, Christian Gieger, Thomas Meitinger, Elisabeth Steinhagen-Thiessen, Winfried Maerz, Andres Metspalu, Johan L. M. Bjoerkegren, Nilesh J. Samani, Florian Kronenberg, Bertram Mueller-Myhsok, Heribert Schunkert
Summary: This study attempts to identify non-additive genetic effects associated with CAD, specifically epistatic interactions. A SNP pair located in cis at the LPA locus was found to be jointly associated with risk for CAD, peripheral arterial disease, aortic stenosis, hepatic lipoprotein(a) levels, and Lp(a) serum levels, while individual SNPs displayed no association. Further exploration revealed a strong dependency on a rare variant influencing risk through additive genetic as well as epistatic effects.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Stefan J. Schunk, Marcus E. Kleber, Winfried Maerz, Shichao Pang, Stephen Zewinger, Sarah Triem, Philipp Ege, Matthias C. Reichert, Marcin Krawczyk, Susanne N. Weber, Isabella Jaumann, David Schmit, Tamim Sarakpi, Stefan Wagenpfeil, Rafael Kramann, Eric Boerwinkle, Christie M. Ballantyne, Megan L. Grove, Vinicius Tragante, Anna P. Pilbrow, A. Mark Richards, Vicky A. Cameron, Robert N. Doughty, Marie-Pierre Dube, Jean-Claude Tardif, Yassamin Feroz-Zada, Maxine Sun, Chang Liu, Yi-An Ko, Arshed A. Quyyumi, Jaana A. Hartiala, W. H. Wilson Tang, Stanley L. Hazen, Hooman Allayee, Caitrin W. McDonough, Yan Gong, Rhonda M. Cooper-DeHoff, Julie A. Johnson, Markus Scholz, Andrej Teren, Ralph Burkhardt, Andreas Martinsson, J. Gustav Smith, Lars Wallentin, Stefan K. James, Niclas Eriksson, Harvey White, Claes Held, Dawn Waterworth, Stella Trompet, J. Wouter Jukema, Ian Ford, David J. Stott, Naveed Sattar, Sharon Cresci, John A. Spertus, Hannah Campbell, Sascha Tierling, Joern Walter, Emmanuel Ampofo, Barbara A. Niemeyer, Peter Lipp, Heribert Schunkert, Michael Boehm, Wolfgang Koenig, Danilo Fliser, Ulrich Laufs, Thimoteus Speer
Summary: The NLRP3 intronic variant rs10754555 is associated with increased systemic inflammation, inflammasome activation, prevalent coronary artery disease, and mortality. This study provides evidence for a substantial role of genetically driven systemic inflammation in CVD and highlights the NLRP3 inflammasome as a therapeutic target.
EUROPEAN HEART JOURNAL
(2021)
Letter
Cardiac & Cardiovascular Systems
Mika Hilvo, Mitja Laaperi, Antti Jylhae, Marcus E. Kleber, Reini Hurme, Hubert Scharnagl, Winfried Maerz, Juha Sinisalo, Reijo Laaksonen
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Markus Scholz, Katrin Horn, Janne Pott, Arnd Gross, Marcus E. Kleber, Graciela E. Delgado, Pashupati Prasad Mishra, Holger Kirsten, Christian Gieger, Martina Muller-Nurasyid, Anke Tonjes, Peter Kovacs, Terho Lehtimaki, Olli Raitakari, Mika Kahonen, Helena Gylling, Ronny Baber, Berend Isermann, Michael Stumvoll, Markus Loeffler, Winfried Marz, Thomas Meitinger, Annette Peters, Joachim Thiery, Daniel Teupser, Uta Ceglarek
Summary: Phytosterol serum concentrations are genetically controlled and have a controversial relationship with coronary artery disease. Genome-wide analyses identify multiple genetic loci associated with phytosterol traits and demonstrate a causal relationship between sitosterol concentrations and coronary artery disease.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Thomas Metzner, Deborah R. Leitner, Gudrun Dimsity, Felix Gunzer, Peter Opriessnig, Karin Mellitzer, Andrea Beck, Harald Sourij, Tatjana Stojakovic, Hannes Deutschmann, Winfried Maerz, Ulf Landmesser, Marianne Brodmann, Gernot Reishofer, Hubert Scharnagl, Hermann Toplak, Guenther Silbernagel
Summary: The study investigated the short-term effects of alirocumab on vascular function using non-invasive methods. The results showed that significant effects of short-term alirocumab treatment on vascular function were not detectable. Further research is needed to evaluate the potential value of carotid fractional anisotropy in clinical atherosclerosis research.
Article
Biochemistry & Molecular Biology
Thomas Metzner, Deborah R. Leitner, Karin Mellitzer, Andrea Beck, Harald Sourij, Tatjana Stojakovic, Gernot Reishofer, Winfried Maerz, Ulf Landmesser, Hubert Scharnagl, Hermann Toplak, Guenther Silbernagel
Summary: The effects of alirocumab on triglyceride metabolism were not significant in the ALIROCKS trial. The total circulating PCSK9 concentration may serve as a useful biomarker to differentiate non-adherence from non-response to PCSK9 antibodies.
Correction
Multidisciplinary Sciences
Markus Scholz, Katrin Horn, Janne Pott, Arnd Gross, Marcus E. Kleber, Graciela E. Delgado, Pashupati Prasad Mishra, Holger Kirsten, Christian Gieger, Martina Muller-Nurasyid, Anke Tonjes, Peter Kovacs, Terho Lehtimaki, Olli Raitakari, Mika Kahonen, Helena Gylling, Ronny Baber, Berend Isermann, Michael Stumvoll, Markus Loeffler, Winfried Marz, Thomas Meitinger, Annette Peters, Joachim Thiery, Daniel Teupser, Uta Ceglarek
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Yong Li, Yurong Cheng, Francesco Consolato, Guglielmo Schiano, Michael R. Chong, Maik Pietzner, Ngoc Quynh H. Nguyen, Nora Scherer, Mary L. Biggs, Marcus E. Kleber, Stefan Haug, Burulca Goecmen, Marie Pigeyre, Peggy Sekula, Inga Steinbrenner, Pascal Schlosser, Christina B. Joseph, Jennifer A. Brody, Morgan E. Grams, Caroline Hayward, Ulla T. Schultheiss, Bernhard K. Kraemer, Florian Kronenberg, Annette Peters, Jochen Seissler, Dominik Steubl, Cornelia Then, Matthias Wuttke, Winfried Maerz, Kai-Uwe Eckardt, Christian Gieger, Eric Boerwinkle, Bruce M. Psaty, Josef Coresh, Peter J. Oefner, Guillaume Pare, Claudia Langenberg, Jurgen E. Scherberich, Bing Yu, Shreeram Akilesh, Olivier Devuyst, Luca Rampoldi, Anna Koettgen
Summary: Uromodulin (UMOD) is a major risk gene for kidney disease and is highly abundant in urine. This study identified genetic variants associated with circulating uromodulin and found an upstream variant in the UMOD locus that affects its synthesis in kidney cells. The study also found shared association patterns between UMOD and complex traits like chronic kidney disease. Furthermore, the study revealed the role of glycan marks and their enzymes and receptors in uromodulin glycosylation.
Article
Multidisciplinary Sciences
Angela P. Moissl, Graciela E. Delgado, Bernhard K. Kramer, Christine Dawczynski, Tatjana Stojakovic, Winfried Marz, Marcus E. Kleber, Stefan Lorkowski
Summary: This Data in Brief article provides additional sensitivity analysis data for the article Alcohol consumption and mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. The data collected from participants in the LURIC study were used to calculate alcohol consumption in grams of ethanol per day. The results are presented by gender and replicated using different classification criteria. Additionally, the analysis presents alcohol consumption data for smokers and non-smokers separately.
Article
Cardiac & Cardiovascular Systems
Guenther Silbernagel, Yan Q. Chen, Martin Rief, Marcus E. Kleber, Michael M. Hoffmann, Tatjana Stojakovic, Andreas Stang, Mark A. Sarzynski, Claude Bouchard, Winfried Maerz, Yue-Wei Qian, Hubert Scharnagl, Robert J. Konrad
Summary: Apolipoprotein C-II (ApoC-II) has an inverse J-shaped relationship with cardiovascular mortality, with the lowest risk observed in the middle quintile. Increasing low circulating ApoC-II levels may reduce cardiovascular risk.
EUROPEAN HEART JOURNAL
(2023)
Article
Substance Abuse
Graciela E. Delgado, Bernhard K. Kraemer, Winfried Maerz, Peter Hellstern, Marcus E. Kleber, Jan Leipe
Summary: Smoking leads to inflammation and changes in levels of leukocyte subtypes, which are associated with cardiovascular disease. Lymphocyte counts were inversely associated with mortality in never-smokers, but not in active smokers. Adding markers of immune function improved risk prediction in never-smokers only.
NICOTINE & TOBACCO RESEARCH
(2021)