Article
Gastroenterology & Hepatology
Dong Hyun Sinn, Danbee Kang, Sung Chul Choi, Yun Soo Hong, Di Zhao, Eliseo Guallar, Yewan Park, Juhee Cho, Geum-Youn Gwak
Summary: The clinical implications of nonalcoholic fatty liver disease (NAFLD) in subjects who fulfill the diagnostic criteria of metabolic (dysfunction)-associated fatty liver disease (MAFLD) are unknown.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Catalina M. Mascaro, Cristina Bouzas, Sofia Montemayor, Miguel Casares, Cristina Gomez, Lucia Ugarriza, Pere-Antoni Borras, Jose Alfredo Martinez, Josep A. Tur
Summary: MetS patients with high PA showed a more positive relationship in NAFLD, MetS parameters, and liver profile (ALT, GGT, IFC-NMR) compared to those with low PA, but not for AST. The difference between calories ingested and expended influenced this relationship.
Article
Endocrinology & Metabolism
Min Tang, Xiao-Hui Wei, Han Cao, Qin Zhen, Fang Liu, Yu-Fan Wang, Neng-Guang Fan, Yong-De Peng
Summary: The study aimed to investigate the correlation between the Chinese visceral adiposity index (CVAI) and metabolic-associated fatty liver disease (MAFLD) in Chinese adults with type 2 diabetes mellitus (T2DM). The results showed that CVAI was positively correlated with MAFLD, suggesting that it could be used as a diagnostic indicator for MAFLD in clinical practice for T2DM patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Emir Muzurovic, Dimitri P. Mikhailidis, Christos Mantzoros
Summary: NAFLD is closely related to insulin resistance, metabolic syndrome, and cardiovascular disease risk, but its independent impact on the development of cardiovascular disease remains controversial.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Endocrinology & Metabolism
Wei Li, Yan Wang, Shengrong Ouyang, Mengdi Li, Rui Liu, Yuqi Zhang, Xiaojun Liu, Tianfang Li, Shengyun Liu
Summary: In patients with type 2 diabetes mellitus, elevated serum uric acid levels are closely associated with metabolic syndrome and its components, but not with carotid atherosclerosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Georgia Anastasiou, Evangelos Liberopoulos, Ermioni Petkou, Amalia Despoina Koutsogianni, Petros Spyridwnas Adamidis, George Liamis, Evangelia Ntzani, Fotios Barkas
Summary: The fatty liver index (FLI) is significantly and independently associated with the risk of new-onset type 2 diabetes (T2D) in patients initiating statin therapy.
Article
Medicine, General & Internal
Chenxi Wang, Zhensheng Cai, Xia Deng, Haoxiang Li, Zhicong Zhao, Chang Guo, Panpan Zhang, Lian Li, Tian Gu, Ling Yang, Li Zhao, Dong Wang, Guoyue Yuan
Summary: The study found that HSI and FLI are independently correlated with carotid atherosclerosis in patients with type 2 diabetes mellitus. Increasing values of HSI and FLI were significantly associated with CIMT across different age and hypertension categories. These indices may serve as simple and useful markers for evaluating the progression of diabetic macrovascular complications.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Alessandro Mantovani, Alessandro Csermely, Antonio Taverna, Davide Cappelli, Giovanni Benfari, Stefano Bonapace, Christopher D. Byrne, Giovanni Targher
Summary: The presence and severity of metabolic dysfunction-associated fatty liver disease (MAFLD) is strongly associated with an increased risk of supraventricular and ventricular tachyarrhythmias in patients with type 2 diabetes mellitus (T2DM), especially in those with severe fibrosis indicated by FIB-4 index.
DIABETES & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Jaehyun Bae, Byung-Wan Lee
Summary: This review examines previous studies on the association between ketogenesis and MAFLD, and reviews candidate mechanisms that can explain this association.
Article
Immunology
Eleana Bolla, Nikolaos Tentolouris, Petros P. Sfikakis, Maria G. Tektonidou
Summary: This study aimed to evaluate the prevalence of Metabolic Syndrome (MetS) in antiphospholipid syndrome (APS) patients and its associations with cardiovascular risk biomarkers, physical activity, and subclinical atherosclerosis. The results showed that MetS was present in approximately one-fourth of APS patients and was associated with arterial thrombosis, cardiovascular risk biomarkers, physical activity, and subclinical atherosclerosis. This suggests that MetS plays an important role in cardiovascular risk stratification and management in APS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yasuhiro Matsubayashi, Kazuya Fujihara, Mayuko Yamada-Harada, Yurie Mitsuma, Takaaki Sato, Yuta Yaguchi, Taeko Osawa, Masahiko Yamamoto, Masaru Kitazawa, Takaho Yamada, Satoru Kodama, Hirohito Sone
Summary: This study examines the impact of metabolic syndrome (MetS) and/or metabolic dysfunction-associated fatty liver disease (MAFLD) on the development of cardiovascular disease. The findings suggest that accurately identifying patients with these conditions can help in predicting the risk of cardiovascular disease, especially in the presence of type 2 diabetes and by considering gender differences.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Timothy M. E. Davis
Summary: MAFLD is a relatively novel classification that emphasizes the importance of metabolic risk factors in the progression of NAFLD-associated pathology, including in patients with T2D and higher hepatic fat content. This review assesses contemporary methods for quantifying liver fat and fibrosis, with a focus on prognostic implications and interventions for T2D patients. Discussions also include changing epidemiology of obesity and cardiovascular disease, as well as new therapies for MAFLD with potential implications for T2D.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Review
Endocrinology & Metabolism
Chen Liang, Zhiyuan Yu, Li Bai, Wei Hou, Shan Tang, Wei Zhang, Xinyue Chen, Zhongjie Hu, Zhongping Duan, Sujun Zheng
Summary: This study evaluated the association between serum bilirubin levels and metabolic syndrome (MetS) and non-alcoholic fatty liver disease (NAFLD). The results showed an inverse correlation between serum total bilirubin (TBIL) and direct bilirubin (DBIL) levels with MetS in healthy population. Serum indirect bilirubin (IBIL) levels were inversely associated with the onset and degree of non-alcoholic steatohepatitis (NASH) in NAFLD patients. Exogenous bilirubin supplement may be a potential strategy to lower the risk of developing MetS and NAFLD.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Da Hea Seo, Yongin Cho, Seongha Seo, Seong Hee Ahn, Seongbin Hong, Kyung Hwa Ha, Jee-Seon Shim, Hyeon Chang Kim, Dae Jung Kim, So Hun Kim
Summary: We found no significant association between metabolically healthy obesity and subclinical atherosclerosis in patients without previous cardiovascular disease, suggesting that metabolic health may not play a role in the development of early stage atherosclerosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Marzena Jabczyk, Justyna Nowak, Bartosz Hudzik, Barbara Zubelewicz-Szkodzinska
Summary: Recent epidemiological studies suggest a connection between metabolic disorders and nutrition, indicating that a healthy diet rich in polyphenols could be beneficial in treating metabolic diseases. Curcumin, a polyphenol found in turmeric, has various health benefits, including antioxidant, anti-inflammatory, hepatoprotective, anti-atherosclerotic, and antidiabetic properties, which can help improve metabolic parameters in selected metabolic disorders.
Review
Cardiac & Cardiovascular Systems
Abraham S. Arellano-Buendia, Juan G. Juarez-Rojas, Fernando E. Garcia-Arroyo, Laura G. Sanchez-Lozada, Horacio Osorio-Alonso
Summary: Cardiovascular diseases (CVD) affect blood vessels, heart, and heart rate, with high treatment costs. Multiple treatments have not addressed the fact that CVD remains a leading cause of death, necessitating combination drug therapy. Allicin has shown potential in treating CVD by regulating signaling pathways and risk factors.
ARCHIVOS DE CARDIOLOGIA DE MEXICO
(2022)
Review
Biochemistry & Molecular Biology
Jose L. Sanchez-Gloria, Abraham S. Arellano-Buendia, Juan G. Juarez-Rojas, Fernando E. Garcia-Arroyo, Raul Arguello-Garcia, Fausto Sanchez-Munoz, Laura G. Sanchez-Lozada, Horacio Osorio-Alonso
Summary: Cardiovascular diseases are a group of diseases that can be treated with allicin, a sulfur compound derived from garlic, to regulate cellular mechanisms and signaling pathways and improve cardiovascular risk factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
F. D. Martinez-Sanchez, A. X. Medina-Urrutia, E. Jorge-Galarza, M. Del Rocio Martinez-Alvarado, J. Reyes-Barrera, H. Osorio-Alonso, A. S. Arellano-Buendia, M. Del Carmen Gonzalez-Salazar, R. Posadas-Sanchez, G. Vargas-Alarcon, C. Posadas-Romero, J. G. Juarez-Rojas
Summary: This study aimed to analyze the composite control of blood pressure, lipids, and glucose in patients with premature coronary artery disease (CAD). The study found that achieving control targets for blood lipids, blood pressure, and blood glucose significantly reduced the risk of recurrent major adverse cardiovascular events (MACE).
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Anthropology
Juan Reyes-Barrera, Aida X. Medina-Urrutia, Horacio Osorio-Alonso, Esteban Jorge-Galarza, Gabriela Olvera-Mayorga, Nestor A. Sanchez-Ortiz, Abraham S. Arellano-Buendia, Jose E. Marquez-Garcia, Felipe Santibanez-Escobar, Elizabeth Perez-Rodriguez, Margarita Torres-Tamayo, Omar Granados-Portillo, Ivan Torre-Villalvazo, Juan G. Juarez-Rojas
Summary: This study investigated the association of EPA and DHA with PAI-1 and resistin, as well as their impact on glucose metabolism in apparently healthy individuals. The results showed that EPA and DHA can modulate glucose metabolism across different functional states of adipose tissue, and this association is independent of other metabolic risk factors.
ANNALS OF HUMAN BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jose L. Sanchez-Gloria, Karla M. Rada, Juan G. Juarez-Rojas, Laura G. Sanchez-Lozada, Ivan Rubio-Gayosso, Fausto Sanchez-Munoz, Horacio Osorio-Alonso
Summary: This article reviews the biological properties of sulfur compounds in garlic for the treatment of asthma. Studies have shown that garlic compounds may have potential therapeutic effects on asthma by modulating inflammation and oxidative stress, as well as exhibiting antibiotic and antiviral activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Luis M. Amezcua-Guerra, Fernanda Espinosa-Bautista, Karen Hopf-Estandia, Melisa Valdivieso-Ruiz, Dania Coronel, Sandra Robledo, Varna Ramos-Rosillo, Maria del Rocio Martinez-Alvarado, Mariana Patlan, Araceli Paez, Luis H. Silveira, Claudia Tavera-Alonso, Felipe Masso, Carina Soto-Fajardo, Carlos Pineda
Summary: This study characterized CD4(+)CD28(null) cells in patients with chronic hyperuricemia and investigated the effect of allopurinol on CD28 expression and the balance of T helper phenotypes. The results showed that hyperuricemic patients had an expanded CD4(+)CD28(null) cell subset with an increase in T-bet(+) cells and a decrease in ROR?t(+) cells. After allopurinol treatment, CD4(+)CD28(null) cells decreased, T-bet(+) cells decreased, GATA-3(+) cells increased, and ROR?t(+) cells increased. These findings suggest that allopurinol partially restores CD28 expression and rebalances T helper phenotypes in chronic hyperuricemia patients.
CLINICAL RHEUMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yazmin Estela Torres-Paz, Ricardo Gamboa, Giovanny Fuentevilla-Alvarez, Maria Elena Soto, Nadia Gonzalez-Moyotl, Rocio Martinez-Alvarado, Margarita Torres-Tamayo, Edgar Samuel Ramirez-Marroquin, Xicotencatl Vasquez-Jimenez, Victor Sainz-Escarrega, Claudia Huesca-Gomez
Summary: This study investigated the expression and role of microRNAs (miRs) in monocytes in coronary arterial disease (CAD). The results showed that miR-21-5p and miR-221-5p were significantly upregulated in CAD patients, while miR-155-5p was significantly downregulated. Furthermore, the upregulation of miR-21-5p and miR-221-5p was associated with an increased risk of CAD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
J. Antonio G. Gonzalez-Hermosillo G, Esteban Jorge Galarza, Onasis Vicente Fermin, Jose Manuel Nunez Gonzales, Lucia Mariel Felix Alvarez Tostado, Marco Antonio Estrada Lozano, Claudia Ruiz Rabasa, Maria del Rocio Martinez Alvarado
Summary: This study investigated the effect of COVID-19 on blood pressure during the orthostatic challenge after recovery. It found that about one-third of PASC patients had abnormal blood pressure responses during the challenge, which supports the hypothesis of neurogenic hypertension as a phenotype.
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
(2023)
Article
Multidisciplinary Sciences
Abraham Said Arellano Buendia, Juan Gabriel Juarez Rojas, Fernando Garcia-Arroyo, Omar Emiliano Aparicio Trejo, Fausto Sanchez-Munoz, Raul Arguello-Garcia, Laura Gabriela Sanchez-Lozada, Rafael Bojalil, Horacio Osorio-Alonso
Summary: This study found that allicin has antioxidant and anti-inflammatory effects on metabolic syndrome, reducing systemic and renal inflammation as well as oxidative stress. These findings suggest that allicin may be a therapeutic option for kidney injury caused by metabolic syndrome risk factors.
Article
Nutrition & Dietetics
Aida Medina-Urrutia, Esteban Jorge-Galarza, Mohammed El Hafidi, Juan Reyes-Barrera, Araceli Paez-Arenas, Felipe A. Masso-Rojas, Froylan D. Martinez-Sanchez, Angel R. Lopez-Uribe, Maria del Carmen Gonzalez-Salazar, Margarita Torres-Tamayo, Juan Gabriel Juarez-Rojas
Summary: This study aims to analyze the effect of chia seed supplementation on glucose metabolism, adipose tissue inflammation, and endothelial function in patients with NAFLD and early stages of diabetes. The results showed that a chia-supplemented diet can promote a healthier adipose tissue and improve pancreatic beta-cell and endothelial function.
NUTRICION HOSPITALARIA
(2022)
Article
Endocrinology & Metabolism
Juan Reyes-Barrera, Victor H. Sainz-Escarrega, Aida X. Medina-Urritia, Esteban Jorge-Galarza, Horacio Osorio-Alonso, Margarita Torres-Tamayo, Gabriela Leal-Escobar, Carlos Posadas-Romero, Ivan Torre-Villalvazo, Juan G. Juarez-Rojas
Summary: This study establishes a dysfunctional adiposity index (DAI) as an early predictor of cardiometabolic abnormalities, independently associated with diseases such as diabetes, non-alcoholic fatty liver disease, subclinical atherosclerosis, and hypertension. By evaluating adipocyte morphology and functionality, and correlating with parameters such as adipocyte mean area, number, and adiponectin/leptin ratio, DAI provides a method for early identification of adipose tissue abnormalities.
