Article
Medicine, General & Internal
Maria Narres, Tatjana Kvitkina, Heiner Claessen, Ellen Ubach, Georg Wolff, Maria-Inti Metzendorf, Bernd Richter, Andrea Icks
Summary: This study aims to analyze the incidence of AMI in people with and without diabetes and investigate the time trends. The review will summarize the available data on the incidence, relative risks, and time trends of AMI in these populations through a systematic literature search.
SYSTEMATIC REVIEWS
(2022)
Article
Pediatrics
Clemens Kamrath, Joachim Rosenbauer, Alexander J. Eckert, Angeliki Pappa, Felix Reschke, Tilman R. Rohrer, Kirsten Moenkemoeller, Michael Wurm, Kathrin Hake, Klemens Raile, Reinhard W. Holl
Summary: This study aimed to quantify the relative risk of diabetic ketoacidosis in children with newly diagnosed type 1 diabetes in 2020 and examine its association with regional COVID-19 incidence. The findings indicate a significant increase in ketoacidosis frequency compared to expected rates during certain months in 2020, with a positive association between regional COVID-19 incidence and ketoacidosis risk in the first half of the year. However, this association was not observed in the second half of 2020.
Article
Nutrition & Dietetics
Zhijun Wu, Zhe Huang, Alice H. Lichtenstein, Cheng Jin, Shuohua Chen, Shouling Wu, Xiang Gao
Summary: The study revealed that high HDL-cholesterol concentrations were paradoxically associated with a higher risk of CVD outcomes in individuals with or without diabetes mellitus. On the other hand, low HDL-cholesterol concentrations failed to predict future CVD risk in individuals with DM.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Medicine, General & Internal
Maria Isabel Smaradottir, Karl Andersen, Vilmundur Gudnason, Per Nasman, Lars Ryden, Linda Garcia Mellbin
Summary: Elevated copeptin, a marker for vasopressin release, is associated with impaired prognosis in acute myocardial infarction. This study found that copeptin levels were higher in individuals with previous MI, regardless of whether it was recognized or not. Copeptin showed weak correlation with cortisol and NTproBNP, and remained independently associated with total mortality in a multiple model analysis.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Medicine, General & Internal
Mohammed A. A. Talle, Ellen Ngarande, Anton F. F. Doubell, Philip G. G. Herbst
Summary: This systematic review aims to determine the prevalence of myocardial infarction and its subtypes, and the prevalence of myocardial injury in patients with hypertensive emergencies. The results showed that the prevalence of myocardial infarction ranged from 3.6% to 59.6%, with only two studies specifically indicating the prevalence of ST-elevation and non-ST-elevation myocardial infarction. The prevalence of myocardial injury ranged from 15% to 63%. This highlights the need for more research in this area to guide patient management and identify those at increased risk of major adverse cardiovascular events.
Review
Public, Environmental & Occupational Health
Rock Bum Kim, Jang-Rak Kim, Jin Yong Hwang
Summary: This review provides a comprehensive analysis of the epidemiological indicators of myocardial infarction in Korea, comparing them with other high-income countries. The results indicate that although there is an increasing trend, the hospitalization incidence, prevalence, and mortality rate of myocardial infarction are lower in Korea than in other countries. The study emphasizes the need for comprehensive national-level support and surveillance systems to collect accurate epidemiological indicators.
EPIDEMIOLOGY AND HEALTH
(2022)
Article
Endocrinology & Metabolism
Pierre Henri Ducluzeau, Gregoire Fauchier, Julien Herbert, Carl Semaan, Jean Michel Halimi, Denis Angoulvant, Laurent Fauchier
Summary: This study compared the risks of cardiovascular and renal diseases in patients with type 1 and type 2 diabetes. It found that patients with type 1 diabetes had a higher risk of myocardial infarction, heart failure, and disease-related death above 60 years of age, indicating the need for improved prevention strategies in this population.
DIABETES & METABOLISM
(2023)
Review
Psychiatry
Phoebe Yue Aw, Xian Zheng Pang, Caitlin Fern Wee, Natalie Hynn Wei Tan, Ern-Wei Peck, Yao Neng Teo, Yao Hao Teo, Nicholas L. Syn, Mark Y. Chan, Benjamin Y. Q. Tan, Keith Andrew Chan, Leonard L. L. Yeo, Ping Chai, Tiong-Cheng Yeo, Ching-Hui Sia
Summary: This study investigated the co-prevalence of depression and anxiety with stroke and myocardial infarction through a systematic search across five databases. The results showed a high prevalence of depression in patients with stroke and myocardial infarction, suggesting the need for further research to evaluate the effectiveness of screening depression/anxiety in myocardial infarction/stroke.
JOURNAL OF PSYCHOSOMATIC RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Florian Schnitzer, Lukas Forer, Sebastian Scho, Christian Gieger, Harald Grallert, Florian Kronenberg, Annette Peters, Claudia Lamina
Summary: This study found that both genetic risk scores and family history are relevant for the assessment of myocardial infarction (MI) risk, and they have independent contributions to the occurrence and prediction of MI. Adding both genetic risk scores and family history to a model significantly enhances the prediction of MI.
Article
Medicine, General & Internal
Murat Cimci, Fabienne Witassek, Dragana Radovanovic, Hans Rickli, Giovanni B. Pedrazzini, Paul Erne, Olivier Mueller, Franz R. Eberli, Marco Roffi
Summary: Among AMI patients in Switzerland over two decades, the age at presentation remained stable, while the mean number of CVRF increased in both men and women. The prevalence of smoking increased significantly in women, reducing the gender gap over time, while diabetes prevalence remained stable and obesity prevalence increased in men, with hypertension and dyslipidemia increasing in both genders.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
Bernard R. Chaitman, Karen P. Alexander, Derek D. Cyr, Jeffrey S. Berger, Harmony R. Reynolds, Sripal Bangalore, William E. Boden, Renato D. Lopes, Marcin Demkow, Gian Piero Perna, Robert K. Riezebos, Edward O. McFalls, Subhash Banerjee, Akshay Bagai, Gilbert Gosselin, Sean M. O'Brien, Frank W. Rockhold, David D. Waters, Kristian A. Thygesen, Gregg W. Stone, Harvey D. White, David J. Maron, Judith S. Hochman
Summary: The ISCHEMIA trial showed that an initial invasive strategy did not reduce cardiovascular events or all-cause mortality in patients with stable ischemic heart disease. Procedural MI rates were higher with the invasive strategy compared to conservative strategy, with the use of the secondary MI definition.
Article
Cardiac & Cardiovascular Systems
Bochra Zareini, Katrine Kold Sorensen, Paul Blanche, Alexander C. Falkentoft, Emil Fosbol, Lars Kober, Christian Torp-Pedersen
Summary: This study investigated the impact of T2D on the rate of depression in different subtypes of CVD. The results showed that the presence of T2D had the most significant effect on the incidence of depression in patients with MI and PAD.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Yingting Zuo, Anxin Wang, Shuohua Chen, Xue Tian, Shouling Wu, Yan He
Summary: Analysis of data from a prospective study revealed five distinct eGFR trajectories among individuals with diabetes or prediabetes, and showed an association between eGFR trajectories and the risk of myocardial infarction (MI).
JOURNAL OF DIABETES
(2021)
Article
Multidisciplinary Sciences
Goran Bratt, Johanna Brannstrom, Catharina Missalidis, Thomas Nystrom
Summary: The study revealed a high incidence of T2D and insulin resistance in a cohort of HIV patients receiving effective treatment, highlighting the increased risk of diabetes-related complications in individuals with HIV. Predictive factors associated with the development of T2D were identified as baseline insulin resistance, hypertriglyceridemia, central obesity, and statin treatment, suggesting that HIV-related factors were not directly linked to T2D development. These findings emphasize the importance of lifestyle changes in preventing T2D in people living with HIV.
Article
Multidisciplinary Sciences
S. Macherey, M. M. Meertens, C. Adler, S. Braumann, S. Heyne, T. Tichelbaecker, F. S. Niessen, H. Christ, I Ahrens, F. M. Baer, F. Eberhardt, M. Horlitz, A. Meissner, J. M. Sinning, S. Baldus, S. Lee
Summary: The study analyzed the impact of respiratory infectious diseases on STEMI, showing that these diseases did not lead to treatment delays or an increase in mortality rates.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Matthew M. Y. Lee, Ross T. Campbell, Brian L. Claggett, Eldrin F. Lewis, Kieran F. Docherty, Moritz Lindner, Jiankang Liu, Scott D. Solomon, John J. McMurray, Elke Platz
Summary: In this study, patient-reported symptoms in acute heart failure patients were associated with NYHA class, dyspnoea, and peripheral oedema, but not with the extent of pulmonary congestion assessed by lung ultrasound, chest X-ray, or physical examination. These findings suggest that factors other than pulmonary congestion may contribute to the reduction in symptom score in AHF patients.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Safia Chatur, Brian L. Claggett, Orly Vardeny, Karola Jering, Akshay S. Desai, Marc A. Pfeffer, Martin Lefkowitz, John J. McMurray, Scott D. Solomon, Muthiah Vaduganathan
Summary: In HFpEF, the use of SACUBITRIL/VALSARTAN may reduce the risk of heart failure events and have an impact on diuretic requirements. The safety profile of SACUBITRIL/VALSARTAN remains consistent regardless of baseline diuretic dose.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Finnian R. Mc Causland, Brian L. Claggett, Muthiah Vaduganathan, Akshay S. Desai, Pardeep Jhund, Rudolf A. de Boer, Kieran Docherty, James Fang, Adrian F. Hernandez, Silvio E. Inzucchi, Mikhail N. Kosiborod, Carolyn S. P. Lam, Felipe Martinez, Jose F. Kerr Saraiva, Martina M. McGrath, Sanjiv J. Shah, Subodh Verma, Anna Maria Langkilde, Magnus Petersson, John J. McMurray, Scott D. Solomon
Summary: Dapagliflozin has no effect on baseline kidney function in patients with heart failure and a mildly reduced or preserved ejection fraction. Dapagliflozin does not significantly reduce the frequency of kidney composite outcomes, but can slow the decline in eGFR.
Article
Medicine, General & Internal
Meir Schechter, Niels Jongs, Glenn M. Chertow, Ofri Mosenzon, John J. McMurray, Ricardo Correa-Rotter, Peter Rossing, Anna Maria Langkilde, C. David Sjostrom, Robert D. Toto, David C. Wheeler, Hiddo J. L. Heerspink
Summary: This study aimed to determine the effects of dapagliflozin on hospitalizations in patients with chronic kidney disease (CKD). The results showed that dapagliflozin reduced the risk of hospitalization for any cause in patients with CKD, regardless of whether they had type 2 diabetes or not.
ANNALS OF INTERNAL MEDICINE
(2023)
Editorial Material
Rheumatology
Nathalie Conrad, Iain B. McInnes, John J. Mcmurray, Naveed Sattar
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Mikhail N. Kosiborod, Ankeet S. Bhatt, Brian L. Claggett, Muthiah Vaduganathan, Ian J. Kulac, Carolyn S. P. Lam, Adrian F. Hernandez, Felipe A. Martinez, Silvio E. Inzucchi, Sanjiv J. Shah, Rudolf A. de Boer, Pardeep S. Jhund, Akshay S. Desai, James C. Fang, Yaling Han, Josep Comin-Colet, Orly Vardeny, Daniel Lindholm, Ulrica Wilderaeng, Olof Bengtsson, John J. V. McMurray, Scott D. Solomon
Summary: In the DELIVER trial, dapagliflozin was found to significantly improve the health status of heart failure patients, as assessed by the Kansas City Cardiomyopathy Questionnaire. The effects were particularly pronounced in patients with higher baseline symptom burden.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Araz Rawshani, Darren K. McGuire, Elmir Omerovic, Naveed Sattar, John J. V. McMurray, Ulf Smith, Bjorn Redfors, Lennart Bergfeldt, Bjorn Eliasson, Jan Boren, Deepak L. Bhatt, Goran Bergstrom, Aidin Rawshani
Summary: This study investigated the association between type 2 diabetes and cardiac arrhythmias and conduction disturbances. The results showed that patients with diabetes had a higher risk of arrhythmias and conduction abnormalities, but among patients with all risk factors controlled within target range, the excess risk associated with diabetes was virtually not evident.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Endocrinology & Metabolism
Naveed Sattar, John J. McMurray, Iain B. McInnes, Vanita R. Aroda, Mike E. J. Lean
Summary: Few people reach old age without taking multiple drugs and undergoing investigations, often due to chronic conditions caused or exacerbated by excess adiposity. Weight management, which is rarely discussed or attempted, can play a role in addressing these conditions. There is a need for more research on the effects of effective weight management on age and weight-mediated symptoms.
LANCET DIABETES & ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Carly Adamson, Paul Welsh, Kieran F. Docherty, Rudolf A. de Boer, Mirta Diez, Jaroslaw Drozdz, Andre Dukat, Silvio E. Inzucchi, Lars Kober, Mikhail N. Kosiborod, Charlotta E. A. Ljungman, Felipe A. Martinez, Piotr Ponikowski, Marc S. Sabatine, David A. Morrow, Daniel Lindholm, Ann Hammarstedt, David W. Boulton, Peter J. Greasley, Anna Maria Langkilde, Scott D. Solomon, Naveed Sattar, John J. V. McMurray, Pardeep S. Jhund
Summary: Elevation in IGFBP-7 is associated with worse clinical outcomes in patients with heart failure with reduced ejection fraction. IGFBP-7 provides prognostic information incremental to clinical variables, NT-proBNP, and hsTnT. Dapagliflozin does not modulate IGFBP-7 levels.
JACC-HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Jawad H. Butt, Mark C. Petrie, Pardeep S. Jhund, Naveed Sattar, Akshay S. Desai, Lars Kober, Jean L. Rouleau, Karl Swedberg, Michael R. Zile, Scott D. Solomon, Milton Packer, John J. McMurray
Summary: This study found that newer anthropometric measures such as waist-to-height ratio, rather than body mass index (BMI), accurately predicted the risk of heart failure hospitalization and cardiovascular death in patients with heart failure. The study also showed a positive correlation between waist-to-height ratio and higher levels of obesity, as well as increased risk of heart failure hospitalization.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Paolo Tolomeo, Jawad H. Butt, Toru Kondo, Gianluca Campo, Akshay S. Desai, Pardeep S. Jhund, Lars Kober, Martin P. Lefkowitz, Jean L. Rouleau, Scott D. Solomon, Karl Swedberg, Muthiah Vaduganathan, Michael R. Zile, Milton Packer, John J. McMurray
Summary: The 2021 CKD-EPI equation combining creatinine and cystatin C provides a better estimation of GFR compared to the creatinine-only equation. The creatinine-cystatin equation led to a substantial reclassification of chronic kidney disease stages and was associated with higher mortality and worsening of clinical scores in heart failure patients.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Safia Chatur, Brian L. Claggett, Finnian R. McCausland, Jean Rouleau, Michael R. Zile, Milton Packer, Marc A. Pfeffer, Martin Lefkowitz, John J. V. McMurray, Scott D. Solomon, Muthiah Vaduganathan
Summary: An investigation found that moderate estimated glomerular filtration rate decline when transitioning from RASi to sacubitril/valsartan is not consistently associated with adverse outcomes, and its long-term benefits are retained across a broad range of eGFR declines in heart failure patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Tor Biering-Sorensen, Maja Cikes, Mats C. H. Lassen, Brian Claggett, Masatoshi Minamisawa, Angela B. S. Santos, Elisabeth Pieske-Kraigher, Amil M. Shah, Michael R. Zile, John J. McMurray, Scott D. Solomon, Susan Cheng
Summary: This study aimed to investigate whether regional differences in impaired myocardial function contribute to the greater mechanical dysfunction seen in HFPEF compared to HHD.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Glenn M. Chertow, Ricardo Correa-Rotter, Priya Vart, Niels Jongs, John J. V. McMurray, Peter Rossing, Anna Maria Langkilde, C. David Sjostrom, Robert D. Toto, David C. Wheeler, Hiddo J. L. Heerspink
Summary: In the DAPA-CKD trial, dapagliflozin was found to reduce the risk of kidney and cardiovascular events in patients with chronic kidney disease and albuminuria. The treatment effect of dapagliflozin was consistent regardless of baseline cardiovascular medication use.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Toru Kondo, Pooja Dewan, Inder S. Anand, Akshay S. Desai, Milton Packer, Michael R. Zile, Marc A. Pfeffer, Scott D. Solomon, William T. Abraham, Sanjiv J. Shah, Carolyn S. P. Lam, Pardeep S. Jhund, John J. V. Mcmurray
Summary: By analyzing LVEF data in HF patients, we found that there is a threshold between 40% and 50% LVEF, below which the pattern of patient characteristics changes, and event rates begin to increase. This provides support for the current prognosis-based definition of HF with mildly reduced ejection fraction based on upper LVEF thresholds.
