Article
Endocrinology & Metabolism
Sebastian Hoerber, Rainer Lehmann, Louise Fritsche, Juergen Machann, Andreas L. Birkenfeld, Hans-Ulrich Haering, Norbert Stefan, Martin Heni, Andreas Fritsche, Andreas Peter
Summary: Lifestyle intervention over one year significantly reduces coagulation factor activities, improves coagulation status, and lowers the risk of thrombosis. In addition to body weight, reducing liver fat, improving insulin sensitivity, and decreasing low-grade inflammation also contribute to improvements in hemostasis.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Jemina Kivela, Jelena Meinila, Matti Uusitupa, Jaakko Tuomilehto, Jaana Lindstrom
Summary: This study examines the interaction between lifestyle intervention and the association between circulating branched-chain amino acids (BCAAs) and the risk of type 2 diabetes (T2D). The findings show that lifestyle intervention modifies the association of baseline BCAA concentration and BCAA trajectories with the incidence of T2D.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, General & Internal
Tingting Geng, Kai Zhu, Qi Lu, Zhenzhen Wan, Xue Chen, Liegang Liu, An Pan, Gang Liu
Summary: This study aimed to examine the associations of overall lifestyle behaviors with risks of microvascular complications among patients with type 2 diabetes and explore the potential mediation effects of metabolic biomarkers. The study found that adherence to healthy lifestyle behaviors was associated with a significantly lower risk of microvascular complications, and these associations were mediated, in part, through improving metabolic biomarkers.
Article
Nutrition & Dietetics
Heidi M. Leskinen, Maaria Tringham, Heli Karjalainen, Terhi K. Iso-Touru, Hanna-Leena Hietaranta-Luoma, Pertti J. Marnila, Juha-Matti Pihlava, Timo Hurme, Santeri J. Kankaanpaa, Hannu Puolijoki, Kari Akerman, Laura Tanner, Mari Sandell, Kirsi Vahakangas, Anu Hopia, Raija Tahvonen, L. Susanna Rokka
Summary: The study aimed to investigate the impact of APOE epsilon 4 genotype on lifestyle intervention, finding that lifestyle guidance led to improvements in vegetable consumption, dietary fat quality, and cholesterol levels, with no significant differences observed between epsilon 4 carriers and non-carriers in response to the intervention.
JOURNAL OF NUTRITION
(2021)
Article
Biochemistry & Molecular Biology
Robert Wagner, Martin Heni, Adam G. Tabak, Juergen Machann, Fritz Schick, Elko Randrianarisoa, Martin Hrabe de Angelis, Andreas L. Birkenfeld, Norbert Stefan, Andreas Peter, Hans-Ulrich Haering, Andreas Fritsche
Summary: Analysis of high-risk individuals revealed six distinct subphenotypes of type 2 diabetes, among which three had elevated glycemia levels, with clusters 3 and 5 having imminent diabetes risks.
Article
Cardiac & Cardiovascular Systems
Qi Lu, Junxiang Chen, Rui Li, Yi Wang, Zhouzheng Tu, Tingting Geng, Liegang Liu, An Pan, Gang Liu
Summary: This study aimed to identify metabolites associated with different lifestyle factors and estimate their mediating roles between lifestyle and cardiovascular disease (CVD) risk among people with diabetes. The results showed that metabolites, especially fatty acids, partially explained the association between adherence to multiple healthy lifestyle factors and lower CVD risk in individuals with diabetes.
Article
Cell Biology
Louis-Pascal Xhonneux, Oliver Knight, Ake Lernmark, Ezio Bonifacio, William A. Hagopian, Marian J. Rewers, Jin-Xiong She, Jorma Toppari, Hemang Parikh, Kenneth G. C. Smith, Anette-G Ziegler, Beena Akolkar, Jeffrey P. Krischer, Eoin F. McKinney
Summary: Research shows that early and longitudinal changes in gene expression play a significant role in the progression of type 1 diabetes, informing the immunopathology and facilitating prediction of the disease course.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Raija Lithovius, Anni A. Antikainen, Stefan Mutter, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Niina Sandholm, Per-Henrik Groop
Summary: This study explores the use of a genetic risk score (GRS) for coronary artery disease (CAD) risk prediction in individuals with type 1 diabetes. The GRS showed similar predictive performance to established clinical markers and was more effective in younger individuals.
Article
Medicine, Research & Experimental
Arnaud D. Kaze, Matthew F. Yuyun, Rexford S. Ahima, Michael R. Rickels, Justin B. Echouffo-Tcheugui
Summary: This study evaluated the association between cardiac autonomic neuropathy (CAN) and severe hypoglycemia in individuals with type 2 diabetes. The findings showed that CAN was independently associated with higher risks of first and recurrent episodes of severe hypoglycemia, particularly among those on standard glycemic management.
Article
Endocrinology & Metabolism
Jian-Jun Liu, Sylvia Liu, Jiexun Wang, Janus Lee, Justin I-Shing Tang, Resham L. Gurung, Keven Ang, Yi Ming Shao, Subramaniam Tavintharan, Wern Ee Tang, Chee Fang Sum, Su Chi Lim
Summary: Individuals with early-onset diabetes have a higher risk for incident heart failure, which is primarily associated with cardiorenal risk factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Mary D. Adu, Catherine P. Bondonno, Benjamin H. Parmenter, Marc Sim, Raymond J. Davey, Kevin Murray, Simone Radavelli-Bagatini, Dianna J. Magliano, Robin M. Daly, Jonathan E. Shaw, Joshua R. Lewis, Jonathan M. Hodgson, Nicola P. Bondonno
Summary: This study examined the association between flavonoid intake and measures of glucose tolerance and insulin sensitivity in adults, as well as the long-term risk of type 2 diabetes. The results suggest that consuming flavonoid-rich foods may protect against type 2 diabetes by improving glucose tolerance and insulin sensitivity.
Article
Environmental Sciences
Rui Li, Miao Cai, Zhengmin (Min) Qian, Xiaojie Wang, Zilong Zhang, Chongjian Wang, Yuqin Wang, Lauren D. Arnold, Steven W. Howard, Haitao Li, Hualiang Lin
Summary: This study investigated the combined effects of ambient air pollution, lifestyle, and genetic predisposition on incident Type 2 Diabetes (T2D) using data from the UK Biobank. The results showed that air pollution had a stronger association with T2D in individuals with unhealthier lifestyle, and about 25% of T2D cases could be attributable to air pollution and associated interactions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Medicine, General & Internal
Giulia Testa, Lucia Camacho-Barcia, Carlos Gomez-Martinez, Bernat Mora-Maltas, Rafael de la Torre, Xavier Pinto, Dolores Corella, Roser Granero, Aida Cuenca-Royo, Susana Jimenez-Murcia, Nancy Babio, Rebeca Fernandez-Carrion, Virginia Esteve-Luque, Laura Forcano, Jiaqi Ni, Mireia Malcampo, Sara De las Heras-Delgado, Montse Fito, Jordi Salas-Salvado, Fernando Fernandez-Aranda
Summary: The study found that impulsivity traits in individuals with T2D seem to affect long-term weight control, but not glycemic control.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Shuai Yuan, Dipender Gill, Edward L. Giovannucci, Susanna C. Larsson
Summary: This study using Mendelian randomization found causal relationships between obesity, type 2 diabetes, and smoking with gallstone disease, while coffee consumption was inversely associated with the disease.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Zimin Song, Ruotong Yang, Wenxiu Wang, Ninghao Huang, Zhenhuang Zhuang, Yuting Han, Lu Qi, Ming Xu, Yi-da Tang, Tao Huang
Summary: Adherence to a healthy lifestyle pattern, including a healthy sleep pattern, is associated with a lower risk of developing T2DM in hypertensives, with even greater benefits observed in normotensives.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Multidisciplinary Sciences
Rafael Gabriel, Nisa Boukichou Abdelkader, Tania Acosta, Aleksandra Gilis-Januszewska, Ricardo Gomez-Huelgas, Konstantinos Makrilakis, Zdravko Kamenov, Bernhard Paulweber, Ilhan Satman, Predrag Djordjevic, Abdullah Alkandari, Asimina Mitrakou, Nebojsa Lalic, Stephen Colagiuri, Jaana Lindstrom, Jesus Egido, Andrea Natali, J. Carlos Pastor, Yvonne Teuschl, Marcus Lind, Luis Silva, Ruy Lopez-Ridaura, Jaakko Tuomilehto
Article
Public, Environmental & Occupational Health
Katri Hemio, Jaana Lindstrom, Markku Peltonen, Mikko Harma, Katriina Viitasalo, Sampsa Puttonen
Summary: The study found that poor recovery from work was associated with higher unhealthy food intake in men and increased consumption of fast food and sweets in women. Sleep problems were related to unfavorable dietary habits in both men and women.
PUBLIC HEALTH NUTRITION
(2021)
Article
Endocrinology & Metabolism
Yannis Manios, Christina Mavrogianni, Christina-Paulina Lambrinou, Greet Cardon, Jaana Lindstrom, Violeta Iotova, Tsvetalina Tankova, Fernando Civeira, Jemina Kivela, Zoltan Jancso, Samyah Shadid, Kaloyan Tsochev, Rocio Mateo-Gallego, Sandorne Rado, George Dafoulas, Konstantinos Makrilakis, Odysseas Androutsos
BMC ENDOCRINE DISORDERS
(2020)
Review
Endocrinology & Metabolism
Jemina Kivela, Katja Wikstrom, Eeva Virtanen, Michael Georgoulis, Greet Cardon, Fernando Civeira, Violeta Iotova, Ernest Karuranga, Winne Ko, Stavros Liatis, Konstantinos Makrilakis, Yannis Manios, Rocio Mateo-Gallego, Anna Nanasi, Imre Rurik, Tsvetalina Tankova, Kaloyan Tsochev, Vicky Van Stappen, Jaana Lindstrom
BMC ENDOCRINE DISORDERS
(2020)
Review
Endocrinology & Metabolism
Christina-Paulina Lambrinou, Odysseas Androutsos, Eva Karaglani, Greet Cardon, Nele Huys, Katja Wikstrom, Jemina Kivela, Winne Ko, Ernest Karuranga, Kaloyan Tsochev, Violeta Iotova, Roumyana Dimova, Pilar De Miguel-Etayo, Esther M. Gonzalez-Gil, Hajnalka Tamas, Zoltan Jancso, Stavros Liatis, Konstantinos Makrilakis, Yannis Manios
BMC ENDOCRINE DISORDERS
(2020)
Article
Endocrinology & Metabolism
Eeva Virtanen, Jemina Kivela, Katja Wikstrom, Christina-Paulina Lambrinou, Pilar De Miguel-Etayo, Nele Huys, Katalin Vrauko-Toth, Luis A. Moreno, Natalya Usheva, Nevena Chakarova, Sandorne A. Rado, Violeta Iotova, Konstantinos Makrilakis, Greet Cardon, Stavros Liatis, Yannis Manios, Jaana Lindstrom
BMC ENDOCRINE DISORDERS
(2020)
Article
Environmental Sciences
Jaana Lindstrom, Kirsikka Aittola, Auli Polonen, Katri Hemio, Kirsti Ahonen, Leila Karhunen, Reija Mannikko, Ulla Siljamaki-Ojansuu, Tanja Tilles-Tirkkonen, Eeva Virtanen, Jussi Pihlajamaki, Ursula Schwab
Summary: The study showed that the Healthy Diet Index (HDI) is inversely correlated with total fat, saturated fat, monounsaturated fat, and glycaemic index of diet, while positively correlated with carbohydrates, protein, fibre, magnesium, iron, and vitamin D. HDI is also associated with various biomarkers and anthropometric measurements, making it a valid tool for measuring adherence to a health-promoting diet and supporting individualised dietary counselling.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Nutrition & Dietetics
Vanessa Derenji de Mello, Tuomas Selander, Jaana Lindstroem, Jaakko Tuomilehto, Matti Uusitupa, Kai Kaarniranta
Summary: Elevated serum plasmalogen dm16:0, saturated odd-chain FA 15.0, and omega-3 very long-chain FAs were found to be associated with a decreased occurrence of retinal microaneurysms (MA). The correlation of high serum triglycerides with MA occurrence was attenuated when considering these MA-associated serum lipid markers.
Article
Nutrition & Dietetics
Kirsikka Aittola, Leila Karhunen, Reija Maennikkoe, Elina Jaervelae-Reijonen, Santtu Mikkonen, Pilvikki Absetz, Marjukka Kolehmainen, Ursula Schwab, Marja Harjumaa, Jaana Lindstroem, Timo Lakka, Tanja Tilles-Tirkkonen, Jussi Pihlajamaeki
Summary: The study found that improvements in eating competence were associated with increased diet quality, high-density lipoprotein cholesterol levels, and decreased body mass index and waist circumference, regardless of baseline eating competence. Therefore, eating competence could be a potential target in lifestyle interventions aiming to improve the cardiometabolic health of people at risk of type 2 diabetes.
Article
Nutrition & Dietetics
Eeva Rantala, Saara Vanhatalo, Tanja Tilles-Tirkkonen, Markus Kanerva, Pelle Guldborg Hansen, Marjukka Kolehmainen, Reija Mannikko, Jaana Lindstrom, Jussi Pihlajamaki, Kaisa Poutanen, Leila Karhunen, Pilvikki Absetz
Summary: Redesigning choice environments shows potential for promoting healthier eating and physical activity in workplace settings. However, successful implementation relies on factors such as adequate training for implementers, careful planning, integration into workplace values and activities, and support from management.
Article
Nutrition & Dietetics
Janne Martikainen, Kari Jalkanen, Jari Heiskanen, Piia Lavikainen, Markku Peltonen, Tiina Laatikainen, Jaana Lindstrom
Summary: The prevalence of type 2 diabetes is increasing globally, and a healthy diet plays a crucial role in its prevention. Increased consumption of whole grain foods could lead to significant health and economic benefits in the Finnish adult population, reducing T2D-related costs and improving quality-adjusted life years.
Article
Nutrition & Dietetics
George Moschonis, George Siopis, Costas Anastasiou, Violeta Iotova, Tanya Stefanova, Roumyana Dimova, Imre Rurik, Anette Si Rado, Greet Cardon, Marieke De Craemer, Jaana Lindstrom, Luis A. Moreno, Pilar De Miguel-Etayo, Konstantinos Makrilakis, Stavros Liatis, Yannis Manios
Summary: The Feel4Diabetes study recruited 12,193 children and their parents from six European countries to investigate the prevalence of childhood obesity and its association with socio-demographic characteristics and parental obesity status. The study found that living in low income or economically crisis countries, having a father with less education, and having one or both parents who were obese were associated with a higher likelihood of childhood obesity. These findings suggest the importance of targeting the whole family and considering socioeconomic factors in childhood obesity prevention programs.
Article
Medicine, General & Internal
Elisa Neuvonen, Jenni Lehtisalo, Tiia Ngandu, Esko Levaelahti, Riitta Antikainen, Tuomo Hanninen, Tiina Laatikainen, Jaana Lindstrom, Teemu Paajanen, Hilkka Soininen, Timo Strandberg, Jaakko Tuomilehto, Miia Kivipelto, Alina Solomon
Summary: Depressive symptoms may affect improvement in cognitive abilities, with clinically significant symptoms potentially impacting the effectiveness of interventions, warranting further attention in dementia prevention strategies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Environmental Sciences
Mika Venojarvi, Jaana Lindstrom, Sirkka Aunola, Pirjo Nuutila, Mustafa Atalay
Summary: This study aimed to investigate the effects of long-term exercise and dietary intervention on glucose metabolism in middle-aged obese individuals with impaired glucose tolerance. The intervention resulted in decreased leptin levels, increased adiponectin levels, improved insulin sensitivity and maximal oxygen uptake in responders, but did not affect glucose transporter gene expression.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Nutrition & Dietetics
Ratika Sehgal, Vanessa D. de Mello, Ville Mannisto, Jaana Lindstrom, Jaakko Tuomilehto, Jussi Pihlajamaki, Matti Uusitupa
Summary: The relationship between gut microbiota, diet, and the human body is complex, with tryptophan derivative indolepropionic acid (IPA) playing a crucial role in metabolic and immune functions and in the onset and development of metabolic disorders such as T2D and NAFLD. IPA levels are heavily influenced by diet, particularly dietary fiber, and show significant variations among individuals, which may be partially explained by genetic variants associated with specific diseases like T2D.
