Article
Endocrinology & Metabolism
Ellen C. Francis, Dana Dabelea, Brandy M. Ringham, Katherine A. Sauder, Wei Perng
Summary: This study found that children born to mothers with higher HbA(1c) levels during pregnancy had higher fasting glucose and lower insulin sensitivity in early childhood. However, these relationships were largely unaffected by the child's own adiposity.
Review
Endocrinology & Metabolism
Joon Ho Moon, Hak Chul Jang
Summary: Gestational diabetes mellitus (GDM) is a common complication during pregnancy, associated with adverse pregnancy outcomes and long-term complications. There are two diagnostic approaches with controversial clinical benefits.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Endocrinology & Metabolism
Yi Huang, Jazmin Osorio Mendoza, Min Li, Zengguang Jin, Baoguo Li, Yingga Wu, Jacques Togo, John R. Speakman
Summary: The study found that maternal dietary fat content was positively related to offspring body weight and adiposity, with offspring of mothers exposed to HFD having higher levels. The effects of different levels of maternal dietary fat on offspring were nonlinear and sex dependent. Offspring of mothers on 8.3% and 25% fat diets had the highest daily energy expenditure and respiratory exchange ratio.
Article
Multidisciplinary Sciences
Rebecca Oelkrug, Lisbeth Harder, Mehdi Pedaran, Anne Hoffmann, Beke Kolms, Julica Inderhees, Sogol Gachkar, Julia Resch, Kornelia Johann, Olaf Joehren, Kerstin Krause, Jens Mittag
Summary: Maternal hyperthyroidism during pregnancy can program the offspring's glucose sensitivity and response to cold via activation of maternal thyroid hormone receptor beta in a sex-dependent manner.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
You-Lin Tain, Chien-Ning Hsu
Summary: Maternal high-fat diet is linked to offspring hypertension, and potential mechanisms have been revealed through animal studies. Reprogramming interventions can prevent high-fat-diet-induced hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Chengjun Hu, Yunyu Yang, Minxia Chen, Xiangyu Hao, Shuqi Wang, Linfang Yang, Yulong Yin, Chengquan Tan
Summary: Maternal high-fat/low-fiber diet during pregnancy impairs glucose tolerance, induces changes in muscle fiber types in neonatal offspring, and decreases mitochondrial function.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Multidisciplinary Sciences
Gitte Hedermann, Paula L. Hedley, Ida N. Thagaard, Lone Krebs, Charlotte Kvist Ekelund, Thorkild I. A. Sorensen, Michael Christiansen
Summary: The study evaluates the association between maternal metabolic disorders (such as obesity, diabetes, hypertension, preeclampsia, dyslipidaemia) and congenital heart defects (CHDs) in offspring, as well as the significance of metabolic syndrome combinations as risk factors for CHDs. Some metabolic disorders (obesity, gestational diabetes, hypertension) slightly increased the risk of CHDs, while pre-gestational diabetes and early-onset preeclampsia were strongly associated with CHDs, with no consistent differences between CHD subtypes.
Review
Nutrition & Dietetics
Kinga Gawlinska, Dawid Gawlinski, Malgorzata Filip, Edmund Przegalinski
Summary: A maternal high-fat diet during pregnancy and lactation can have irreversible effects on the health of offspring, leading to increased risk of depressive and aggressive behaviors, reduced cognitive development, and symptoms of metabolic syndrome. Epigenetic and molecular studies have shown that maternal nutrition during pregnancy and the suckling period can modify the development of neurotransmitter circuits and other factors important to central nervous system development.
Article
Endocrinology & Metabolism
Ellen C. Francis, Dana Dabelea, Kartik Shankar, Wei Perng
Summary: Limited data exist on the association between maternal diet quality during pregnancy and metabolic traits in offspring during early childhood. The study aimed to examine the association of maternal diet quality with offspring metabolic biomarkers and body composition at age 4-7 years. Maternal HEI >57 was associated with lower fasting glucose, insulin, HOMA-IR, and adiponectin levels in boys, while associations in girls were attenuated following covariate adjustment. Future studies are needed to confirm these findings and determine underlying mechanisms.
Article
Endocrinology & Metabolism
Jelena Stevanovic-Silva, Jorge Beleza, Pedro Coxito, Susana Pereira, Hugo Rocha, Tiago Bordeira Gaspar, Fatima Gartner, Rossana Correia, Maria Joao Martins, Tiago Guimaraes, Sandra Martins, Paulo J. Oliveira, Antonio Ascensao, Jose Magalhaes
Summary: The study shows that gestational exercise can delay the metabolic changes in GDM mothers and protect offspring from the adverse effects of maternal diet. Gestational exercise reduces hepatic triglycerides accumulation and improves liver mitochondrial respiration capacity in offspring.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Cell Biology
Yuri Karen Sinzato, Veronyca Goncalves Paula, Franciane Quintanilha Gallego, Rafaianne Q. Moraes-Souza, Jose Eduardo Corrente, Gustavo Tadeu Volpato, Debora Cristina Damasceno
Summary: Maternal diabetes and high-fat diet have similar adverse effects on the health of F1 and F2 generations, including infertility, decreased insulin sensitivity, and fetal growth restriction. The combination of both factors also results in increased lipoperoxidation, decreased glucose tolerance, and increased fetal leptin levels.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Marina Galleazzo Martins, Zachary Silver, Kiara Ayoub, Lindsay Hyland, Barbara Woodside, Ana Carolina Inhasz Kiss, Alfonso Abizaid
Summary: Gestational diabetes is associated with negative outcomes for both mothers and offspring. This study found that maternal hyperglycemia, combined with exposure to an obesogenic diet, leads to adult metabolic alterations in offspring, particularly in females, with increased hypothalamic expression of POMC.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Hsi-Yun Liu, Chen-Hao Lee, Chien-Ning Hsu, You-Lin Tain
Summary: A balanced diet during gestation is crucial for fetal development, and excessive intake of saturated fats during this period is linked to increased risk of offspring kidney disease. Maternal high-fat diet influences kidney health and disease in offspring through renal programming. This review summarizes preclinical research on the connection between maternal high-fat diet during gestation and lactation and offspring kidney disease, the molecular mechanisms behind renal programming, and early-life interventions to mitigate adverse programming effects. Animal models suggest that perinatal supplementation with polyunsaturated fatty acids, changes in gut microbiota, and modulation of nutrient-sensing signals can improve offspring kidney health. These findings emphasize the importance of a balanced maternal diet for offspring kidney health.
Article
Cell Biology
Dongdong Wang, Haiting Zhang, Miao Zeng, Xiaocui Tang, Xiangxiang Zhu, Yinrui Guo, Longkai Qi, Yizhen Xie, Mei Zhang, Diling Chen
Summary: A maternal high sugar and high fat diet during pregnancy was found to significantly impact the gut microbiota structure, neuronal types, and inflammation levels in the offspring. Activation of certain genes beneficial against nervous system diseases and increased expression of cholinergic and GABAergic neurons biomarker protein were observed as the offspring grew older.