Article
Surgery
Mateo Lopez-Moral, Yolanda Garcia-Alvarez, Raul J. Molines-Barroso, Aroa Tardaguila-Garcia, Marta Garcia-Madrid, Jose Luis Lazaro-Martinez
Summary: This study compares the effectiveness of different routine noninvasive techniques with hyperspectral imaging (HSI) in predicting the healing prognosis of diabetic foot ulcers (DFU5). The results show that Tcp02 values are the only variable associated with wound healing at 24 weeks, and HSI performs well in predicting healing outcomes.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Onno A. Mennes, Jaap J. van Netten, Jeff G. van Baal, Riemer H. J. A. Slart, Wiendelt Steenbergen
Summary: This study aimed to investigate the association between microcirculation and healing of diabetic foot ulcers, measured using LSCI and non-invasive blood pressure measurements. The results showed no significant association between healing and either type of measurement, indicating limited predictive ability of current blood pressure measurements or LSCI for diabetic foot ulcer healing.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Golnaz Mahmoudvand, Arian Karimi Rouzbahani, Zahra Sadat Razavi, Mohamad Mahjoor, Hamed Afkhami
Summary: Diabetic foot ulcer (DFU) is a severe complication of diabetes mellitus (DM) that can lead to amputation. The wound-healing process is impaired in diabetic patients, making conventional treatments ineffective. Mesenchymal stem cells (MSCs) have gained attention for their potential in improving wound healing. MSC therapy improves healing in DFU through immunomodulation, differentiation, and angiogenesis.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Afnan Harb, Mahmoud H. Elbatreek, Ahmed Elshahat, Nadia El-Akabawy, Waleed Barakat, Nesreen MIM. Elkomy
Summary: This study reveals the potential of alagebrium in the treatment of diabetic foot ulcer (DFU), as it promotes wound healing, improves sensory function and gait, reduces inflammation, and enhances angiogenesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Yu-Chi Wang, Hsiao-Chen Lee, Chien-Lin Chen, Ming-Chun Kuo, Savitha Ramachandran, Rong-Fu Chen, Yur-Ren Kuo
Summary: The study found that silver-releasing foam dressings were more effective in promoting wound healing of diabetic foot ulcers compared to silver-containing cream, particularly in the initial three weeks of treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Suman Baral, Satyan Rajbhandari
Summary: Nepal, a developing country, is facing a major health challenge with a high prevalence of diabetes (8.5%) affecting around 2 million people. Limited resources pose barriers to providing affordable and convenient diabetes care or regular screening for complications. There is no reliable data on the incidence, prevalence, and complications of diabetic foot problems in Nepal.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Ching-Wen Lin, Chien-Min Hung, Wan-Jiun Chen, Jui-Ching Chen, Wen-Yen Huang, Chia-Sing Lu, Ming-Liang Kuo, Shyi-Gen Chen
Summary: Diabetic foot ulcers are costly and problematic complications of diabetes. The chronicity of these ulcers presents a challenge in treatment. Modulating the activity of M1 and M2 macrophages seems to be an effective approach in improving the healing process of DFUs.
Article
Dermatology
Rebecca A. Burmeister, Christine Jarocki, Crystal M. Holmes, Gary M. Rothenberg, Michael E. Munson, Brian M. Schmidt
Summary: The study found that patients discharged to skilled nursing facilities after diabetes-related limb salvage surgery had longer healing time, increased risk of rehospitalization and subsequent major lower-extremity amputation on the same side, as well as a higher mortality rate compared to patients discharged home.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
Fatemeh Niami, Shahram Molavynejad, Ali Asghar Hemmati, Darioush Bijan Nejad, Leila Yazdanpanah, Nader Shakiba Maram, Amal Saki Malehi, Mandana Mahmoudi
Summary: This study aimed to evaluate the effect of an amniotic fluid gel on wound healing in diabetic foot ulcers. The results showed that the gel significantly improved wound grade, wound color, condition of the tissues surrounding the wound, overall wound condition, and duration of wound healing in diabetic patients.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Changhong Chen, Qinghua Wang, Daibin Li, Zhijian Qi, Yaofei Chen, Shanzheng Wang
Summary: This study found that exosomes isolated from platelet-rich plasma (PRP-exos) can serve as an optimized therapeutic strategy in treating diabetic foot ulcers (DFUs). The researchers aimed to investigate the role of MALAT1 in DFU wound healing through PRP-exos treatment and explore the underlying mechanism.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Computer Science, Information Systems
Sheena Punai Philimon, Audrey Kah Ching Huong
Summary: The study aimed to develop a reliable diagnostic tool for diabetic foot ulcer (DFU) through predicting transcutaneous oxygen saturation (StO2) and relative blood perfusion (tau). The results indicated that high tissue oxygenation and perfusion levels are crucial for ensuring progressive wound healing.
Article
Biochemistry & Molecular Biology
Lizong Tang, Zeyu Zhang, Shaojin Lei, Jie Zhou, Yufei Liu, Xinyi Yu, Jie Wang, Dongdong Wan, Jie Shi, Shufang Wang
Summary: In this study, a thermosensitive and pH-responsive injectable self-healing hydrogel loaded with drug was developed to promote angiogenesis and wound healing of diabetic foot ulcer. The hydrogel showed excellent biocompatibility and significantly enhanced therapeutic effects in vitro and in vivo.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Dermatology
Irena Pastar, Jelena Marjanovic, Liang Liang, Rivka C. Stone, Olga Kashpur, Ivan Jozic, Cheyanne R. Head, Avi Smith, Behzad Gerami-Naini, Jonathan A. Garlick, Marjana Tomic-Canic
Summary: By studying the miR-regulated changes triggered by cell reprogramming, it was found that iPSC reprogramming is an effective approach for erasing the non-healing miR-mediated epigenetic signature in diabetes, promoting a pro-healing cellular phenotype.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Frank P. P. Guerriero, Robyn A. A. Clark, Michelle Miller, Christopher L. L. Delaney
Summary: This single-center prospective observational study assesses the impact of bilayer biodegradable synthetic matrix technology (NovoSorb BTM) on the healing and amputation rates of patients with diabetes-related foot ulceration. The results suggest that NovoSorb BTM is a safe and effective treatment for moderate to severe diabetes-related foot ulceration.
Article
Medicine, General & Internal
Angel Ortiz-Zuniga, Jordi Samaniego, Betina Biagetti, Nicolas Allegue, Anna Gene, Andrea Sallent, Almudena Crespo, Jordi Serracanta, Carme Torrents, Daniela Issa, Danilo Rivas, Maria Teresa Veintemillas, Nuria Fernandez-Hidalgo, Rosa Busquets, Josep Royo, Cristina Hernandez
Summary: The aim of this study was to compare the incidence of lower-extremity amputations (LEA-DFD) before and after the establishment of a Diabetic Foot Multidisciplinary Unit. The results showed a significant reduction in the rate of amputations due to foot disease in patients with diabetes after the establishment of the unit.
JOURNAL OF CLINICAL MEDICINE
(2023)
Letter
Endocrinology & Metabolism
Metin Yayuz, Ryan W. Brem, Alan G. Glaros, Alan Garrett, Michael Flyzik, Lawrence Layery, Brian L. Davis, Henry Hilario, Linda S. Adams
Article
Biophysics
Visar Berki, Melissa A. Boswell, Daniela Ciltea, Loredana M. Guseila, Larry Goss, Scott Barnes, Necip Berme, Grant R. McMillan, Brian L. Davis
JOURNAL OF BIOMECHANICS
(2015)
Article
Biophysics
Christina M. Webber, Brian L. Davis
JOURNAL OF BIOMECHANICS
(2015)
Article
Biophysics
Visar Berki, Brian L. Davis
JOURNAL OF BIOMECHANICS
(2016)
Article
Biophysics
Brian Davis, Mariam Crow, Visar Berki, Daniela Ciltea
JOURNAL OF BIOMECHANICS
(2017)
Article
Engineering, Biomedical
Hande Argunsah Bayram, Chih-Hao Chien, Brian L. Davis
CLINICAL BIOMECHANICS
(2014)
Article
Biophysics
Metin Yavuz, Ryan W. Brem, Brian L. Davis, Jalpa Patel, Abe Osbourne, Megan R. Matassini, David A. Wood, Irene O. Nwokolo
JOURNAL OF BIOMECHANICS
(2014)
Article
Engineering, Multidisciplinary
Larry P. Goss, Jim W. Crafton, Brian L. Davis, Grant R. McMillan, Visar Berki, Amelia E. Howe, Marisa Papp
MEASUREMENT SCIENCE AND TECHNOLOGY
(2020)
Article
Biophysics
S. Cyrus Rezvanifar, Stephen Conklin, Brian L. Davis
JOURNAL OF BIOMECHANICS
(2020)
Article
Engineering, Biomedical
B. L. Davis, S. M. Tiell, G. R. McMillan, L. P. Goss, J. W. Crafton
Summary: Charcot neuropathy is a common complication of diabetes and peripheral neuropathy, leading to midfoot collapse. A study developed a foot model to show the dependence of interface stresses on altered arch support. The findings suggest that a decrease in plantar spring stiffness may lead to an increase in frictional force difference, which can be assessed using shear sensors.
CLINICAL BIOMECHANICS
(2021)
Article
Neurosciences
Brittany N. Sommers, Brian L. Davis
Summary: This study found that patients with Arnold-Chiari malformation exhibit significantly impaired postural stability, with those who have undergone decompression surgery showing even greater impairment. The results of this research can provide valuable insights for neurologists and therapists in understanding the disorder and planning effective rehabilitation and pain relief methods.
Article
Critical Care Medicine
Tanetta L. Curenton, Brian L. Davis, James E. Darnley, Scott D. Weiner, Josiah S. Owusu-Danquah
Summary: The study examined the mechanical performance of shape memory and superelastic nitinol bone staples with different bridge geometries, finding that the 20 mm bridge length staples provide higher contact forces and lower stresses in various bone types. This may be beneficial in bones with diminishing mechanical properties.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2021)
Article
Biophysics
Shaye M. Tiell, S. Cyrus Rezvanifar, Brian L. Davis
Summary: Currently, there are no viable systems for acquiring in-shoe measurement of distributed shear forces. Skin shear is notoriously difficult to measure, especially under the presence of forces normal to the skin surface that result in crosstalk between pressure and shear signals. This study showed that factors like coefficient of friction and sock stiffness can significantly affect the accuracy of shear measurements against the skin.
JOURNAL OF BIOMECHANICS
(2021)
Article
Orthopedics
Jessi K. Martin, Brian L. Davis
FOOT AND ANKLE CLINICS
(2023)
Proceedings Paper
Computer Science, Information Systems
SaiPrakash R. Gaddam, Mukesh K. Chippa, Shivakumar Sastry, Anthony Ange, Visar Berki, Brian L. Davis
2015 INTERNATIONAL CONFERENCE ON COMPUTATIONAL SCIENCE AND COMPUTATIONAL INTELLIGENCE (CSCI)
(2015)