Article
Endocrinology & Metabolism
Xi Wen, Huijun Yang, Man Yang, Wenyu Tao, Jiaoli Chen, Shanshan Zhao, Mingliu Yin, Xing Zhou, Ying Yang, Yiping Li
Summary: The impaired pancreatic beta-cell function may be a clinical determining factor of glucose variability in people with T2DM.
DIABETES OBESITY & METABOLISM
(2023)
Article
Chemistry, Analytical
Yiqun Liu, Li Yang, Yue Cui
Summary: Diabetes is a prevalent and chronic metabolic disease, and continuous monitoring is crucial for its management. Transdermal glucose biosensors offer accurate monitoring, but face challenges in biosensing principles, device configuration, and material integration. This review aims to address these questions and explore the practical applications of transdermal glucose biosensors.
Review
Biotechnology & Applied Microbiology
Lucy Johnston, Gonglei Wang, Kunhui Hu, Chungen Qian, Guozhen Liu
Summary: Continuous glucose monitors for non-invasive monitoring of diabetes are constantly being developed and improved, with increasing exploration of biosensing technologies using different bodily fluids to accurately measure blood glucose concentrations. Challenges still exist in terms of sensitivity at high or low glucose concentrations, but recent developments such as contact lenses or mouthguards show potential for improving wearability. This review summarizes the advances in wearable glucose biosensors over the past 5 years and discusses perspectives on the development of wearables for glucose biosensing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Yilin Li, Yueyue Chen
Summary: This paper reviews the research progress of noninvasive continuous blood glucose monitoring (CGM), focusing on the replacement of biological liquids for blood in monitoring systems, the technical principles of continuous noninvasive glucose detection, and the output and calibration of sensor signals. Additionally, the existing limitations and future prospects of noninvasive CGM systems are discussed.
Article
Medical Laboratory Technology
Guido Freckmann, James H. Nichols, Rolf Hinzmann, David C. Klonoff, Yi Ju, Peter Diem, Konstantinos Makris, Robbert J. Slingerland
Summary: People with diabetes need to monitor their glucose levels regularly, and traditional self-monitoring systems are being replaced by minimally invasive continuous glucose monitoring systems. However, these CGM systems face challenges with accuracy and lack of international reference measurement procedures.
CLINICA CHIMICA ACTA
(2021)
Article
Materials Science, Multidisciplinary
Israr Ahmed, Mohamed Elsherif, Murad Ali, Amal Al Ghaferi, Baker Mohammad, Haider Butt
Summary: Diabetes is a leading cause of death worldwide. Developing low-cost, rapid, and reusable sensors can provide a solution for continuous glucose monitoring to reduce the potentially fatal complications of diabetes. In this study, Phenylboronic acid (PBA)-based hydrogel sensors with embedded photonic nanostructures were developed for rapid and continuous glucose quantification within the physiological range.
MATERIALS & DESIGN
(2023)
Review
Endocrinology & Metabolism
Chris Worth, Lucy Hoskyns, Maria Salomon-Estebanez, Paul W. Nutter, Simon Harper, Terry G. J. Derks, Kathy Beardsall, Indraneel Banerjee
Summary: Childhood hypoglycemia remains a major health problem and risk factor for adverse neurodevelopment. Continuous Glucose Monitoring (CGM) devices have been used for detection and prevention, but there are challenges in accuracy, access, and cost. Despite this, CGM has aided in understanding the disease and improved trial design.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Kevin J. Scully, Jordan S. Sherwood, Kimberly Martin, Melanie Ruazol, Peter Marchetti, Mary Larkin, Hui Zheng, Gregory S. Sawicki, Ahmet Uluer, Isabel Neuringer, Lael M. Yonker, Leonard Sicilian, Deborah J. Wexler, Melissa S. Putman
Summary: This study investigated the correlation between continuous glucose monitoring (CGM) measures and clinical outcomes in adults with cystic fibrosis (CF), as well as the relationship between hemoglobin A1c (HbA1c) and CGM-derived average glucose (AG). The findings suggest that CGM measures of hyperglycemia and glycemic variability are superior to HbA1c in distinguishing those with and without cystic fibrosis-related diabetes (CFRD), with CGM-derived AG strongly correlated with HbA1c in this population. Future research is needed to explore the potential of using CGM as a diagnostic and screening tool for CFRD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Engineering, Biomedical
Jagannath Malik, Seongmun Kim, Jong Mo Seo, Young Min Cho, Franklin Bien
Summary: This paper presents a durable and minimally invasive implant type electromagnetic sensor for continuous glucose monitoring. The proposed sensor is capable of tracking minute changes in blood glucose level, and it has been successfully tested on live rodent models. The results demonstrate that the sensor is suitable for long term CGMS applications with high accuracy.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Endocrinology & Metabolism
Myat Win, Rowan Beckett, Lynn Thomson, Ajay Thankamony, Kathryn Beardsall
Summary: This retrospective study introduces the use of real-time CGM in monitoring persistent neonatal hypoglycemia. The study found significant fluctuations in glucose levels in babies with congenital hyperinsulinism, highlighting the challenges of preventing hypoglycemia. The results also suggest the potential application of CGM as an adjunct to clinical care in managing neonatal hypoglycemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Nutrition & Dietetics
Souptik Barua, Raven A. Wierzchowska-McNew, Nicolaas E. P. Deutz, Ashutosh Sabharwal
Summary: This study found discordance between plasma glucose measurements made using continuous glucose monitoring (CGM) and fingerstick meter after meals. CGM underestimated the rise in glucose levels and time spent in the normal range, while the fingerstick meter was more accurate. These discordances may have implications for applications such as precision nutrition and early detection of diabetes.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Optics
Siyang Liu, Xiaofeng Fang, Feixue Mi, Kai Sun, Changfeng Wu
Summary: In this study, covalent incorporation of metalloporphyrin in polymer dots was used to improve the stability and reproducibility of long-term glucose monitoring. Compared to traditional dye doping strategies, this method overcomes dye aggregation issues and shows good performance in a mouse model.
JOURNAL OF LUMINESCENCE
(2022)
Article
Automation & Control Systems
Abhinoy Kumar Singh, Mihailo V. Rebec, Ahmad Haidar
Summary: A continuous glucose monitoring system consists of a glucose sensor and an estimation algorithm, which can monitor blood glucose levels in real-time. The sensor generates electrical current when inserted under the skin, while the algorithm infers glucose levels in the blood. The study proposes a Kalman filter-based estimation algorithm, which provides more accurate results compared to alternative algorithms.
IEEE TRANSACTIONS ON CONTROL SYSTEMS TECHNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Chao Ji, Yang Xia, Huixu Dai, Zhiying Zhao, Tiancong Liu, Shuhui Tong, Xiaohang Zhang, Yuhong Zhao
Summary: This study aimed to determine age- and sex-specific reference values of PEF in the middle-aged and elderly Chinese population. PEF was found to decrease with age and be higher in men than in women. Factors such as height, weight, handgrip strength, and residence in rural areas were positively associated with PEF.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Biophysics
Xiaofeng Jin, Guanhua Li, Tailin Xu, Lei Su, Dan Yan, Xueji Zhang
Summary: Continuous glucose monitoring platform with optimized linear range and long-term stability was developed using a biocompatible conjugated polymer. The system included a small design with signal conditioning, programmable electrochemical chip, and wireless connection. Biocompatibility tests and animal experiments confirmed successful in vivo blood glucose monitoring.
BIOSENSORS & BIOELECTRONICS
(2022)