Article
Endocrinology & Metabolism
Navoda Atapattu, Marie Amoroso, Michael Powell, D. G. Harendra de Silva, K. Shamya H. de Silva, Jadwiga Furmaniak, Bernard Rees Smith, Lakdasa D. Premawardhana
Summary: This study assessed the prevalence of insulin and thyroid-related autoantibodies in children with type 1 diabetes (T1D) and their siblings in Sri Lanka. The results showed a high prevalence of autoantibodies in T1D children, and a correlation between insulin and thyroid autoantibodies. Additionally, the study found differences in the prevalence of insulin and thyroid autoantibodies between T1D children and unaffected siblings.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Falastin Salami, Roy Tamura, Lu You, Ake Lernmark, Helena Elding Larsson, Markus Lundgren, Jeffrey Krischer, Anette-Gabriele Ziegler, Jorma Toppari, Riitta Veijola, Marian Rewers, Michael J. Haller, William Hagopian, Beena Akolkar, Carina Torn
Summary: The study found that increased levels of HbA1c were associated with a higher risk of type 1 diabetes, while a decrease in HbA1c levels predicted the development of IA-2A autoantibody. The trajectory of HbA1c can predict the appearance of autoantibodies and the onset of type 1 diabetes.
PEDIATRIC DIABETES
(2022)
Article
Endocrinology & Metabolism
Carina Torn, Fariba Vaziri-Sani, Anita Ramelius, Helena Elding Larsson, Sten Anders Ivarsson, Marie Amoroso, Jadwiga Furmaniak, Michael Powell, Bernard Rees Smith
Summary: This study evaluated the RSR 3 Screen ICA (TM) and 2 Screen ICA (TM) for detection of islet cell autoimmunity in healthy Swedish subjects and patients with newly diagnosed type 1 diabetes. The results showed that both 3 Screen and 2 Screen had high sensitivity and specificity, indicating their suitability for screening islet cell autoimmunity.
ACTA DIABETOLOGICA
(2022)
Article
Endocrinology & Metabolism
Sian Louise Grace, Jack Bowden, Helen C. Walkey, Akaal Kaur, Shivani Misra, Beverley M. Shields, Trevelyan J. McKinley, Nick S. Oliver, Timothy McDonald, Desmond G. Johnston, Angus G. Jones, Kashyap A. Patel
Summary: This study aimed to assess the association between glutamate decarboxylase (GADA), islet antigen-2 (IA-2A), and zinc transporter 8 (ZnT8A) autoantibody levels with clinical and genetic characteristics at diagnosis of type 1 diabetes (T1D).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Multidisciplinary Sciences
Kristina Podolakova, Lubomir Barak, Emilia Jancova, Simona Tarnokova, Ludmila Podracka, Zuzana Dobiasova, Martina Skopkova, Daniela Gasperikova, Juraj Stanik
Summary: Little is known about complete remission in Type 1 diabetes mellitus (T1D) with the discontinuance of insulin treatment. This study analyzed the frequency and factors of onset and duration of remission in children with T1D. A new factor, higher C-peptide levels, was identified for complete remission onset. Complete remitters had longer remission durations and lower HbA1c levels compared to other remitters.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Roi Anteby, Aaron Lucander, Piotr J. Bachul, Jordan Pyda, Damian Grybowski, Lindsay Basto, Gabriela S. Generette, Laurencia Perea, Karolina Golab, Ling-jia Wang, Martin Tibudan, Celeste Thomas, John Fung, Piotr Witkowski
Summary: This study evaluated the prognostic utility of monitoring islet autoantibodies in diabetic patients after islet transplantation. It was found that GAD antibody levels could potentially serve as a predictive marker for outcomes post-transplant, while IA-2A and ZnT8A were undetectable in all patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Virology
Amir-Babak Sioofy-Khojine, Jussi P. Lehtonen, Noora Nurminen, Jutta E. Laiho, Jorma Toppari, Riitta Veijola, Johanna Lempainen, Jorma Ilonen, Mikael Knip, Heikki Hyoty
Summary: This study examined the immune response to the poliovirus vaccine in children at risk for type 1 diabetes (T1D) and whether the presence of islet autoimmunity affects this response. No differences were found in antibody levels between children with and without genetic risk for T1D. Furthermore, there was no difference in antibody levels between children with and without islet autoimmunity, regardless of the timing of autoimmunity onset or the specific autoantigen.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Review
Endocrinology & Metabolism
Carlo Ross, Zachary J. Ward, Apoorva Gomber, Maira Owais, Jennifer M. Yeh, Che-L. Reddy, Rifat Atun
Summary: This study provides a global synthesis of the prevalence of iAb in children and adolescents with type 1 diabetes from different countries and regions, revealing IA-2A as the most prevalent in new-onset diabetes and GADA as the most common in established cases. There are substantial variations in prevalence across different regions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Quynh Thi Vu Huynh, Minh Thi Tuyet Trinh, Khang Kim Doan, Ban Tran Ho, Szu-Chuan Shen, Tung Huu Trinh, Thanh Hoa Vo, Nguyen Quoc Khanh Le, Ngan Thi Kim Nguyen
Summary: Asian children in Vietnam are being diagnosed with both type 1 and type 2 diabetes, and the presence of islet autoantibodies makes the diagnosis more complicated. A study found that the prevalence of islet cell autoantibodies (ICAs) and glutamic acid decarboxylase 65 autoantibodies (GADAs) in children with type 1 diabetes was not significantly different from those with type 2 diabetes. Older children with type 1 diabetes were more likely to have ICAs or ICAs and GADAs, while a small proportion of young children had GADAs. However, a significant number of older children with type 2 diabetes were positive for GADAs, and all of them were classified as overweight or obese. The study suggests that further investigation is needed to find better biomarkers or an appropriate time to confirm diabetes type.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Anna Parkkola, Maaret Turtinen, Taina Harkonen, Jorma Ilonen, Mikael Knip
Summary: Family history of type 2 diabetes may impact the phenotype and genotype of children with type 1 diabetes, as children with a positive family history for type 2 diabetes tend to have features associated with type 2 diabetes at the time of type 1 diabetes diagnosis.
Article
Endocrinology & Metabolism
Neihenuo Chuzho, Neeraj Kumar, Neetu Mishra, Nikhil Tandon, Uma Kanga, Gurvinder Kaur, Paras Singh, Gunja Mishra, Shreya Sharma, Narinder K. Mehra
Summary: Our study evaluated the prevalence of GAD65 and IA-2 autoantibodies in 252 T1D patients from North India and found that GADA and IA2A were detected in 50.79% and 15.87% of patients, respectively. Genetic association analysis revealed that HLA-DRB1*03 and HLA-DQB1*02 were significantly associated with the development of GADA in T1D patients. This suggests that HLA-DRB1*03/DQB1*02 and HLA-DRB1*04/DQB1*03 may play a significant role in the development of GADA and IA2A, respectively.
JOURNAL OF DIABETES RESEARCH
(2021)
Article
Nutrition & Dietetics
Cincione Raffaele Ivan, Antonietta Messina, Giuseppe Cibelli, Giovanni Messina, Rita Polito, Francesca Losavio, Ester La Torre, Vincenzo Monda, Marcellino Monda, Stefano Quiete, Elias Casula, Nicola Napoli, Giuseppe Defeudis
Summary: Our study suggests that a very low-calorie ketogenic Mediterranean diet can rapidly improve metabolic, anthropometric, and body composition parameters in patients with prediabetes or diabetes and overweight/obesity.
Article
Endocrinology & Metabolism
Yu-Min Huang, Yen-Kuang Lin, Wei-Jei Lee, Kyoung Yul Hur, Kazunori Kasama, Anton Kui Sing Cheng, Ming-Hsien Lee, Simon Kin-Hung Wong, Tien-Chou Soong, Kuo-Ting Lee, Davide Lomanto, Muffazal Lakdawala, Yen-Hao Su, Weu Wang
Summary: Metabolic surgery significantly improved body weight, T2D, and other metabolic disorders in Asian patients, with different surgical procedures showing varied outcomes.
DIABETES OBESITY & METABOLISM
(2021)
Article
Multidisciplinary Sciences
Houda Afyouni, Basma Haris, Najeeb Syed, Ikhlak Ahmed, Noor Hamed, Tasneem Abdel-Karim, Shayma Mohammed, Amel Khalifa, Maryam Al-Maadheed, Mahmoud Zyoud, Ahmed Elawwa, Fawziya Al-Khalaf, Goran Petrovski, Khalid Hussain
Summary: This study describes the clinical, biochemical, and genetic characteristics of sib-pair familial type 1 diabetes in Qatar. Out of 44 families, 2 families had 4 affected siblings and 5 families had 3 affected siblings. The prevalence of sib-pair diabetes was found to be 3.64%, and the second affected siblings were older.
Review
Biochemistry & Molecular Biology
Witold Bauer, Attila Gyenesei, Adam Kretowski
Summary: Type 1 Diabetes (T1D) is caused by autoimmune destruction of insulin producing pancreatic ss-cells, leading to the lifelong need for insulin injections and careful monitoring of blood glucose levels. Despite current therapies, T1D still shortens life expectancy due to complications affecting multiple organs. The incidence of T1D in childhood is increasing, and the disease process is influenced by genetic susceptibility, environmental factors, and the number of autoimmune antibodies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Ilaria Barchetta, Carla Lubrano, Flavia Agata Cimini, Sara Dule, Giulia Passarella, Arianna Dellanno, Alberto Di Biasio, Frida Leonetti, Gianfranco Silecchia, Andrea Lenzi, Maria Gisella Cavallo
Summary: This study found a close relationship between NAFLD-related liver fibrosis, lower bone mineral density, and degraded microarchitecture in obese individuals. This suggests potential common pathways underlying liver and bone involvement in obesity and insulin resistance-associated disorders.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
D. Bruttomesso, C. Irace, P. Pozzilli
Summary: This study reported on glycemic control in Italian participants with type 1 diabetes and found that younger patients had better glycemic control compared to older patients. Factors such as body mass index and adherence to diet were associated with glycemic control.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Review
Andrology
Daniele Tienforti, Chiara Castellini, Francesca Di Giulio, Maria Totaro, Gilda Dalmazio, Luca Spagnolo, Mario Muselli, Giovanni Corona, Marco Giorgio Baroni, Arcangelo Barbonetti
Summary: This study aimed to determine the effectiveness and safety of selective estrogen receptor modulators in men with obesity-related functional androgen deficiency. The results of the clinical trial with 292 men showed a significant increase in testosterone levels with clomiphene and enclomiphene citrate treatment, with no unexpected safety findings.
Article
Endocrinology & Metabolism
M. L. Morieri, I. Raz, A. Consoli, M. Rigato, A. Lapolla, F. Broglio, E. Bonora, A. Avogaro, G. P. Fadini
Summary: This study compared the effectiveness of dapagliflozin to DPP-4 inhibitors in achieving individualized HbA1c targets and extra-glycaemic endpoints in elderly patients with type 2 diabetes. The results showed that patients initiating dapagliflozin had a lower likelihood of reaching individualized HbA1c targets compared to those initiating DPP-4 inhibitors. However, they experienced greater improvements in body weight and blood pressure.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Ernesto Maddaloni, Lucia Coraggio, Rocco G. Amendolara, Marco G. Baroni, Maria Cavallo, Massimiliano Copetti, Efisio Cossu, Paola D'Angelo, Luca D'Onofrio, Salvatore De Cosmo, Frida Leonetti, Susanna Morano, Lelio Morviducci, Nicola Napoli, Sabrina Prudente, Giuseppe Pugliese, Kyoungmin R. Park, Rury Holman, Vincenzo Trischitta, Raffaella Buzzetti, UMMER Study Diabet Grp
Summary: This study evaluated the possible associations of osteocalcin, osteoprotegerin, and osteopontin with cardiovascular disease (CVD) and diabetic retinopathy (DR) in type 2 diabetes patients. The findings showed that osteocalcin was associated with CVD, while osteoprotegerin and osteopontin were associated with DR.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Federica Sentinelli, Ilaria Barchetta, Flavia Agata Cimini, Sara Dule, Diego Bailetti, Efisio Cossu, Arcangelo Barbonetti, Maria Totaro, Olle Melander, Maria Gisella Cavallo, Marco Giorgio Baroni
Summary: Neurotensin (NT) is a small protein that regulates energy balance and functions as both a neurotransmitter in the brain and a gastrointestinal peptide. This study aimed to investigate the genetic regulation of plasma pro-NT levels. Seven sequence variations in the NT gene (NTS) were identified, including a polymorphism (rs2234762) that was more frequent in individuals with lower pro-NT levels. Carriers of the rs2234762 variant had lower pro-NT levels and reduced insulin resistance, independent of metabolic confounders. This suggests that the NTS rs2234762 gene variant may contribute to a more favorable metabolic profile in overweight and obese children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Flavia Agata Cimini, Antonella Tramutola, Ilaria Barchetta, Valentina Ceccarelli, Elena Gangitano, Simona Lanzillotta, Chiara Lanzillotta, Maria Gisella Cavallo, Eugenio Barone
Summary: BVRA protein levels can change dynamically in response to insulin and are greater in individuals with lower insulin sensitivity, indicating a correlation with insulin resistance and secretion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Alessandra Dei Cas, Raffaella Aldigeri, Alessandro Mantovani, Maria Masulli, Luisa Palmisano, Franco Cavalot, Katia Bonomo, Marco Giorgio Baroni, Efisio Cossu, Gisella Cavallo, Flavia Agata Cimini, Raffaella Buzzetti, Carmen Mignogna, Frida Leonetti, Simonetta Bacci, Roberto Trevisan, Mario Luca Morieri, Riccardo Maria Pollis, Giovanni Targher, Saula Vigili de Kreutzenberg
Summary: This observational study aimed to evaluate sex-related differences in cardiovascular disease (CVD) prevalence and risk in adults with type 1 diabetes. The study found that men had a higher prevalence of CVD than women aged 55 years and above, but the prevalence was comparable between the two sexes in those below 55 years of age. In patients without pre-existing CVD, men had a higher 10-year estimated CVD risk than women until the age of 55, but this difference disappeared after that age.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
F. Di Giulio, C. Castellini, D. Tienforti, G. Felzani, M. G. Baroni, A. Barbonetti
Summary: This study aimed to assess the independent association between low 25-hydroxy vitamin D (25(OH)D) levels and non-alcoholic fatty liver disease (NAFLD). The results showed that patients with lower 25(OH)D levels were more likely to have NAFLD and had other related factors. This study's findings suggest a relationship between vitamin D and NAFLD.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Alessandro Csermely, Alessandro Mantovani, Mario Luca Morieri, Luisa Palmisano, Maria Masulli, Efisio Cossu, Marco Giorgio Baroni, Katia Bonomo, Flavia Agata Cimini, Gisella Cavallo, Raffaella Buzzetti, Carmen Mignogna, Frida Leonetti, Simonetta Bacci, Roberto Trevisan, Riccardo Maria Pollis, Raffaella Aldigeri, Alessandra Dei Cas, Saula Vigili de Kreutzenberg, Giovanni Targher
Summary: A study of 1,417 adult T1DM patients found that the prevalence of MAFLD with significant fibrosis was lower in those using CSII therapy compared to MDI therapy, primarily due to age differences.
DIABETES & METABOLISM
(2023)
Letter
Endocrinology & Metabolism
Ernesto Maddaloni, Angela Carlone, Dario Pitocco, Giulia Leanza, Concetta Suraci, Maria G. Altomare, Maria Cavallo, Ilaria Barchetta, Susanna Morano, Chiara Moretti, Lucia Coraggio, Natalia Visalli, Flavia Tramontana, Riccardo Schiaffini, Antonino Crino, Raffaella Buzzetti, Paolo Pozzilli, MDIAB study grp
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Massimiliano Copetti, Marco Giorgio Baroni, Raffaella Buzzetti, Maria Gisella Cavallo, Efiso Cossu, Paola D'Angelo, Salvatore De Cosmo, Frida Leonetti, Susanna Morano, Lelio Morviducci, Nicola Napoli, Sabrina Prudente, Giuseppe Pugliese, Antonio Fernando Savino, Vincenzo Trischitta
Summary: This study aimed to validate the association of a 14-metabolite score with all-cause mortality in type 2 diabetes and explore whether it could improve existing mortality prediction models. The results showed a significant association between the 14-metabolite score and mortality in type 2 diabetes, although the effect size was lower compared to the general population. However, a simplified version of the score without two specific metabolites improved patient analysis and classification of mortality risk.
DIABETES-METABOLISM RESEARCH AND REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Valentina Maria Cambuli, Marco Giorgio Baroni
Summary: This article provides a synthetic overview of research in the treatment of type 1 diabetes, focusing on the development of intelligent insulins and the use of artificial intelligence in automated insulin therapy. It outlines the latest developments in the search for intelligent insulins and the promising advances in the use of artificial intelligence for glucose control. The future of insulin treatment in type 1 diabetes appears promising with the potential for a closed-loop artificial pancreas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sara Dule, Ilaria Barchetta, Flavia Agata Cimini, Giulia Passarella, Arianna Dellanno, Tiziana Filardi, Vittorio Venditti, Enrico Bleve, Diego Bailetti, Elisabetta Romagnoli, Susanna Morano, Marco Giorgio Baroni, Maria Gisella Cavallo
Summary: Type 2 diabetes mellitus is associated with increased fracture risk. This study aimed to explore differences in bone alterations between women with type 2 diabetes and controls, and to identify clinical predictors of bone impairment in type 2 diabetes. The results showed that type 2 diabetes patients had a lower normal bone category and their bone status was correlated with high-density lipoprotein cholesterol and vitamin D levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)