Article
Geriatrics & Gerontology
KayLoni L. Olson, Marjorie Howard, Jeanne M. McCaffery, Gareth R. Dutton, Mark A. Espeland, Felicia R. Simpson, Karen C. Johnson, Medha Munshi, Thomas A. Wadden, Rena R. Wing
Summary: Psychological resilience is associated with factors related to healthy aging in older adults with type 2 diabetes. Higher levels of psychological resilience are correlated with lower BMI, fewer hospitalizations, better physical functioning, fewer depressive symptoms, and better mental quality of life.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2023)
Article
Endocrinology & Metabolism
Rena R. Wing, Marjorie J. Howard, KayLoni L. Olson, Jessica L. Unick, Ariana M. Chao, Thomas A. Wadden, Lynne E. Wagenknecht
Summary: The study aimed to examine weight changes in older adults with type 2 diabetes and overweight or obesity during the COVID-19 shutdown, and compare the behavioral and psychosocial effects in individuals with different weight changes. The results showed that participants lost an average of 2.2 kg during the shutdown, with a higher percentage of weight loss compared to weight gain. Decreases in physical activity and increases in screen time were reported across all weight-change categories. Overall, there were few differences in psychosocial measures or self-reported effects of the shutdown among the weight-change groups, except for a more negative impact in those who gained weight.
Article
Medicine, General & Internal
Arnaud D. Kaze, Bernard G. Jaar, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui
Summary: The study found that increasing albuminuria and worsening stages of early CKD were independently associated with a higher risk of incident stroke in adults with type 2 diabetes.
Article
Cardiac & Cardiovascular Systems
Tasuku Terada, Jennifer L. Reed, Sol Vidal-Almela, Matheus Mistura, Kentaro Kamiya, Kimberley L. Way
Summary: This study examined the sex-specific interplay between fat mass and muscle mass on cardiovascular disease (CVD) risk factors in adults with type 2 diabetes living with overweight and obesity. The results showed that the effects of fat mass and muscle mass on A1C differed between genders.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Ping Zhang, Karen M. Atkinson, George A. Bray, Haiying Chen, Jeanne M. Clark, Mace Coday, Gareth R. Dutton, Caitlin Egan, Mark A. Espeland, Mary Evans, John P. Foreyt, Frank L. Greenway, Edward W. Gregg, Helen P. Hazuda, James O. Hill, Edward S. Horton, Van S. Hubbard, Peter J. Huckfeldt, Sharon D. Jackson, John M. Jakicic, Robert W. Jeffery, Karen C. Johnson, Steven E. Kahn, Tina Killean, William C. Knowler, Mary Korytkowski, Cora E. Lewis, Nisa M. Maruthur, Sara Michaels, Maria G. Montez, David M. Nathan, Jennifer Patricio, Anne Peters, Xavier Pi-Sunyer, Henry Pownall, Bruce Redmon, Julia T. Rushing, Helmut Steinburg, Thomas A. Wadden, Rena R. Wing, Holly Wyatt, Susan Z. Yanovski
Summary: The cost-effectiveness of an intensive lifestyle intervention (ILI) compared with standard diabetes support and education (DSE) over 9 years was unclear, as different health utility measures led to different conclusions regarding the additional quality-adjusted life years gained by ILI.
Article
Orthopedics
William M. Mihalko, Karen C. Johnson, Rebecca H. Neiberg, Judy L. Bahnson, Kunal Singhal, Phyllis A. Richey
Summary: A study found that patients with obesity who have undergone TKA can continue to maintain or lose weight after the surgery, especially when participating in an intensive lifestyle intervention program. The analysis also showed that the weight loss was more significant in the intervention group compared to the diabetes support and education group, both before and after TKA.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Peripheral Vascular Disease
Zeid Khitan, Tanmay Nath, Prasanna Santhanam
Summary: This study utilized machine learning techniques to predict the risk of albuminuria in persons with diabetes, finding that factors such as duration of diabetes, A1C, serum triglycerides were important for the classification of albuminuria.
JOURNAL OF CLINICAL HYPERTENSION
(2021)
Article
Orthopedics
William M. Mihalko, Karen C. Johnson, Rebecca H. Neiberg, Judy L. Bahnson, Kunal Singhal, Phyllis A. Richey
Summary: This study found that patients who have obesity can continue to maintain or lose weight after total knee arthroplasty (TKA) when participating in a weight loss program. The results showed that participants in the intensive lifestyle intervention (ILI) group had a greater percentage of weight loss both before and after TKA compared to the diabetes support and education (DSE) group.
JOURNAL OF ARTHROPLASTY
(2023)
Article
Public, Environmental & Occupational Health
Pan Ke, Minzhi Xu, Jie Feng, Qingfeng Tian, Yan He, Kai Lu, Zuxun Lu
Summary: This study found that obesity in middle and late adulthood is associated with an increased risk of type 2 diabetes (T2D) complicated with liver fibrosis. The prevalence of liver fibrosis was higher in T2D patients compared to non-T2D participants, and weight change was associated with a greater risk of fibrosis in the former group.
JOURNAL OF GLOBAL HEALTH
(2023)
Article
Endocrinology & Metabolism
Ariana M. Chao, Thomas A. Wadden, Jeanne M. Clark, Kathleen M. Hayden, Marjorie J. Howard, Karen C. Johnson, Blandine Laferrere, Jeanne M. McCaffery, Rena R. Wing, Susan Z. Yanovski, Lynne E. Wagenknecht
Summary: The prevalence of mild or greater depressive symptoms in older adults with diabetes was more than 1.6 times higher during COVID-19 than before the pandemic. The prevalence of loneliness increased, while the prevalence of insomnia remained stable.
Article
Endocrinology & Metabolism
Rena R. Wing
Summary: This paper reviews the findings of the Look AHEAD Trial, which tested the effects of intensive lifestyle interventions on health outcomes in individuals with overweight/obesity and type 2 diabetes. The study showed positive impacts of ILI on various health parameters, but also found that some outcomes did not significantly differ between the intervention and control groups. Post hoc analyses suggested potential subgroup differences, indicating that ILI may benefit some individuals while potentially harming others.
Article
Multidisciplinary Sciences
Yu Chen, Xilin Zhou, Kai McKeever Bullard, Ping Zhang, Giuseppina Imperatore, Deborah B. Rolka
Summary: The prevalence of diabetes has increased in the United States over the past two decades, with low-income populations being disproportionately affected. This study aimed to examine income-related inequalities in diabetes prevalence and identify contributing factors. Using data from the National Health Interview Survey, the study found that income-related inequalities in diabetes persisted throughout the study period, with a decrease during 2001-2011 and an increase during 2011-2018. Factors such as income, obesity, physical activity levels, and race/ethnicity were important contributors to diabetes inequalities at almost all time points, while changes in age and income explained the changes in diabetes inequalities over time.
Article
Cardiac & Cardiovascular Systems
Kershaw V. Patel, Muhammad Shahzeb Khan, Matthew W. Segar, Judy L. Bahnson, Katelyn R. Garcia, Jeanne M. Clark, Ashok Balasubramanyam, Alain G. Bertoni, Muthiah Vaduganathan, Michael E. Farkouh, James L. Januzzi, Subodh Verma, Mark Espeland, Ambarish Pandey
Summary: Evaluation of baseline and longitudinal changes in cardiometabolic health indicates their contribution to heart failure risk among adults with type 2 diabetes.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Arnaud D. Kaze, Sebhat Erqou, Prasanna Santhanam, Alain G. Bertoni, Rexford S. Ahima, Gregg C. Fonarow, Justin B. Echouffo-Tcheugui
Summary: This study found that greater variability in adiposity indices in individuals with type 2 diabetes was associated with a higher risk of incident heart failure, independently of traditional risk factors and baseline adiposity levels.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Endocrinology & Metabolism
Whitney Wharton, Andrea Anderson, Kathleen M. Hayden, Owen T. Carmichael, Jeanne M. Clark, Jose A. Luchsinger, Mark Espeland, Sevil Yasar
Summary: The aim of this study was to investigate whether antihypertensive medication acting through the renin angiotensin system (RAS-AHM) could mitigate cognitive function impairment and the risk of cognitive decline compared to other antihypertensive medication in individuals with type 2 diabetes mellitus (T2DM). The results showed that RAS-AHM users had a slower decline in processing speed, executive function, verbal memory, and composite score compared to other AHM users in this cohort of adults with T2DM who were free of dementia at the beginning of the study.
DIABETES OBESITY & METABOLISM
(2022)
Article
Peripheral Vascular Disease
Leo Gozdecki, Holly Kramer, Matthew Thomas, Karam Gardezi, Elizabeth Tarlov, Ashley Hughes, Kevin Stroupe, Meghan O'Halloran
Summary: This 20-week quality improvement study examines the implementation of a hypertension identification and management program using a standardized oscillometric blood pressure measurement protocol. The study found that the implementation of the protocol reduced digit preference and improved hypertension treatment.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Chemistry, Medicinal
Kristina. J. J. Cook, Ann Coulter, Michael Keenan, Frank Greenway, Jack. N. N. Losso
Summary: This study evaluated the beneficial effects of sodium butyrate (NaB) and sodium propionate (NaP) on fatty acid oxidation (FAO) genes and proinflammatory cytokine production related to nonalcoholic fatty liver disease (NAFLD). The results showed that NaP and NaB promoted FAO, regulated lipolysis, and reduced reactive oxygen species production in HepG2 cells. NaP and NaB also increased the mRNA expression of key genes related to FAO in different models. Additionally, only NaP treatment significantly decreased tumor necrosis factor alpha (TNF-alpha) expression in LPS-induced HepG2 cells. The findings suggest that NaP and NaB have potential for further in vivo studies on NAFLD.
JOURNAL OF MEDICINAL FOOD
(2023)
Article
Endocrinology & Metabolism
Stefany D. Primeaux, Robert Dubin, Frank L. Greenway
Summary: This study aimed to investigate the effects of an orlistat mouth rinse on the intake of a high-fat meal. The results showed that the orlistat mouth rinse decreased total and fat calories consumed during the high-fat meal in high-fat consumers, but did not alter calories consumed in low-fat consumers (P < 0.05).
DIABETES OBESITY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Candida J. Rebello, Dachuan Zhang, John P. Kirwan, Adam C. Lowe, Carlante J. Emerson, Chelsea L. Kracht, Lori C. Steib, Frank L. Greenway, William D. Johnson, Justin C. Brown
Summary: This study systematically summarized the effect of exercise training on whole-body insulin sensitivity and found that exercise training significantly increases insulin-stimulated glucose disposal. Weight loss may maximize the effect and improve hepatic insulin sensitivity. Differences in tracer methodology contribute to divergent outcomes and should be considered in research conclusions.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Peripheral Vascular Disease
Meghan O'Halloran, Ashley M. Hughes, Zhiping Huo, Frances Weaver, Kevin Stroupe, Elizabeth Tarlov, Holly Kramer
Summary: This study examines the accuracy of blood pressure measurement in Veterans Affairs (VA) medical centers and the perceptions of clinicians regarding blood pressure measurement. The results show that terminal digit preference (TDP) exists in VA medical centers, indicating a bias in BP measurement. The study also finds that the level of TDP varies among different centers and is associated with higher blood pressure control rates. Clinicians reported using semi-automated oscillometric devices for BP measurement, but still relied on auscultatory methods for confirmation. This highlights the importance of addressing TDP and improving the accuracy of BP measurement in VA medical centers.
JOURNAL OF CLINICAL HYPERTENSION
(2023)
Article
Endocrinology & Metabolism
John W. Apolzan, Jessica Gokee LaRose, Stephen D. Anton, Robbie A. Beyl, Frank L. Greenway, Edmond P. Wickham, Autumn Lanoye, Melissa N. Harris, Corby K. Martin, Tiffany Bullard, Gary D. Foster, Michelle I. Cardel
Summary: The efficacy of a scalable, virtually delivered, diabetes-tailored weight management program on glycemic control in adults with type 2 diabetes was tested. The results showed that the program had positive and clinically meaningful effects on glycemic control, body weight, and psychosocial outcomes.
NUTRITION & DIABETES
(2023)
Article
Endocrinology & Metabolism
Ann A. Coulter, Frank L. Greenway, Dachuan Zhang, Sujoy Ghosh, Cathryn R. Coulter, Sarah L. James, Yanlin He, Luke A. Cusimano, Candida J. Rebello
Summary: Naringenin, an activator found in citrus fruits, has beneficial effects on thermogenesis and insulin sensitivity. Our study investigated if carotenoids can enhance the metabolic effects of naringenin on adipocytes. Results showed that beta-carotene acts synergistically with naringenin to improve thermogenesis and glucose metabolism genes.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Editorial Material
Endocrinology & Metabolism
Hassan M. Heshmati, Livio Luzi, Frank L. Greenway, Candida J. Rebello
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Physiology
Alyssa N. Varanoske, Melissa N. Harris, Callie Hebert, Neil M. Johannsen, Steven B. Heymsfield, Frank L. Greenway, Arny A. Ferrando, Jennifer C. Rood, Stefan M. Pasiakos
Summary: The physical performance decrements observed during multi-stressor military operations may be attributed to cellular membrane dysfunction, which can be quantified using phase angle (PhA) derived from bioelectrical impedance analysis (BIA). Positive associations between PhA and performance have been reported, but it is unknown whether changes in PhA indicate acute decrements in performance during military operations.
PHYSIOLOGICAL REPORTS
(2023)
Article
Behavioral Sciences
Zheng Wang, Guillaume Spielmann, Neil Johannsen, Frank Greenway, Brian A. Irving, Marc Dalecki
Summary: This study demonstrates that normo-baric oxygen treatment can significantly improve participants' sequence learning processing speed, and this improvement consolidates after overnight sleep.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Review
Endocrinology & Metabolism
Candida J. Rebello, Tyler S. Morales, Katsya Chuon, Shu Dong, V. Tyrone Lam, Dan Purner, Stanley Lewis, Jonathan Lakey, Robbie A. Beyl, Frank L. Greenway
Summary: Insulin is secreted in pulses to regulate blood glucose levels. In type 2 diabetes, irregularities in insulin secretion occur. Native Americans have a higher prevalence of type 2 diabetes and are genetically predisposed to low beta-cell function. A retrospective chart review of metabolic outcomes in Native Americans showed improvements after physiologic hormone administration, suggesting the need for further investigation in randomized controlled trials.
Article
Multidisciplinary Sciences
Christoph Hoechsmann, Shengping Yang, Jose M. Ordovas, James L. Dorling, Catherine M. Champagne, John W. Apolzan, Frank L. Greenway, Michelle I. Cardel, Gary D. Foster, Corby K. Martin
Summary: Weight loss differences between isocaloric high-carbohydrate and high-fat diets are generally small, but individual weight loss varies within diet groups. Genotype patterns may modify diet effects on weight loss.
NATURE COMMUNICATIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Olivia N. Gilbert, Robert J. Mentz, Alain G. Bertoni, Dalane W. Kitzman, David J. Whellan, Gordon R. Reeves, Pamela W. Duncan, Michael Benjamin Nelson, Vanessa Blumer, Haiying Chen, Shelby D. Reed, Bharathi Upadhya, Christopher M. O'Connor, Amy M. Pastva
Summary: This study found that a 3-month rehabilitation intervention improved physical function and health-related quality of life in both older Black and White patients with acute decompensated heart failure, without significant differences between the two racial groups. However, the association between intervention and reduced all-cause rehospitalizations was stronger in White patients compared to Black patients, suggesting the need for further research.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Nutrition & Dietetics
Candida J. Rebello, Stephen Boue, Ronald J. Levy, Renee Puyau, Robbie A. Beyl, Frank L. Greenway, Mark L. Heiman, Jeffrey N. Keller, Charles F. Reynolds, John P. Kirwan
Summary: This study examined the safety of soybean products in Western diets and conducted a dose-escalating clinical trial in older adults with obesity. The results showed that consuming less than 30g of soybean flour per day is beneficial for cardiovascular and overall health, and can reduce the dependence on other food groups and nutrients in older adults with obesity.
Meeting Abstract
Sport Sciences
Alyssa N. Varanoske, Melissa N. Harris, Callie Hebert, Emily E. Howard, Neil M. Johannsen, Steven B. Heymsfield, Frank L. Greenway, Lee M. Margolis, Harris R. Lieberman, David D. Church, Arny A. Ferrando, Jennifer C. Rood, Stefan M. Pasiakos
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
