Decaffeinated Coffee and Glucose Metabolism in Young Men

OBJECTIVE - The epidemiological association between coffee drinking and decreased risk Of type 2 diabetes is strong. However, caffeinated coffee acutely impairs glucose metabolism. We assessed acute effects of decaffeinated coffee on glucose and insulin levels. RESEARCH DESIGN AND METHODS - This was a randomized, cross-over, placebo-controlled trial of the effects of decaffeinated coffee, caffeinated coffee, and caffeine on glucose, insulin, and glucose-de pendent insulinotropic poly-peptide (GIP) levels during a 2-h Oral glucose tolerance test (OGTT) in 11 young men. RESULTS - Within the first hour Of the CGTT, glucose and insulin were higher for decaffeinated coffee than for placebo (P < 0.05). During the whole OGTT, decaffeinated coffee yielded higher insulin than placebo and lower glucose and a higher insulin sensitivity index than caffeine. Changes in GIP could not explain any beverage effects on glucose and insulin. CONCLUSIONS - Some types of decaffeinated coffee may acutely impair glucose metabolism but less than caffeine.