Article
Endocrinology & Metabolism
Ashleigh K. Schneider, Shalem Y. Leemaqz, Julia Dalton, Petra E. Verburg, Ben W. Mol, Gus A. Dekker, Claire T. Roberts, Jessica A. Grieger
Summary: This study investigated the association between Metabolic Syndrome (MetS) and gestational diabetes mellitus (GDM) in pregnant nulliparous women, finding that physical activity did not significantly modify this association. The results suggest that more detailed information on physical activity is needed to determine its true impact on the relationship between MetS and GDM.
ACTA DIABETOLOGICA
(2021)
Article
Immunology
Eleana Bolla, Nikolaos Tentolouris, Petros P. Sfikakis, Maria G. Tektonidou
Summary: This study aimed to evaluate the prevalence of Metabolic Syndrome (MetS) in antiphospholipid syndrome (APS) patients and its associations with cardiovascular risk biomarkers, physical activity, and subclinical atherosclerosis. The results showed that MetS was present in approximately one-fourth of APS patients and was associated with arterial thrombosis, cardiovascular risk biomarkers, physical activity, and subclinical atherosclerosis. This suggests that MetS plays an important role in cardiovascular risk stratification and management in APS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Computer Science, Artificial Intelligence
Hui Yang, Yamei Luo, Xiaolei Ren, Ming Wu, Xiaolin He, Bowen Peng, Kejun Deng, Dan Yan, Hua Tang, Hao Lin
Summary: The study designed a computational system to predict diabetes risk by combining various types of physical examination data. Statistical analysis was conducted on different physical examination indexes to develop a model that can distinguish diabetes patients from healthy individuals. A diabetes risk scorecard was established to improve the convenience and flexibility of the model. Lastly, an online diabetes risk assessment system was set up to enhance diabetes cascade screening and personal lifestyle management.
INFORMATION FUSION
(2021)
Article
Endocrinology & Metabolism
Emily K. Sims, David Cuthbertson, Kevan C. Herold, Jay M. Sosenko
Summary: Metabolic changes in high-risk individuals receiving teplizumab treatment were visually and quantitatively assessed over a 6-month period, revealing delayed rapid metabolic decline and sustained improvement compared to the placebo group. Visual evidence and novel end points indicated a significant treatment effect within 3 months after treatment initiation and lasting for at least 6 months.
Article
Oncology
Xuechen Chen, Feng Guo, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner
Summary: This study aimed to investigate the relationship between physical activity (PA) and colorectal cancer (CRC), and assess the impact of PA on CRC risk based on genetic risk levels. The results showed that physical activity was associated with lower CRC risk regardless of genetic risk for CRC.
Article
Oncology
Yaqian Liu, Caiwang Yan, Shuangshuang Yin, Tianpei Wang, Meng Zhu, Li Liu, Guangfu Jin
Summary: Metabolic syndrome and genetic factors may contribute jointly to the risk of gastrointestinal cancer, and quantitative measurements can be used to identify high-risk populations for precise prevention.
Article
Endocrinology & Metabolism
Shiwen Li, Tingjing Zhang, Honghao Yang, Qing Chang, Yuhong Zhao, Liangkai Chen, Li Zhao, Yang Xia
Summary: Metabolic syndrome and genetic predisposition have an impact on the risk of developing chronic obstructive pulmonary disease (COPD), with individuals with MetS being at higher risk and those with high genetic predisposition having an increased risk. However, there is no significant interaction between MetS and genetic risk in relation to COPD risk.
DIABETES OBESITY & METABOLISM
(2023)
Review
Nutrition & Dietetics
Gabriela de Oliveira Lemos, Raquel Susana Torrinhas, Dan Linetzky Waitzberg
Summary: Metabolic syndrome (MetS) is a cluster of metabolic risk factors associated with various diseases. High intake of long-chain saturated fatty acid and sugar contributes to lipotoxicity and MetS through several pathways. However, intake of monounsaturated, polyunsaturated, and medium-chain saturated fatty acids, as well as plant-based proteins and whey protein, can improve metabolic profile. In addition, regular exercises can target sphingolipid metabolism and improve mitochondrial function and MetS components.
Article
Public, Environmental & Occupational Health
Angel Arturo Lopez-Gonzalez, Pere Riutord Sbert, Sebastiana Arroyo Bote, Hilda Gonzalez San Miguel, Carmen Vidal Real, Jose Ignacio Ramirez-Manent
Summary: Evaluating cardiovascular risk among construction workers through various scales can provide valuable insights for occupational health professionals in establishing prevention strategies.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2021)
Article
Construction & Building Technology
Mahdi Ghafoori, Caroline Clevenger, Moatassem Abdallah, Kevin Rens
Summary: This study models and forecasts the heart rate of construction workers using deep learning algorithms. The results show that the LSTM model has the best performance in heart rate prediction. These models can help reduce cardiovascular strain and prevent accidents in the construction industry.
AUTOMATION IN CONSTRUCTION
(2023)
Article
Public, Environmental & Occupational Health
Robert Ssekubugu, Fredrick Makumbi, Rocio Enriquez, Susanne R. Lagerstrom, Ping Teresa Yeh, Caitlin E. Kennedy, Ronald H. Gray, Lilian Negesa, David M. Serwadda, Godfrey Kigozi, Anna Mia Ekstrom, Helena Nordenstedt
Summary: This study qualitatively assessed the local knowledge of cardiovascular disease and type 2 diabetes risk scores in a rural Ugandan setting. The findings indicate that while most participants had a good understanding of the risk score items, there is a need for further clarification on the concept of physical activity. Additionally, the seasonality of fruits and vegetables should be taken into account in resource-poor rural settings.
Article
Cardiac & Cardiovascular Systems
Laura Gallardo-Alfaro, Maria del Mar Bibiloni, Cristina Bouzas, Catalina M. Mascaro, Miguel Angel Martinez-Gonzalez, Jordi Salas-Salvado, Dolores Corella, Helmut Schroder, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, Luis Serra-Majem, Aurora Bueno-Cavanillas, Rafael M. Mico, Xavier Pinto, Jose J. Gaforio, Maria Ortiz-Ramos, Andreu Altes-Boronat, Bogdana L. Luca, Lidia Daimiel, Emilio Ros, Carmen Sayon-Orea, Nerea Becerra-Tomas, Ignacio Manuel Gimenez-Alba, Olga Castaner, Itziar Abete, Lucas Tojal-Sierra, Jessica Perez-Lopez, Laura Torres-Collado, Antoni Colom, Antonio Garcia-Rios, Sara Castro-Barquero, Rosa Bernal, Jose Manuel Santos-Lozano, Cesar Fernandez-Lazaro, Pablo Hernandez-Alonso, Carmen Saiz, Maria Dolors Zomeno, Maria Angeles Zulet, Maria C. Bello-Mora, F. Javier Basterra-Gortari, Silvia Canudas, Albert Goday, Josep A. Tur
Summary: Reducing metabolic syndrome severity is associated with an anti-inflammatory dietary pattern, increased physical activity, high adherence to the Mediterranean diet, low sedentary time, and low depression risk, according to a one-year study on older adults at high cardiovascular risk.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Yan Zhang, Jaina Razbek, Deyang Li, Lei Yang, Liangliang Bao, Wenjun Xia, Hongkai Mao, Mayisha Daken, Xiaoxu Zhang, Mingqin Cao
Summary: This study aimed to construct simple and practical risk prediction models for metabolic syndrome (MetS) based on data from inhabitants of Urumqi. The logistic regression (LR) and decision tree (DT) models showed good prediction performance, with the DT model performing better. The models identified important risk and protective factors for MetS, providing methodological references for prevention and control.
Article
Endocrinology & Metabolism
Dominik Pesta, Tomas Jelenik, Oana-Patricia Zaharia, Pavel Bobrov, Sven Gorgens, Kalman Bodis, Yanislava Karusheva, Nina Krako Jakovljevic, Nebojsa M. Lalic, Daniel F. Markgraf, Volker Burkart, Karsten Mussig, Birgit Knebel, Jorg Kotzka, Jurgen Eckel, Klaus Strassburger, Julia Szendroedi, Michael Roden
Summary: The rs540467 SNP in the NDUFB6 gene is associated with adaptations to exercise training, with a notable impact on individuals with diabetes, particularly those with type 2 diabetes. Additionally, increasing physical activity levels may not always lead to improved insulin sensitivity in diabetes patients, where the polymorphism of the NDUFB6 gene could be a crucial factor.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Cuihong Huang, Lifang Chen, Jiangtao Li, Juanjuan Ma, Jun Luo, Qian Lv, Jian Xiao, Pan Gao, Wen Chai, Xu Li, Ming Zhang, Fulan Hu, Dongsheng Hu, Pei Qin
Summary: Through a systematic review and meta-analysis, we found an association between mitochondrial DNA copy number and diabetes mellitus and metabolic syndrome. Lower copy numbers were associated with increased risk of diabetes mellitus and metabolic syndrome.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Genetics & Heredity
Julie P. Taylor, Alka Malhotra, Nicole J. Burns, Amanda R. Clause, Carolyn M. Brown, Brendan T. Burns, Anjana Chandrasekhar, Zinayida Schlachetzki, Maren Bennett, Erin Thorpe, Ryan J. Taft, Denise L. Perry, Alison J. Coffey
Summary: Whole-genome sequencing (WGS) has increased the speed of gene discovery and emphasized the importance of open and collaborative data sharing. GeneMatcher (GM) connects researchers and clinicians to identify patients with variants in the same disease genes. Our experience with GM has been successful, resulting in published articles and ongoing collaborations with potential for publication.
Review
Medicine, General & Internal
Nicole Burns, Janice Linton, Nathaniel J. Pollock, Laura Jane Brubacher, Nadia Green, Arn Keeling, Alex Latta, Jessica Martin, Jenny Rand, Melody E. Morton Ninomiya
Summary: This paper examines the impacts of industrial resource development on the mental health of Indigenous Peoples through a literature review. The study finds a connection between the environment and Indigenous wellbeing. The research methods include literature search and screening, with the results being relevant for land use policy, health impact assessments, economic development, mental health service planning, and communities engaging in development projects.
SYSTEMATIC REVIEWS
(2022)
Article
Endocrinology & Metabolism
Hood Thabit
Summary: In this study, the accuracy and performance of a seventh-generation G7 continuous glucose monitor system were examined in participants with type 1 diabetes aged 2 to 17 years. The study had notable points that increase its applicability to clinical practice, such as assessing accuracy under various conditions and highlighting enhanced features of the G7 system. However, there were relatively few accuracy measurements in the younger age group.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2023)
Article
Medicine, General & Internal
Lalantha Leelarathna, Mark L. L. Evans, Sankalpa Neupane, Gerry Rayman, Sarah Lumley, Iain Cranston, Parth Narendran, Katharine Barnard-Kelly, Christopher J. J. Sutton, Rachel A. A. Elliott, Vicky P. P. Taxiarchi, Georgios Gkountouras, Matthew Burns, Womba Mubita, Naresh Kanumilli, Maisie Camm, Hood Thabit, Emma G. G. Wilmot
Summary: This study investigated the efficacy of intermittently scanned continuous glucose monitoring in patients with type 1 diabetes. The results showed that compared to traditional fingerstick testing, the use of intermittently scanned continuous glucose monitoring significantly reduced glycated hemoglobin levels and improved blood glucose control.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Hood Thabit, Womba Mubita, Jose Rubio, Mini Karuppan, Jonathan Schofield, Malgorzata E. Willinska, Roman Hovorka, Lalantha Leelarathna
DIABETES OBESITY & METABOLISM
(2023)
Letter
Endocrinology & Metabolism
Hood Thabit, Charlotte Boughton, Womba Mubita, Jose Rubio, Julia K. Mader, Parth Narendran, Mark Evans, Lalantha Leelarathna, Malgorzata E. Wilinska, Catherine Fullwood, Alice M. Gregory, Roman Hovorka, Martin K. Rutter
DIABETES OBESITY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Filip Kolodziej, Brian McDonagh, Nicole Burns, Katarzyna Goljanek-Whysall
Summary: Oxidative stress and inflammation are associated with muscle function decline, but paradoxically, they are also important for adaptive responses to exercise. MicroRNAs play a key role in regulating skeletal muscle metabolism and phenotype. Regular aerobic exercise, accompanied by a healthy diet, can promote metabolic health and muscle hypertrophy through miRNA-mediated regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Julia Ware, Malgorzata E. Wilinska, Yue Ruan, Janet M. Allen, Charlotte K. Boughton, Sara Hartnell, Lia Bally, Carine de Beaufort, Rachel E. J. Besser, Fiona M. Campbell, Katharine Draxlbauer, Daniela Elleri, Mark L. Evans, Elke Frohlich-Reiterer, Atrayee Ghatak, Sabine E. Hofer, Thomas M. Kapellen, Lalantha Leelarathna, Julia K. Mader, Womba M. Mubita, Parth Narendran, Tina Poettler, Birgit Rami-Merhar, Martin Tauschmann, Tabitha Randell, Hood Thabit, Ajay Thankamony, Nicola Trevelyan, Roman Hovorka
Summary: The safety of the algorithm intensification mode (Boost) in a hybrid closed-loop (HCL) system was evaluated in this study. The results showed that the use of the Boost mode in HCL therapy is safe across all age groups with type 1 diabetes, but it may lead to longer periods of hyperglycemia.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Mustafa Fattah, Charlotte K. Boughton, Julia Ware, Janet M. Allen, Sara Hartnell, Malgorzata E. Willinska, Ajay Thankamony, Carine de Beaufort, Fiona M. Campbell, Elke Froehlich-Reiterer, Sabine E. Hofer, Thomas M. Kapellen, Birgit Rami-Merhar, Atrayee Ghatak, Tabitha L. Randell, Rachel E. J. Besser, Daniela Elleri, Nicola Trevelyan, Louise Denvir, Nikki Davis, Lia Bally, Hood Thabit, Lalantha Leelarathna, Mark L. Evans, Julia K. Mader, Roman Hovorka
Summary: Personal glucose targets have an impact on glycemic control, with higher targets leading to poorer control.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY
(2022)
Article
Endocrinology & Metabolism
Heba Alwan, Julia Ware, Charlotte E. Boughton, Malgorzata M. Wilinska, Janet Allen, Rama Lakshman, Munachiso Nwokolo, Sara Hartnell, Lia Bally, Carine de Beaufort, Rachel E. J. Besser, Fiona M. Campbell, Nikki Davis, Louise Denvir, Mark L. Evans, Elke Froehlich-Reiterer, Atrayee Ghatak, Sabine E. Hofer, Thomas M. Kapellen, Lalantha Leelarathna, Julia K. Mader, Parth Narendran, Birgit Rami-Mehrar, Martin Tauschmann, Hood Thabit, Ajay Thankamony, Roman Hovorka
Summary: This study aimed to assess the difference in percentage of time spent in hypoglycemia during closed-loop insulin delivery among different age groups and time of day. The results showed that the median time spent in hypoglycemia over the 24-hour period was highest in children and adolescents, followed by very young children, adults, and older adults. Time spent in hypoglycemia during nighttime was lower than during daytime across all age groups.
DIABETES TECHNOLOGY & THERAPEUTICS
(2023)
Letter
Endocrinology & Metabolism
Hood Thabit, Jonathan Schofield, Lalantha Leelarathna
Article
Endocrinology & Metabolism
A. K. Schneider-Utaka, S. Hanes, C. K. Boughton, S. Hartnell, H. Thabit, W. M. Mubita, K. Draxlbauer, T. Poettler, J. Hayes, M. E. Wilinska, J. K. Mader, P. Narendran, L. Leelarathna, M. L. Evans, R. Hovorka, K. K. Hood
Summary: The use of the CamAPS FX hybrid closed loop system has been found to improve time in range and glycated hemoglobin A1c levels across all age groups. However, there is limited research on its effects on patient-reported outcomes (PROs). This study compared CamAPS FX to sensor-augmented pump in older adults with type 1 diabetes. The results showed that the use of the CL system led to improved PROs and subjective user experience benefits.
Review
Endocrinology & Metabolism
Abdulrahman O. Al-Naseem, Ahmed Attia, Ahmed Reda Gonnah, Abdulaziz O. A. S. Al-Naseem, Harry V. M. Spiers, Angelika Gruessner, Lalantha Leelarathna, Hood Thabit, Titus Augustine
Summary: Pancreas or islet transplantation is currently the only cure for type 1 diabetes mellitus. While alternative therapies such as automated insulin delivery systems and islet cell transplantation are being used, further development is needed to treat a larger proportion of diabetes patients.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Rachel A. Elliott, Gabriel Rogers, Mark L. Evans, Sankalpa Neupane, Gerry Rayman, Sarah Lumley, Iain Cranston, Parth Narendran, Christopher J. Sutton, Vicky P. Taxiarchi, Matthew Burns, Hood Thabit, Emma G. Wilmot, Lalantha Leelarathna, FLASH UK Trial Study Grp
Summary: This study aims to assess the economic impact of intermittently scanned continuous glucose monitoring (isCGM) compared with self-monitoring of blood glucose with finger pricking (SMBG). The results show that although isCGM is associated with increased short-term costs, its benefits in lowering HbA1c justify the costs in the long-term, as long as the effect lasts into the medium term.
Letter
Endocrinology & Metabolism
Hood Thabit, Charlotte Boughton, Womba Mubita, Jose Rubio, Stuart Allen, Robert Heugh, Julia K. Mader, Parth Narendran, Mark Evans, Lalantha Leelarathna, Malgorzata E. Wilinska, Catherine Fullwood, Clifford Garratt, Roman Hovorka, Martin K. Rutter
DIABETES OBESITY & METABOLISM
(2023)