Article
Biochemistry & Molecular Biology
Alexandra Katsimardou, Dimitrios Patoulias, Ioanna Zografou, Fotios Siskos, Konstantinos Stavropoulos, Konstantinos Imprialos, Zoi Tegou, Aristi Boulmpou, Vivian Georgopoulou, Nikoleta Hatzipapa, Christodoulos Papadopoulos, Michael Doumas
Summary: This study aimed to examine the impact of metabolic syndrome and its components on the erectile function of patients with type 2 diabetes mellitus. The results showed that metabolic syndrome was not associated with erectile dysfunction (ED) or its severity. However, high-density lipoprotein cholesterol (HDL) was found to be associated with ED and erectile function scores.
Article
Obstetrics & Gynecology
Khalid M. Alshehri, Raghad A. Althobaiti, Athar Alqurashi, Nada E. Algethami, Khaled A. Alswat
Summary: This study investigated the prevalence of female sexual dysfunction (FSD) in women with diabetes and/or thyroid disorders and analyzed the impact of disease control on the ASEX score. The results showed a high prevalence of FSD among women with diabetes and/or thyroid disorders, with the highest ASEX scores observed in patients with type 1 diabetes.
INTERNATIONAL JOURNAL OF WOMENS HEALTH
(2022)
Article
Immunology
Hui Wang, Kangli Cao, Siyu Liu, Yuanhong Xu, Ling Tang
Summary: The study found that the frequency and absolute number of NK cells in patients with type 2 diabetes mellitus were significantly lower than in healthy individuals. The expression of surface receptors and cytokine production in NK cells were affected in patients, and correlated with high blood glucose levels.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
Thea N. Golden, Rebecca A. Simmons
Summary: Intrauterine growth restriction (IUGR) is a common complication of pregnancy that increases the risk of type 2 diabetes mellitus (T2DM) later in life for the offspring. The development and balance of the fetal immune system, the role of pancreatic-resident macrophages, and cytokines derived from beta-cells and macrophages play key roles in islet development and function. Therapeutic immunomodulation may be beneficial for treating T2DM, particularly in cases induced by IUGR.
NATURE REVIEWS ENDOCRINOLOGY
(2021)
Review
Medicine, Research & Experimental
Arpita Arora, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Eduardo Sobarzo-Sanchez, Simona Bungau
Summary: Type 2 diabetes mellitus is a prevalent metabolic disorder characterized by high blood sugar, high blood lipids, and insulin resistance, with genetic mutations, obesity, lack of physical activity, and imbalances in gut microbiota being possible contributing factors. The balance of gut microbiota is crucial for maintaining human health.
Review
Biochemistry & Molecular Biology
Ding Yao, Yang GangYi, Wu QiNan
Summary: Recent studies have shown that autophagy plays a crucial role in maintaining the function of islet beta cells and inhibiting insulin resistance and apoptosis induced by oxidative stress. However, dysfunction of autophagy may also have negative effects on type 2 diabetes mellitus.
Letter
Medicine, General & Internal
Juan P. Frias, Laura Fernandez Lando, Katelyn Brown
Summary: In the SURPASS-2 trial, treatment with Tirzepatide showed better glycemic control and greater weight loss compared to Semaglutide in patients with type 2 diabetes. Additionally, there were no significant differences in mean systolic blood pressure among the enrolled patients in different treatment groups.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Maren E. H. Buskoven, Eir K. H. Kjorholt, Ragnhild B. Strandberg, Eirik Softeland, Anne Haugstvedt
Summary: This study aimed to explore the experiences of sexual health and sexual challenges in women with type 1 diabetes (T1D). The results found that women with T1D faced various challenges related to their sexual health, including reduced sexual desire, vaginal dryness, and pain during intercourse. The study emphasizes the importance of addressing sexual health in diabetes follow-up to provide comprehensive health services.
Article
Endocrinology & Metabolism
Mariangela Gaudio, Nicoletta Dozio, Michael Feher, Marina Scavini, Amelia Caretto, Mark Joy, Jeremy Van Vlymer, William Hinton, Simon de Lusignan
Summary: The study aimed to describe trends in modifiable and non-modifiable unfavorable factors affecting pregnancy outcomes in women with diabetes of childbearing age from an English primary care perspective. Despite improvements in general diabetes care, the majority of women with Type 1 or Type 2 diabetes still have unfavorable, mostly modifiable factors for the start of pregnancy. Good diabetes care for women of childbearing age should consider the possibility of pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Health Care Sciences & Services
Julia Samoilova, Mariia Matveeva, Olga Tonkih, Dmitry Kudlau, Oxana Oleynik, Aleksandr Kanev
Summary: The study explored metabolic changes in the hippocampus of patients with type 1 and type 2 diabetes, finding different factors influencing the changes. Modifying specific risk factors can slow down the progression of cognitive dysfunction in diabetes patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Obstetrics & Gynecology
Leandro Cordero, Michael R. Stenger, Mark B. Landon, Craig A. Nankervis
Summary: This study compared the differences in exclusive breastfeeding and breastfeeding initiation among women with different types of diabetes, and found that women with type 1 diabetes had a higher intention for exclusive breastfeeding. At discharge, women with type 1 diabetes had lower rates of exclusive breastfeeding and breastfeeding initiation and a higher rate of formula feeding compared to women with type 2 diabetes.
BMC PREGNANCY AND CHILDBIRTH
(2022)
Article
Multidisciplinary Sciences
Yiming Li, Cungang Wu, Yuhong Li
Summary: The global incidence of diabetes and its complications, particularly cardiovascular complications, is increasing. This study examined left ventricular function in individuals with type 2 diabetes mellitus (T2D) using automated cardiac motion quantification (aCMQ) and found significant differences in strain parameters among different disease stages and decreased parameters with longer disease duration. The study also demonstrated that aCMQ and tissue motion mitral annular displacement technique (TMAD) were effective in detecting altered left ventricular function in T2D patients, with high agreement and predictive value. Overall, this study highlights the importance of assessing and monitoring left ventricular function in T2D patients.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Alexandra Katsimardou, Dimitrios Patoulias, Ioanna Zografou, Zoi Tegou, Konstantinos Imprialos, Konstantinos Stavropoulos, Maria Toumpourleka, Asterios Karagiannis, Konstantinos Petidis, Michael Doumas
Summary: This study aimed to assess the association between diabetic kidney disease (DKD) and sexual dysfunction (SD), including erectile dysfunction (ED) and female sexual dysfunction (FSD), in type 2 diabetes mellitus (T2DM) patients. The results showed that SD was common in older T2DM patients, with DKD affecting almost half of them. The eGFR was significantly associated with SD, ED, and FSD.
MEDICINA-LITHUANIA
(2023)
Article
Endocrinology & Metabolism
Annika Vestergaard Kvist, Mohamad I. Nasser, Peter Vestergaard, Morten Frost, Andrea M. Burden
Summary: A study in Denmark from 1997 to 2017 found that the incidence rates of fractures were higher in patients with type 1 and type 2 diabetes compared to those without diabetes, except for foot fractures. The incidence of hip fractures decreased by 35.2%, 47.0%, and 23.4% in patients with type 1 diabetes, type 2 diabetes, and without diabetes, respectively, over the last 5 years. However, vertebral fractures increased by 14.8%, 18.5%, and 38.9% in the same groups. After age adjustment, patients with type 1 diabetes still had a higher risk of fractures compared to those without diabetes, while patients with type 2 diabetes had a risk similar to those without diabetes.
Article
Multidisciplinary Sciences
Joan Khoo, Christoph E. Hagemeyer, Darren C. Henstridge, Sumukh Kumble, Ting-Yi Wang, Rong Xu, Linsey Gani, Thomas King, Shui-Boon Soh, Troy Puar, Vanessa Au, Eberta Tan, Tunn-Lin Tay, Carmen Kam, Eng-Kiong Teo
Summary: ELO water increases arterial blood oxygen levels, has a protective effect on hyperglycaemia-induced reduction in mitochondrial mass and dysfunction, and may be an effective adjuvant therapy for type 2 diabetes.
