Review
Immunology
Ariadna Anunciacion-Llunell, Francesc Miro-Mur, Enrique Esteve-Valverde, Joana Marques-Soares, Josep Pardos-Gea, Jaume Alijotas-Reig
Summary: Identification of differentially expressed proteins in antiphospholipid syndrome (APS) through proteomics research provides insights into the pathological mechanisms and potential clinical applications. Dysregulated proteins in APS patients are connected to cellular activation and thrombosis, highlighting the need for validation and targeted therapies for different clinical subtypes.Exploration of new autoantibodies and post-translational modifications also contribute to understanding the antigen-autoantibody recognition in APS.
AUTOIMMUNITY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Miji Shin, Sang Hyun Park, Sora Mun, Jiyeong Lee, Hee-Gyoo Kang
Summary: Acute coronary syndrome (ACS) is a condition where the coronary artery is obstructed, leading to abnormalities in blood supply to the heart. This study aimed to identify new ACS diagnostic biomarkers using a proteomic approach, showing potential for increasing the accuracy of ACS diagnosis. By analyzing proteins in ACS patients and healthy controls, specific biomarkers such as hemopexin and vitronectin were found to be upregulated, while fibronectin was downregulated.
Review
Hematology
Natasha Letunica, Suelyn Van den Helm, Conor McCafferty, Ella Swaney, Tengyi Cai, Chantal Attard, Vasiliki Karlaftis, Paul Monagle, Vera Ignjatovic
Summary: Proteomics is an innovative approach to study all proteins in a given cell, tissue or organism. Recent technological advancements have increased its application in thrombosis and hemostasis research, allowing for the identification of novel markers associated with disease diagnosis and prognosis.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Medicine, General & Internal
Valentin Chioncel, Catalina Liliana Andrei, Radu Brezeanu, Crina Sinescu, Anamaria Avram, Alin Laurentiu Tatu
Summary: The development of coronary stents has revolutionized the treatment of coronary heart disease, but allergic reactions are a common complication. Careful selection of treatment for allergic patients can help reduce the occurrence of complications.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Yu-Lun Cai, Ben-Chuan Hao, Jian-Qiao Chen, Yue-Rui Li, Hong-Bin Liu
Summary: In this study, plasma proteomics was used to identify potential prognostic biomarkers for chronic coronary syndrome (CCS). The proteins EPCR and CETP were found to be promising indicators for predicting major adverse cardiovascular events (MACEs) in CCS patients. Combining these biomarkers with the Framingham coronary heart disease (CHD) risk model significantly improved the predictive accuracy of MACEs in CCS patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Fumi Yamamoto, Masahiro Natsuaki, Shoichi Kuramitsu, Masanobu Ohya, Hiromasa Otake, Kazunori Horie, Futoshi Yamanaka, Hiroki Shiomi, Gaku Nakazawa, Kenji Ando, Kazushige Kadota, Shigeru Saito, Takeshi Kimura, Koichi Node
Summary: This study assessed the association between clinical presentation at index procedure and mortality in patients with second-generation drug-eluting stent thrombosis. The results showed that the cumulative 3-year incidence of all-cause death after the index ST events was similar between patients with acute coronary syndrome (ACS) and chronic coronary syndrome (CCS), but patients in the ACS group were more likely to have early ST and higher incidences of target lesion revascularization and recurrent ST compared to the CCS group.
JACC-CARDIOVASCULAR INTERVENTIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Hyo-Soo Kim, Jeehoon Kang, Doyeon Hwang, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon-Kwon Koo, Seok Yeon Kim, Keun-Ho Park, Seung-Woon Rha, Won-Yong Shin, Hong-Seok Lim, Kyungil Park, Kyung Woo Park
Summary: The study demonstrated that in patients with acute coronary syndrome (ACS), durable polymer drug-eluting stents (DP-DES) were noninferior to biodegradable polymer DES (BP-DES) in terms of patient-oriented composite outcomes at 12 months after percutaneous coronary intervention.
Article
Cardiac & Cardiovascular Systems
Yiping Ma, Yujuan Yuan, Zulipiya Aili, Miribani Maitusong, Hao Li, Muyesai Nijiati
Summary: This study used proteomics to investigate the differential protein expression and biological functions in coronary microparticles of patients with AMI and SCAD. The results showed significant differences in protein expression between AMI and SCAD patients, with involvement of various metabolic pathways and molecular functions. These differentially expressed proteins may provide insights into the molecular mechanisms underlying acute thrombosis in AMI patients.
CARDIOLOGY JOURNAL
(2023)
Article
Clinical Neurology
Hongcheng Mai, Tianyuan Zhang, Tao Zhang, Aijun Lu, Zhengdong Wu, Bing Yang, Niu He, Xiaoyan Liu, Chi Kwan Tsang, Anding Xu, Dan Lu
Summary: This study aimed to understand the molecular pathological differences between the soft and stiff regions of human arterial thrombus. By analyzing human arterial thrombi using a spatial proteomic workflow, researchers identified distinct protein compositions in the soft and stiff regions. In a mouse model, inhibition of TGF-beta 1 delayed arterial thrombosis and accelerated blood flow restoration. This study suggests that TGF-beta 1 is a key therapeutic target for promoting arterial thrombolysis.
Article
Biochemistry & Molecular Biology
Botond Barna Matyas, Imre Benedek, Emanuel Blindu, Renata Gerculy, Aurelian Rosca, Nora Rat, Istvan Kovacs, Diana Opincariu, Zsolt Parajko, Evelin Szabo, Bianka Benedek, Theodora Benedek
Summary: This study investigated the impact of COVID-19 infection on coronary artery disease (CAD) using an AI-powered solution called CaRi-Heart((R)) in patients who underwent computed tomography angiography (CCTA) for chest pain. The results showed that patients with a previous COVID-19 infection had higher levels of pericoronary inflammation, suggesting an increased risk of coronary plaque destabilization. This study highlights the potential long-term impact of COVID-19 on cardiovascular health and emphasizes the importance of monitoring and managing cardiovascular risk factors in recovering patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Cristina de Cortina Camarero, Eloy Gomez Mariscal, Victoria Espejo Bares, Alberto Nunez Garcia, Roberto Munoz Aguilera, Javier Botas Rodriguez
Summary: The incidence of ACS is higher in COVID-19 patients, often associated with severe infection and poor prognosis. This suggests the need for careful monitoring and management in this patient population.
Article
Biochemistry & Molecular Biology
Ekaterina Mikhailovna Stakhneva, Elena Vladimirovna Kashtanova, Yana Vladimirovna Polonskaya, Eugeniia Vitalievna Striukova, Viktoriya Sergeevna Shramko, Evgeny Viktorovich Sadovski, Alexey Vitalievich Kurguzov, Ivan Sergeevich Murashov, Alexander Mikhailovich Chernyavskii, Yuliya Igorevna Ragino
Summary: Quantitative proteomics studies revealed associations between several blood proteins and the presence of unstable atherosclerotic plaques in the arteries of patients with coronary atherosclerosis, including afamin, attractin, components of the complement system, hemopexin, and haptoglobin. These findings provide insight into the potential roles of these blood proteins in the development of coronary atherosclerosis and their potential as biomarkers for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Integrative & Complementary Medicine
Gaosong Wu, Jing Zhao, Nixue Song, Ningning Zheng, Yuanyuan Zeng, Tingting Yao, Jingfang Zhang, Jieqiong Weng, Mengfei Yuan, Hu Zhou, Xiaoxu Shen, Houkai Li, Weidong Zhang
Summary: This study investigated the biological basis of Syndrome differentiation in Traditional Chinese Medicine for Coronary Heart Disease. The results revealed significant metabolic pathway differences and potential biomarkers between patients with different Syndromes, as well as possible associations with comorbidities. This evidence-based strategy sheds light on translating TCM theory into the practice of precision medicine.
Article
Biochemistry & Molecular Biology
Dulce Maria Delgadillo, Adriana Ivonne Cespedes-Cruz, Emmanuel Rios-Castro, Maria Guadalupe Rodriguez Maldonado, Mariel Lopez-Nogueda, Miguel Marquez-Gutierrez, Rocio Villalobos-Manzo, Lorena Ramirez-Reyes, Misael Dominguez-Fuentes, Jose Tapia-Ramirez
Summary: Autoimmune lymphoproliferative syndrome (ALPS) is a rare disease that is often misdiagnosed. This study provides further insights into the molecular and proteomic analysis of ALPS by studying peripheral blood mononuclear cells (PBMCs) from two ALPS patients, and highlights potential mechanisms involved in the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Iris C. Kreft, Roy R. A. Winiarczyk, Fric J. Tanis, Carmen van der Zwaan, Katharina S. Schmitz, Arie J. Hoogendijk, Rik L. de Swart, Anne Moscona, Matteo Porotto, Daniela C. F. Salvatori, Rory D. de Vries, Moniek P. M. de Maat, Maartje van den Biggelaar, Bart J. M. van Vlijmen
Summary: This study aimed to explore the use of plasma and lung material from SARS-CoV-2-inoculated ferrets to study COVID-19-associated changes in coagulation and thrombosis. The results showed no evidence of vascular thrombosis in the lungs of infected ferrets. Plasma protein profiles in infected ferrets exhibited minor differences with stable coagulation factors.
THROMBOSIS RESEARCH
(2022)