Article
Nutrition & Dietetics
Mette Glavind Bulow Pedersen, Esben Sondergaard, Camilla Bak Nielsen, Mogens Johannsen, Lars Christian Gormsen, Niels Moller, Niels Jessen, Nikolaj Rittig
Summary: Oral lactate administration can directly affect the upper gastrointestinal tract, altering gut hormone secretion, motility, and appetite sensations, which cannot be solely mediated by lactate in the systemic circulation. This may have implications for the treatment of metabolic diseases.
CLINICAL NUTRITION
(2022)
Article
Endocrinology & Metabolism
Cong Xie, Weikun Huang, Linda E. Watson, Stijn Soenen, Richard L. Young, Karen L. Jones, Michael Horowitz, Christopher K. Rayner, Tongzhi Wu
Summary: The study found that gastric emptying is not a determinant of the postprandial GLP-1 response in individuals, but the intrinsic gastric emptying rate is partly determined by the responsiveness of GLP-1 to intestinal nutrients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Fuxun Yang, Fan Zeng, Xiaoxiu Luo, Yu Lei, Jiajia Li, Sen Lu, Xiaobo Huang, Yunping Lan, Rongan Liu
Summary: GLP-1 receptor agonists can not only regulate blood glucose levels but also improve organ function, regulate immunity, and control inflammation in patients with sepsis. They have potential therapeutic benefits for sepsis patients with stress hyperglycemia.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Lara Ribeiro-Parenti, Anne-Charlotte Jarry, Jean-Baptiste Cavin, Alexandra Willemetz, Johanne Le Beyec, Aurelie Sannier, Samira Benadda, Anne-Laure Pelletier, Muriel Hourseau, Thibaut Leger, Bastien Morlet, Anne Couvelard, Younes Anini, Simon Msika, Jean-Pierre Marmuse, Severine Ledoux, Maude Le Gall, Andre Bado
Summary: This study reveals the presence of GLP-1 expressing cells in the stomach, which secrete active GLP-1 and are influenced by weight loss surgeries. Gastric glucose load induces a rapid increase in GLP-1 levels, and obese rats and individuals who undergo surgery exhibit changes in gastric mucosa phenotype.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Hitoshi Kuwata, Daisuke Yabe, Kenta Murotani, Yuuka Fujiwara, Takuya Haraguchi, Sodai Kubota, Saki Kubota-Okamoto, Ryota Usui, Minori Ishitobi, Yuji Yamazaki, Yoshiyuki Hamamoto, Takeshi Kurose, Yusuke Seino, Yuichiro Yamada, Yutaka Seino
Summary: Evidence suggests that lixisenatide and liraglutide have better effects on glucose-lowering and weight reduction, while dulaglutide shows more limited effects in these aspects.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Review
Endocrinology & Metabolism
Christophe E. M. De Block, Eveline Dirinck, Ann Verhaegen, Luc F. Van Gaal
Summary: Glucagon-like peptide-1 receptor agonists and dual GLP-1/glucose-dependent insulinotropic peptide RA tirzepatide have expanded the population of individuals reaching HbA1c and weight targets, showing potential therapeutic benefits. However, further research is needed to determine whether this will lead to improved cardiovascular outcomes and impact treatment guidelines.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Daniel Gonzalez-Izundegui, Alejandro Campos, Gerardo Calderon, Maria L. Ricardo-Silgado, Lizeth Cifuentes, Paul A. Decker, Eric J. Vargas, Linh Tran, Duane Burton, Barham Abu Dayyeh, Michael Camilleri, Jeanette E. Eckel-Passow, Andres Acosta
Summary: This study found an association between gastric emptying and sensations of appetite, with rapid gastric emptying being linked to increased appetite, which could contribute to weight gain.
Article
Multidisciplinary Sciences
Li-Hua Zhao, Qian He, Qingning Yuan, Yimin Gu, Xinheng He, Hong Shan, Junrui Li, Kai Wang, Yang Li, Wen Hu, Kai Wu, Jianhua Shen, H. Eric Xu
Summary: This study reports a new binding mode between a G protein and its receptor, involving a specific small-molecule agonist. The high-resolution structure of the complex is determined, providing insights for designing small-molecule agonists for class B G-protein-coupled receptors.
Article
Multidisciplinary Sciences
Li-Hua Zhao, Qian He, Qingning Yuan, Yimin Gu, Xinheng He, Hong Shan, Junrui Li, Kai Wu, Yang Li, Wen Hu, Kai Wu, Jianhua Shen, H. Eric Xu
Summary: A study reports an orally available small-molecule agonist that binds between a G protein and its receptor, and characterizes this new binding mode.
Article
Anesthesiology
Sandra R. R. Klein, Ion A. A. Hobai
Summary: This case report discusses the association between the use of semaglutide for weight loss and delayed gastric emptying, as well as intraoperative pulmonary aspiration of gastric contents. A 42-year-old patient with Barrett's esophagus, who had been receiving semaglutide injections for weight loss, experienced substantial gastric content during an endoscopy procedure despite fasting for 18 hours. The patient required suctioning and bronchoscopy to remove food remains from the trachea and bronchi.
CANADIAN JOURNAL OF ANESTHESIA-JOURNAL CANADIEN D ANESTHESIE
(2023)
Article
Endocrinology & Metabolism
Rasmus Stenlid, Sara Y. Cerenius, Quan Wen, Banu Kucukemre Aydin, Hannes Manell, Azazul Chowdhury, Hjalti Kristinsson, Iris Ciba, Erik S. Gjessing, Katharina Moerwald, Julian Gomahr, Verena Heu, Daniel Weghuber, Anders Forslund, Peter Bergsten
Summary: Weekly injections of 2 mg exenatide extended release maintain endogenous total GLP-1 levels and lower circulating DPP-4 levels. This provides supportive evidence for the use of exenatide in the treatment of pediatric obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Kirsten Dahl, Ashley Brooks, Firas Almazedi, Tetens Soren Hoff, Cristina Boschini, Tine A. Baekdal
Summary: Oral semaglutide significantly improved both fasting and postprandial glucose and lipid metabolism, and delayed gastric emptying in subjects with type 2 diabetes. However, one serious adverse event (acute myocardial infarction) did occur during the treatment.
DIABETES OBESITY & METABOLISM
(2021)
Article
Pharmacology & Pharmacy
Maria Buur Nordskov Gabe, Laerke Smidt Gasbjerg, Sarina Gadgaard, Peter Lindquist, Jens Juul Holst, Mette Marie Rosenkilde
Summary: This study investigates the regulatory role of the GLP-2 system in the gut and bones by studying the effects of N-terminal truncations of human GLP-2 peptides on GLP-2 receptor activity and selectivity. The results show that the N-terminus of GLP-2 is crucial for GLP-2 receptor activity and selectivity. These findings provide a foundation for the development of tool compounds for further characterization of the GLP-2 system.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Noura G. Eissa, Mahmoud Elsabahy, Ayat Allam
Summary: GLP-1 receptor agonists are increasingly used in the management of type 2 diabetes mellitus, while nanotechnology enables precise drug delivery, enhancing pharmacological efficacy and overcoming application limitations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Psychiatry
Daniel H. Cooper, Ranuk Ramachandra, Felicia Ceban, Joshua D. Di Vincenzo, Taeho Greg Rhee, Rodrigo B. Mansur, Kayla M. Teopiz, Hartej Gill, Roger Ho, Bing Cao, Leanna M. W. Lui, Muhammad Youshay Jawad, Juliet Arsenault, Gia Han Le, Diluk Ramachandra, Ziji Guo, Roger S. McIntyre
Summary: This study aimed to investigate whether GLP-1 receptor agonists can be used prophylactically to lower the risk of incident depression in patients with diabetes mellitus (DM). The results showed mixed findings regarding the effect of GLP-1 receptor agonists on lowering the risk of incident depression. Further research is needed to better understand the potential neuroprotective effects of GLP-1 receptor agonists on depression in patients with DM.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
