Article
Pharmacology & Pharmacy
Maarten A. Mees, Fleur Boone, Thomas Bouwen, Frederik Vanaerschot, Charlotte Titeca, Hanna-Kaisa Vikkula, Leen Catrysse, Anja Vananroye, Erin Koos, Stelios Alexandris, Sabine Rosenfeldt, Samuel Eyley, Joachim Koetz, Geert van Loo, Wim Thielemans, Esther Hoste
Summary: High-mobility group box 1 (HMGB1) released during wounding delays skin regeneration. We discovered that dissolving glycyrrhizin in water forms a hydrogel with remarkable rheological properties. Glycyrrhizin-based hydrogels accelerate the closure of cutaneous wounds in normoglycemic and diabetic mice by influencing keratinocyte migration.
Review
Environmental Sciences
Pooya M. Tehrany, Parham Rahmanian, Aryan Rezaee, Golnaz Ranjbarpazuki, Farima Sohrabi Fard, Yasaman Asadollah Salmanpour, Mohammad Arad Zandieh, Ali Ranjbarpazuki, Sajedeh Asghari, Nazanin Javani, Noushin Nabavi, Amir Reza Aref, Mehrdad Hashemi, Mohsen Rashidi, Afshin Taheriazam, Alireza Motahari, Kiavash Hushmandi
Summary: Hydrogels have diverse biomedical uses and can expedite wound healing by improving inflammation, promoting cell growth, inhibiting bacterial infection, and triggering angiogenesis. Smart hydrogels with responsiveness to external stimuli and environmentally friendly hydrogels show promising potential in wound healing.
ENVIRONMENTAL RESEARCH
(2023)
Article
Chemistry, Applied
Amin Sadeghi, Maryam Zare-Gachi, Mostafa Najjar-Asl, Sarah Rajabi, Mohammad Javad Fatemi, Siamak Farokh Forghani, Hamed Daemi, Mohamad Pezeshki-Modaress
Summary: In this study, a novel biodegradable gelatin/sulfated alginate hybrid scaffold was introduced as a dermal substitute for accelerating the healing of full-thickness diabetic foot ulcers in a diabetic mouse model. The hybrid scaffold exhibited no cytotoxicity and promoted cell growth with increasing sulfated alginate content. The pathology results showed that the hybrid scaffolds-treated wounds had more appropriate epidermal layer formation, more homogeneous distribution of collagenous tissue, and lower immune cell penetration.
CARBOHYDRATE POLYMERS
(2023)
Review
Polymer Science
Weslen Vedakumari Sathyaraj, Lokesh Prabakaran, Jayavardhini Bhoopathy, Sankari Dharmalingam, Ramadoss Karthikeyan, Raji Atchudan
Summary: Diabetic wounds pose a serious health issue for individuals with diabetes, as they have a slow and improper healing process. Current diabetic wound dressings vary in their ability to absorb wound exudates and may cause maceration to surrounding tissues. This review focuses on the recent advances in polymeric biomaterial-based wound dressings and novel therapeutic regimes for diabetic wound treatment, highlighting the importance of developing dressings that can absorb exudates, promote gas exchange, protect against infections, and support the synthesis of crucial biochemical factors for faster wound healing. The use of polymeric wound dressings loaded with bioactive compounds and their in vitro and in vivo performance in treating diabetic wounds are also discussed.
Article
Chemistry, Multidisciplinary
Mingyan Deng, Ye Wu, Yan Ren, Haoyang Song, Li Zheng, Guangzhi Lin, Xin Wen, Yiran Tao, Qingquan Kong, Yu Wang
Summary: A multi-functional hydrogel based on hyaluronic acid was synthesized through a click reaction, showing antibacterial, anti-inflammatory, and pro-angiogenic properties. The hydrogel encapsulated nanoparticles with a smart drug release profile and effectively facilitated the healing of infected wounds in vivo.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Ayesha Khalid, Ahmed Madni, Bareera Raza, Mazhar ul Islam, Amjad Hassan, Fiaz Ahmad, Hussain Ali, Taous Khan, Fazli Wahid
Summary: The study developed a potential composite film for diabetic wound healing by reinforcing the bacterial cellulose (BC) matrix with multiwalled carbon nanotubes (MWCNT). The composite film exhibited excellent antibacterial activity and accelerated the healing process of diabetic wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Endocrinology & Metabolism
Xiaoping Yu, Pan Liu, Zheng Li, Zhengdong Zhang
Summary: Diabetes is a global public health problem, with diabetic foot being one of its severe complications that have a significant impact on patients' economic burden and quality of life. Recent studies have shown that mesenchymal stem cells (MSCs) can effectively treat diabetic foot ulcers by promoting angiogenesis and re-epithelialization, regulating the immune response, and reducing inflammation. MSCs from different sources have similar characteristics and subtle differences, and understanding their features is crucial for improving the therapeutic effect of diabetic foot ulcers.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Wenhao Hao, Huali Meng, Hui Li, Yan Zheng, Chunhong Song, Ziping Jiang, Xue Bai, Zhiyue Zhang, Lei Du, Pei Liu, Hao Wu
Summary: Diabetes impairs wound healing, but the local application of krill oil can accelerate diabetic wound healing by reversing inflammation, impaired collagen deposition, and suppressed neovascularization.
Article
Engineering, Environmental
Shizhou Wu, Boquan Qin, Xiaofang Tang, Ting Cui, Shijiu Yin, Hongxian Dong, Yunjie Liu, Shu Deng, Hui Zhang, Guoying Feng, Huiqi Xie, Lei Lei
Summary: In this study, a multifunctional hyaluronic acid methacrylate (HAMA)/carboxymethyl chitosan (CMCS) core-shell microneedle patch with sodium alginate as a moisture layer was developed to maintain moisture balance in diabetic wounds. The microneedles were held on the wound by a chitosan adhesive layer and had sufficient strength to penetrate the biofilm. S. aureus secreted hyaluronidase to degrade the HAMA shell and promote the release of graphene oxide, which exhibited strong antibacterial activity.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Physical
Zejun Xu, Guiting Liu, Li Zheng, Jun Wu
Summary: A hydrogel with enhanced antimicrobial and antioxidant properties (CMGFC) was developed to accelerate diabetic wound healing. The CMGFC hydrogel showed high antibacterial efficiency and strong ROS scavenging ability, protecting cells from oxidative stress. In vivo results demonstrated reduced inflammatory responses, enhanced angiogenesis, and improved wound healing with the CMGFC hydrogel.
Review
Nanoscience & Nanotechnology
Mpho Phehello Ngoepe, Aidan Battison, Steven Mufamadi
Summary: This article discusses emerging technologies designed to improve wound care upon skin injury. It highlights the impact of diabetes mellitus and burns on the skin's protective barrier, leading to chronic wound healing and reinfections. Traditional wound dressing techniques have limitations, thus requiring the development of different nanomaterials used at different stages for rapid healing and scar prevention.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Engineering, Environmental
Kai Wang, Ruonan Dong, Jiezhang Tang, Huichen Li, Juanli Dang, Zhaoxiang Zhang, Zhou Yu, Baolin Guo, Chenggang Yi
Summary: This study developed a self-healing hydrogel capable of stably releasing exosomes to enhance diabetic wound healing. Through the synergistic effect of exosome release and M2 macrophage polarization, it accelerated angiogenesis and wound healing.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Savannah M. Aitcheson, Francesca D. Frentiu, Sheree E. Hurn, Katie Edwards, Rachael Z. Murray
Summary: Macrophages play a crucial role in wound healing, but in individuals with diabetes, these cells are dysfunctional, hindering the healing process and potentially leading to the formation of diabetic foot ulcers. Understanding macrophage dysregulation in DFUs and developing better therapies can improve healing rates in these patients.
Article
Biochemistry & Molecular Biology
Jinhua Chi, Ai Li, Mingyu Zou, Shuo Wang, Chenqi Liu, Rui Hu, Zhiwen Jiang, Wanshun Liu, Rongju Sun, Baoqin Han
Summary: In this study, dopamine was successfully grafted with oxidized sodium alginate to fabricate OSA-DA hydrogels with enhanced biocompatibility and suitable adhesion. The hydrogels exhibited appropriate swelling ratio and adhesion characteristics, and demonstrated satisfactory cytocompatibility in cells and biocompatibility in animals. Moreover, OSA-DA hydrogels showed remarkable promoting effects on angiogenesis and wound healing, making them a potential clinical wound dressing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Medicine, Research & Experimental
Minqi Shi, Zhen Du, Yuchen Qi, Wanlin Li, Huiqun Hu, Xiuhui Lin, Shoujie Wang, Zhe Tang, Min Zhou
Summary: The study used hollow mesoporous silica nanoparticles to deliver azithromycin and glucose oxidase, achieving a significant synergistic effect in chronic diabetic wounds. This method promotes wound healing by improving the wound microenvironment and eradicating bacterial biofilms.
Article
Dentistry, Oral Surgery & Medicine
Hector L. Sarmiento, Badr Othman, Michael R. Norton, Joseph P. Fiorellini
INTERNATIONAL JOURNAL OF PERIODONTICS & RESTORATIVE DENTISTRY
(2016)
Article
Dentistry, Oral Surgery & Medicine
Saba Kassim, Badr Othman, Sakher AlQahtani, Alemad Mustafa Kawthar, Sterling M. McPherson, Barbara L. Greenberg
Correction
Endocrinology & Metabolism
Fanxing Xu, Badr Othman, Jason Lim, Angelika Batres, Bhaskar Ponugoti, Chenying Zhang, Leah Yi, Jian Liu, Chen Tian, Alhassan Hameedaldeen, Sarah Alsadun, Rohinton Tarapore, Dana T. Graves
Article
Dentistry, Oral Surgery & Medicine
Hamsah Sheerah, Badr Othman, Arwa Jaafar, Alla Alsharif
SAUDI DENTAL JOURNAL
(2019)
Article
Dentistry, Oral Surgery & Medicine
Najla Saeed Dar-Odeh, Badr M. Othman, Rayan H. Bahabri, Ahmad A. Alnazzawi, Sary S. Borzangy, Hani T. Fadel, Albraa B. Alolayan, Osama A. Abu-Hammad
PESQUISA BRASILEIRA EM ODONTOPEDIATRIA E CLINICA INTEGRADA
(2018)
Article
Dentistry, Oral Surgery & Medicine
Harold S. Baumgarten, Badr Othman
CLINICAL ADVANCES IN PERIODONTICS
(2013)
Article
Medicine, General & Internal
Badr Othman, Talal Zahid
Summary: This study compared the detection of mental nerve anterior loop between CBCT and panoramic radiographs, finding CBCT to be more accurate and reliable. The study recommends the use of CBCT as a preoperative assessment tool in mandibular premolar implant placement surgeries to minimize nerve injury-related complications.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Medicine, General & Internal
Badr Othman, Hanadi Khalifa, Abdulmajeed Afandi, Nawaf A. Alshehri, Ahmed Sait, Sultan Abdoun, Talal Zahid
Summary: This retrospective study of 119 adults aged 18-65 found that additional care and assessment should be considered when implanting permanent lateral incisors and canines. The frequency of fenestrations and dehiscence is higher in older adults, with possible management options including guided bone regeneration or pink restorative solutions.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)