In Vivo Pancreatic β-Cell–Specific Expression of Antiaging GeneKlotho: A Novel Approach for Preserving β-Cells in Type 2 Diabetes

Selective turnover of p62/A170/SQSTM1 by autophagy

(2014) Yoshinobu Ichimura et al.   Autophagy

AAV Delivery of Tumor Necrosis Factor-α Short Hairpin RNA Attenuates Cold-Induced Pulmonary Hypertension and Pulmonary Arterial Remodeling

(2014) Patrick Crosswhite et al.   HYPERTENSION

Mitochondrial superoxide mediates mitochondrial and endoplasmic reticulum dysfunctions in TRAIL-induced apoptosis in Jurkat cells

(2013) Toshio Inoue et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox-Sensitive Endoplasmic Reticulum Stress and Autophagy at Rostral Ventrolateral Medulla Contribute to Hypertension in Spontaneously Hypertensive Rats

(2013) Yung-Mei Chao et al.   HYPERTENSION

Klotho gene delivery suppresses Nox2 expression and attenuates oxidative stress in rat aortic smooth muscle cells via the cAMP-PKA pathway

(2012) Yuhong Wang et al.   AGING CELL

Antiaging Gene Klotho Enhances Glucose-Induced Insulin Secretion by Up-Regulating Plasma Membrane Levels of TRPV2 in MIN6 β-Cells

(2012) Yi Lin et al.   ENDOCRINOLOGY

AAV-Based RNAi Silencing of NADPH Oxidase gp91phox Attenuates Cold-Induced Cardiovascular Dysfunction

(2012) Xiuqing Wang et al.   HUMAN GENE THERAPY

Fibroblast Growth Factor 23 (FGF23) and Alpha-Klotho Stimulate Osteoblastic MC3T3.E1 Cell Proliferation and Inhibit Mineralization

(2011) V. Shalhoub et al.   CALCIFIED TISSUE INTERNATIONAL

Proliferating Cell Nuclear Antigen (PCNA) Regulates Primordial Follicle Assembly by Promoting Apoptosis of Oocytes in Fetal and Neonatal Mouse Ovaries

(2011) Bo Xu et al.   PLoS One

High dosage of Exendin-4 increased early insulin secretion in differentiated beta cells from mouse embryonic stem cells

(2010) Hua Li et al.   ACTA PHARMACOLOGICA SINICA

ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic β-cells

(2010) Gabriela da Silva Xavier et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

In Vivo Expression of HGF/NK1 and GLP-1 From dsAAV Vectors Enhances Pancreatic  -Cell Proliferation and Improves Pathology in the db/db Mouse Model of Diabetes

(2010) D. F. Gaddy et al.   DIABETES

The endoplasmic reticulum stress response in the pancreatic β-cell

(2010) A. Volchuk et al.   DIABETES OBESITY & METABOLISM

The role of autophagy in β-cell lipotoxicity and type 2 diabetes

(2010) G. Las et al.   DIABETES OBESITY & METABOLISM

Ribonucleic Acid Interference Knockdown of Interleukin 6 Attenuates Cold-Induced Hypertension

(2010) Patrick Crosswhite et al.   HYPERTENSION

Targeting β-Cell Function Early in the Course of Therapy for Type 2 Diabetes Mellitus

(2010) Jack L. Leahy et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

RNAi silencing of brain klotho potentiates cold-induced elevation of blood pressure via the endothelin pathway

(2010) Xiuqing Wang et al.   PHYSIOLOGICAL GENOMICS

A Practical Guide to Rodent Islet Isolation and Assessment

(2009) Jeffrey D. Carter et al.   BIOLOGICAL PROCEDURES ONLINE

Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders

(2009) Mark P. Mattson   EXPERIMENTAL GERONTOLOGY

Klotho Gene Delivery Prevents the Progression of Spontaneous Hypertension and Renal Damage

(2009) Yuhong Wang et al.   HYPERTENSION

β-Cell deterioration during diabetes: what's in the gun?

(2009) R. Paul Robertson   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism

Glucolipotoxicity: Fuel Excess and β-Cell Dysfunction

(2008) Vincent Poitout et al.   ENDOCRINE REVIEWS

FGF-23–Klotho signaling stimulates proliferation and prevents vitamin D–induced apoptosis

(2008) Damian Medici et al.   JOURNAL OF CELL BIOLOGY

The Identification of Potential Factors Associated with the Development of Type 2 Diabetes

(2008) Hongfang Lu et al.   MOLECULAR & CELLULAR PROTEOMICS

The Klotho gene family as a regulator of endocrine fibroblast growth factors

(2008) Hiroshi Kurosu et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY