Article
Endocrinology & Metabolism
Yuan Liang, Ruili Yu, Rui He, Lijun Sun, Chao Luo, Lu Feng, Hong Chen, Yue Yin, Weizhen Zhang
Summary: This study investigated the role of ghrelin in weight reduction and glycemic and lipid control after Roux-en-Y gastric bypass surgery. The results showed that gastric and circulating ghrelin levels significantly increased after the surgery. However, lowering ghrelin levels did not affect the metabolic benefits induced by the surgery.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Michael O'Laughlin, Jorge Cornejo, Alba Zevallos, Alisa Coker, Michael Schweitzer, Gina Adrales, Christina Li, Raul Sebastian
Summary: Background: The rates of secondary bariatric surgery have increased, with sleeve gastrectomy to gastric bypass conversion being the most common. This study evaluates the outcomes of this conversion compared to primary Roux-en-Y gastric bypass (RYGB) surgery using MBSAQIP data. Methods: The study analyzed the data of patients who underwent sleeve gastrectomy to RYGB conversion and primary laparoscopic RYGB, matching them based on preoperative characteristics. Results: The analysis showed that the conversion from sleeve gastrectomy to RYGB was associated with higher readmissions, interventions, conversion to open surgery, longer hospital stay, and longer operative time compared to primary RYGB. However, there were no significant differences in mortality or rates of bariatric complications. Conclusion: The study concludes that conversion from sleeve gastrectomy to RYGB is a safe and feasible procedure with reasonable outcomes compared to primary RYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Endocrinology & Metabolism
Qinghe Meng, Derek M. Culnan, Tamer Ahmed, Mingjie Sun, Robert N. Cooney
Summary: Roux-en-Y gastric bypass (RYGB) has significant effects on intestinal GLP-1 release and glucose transport in obese rats, potentially improving glycemic control by increasing GRP119 and FFAR2/3.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Surgery
Marta Guimaraes, Catarina Osorio, Diogo Silva, Rui F. Almeida, Antonio Reis, Samuel Cardoso, Sofia S. Pereira, Mariana P. Monteiro, Mario Nora
Summary: The study evaluated the long-term efficacy of Roux-en-Y Gastric Bypass (RYGB) surgery by assessing weight loss and comorbidity improvement in patients 10 years or more after the surgery. Results showed a significant decrease in body mass index (BMI) and successful comorbidity remission. Although a small proportion of patients required revision surgery for weight loss failure, RYGB was confirmed as an effective primary bariatric intervention.
Article
Surgery
Camila Carvalho, Aglecio Luiz de Souza, Gisele Almeida Batista, Louise Franciscato Trivelato Duran, Debora Puzzi Fernandes, Viviane Bressane Claus Molina, Raquel Goncalves, Joelma Silvia Giorgetti, Elintom Adami Chaim, Sarah Monte Alegre
Summary: In a study of 20 morbidly obese patients who underwent RYGB, it was found that after 10 years, high levels of GLP-1 remained, which may be associated with metabolic improvement, especially in patients with normal glucose tolerance.
LANGENBECKS ARCHIVES OF SURGERY
(2022)
Article
Surgery
Mauricio Gonzalez-Urquijo, David E. Hinojosa-Gonzalez, Ale Gibran Alam Gidi, Sofia Hurtado Arellano, Eduardo Flores-Villalba, Javier Rojas-Mendez
Summary: Revisional gastric bypass surgery for failed gastric banding patients showed higher complication rates compared to primary RYGB. Despite a greater postoperative weight increase in the revisional group at 12-month follow-up, the difference was not statistically significant. Changes in weight and BMI did not differ significantly between the two groups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Review
Medicine, General & Internal
Marita Salame, Noura Jawhar, Amanda Belluzzi, Mohammad Al-Kordi, Andrew C. Storm, Barham K. Abu Dayyeh, Omar M. Ghanem
Summary: Marginal ulcers (MU) are a potential complication following Roux-en-Y gastric bypass (RYGB) surgery, with an average prevalence of 4.6%. Early identification and prompt intervention are crucial to prevent further complications. MU is a complex condition influenced by factors such as smoking, Helicobacter pylori infection, NSAID use, and pouch size. Diagnosis is typically made through endoscopy, and treatment involves modifying risk factors and medical therapy with proton pump inhibitors. Surgical intervention may be necessary for complicated ulcers, while endoscopic procedures and vagotomy may be considered for recurrent or challenging cases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
David De Bandt, Claire Rives-Lange, Yvann Frigout, Damien Bergerot, Anne Blanchard, Maude Le Gall, Jean-Marc Lacorte, Jean-Marc Chevallier, Sebastien Czernichow, Tigran Poghosyan, Claire Carette, Johanne Le Beyec
Summary: This study found that one-anastomosis gastric bypass (OAGB) procedure has similar effects as Roux-en-Y gastric bypass (RYGB) in terms of weight loss and diabetes remission. Additionally, OAGB procedure results in high postprandial secretions of gut hormones, particularly GLP-1.
Article
Nutrition & Dietetics
Harsh Shah, Alyssa Kramer, Caitlyn A. Mullins, Marie Mattern, Ritchel B. Gannaban, R. Leigh Townsend, Shawn R. Campagna, Christopher D. Morrison, Hans-Rudolf Berthoud, Andrew C. Shin
Summary: Type 2 diabetes is a global health concern. The effectiveness of lifestyle interventions and approved medications to treat the disease is limited. Bariatric procedures like Roux-en-Y gastric bypass have shown remarkable ability to achieve diabetes remission, but the underlying mechanism is not fully understood. Recent evidence suggests that branched-chain amino acids may contribute to glucose impairment and insulin resistance. This study aims to explore the mechanism by which Roux-en-Y gastric bypass reduces branched-chain amino acids.
Article
Surgery
Samuel Hunter Dunn, Sanaa Tejani, Jaime P. Almandoz, Sarah E. Messiah, Jeffrey Schellinger, Elisa Morales Marroquin, Matthew Mathew, Jay Horton, Anna Tavakkoli
Summary: Transoral gastric outlet reduction (TORe) is a safe and effective treatment for post-prandial hypoglycemia and weight regain after Roux-en-Y gastric bypass (RYGB) in patients with symptoms refractory to medications and dietary changes.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Samuel Hunter Dunn, Sanaa Tejani, Jaime P. Almandoz, Sarah E. Messiah, Jeffrey Schellinger, Elisa Morales Marroquin, Matthew Mathew, Jay Horton, Anna Tavakkoli
Summary: TORe is a safe and effective treatment for patients with refractory symptoms of post-prandial hypoglycemia and weight regain after RYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Multidisciplinary Sciences
Damien Bergeat, S. Blat, Y. Gautier, S. Guerin, I Le Huerou-Luron, R. Thibault, D. Val-Laillet
Summary: Performing RYGBP in obese Yucatan minipigs can be safely done, and the changes induced by the surgery mimic those observed in humans.
SCIENTIFIC REPORTS
(2021)
Review
Endocrinology & Metabolism
Maria Jose Luesma, Jose Fernando, Irene Cantarero, Pilar Lucea, Sonia Santander
Summary: The prevalence of obesity has been increasing rapidly in recent decades, making it one of the most impacting diseases on global health. It is a chronic disease associated with various comorbidities that result in a reduced life expectancy and quality of life. The treatment of obesity requires a multidisciplinary approach by a specialized medical team and can be done through conservative or surgical treatments. Vertical gastrectomy, mixed techniques, and gastric bypass are the most commonly used surgical techniques. The choice of technique should consider the characteristics of each patient and the surgical team's experience.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Surgery
Salvatore Docimo, Jie Yang, Xiaoyue Zhang, Aurora Pryor, Konstantinos Spaniolas
Summary: The study findings suggest that One Anastomosis Gastric Bypass (OAGB) has a similar early safety profile compared to Roux-en-Y Gastric Bypass (RYGB) and that concerns about perioperative risks should not deter its adoption. However, OAGB does not appear to have a significantly improved safety profile over RYGB.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Medicine, General & Internal
Gisele Florencio, Aglecio Souza, Elinton Chaim, Allan Santos, Louise Duran, Camila Carvalho, Sarah Monte Alegre
Summary: This study evaluated the phase angle (PhA) and sarcopenia in young individuals pre- and post-Roux-en-Y gastric bypass surgery. The results showed that the postoperative group had significantly lower PhA and higher resistance (R). Handgrip strength and gait speed were negatively correlated with R, hs-CRP, and leptin. Appendicular lean mass was negatively correlated with reactance and R. Overall, PhA and other components of bioelectrical impedance analysis were found to be correlated with sarcopenia.
JOURNAL OF CLINICAL MEDICINE
(2023)
