Article
Endocrinology & Metabolism
Bing Liu, Yi Zhong, Dandan Huang, Liuye Yang, Pengchao Wang, Liu Yang, Fengxiao Zhang, Xiaoguang Li, Minglu Liang, Kai Huang, Meng Du
Summary: This study identifies a long non-coding RNA NRON as an important regulator of glucose/lipid metabolism and whole-body energy expenditure. Depletion of Nron in obese mice leads to metabolic benefits, including reduced body weight and fat mass, improved insulin sensitivity and serum lipid parameters, attenuated hepatic steatosis, and enhanced adipose function. The mechanism involves the activation of specific signaling pathways and metabolic networks. Inhibition of Nron may have potential as a therapeutic approach for obesity.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Endocrinology & Metabolism
Caroline M. Ancel, Maggie C. Evans, Romy Kerbus, Elliot G. Wallace, Greg M. Anderson
Summary: Neuronal PTP1B deletion partially protects mice from HCD-induced obesity but does not significantly impact HCD-induced infertility.
Article
Medicine, Research & Experimental
Ai Guo, Kai Li, Hong-Chuan Tian, Bai-Long Tao, Qian Xiao, Dian-Ming Jiang
Summary: The study showed that FGF19 has protective effects on obesity-induced bone loss by promoting osteoblast proliferation and reducing cell death in high-fat diet-fed mice and palmitic acid-treated osteoblasts.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Endocrinology & Metabolism
Bynvant Sandhu, Maria C. Perez-Matos, Stephanie Tran, Garima Singhal, Ismail Syed, Linda Feldbruegge, Shuji Mitsuhashi, Julie Pelletier, Jinhe Huang, Yusuf Yalcin, Eva Csizmadia, Shilpa Tiwari-Heckler, Keiichi Enjyoji, Jean Sevigny, Eleftheria Maratos-Flier, Simon C. Robson, Z. Gordon Jiang
Summary: This study investigated the impact of NTPDase3 deficiency on diet-induced obesity and metabolism in mice. The results showed that global NTPDase3 deletion led to resistance to obesity and glucose intolerance, with metabolic changes in adipocytes playing a key role rather than NTPDase3 expression in pancreatic beta-cells.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Article
Biochemistry & Molecular Biology
Chunxia Yu, Sujuan Liu, Yanmei Niu, Li Fu
Summary: Chronic exercise can protect intestinal barrier function against high-fat diet induced permeabilization through SESN2. SESN2 plays a crucial role in exercise-improved intestinal permeability, partly independent of gut microbiota.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Raj Kamal Srivastava, Inigo Ruiz de Azua, Andrea Conrad, Martin Purrio, Beat Lutz
Summary: This study found that the deletion of CB1 in dbh-positive cells prevents diet-induced obesity through multiple mechanisms including increased sympathetic nervous system activity, reduced NPY activity, and decreased basal hypothalamic-pituitary-adrenal axis activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Bernhard Radlinger, Claudia Ress, Sabrina Folie, Karin Salzmann, Ana Lechuga, Bernhard Weiss, Willi Salvenmoser, Michael Graber, Jakob Hirsch, Johannes Holfeld, Christian Kremser, Patrizia Moser, Gabriele Staudacher, Tomas Jelenik, Michael Roden, Herbert Tilg, Susanne Kaser
Summary: This study aimed to test whether empagliflozin can prevent weight gain and metabolic dysfunction in a mouse model of diet-induced obesity and insulin resistance. The results showed that empagliflozin supplementation prevented diet-induced metabolic abnormalities and protected mice from obesity, insulin resistance, and fatty liver. Furthermore, empagliflozin supplementation improved mitochondrial morphology in skeletal muscle.
Article
Endocrinology & Metabolism
Xiao-Bing Cui, Jia Fei, Sisi Chen, Gaylen L. Edwards, Shi-You Chen
Summary: This study identifies adenosine deaminase acting on RNA 1 as a novel factor promoting high-fat diet induced obesity, at least partially, through modulating appetite-related genes ghrelin and PYY.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Yuan Zhang, Xuexue Xu, Jingchang Ma, Yongming Liu, Chujun Duan, Yitian Liu, Chongyang Feng, Wenpeng Li, Yuling Wang, Kun Cheng, Ran Zhuang
Summary: CD226 plays a crucial role in the development of atherosclerosis by promoting foam cell formation. CD226 deficiency reduces plaque accumulation and inhibits atherosclerosis progression.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Cell Biology
Fabiana Oliviero, Wendy Klement, Lucile Mary, Yannick Dauwe, Yannick Lippi, Claire Naylies, Veronique Gayrard, Nicola Marchi, Laila Mselli-Lakhal
Summary: Non-Alcoholic Fatty Liver Disease (NAFLD) is a common chronic liver disease, especially in obese individuals. This study suggests that the nuclear receptor CAR may play a role in the pathogenesis of NAFLD and could be a potential therapeutic target. In mice, deletion of CAR led to a NASH-like hepatic transcriptomic signature and astrogliosis in the hypothalamus of female mice.
Article
Pharmacology & Pharmacy
Xiaoxian Xie, Mengya Zhang, Lei Sun, Ting Wang, Zhengyan Zhu, Ruonan Shu, Fengchun Wu, Zezhi Li
Summary: This study demonstrates that crocin-I may inhibit obesity by reducing body weight, improving glucose resistance, and alleviating intestinal microbial disorders in HFD-induced obese mice. Crocin-I also helps in restoring SCFAs levels and repairing altered intestinal barrier functioning and inflammation in HFD-induced obese mice.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Miaomiao Du, Xueyun Li, Fangyi Xiao, Yinxu Fu, Yu Shi, Sihan Guo, Lifang Chen, Lu Shen, Lan Wang, Huang Cheng, Hao Li, Anran Xie, Yaping Zhou, Kaiqiang Yang, Hezhi Fang, Jianxin Lyu, Qiongya Zhao
Summary: This study demonstrates the importance of SERAC1 protein in lipid metabolism in mice. Serac1 deficiency prevents high-fat diet-induced obesity without affecting energy expenditure. It impairs cholesterol transfer from the liver to the serum and leads to an imbalance in cholesterol distribution. Moreover, Serac1 deficiency may decrease the risk of diet-induced hepatic steatosis.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biochemistry & Molecular Biology
Patricia Recio-Lopez, Ismael Valladolid-Acebes, Per-Olof Berggren, Lisa Juntti-Berggren
Summary: This study demonstrates that reducing apoCIII can prevent and reverse metabolic derangements in white adipose tissue induced by high-fat diet. Lowering apoCIII decreases adipocyte size, reduces inflammation, and increases gene expression related to thermogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Natalie Burchat, Priyanka Sharma, Hong Ye, Sai Santosh Babu Komakula, Agnieszka Dobrzyn, Vladimir Vartanian, R. Stephen Lloyd, Harini Sampath
Summary: Obesity is a multifactorial disease influenced by diet, lifestyle, genetics, and development. DNA repair glycosylases, particularly OGG1, play a critical role in modulating the risk for obesity. Enhanced expression of hOGG1 has been shown to increase resistance to obesity in both genetically-induced and diet-induced models, with maternal transmission of the transgene being essential for this effect. The resistance to obesity mediated by OGG1 is associated with changes in energy balance, whole body energy expenditure, and mitochondrial content in adipose tissue.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuhei Oi, Tomohisa Nagoshi, Haruka Kimura, Yoshiro Tanaka, Akira Yoshii, Rei Yasutake, Hirotake Takahashi, Yusuke Kashiwagi, Toshikazu D. Tanaka, Toshiaki Tachibana, Michihiro Yoshimura
Summary: The study found that exogenous ANP treatment can improve myocardial insulin resistance in obese rats and protect the heart from ischemia-reperfusion injury. ANP treatment restores insulin signaling in the heart and protects mitochondria from lipid overload by trapping lipids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Correction
Biochemistry & Molecular Biology
S. Borrelli, E. Candi, D. Alotto, C. Castagnoli, G. Melino, M. A. Vigano, R. Mantovani
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Milton Fabian Suarez-Ortegon, Alejandra Arbelaez, Jose Maria Moreno-Navarrete, Jose Guillermo Ortega-Avila, Mildrey Mosquera, Jose Manuel Fernandez-Real
Summary: Excessive body iron levels are associated with insulin resistance and cardiometabolic risk, and oxidative stress may play a role in this relationship. This study investigated the association between soluble transferrin receptor (sTfR) levels, antioxidant status, and cardiometabolic risk markers. The results showed that sTfR levels were positively correlated with total antioxidant capacity (TAC) in both men and women. In men, sTfR levels were inversely associated with waist circumference and fasting glucose, and positively associated with LDL cholesterol. The findings suggest that sTfR levels are associated with antioxidant status and specific cardiometabolic risk variables, independent of other factors such as serum ferritin and hepcidin.
Editorial Material
Biochemistry & Molecular Biology
Artem Smirnov, Eleonora Candi
Summary: Skin acts as a barrier to protect the body and is directly exposed to oxygen. The role of oxygen in in vitro generation of skin graft is not clear. Teshima et al. discovered the impact of the HIF pathway on epidermal differentiation in skin models and how air-lifting of cultures affects HIF activity and keratinocyte differentiation.
Article
Biochemistry & Molecular Biology
Manuela Montanaro, Massimiliano Agostini, Lucia Anemona, Elena Bonanno, Francesca Servadei, Enrico Finazzi Agro, Anastasios D. D. Asimakopoulos, Carlo Ganini, Chiara Cipriani, Marta Signoretti, Pierluigi Bove, Francesco Rugolo, Benedetta Imperiali, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: Prostate cancer is a common and deadly cancer in men, and the current clinical tools for prognosis are insufficient. This study found that ZNF750 protein levels are reduced in prostate cancer samples, especially in metastatic samples. It also showed that nuclear expression of ZNF750 is significantly reduced in patients with metastatic cancer. The bioinformatics analysis suggests that ZNF750 expression is positively correlated with better prognosis, indicating its potential as a reliable biomarker for metastatic prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Alejandro Hinojosa-Moscoso, Anna Motger-Alberti, Elena De la Calle-Vargas, Marian Marti-Navas, Carles Biarnes, Maria Arnoriaga-Rodriguez, Gerard Blasco, Josep Puig, Diego Luque-Cordoba, Feliciano Priego-Capote, Jose Maria Moreno-Navarrete, Jose Manuel Fernandez-Real
Summary: Excess iron is associated with dysfunction in adipose tissue and insulin resistance. In this study, it was found that markers of iron status were linked to changes in abdominal adipose tissue over one year. These associations were mainly observed in women and non-obese subjects, and were independent of insulin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ombretta Melaiu, Gianluca Vanni, Ilaria Portarena, Chiara Adriana Pistolese, Lucia Anemona, Silvia Pomella, Roberto Bei, Oreste Claudio Buonomo, Mario Roselli, Alessandro Mauriello, Giovanni Barillari
Summary: Immune checkpoint inhibitors have limited clinical activity as monotherapy against breast cancer, and novel combinatorial strategies are being investigated to improve treatment response. The abnormal vasculature in breast cancer is associated with immune suppression and hampers drug delivery and immune cell trafficking. Combining immune checkpoint inhibitors with tumor vessel normalizing agents shows promise in enhancing antitumor immune responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Alessandra Stella Caporale, Marco Nezzo, Maria Giovanna Di Trani, Alessandra Maiuro, Roberto Miano, Pierluigi Bove, Alessandro Mauriello, Guglielmo Manenti, Silvia Capuani
Summary: This study investigated the potential of Diffusion-Tensor-Imaging (DTI) in detecting microstructural changes in prostate cancer (PCa) using different diffusion weights (b-values) and diffusion lengths (l(D)). The results showed that DTI metrics were able to differentiate between benign and PCa tissue, with the best discrimination at b-values ≥ 1500 s/mm(2) and when l(D) was comparable to the size of the epithelial compartment. The strongest correlations between DTI metrics and Gleason Score (GS) were found at b = 2000 s/mm(2) and for the range 0-2000 s/mm(2).
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Endocrinology & Metabolism
Marisel Rosell-Diaz, Jose Manuel Fernandez-Real
Summary: The decline in cognitive function and the prevalence of neurodegenerative disorders are serious threats to health in old age, with dementia affecting 50 million people worldwide. Type 2 diabetes is linked to an increased risk of cognitive impairment and dementia. Studies have shown that metformin, a medication used to treat type 2 diabetes, may partially restore gut dysbiosis related to diabetes and potentially improve cognitive function.
Review
Biochemistry & Molecular Biology
Dalgisio Lecis, Gianluca Massaro, Daniela Benedetto, Marco Di Luozzo, Giulio Russo, Alessandro Mauriello, Massimo Federici, Giuseppe Massimo Sangiorgi
Summary: Atherosclerotic cardiovascular disease is a common cause of morbidity and death worldwide. It can be controlled through modulation of immune system activity and finding new treatment strategies is of common interest. This review discusses the experimental and clinical data supporting immune-based therapies, specifically vaccination strategies, for lowering cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Jiuwen Sun, Alberic Germain, Gracia Kaglan, Florence Servant, Benjamin Lelouvier, Massimo Federici, Jose Manuel Fernandez Real, Daniela Tatiana Sala, Radu Mircea Neagoe, Anne Bouloumie, Remy Burcelin
Summary: This study found that specific bacterial families in the visceral adipose tissue of obese patients can trigger inflammation and adipose depot development. There are significant differences in the bacterial composition between obese patients and non-obese individuals. These findings generate new hypotheses regarding the relationship between obesity and gut tissue.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Endocrinology & Metabolism
Nuria Oliveras-Canellas, Jose Maria Moreno-Navarrete, Paula M. Lorenzo, Lourdes Garrido-Sanchez, Sara Becerril, Oriol Rangel, Jessica Latorre, Elena de la Calle Vargas, Maria Pardo, Victor Valenti, Juan L. Romero-Cabrera, Wilfredo Oliva-Olivera, Camilo Silva, Carlos Dieguez, Francesc Villarroya, Miguel Lopez, Ana B. Crujeiras, Luisa-Maria Seoane, Jose Lopez-Miranda, Gema Fruhbeck, Francisco Jose Tinahones, Jose-Manuel Fernandez-Real
Summary: This study investigated how outside temperature affects adipose tissue physiology and metabolic traits. The expression of genes associated with browning and adipogenesis in the subcutaneous adipose tissue were found to be negatively associated with temperature. These findings could have implications for the relationship between the obesity pandemic and global warming.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Jose Maria Moreno-Navarrete, Jose Manuel Fernandez-Real
Summary: Iron regulation is crucial for maintaining healthy adipose tissue function. Excessive accumulation of iron in adipose tissue can lead to dysfunction. Understanding the interplay between iron and adipose tissue is important for developing new therapeutic approaches to improve and prevent adipose tissue dysfunction.
Article
Multidisciplinary Sciences
Aina Lluch, Jessica Latorre, Angela Serena-Maione, Isabel Espadas, Estefania Caballano-Infantes, Jose M. Moreno-Navarrete, Nuria Oliveras-Canellas, Wifredo Ricart, Maria M. Malagon, Alejandro Martin-Montalvo, Walter Birchmeier, Witold Szymanski, Johannes Graumann, Maria Gomez-Serrano, Elena Sommariva, Jose M. Fernandez-Real, Francisco J. J. Ortega
Summary: This study reveals that levels of Plakophilin-2 (PKP2) steadily increase during fat cell differentiation, but are compromised in the presence of inflammation. Expression of PKP2 in subcutaneous adipose tissue diminishes in patients with obesity and normalizes upon weight loss. The impaired PKP2 leads to cell cycle dysfunction and premature senescence in adipocytes.
NATURE COMMUNICATIONS
(2023)
Review
Oncology
Manuel Scimeca, Valentina Rovella, Valeria Palumbo, Maria Paola Scioli, Rita Bonfiglio, Gerry Melino, Mauro Piacentini, Luigi Frati, Massimiliano Agostini, Eleonora Candi, Alessandro Mauriello
Summary: Cholangiocarcinoma is a highly aggressive cancer arising from the bile ducts. Recent studies have highlighted the importance of programmed cell death mechanisms in its development and progression. Targeting these cell death pathways may increase the susceptibility of cholangiocarcinoma cells to chemotherapy and immunotherapy. However, further research is necessary to fully understand the intricacies of programmed cell death in cholangiocarcinoma and potentially identify effective therapeutic strategies.