Article
Endocrinology & Metabolism
Antigoni Eleftheriou, Clive J. Petry, Ieuan A. Hughes, Ken K. Ong, David B. Dunger
Summary: The study found variable associations of DR3, DR4, and DQ8 alleles with growth measures and IGF-I levels in infants from the general population, which could explain the heterogeneous growth trajectories observed in genetically at-risk cohorts. These findings suggest distinct mechanisms involving endocrine pathways related to the HLA-conferred type 1 diabetes risk.
Article
Endocrinology & Metabolism
Ziyu Jiang, Wenqian Ren, Hua Liang, Jinhua Yan, Daizhi Yang, Sihui Luo, Xueying Zheng, Guo-Wang Lin, Yingxin Xian, Wen Xu, Bin Yao, Janelle A. Noble, Jin-Xin Bei, Leif Groop, Jianping Weng
Summary: The study aimed to investigate the effects of HLA class I genes on susceptibility to type 1 diabetes with different onset ages, in addition to the well-established effects of HLA class II genes. Results showed that HLA class I alleles played a role in susceptibility to type 1 diabetes with different onset ages, which could improve the understanding of disease heterogeneity and has implications for future studies.
Article
Immunology
Cassandra Ballou, Franca Barton, Elizabeth H. Payne, Thierry Berney, Jean Villard, Raphael P. H. Meier, David Baidal, Rodolfo Alejandro, Mark Robien, Thomas L. Eggerman, Malek Kamoun, Yannick D. Muller
Summary: The exact contribution of HLA matching to graft survival in pancreatic islet transplantation remains unclear. This study evaluated the impact of HLA-DR matching, including the presence of diabetogenic HLA-DR3 or HLA-DR4 matches, on long-term islet survival.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Mohammad Z. Haider, Maysoun Al Rushood, Hind Alsharhan, Majedah A. Rasoul, Maria Al-Mahdi, Hessa Al-Kandari
Summary: This study investigated the genetic susceptibility of Kuwaiti children with type 1 diabetes mellitus (T1DM) and found an association between IL4 and IL13 gene polymorphisms and disease susceptibility, as well as a co-inheritance with high-risk HLA genotypes. These findings contribute to the early identification of childhood diabetes.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Michael Hudec, Iva Jurickova, Kamila Riegerova, Saak Ovsepian, Marie Cerna, Valerie Brid O'Leary
Summary: This study reveals the genetic and extracellular exosomal effects of HLA transfer on T lymphocytes in the context of celiac disease (CeD), providing a deeper insight into this autoimmune disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Patrick M. Carry, Lauren A. Vanderlinden, Randi K. Johnson, Teresa Buckner, Oliver Fiehn, Andrea K. Steck, Katerina Kechris, Ivana Yang, Tasha E. Fingerlin, Marian Rewers, Jill M. Norris
Summary: The study found an association between phosphatidylcholine, sphingomyelin, and carnitine levels and reversion of IA. Principal components analysis showed that PC1, PC2, and PC4 were associated with IA reversion; investigation revealed correlation between nutrients and metabolites.
Article
Immunology
Sulafa Elhassan, Fran Dong, Teresa Buckner, Randi K. Johnson, Jennifer A. Seifert, Patrick M. Carry, Lauren Vanderlinden, Kathleen Waugh, Marian Rewers, Jill M. Norris
Summary: Studies have shown that iron intake may be associated with the risk of developing type 1 diabetes. This study found that individuals with high iron intake had a lower risk of developing type 1 diabetes compared to those with moderate iron intake.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Patrick M. Carry, Kathleen Waugh, Lauren A. Vanderlinden, Randi K. Johnson, Teresa Buckner, Marian Rewers, Andrea K. Steck, Ivana Yang, Tasha E. Fingerlin, Katerina Kechris, Jill M. Norris
Summary: Longitudinal changes in gene expression during islet autoimmunity can provide insights into the biological processes that lead to the progression of type 1 diabetes. This study found evidence of alterations in expression of innate immune genes prior to the onset of type 1 diabetes.
Article
Rheumatology
Jaxaira Maggi, Montserrat Carrascal, Lilian Soto, Oscar Neira, Maria C. Cuellar, Octavio Aravena, Eddie A. James, Joaquin Abian, Dolores Jaraquemada, Diego Catalan, Juan C. Aguillon
Summary: This study analyzed the HLA-DR-associated peptidome of synovial tissue and dendritic cells in rheumatoid arthritis patients, aiming to identify potential T-cell epitopes. The researchers discovered six new epitopes recognized by CD4 + T cells and found a correlation between the frequency of IFN-gamma-producing CD4 + T cells specific for a certain peptide and disease activity.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Immunology
Maximilian Hoffmann, Juergen Enczmann, Vera Balz, Sebastian Kummer, Christina Reinauer, Carsten Doeing, Katharina Foertsch, Alena Welters, Malte Kohns Vasconcelos, Ertan Mayatepek, Thomas Meissner, Marc Jacobsen, Julia Seyfarth
Summary: This study found that serum levels of sIL-7R were higher at the onset of type 1 diabetes and decreased during therapy, while IL-7 was only higher in long-term patients. Multiple linear regression analysis revealed that certain genetic variations in the IL7RA gene and HLA risk haplotypes were influencing the levels of sIL-7R.
CLINICAL IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Anna-Maria Lampousi, Sofia Carlsson, Josefin E. Lofvenborg
Summary: Breastfeeding and late introduction of gluten, fruit, and cow's milk may reduce the risk of T1D, while high childhood intake of cow's milk may increase it.
Article
Immunology
You-Seok Hyun, Hyeong-A Jo, Yong-Hun Lee, Sun-Mi Kim, In-Cheol Baek, Hyun-Jung Sohn, Hyun-Il Cho, Tai-Gyu Kim
Summary: Within an individual, CD4(+) T cell responses are predominantly restricted by a limited number of HLA class II allotypes, with specific highly responsive alleles identified in each HLA-DR, -DQ, and -DP locus.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Nutrition & Dietetics
Valdemar Brimnes Ingemann Johansen, Knud Josefsen, Julie Christine Antvorskov
Summary: This study systematically reviewed the association between maternal dietary factors during gestation and the risk of developing type 1 diabetes and/or islet autoimmunity (IA) in offspring. The most investigated dietary factors were gluten, dietary advanced glycosylated end products (dAGEs), vitamin D, fatty acids, and iron. The results showed that prenatal exposure to a gluten-free environment and certain fatty acids and vitamin D had protective effects against IA development, while in utero exposure to iron and fat correlated with increased risks of IA.
Article
Endocrinology & Metabolism
Bum Chul Kwon, Peter Achenbach, Vibha Anand, Brigitte I. Frohnert, William Hagopian, Jianying Hu, Eileen Koski, Ake Lernmark, Olivia Lou, Frank Martin, Kenney Ng, Jorma Toppari, Riitta Veijola
Summary: Analyzing the levels of autoantibodies can better differentiate children who progress to type 1 diabetes from those who do not.
Article
Endocrinology & Metabolism
Fabio Russo, Antonio Citro, Giorgia Squeri, Francesca Sanvito, Paolo Monti, Silvia Gregori, Maria Grazia Roncarolo, Andrea Annoni
Summary: The study demonstrated that a combination therapy using a lentiviral vector and a suboptimal dose of anti-CD3 monoclonal antibody could effectively control autoimmune diabetes and prevent recurrence of autoimmunity post-islet transplantation in NOD mice. Optimized therapeutic conditioning before alloislet transplantation resulted in normoglycemia and reduced insulitis in diabetic NOD mice, showing a potential for resolving autoimmune diabetes in the presence of residual endogenous beta-cell mass.