Journal
DEVELOPMENTAL NEUROSCIENCE
Volume 34, Issue 2-3, Pages 228-239Publisher
KARGER
DOI: 10.1159/000336645
Keywords
Bromodeoxyuridine (BrdU); Prefrontal cortex; Neurogenesis
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Funding
- Natural Science and Engineering Research Council of Canada
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Removal of the midline frontal cortex on postnatal day 10 is followed by apparent regeneration of the part of the lost cortex, correlated with substantial recovery of function in adulthood. The spontaneous regrowth of the medial frontal cortex after midline frontal lesions on postnatal day 10 was blocked by pretreatment with bromodeoxyuridine (BrdU) on embryonic days 11, 12, 13, 15, or 17. BrdU pretreatment on embryonic day 21 or postnatal day 10 did not block either functional recovery or cortical regrowth. These results demonstrate a teratological effect of BrdU and are consistent with the claim that functional recovery after midline frontal removal on postnatal day 10 is supported by the generation of new midline frontal tissue. Copyright (C) 2012 S. Karger AG, Basel
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