Journal
DEVELOPMENTAL NEUROSCIENCE
Volume 32, Issue 4, Pages 313-320Publisher
KARGER
DOI: 10.1159/000309135
Keywords
Cerebral cortex; Adeno-associated virus; Short hairpin RNA; Pyramidal neuron
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Funding
- NINDS [40960]
- Department of Veterans Affairs
- Loyola Neuroscience Institute
- AHA-SDG
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS040960, R56NS040960] Funding Source: NIH RePORTER
- Veterans Affairs [I01RX000828] Funding Source: NIH RePORTER
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The myelin-associated protein Nogo-A is a well-known inhibitor of axonal regeneration and compensatory plasticity, yet functions of neuronal Nogo-A are not as clear. The present study examined the effects of decreased levels of neuronal Nogo-A on dendritic spines of developing neocortical neurons. Decreased Nogo-A levels in these neurons resulted in lowered spine density and an increase in filopodial type protrusions. These results suggest a role for neuronal Nogo-A in maintaining a spine phenotype in neocortical pyramidal cells. Copyright (c) 2010 S. Karger AG, Basel
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