Journal
DEVELOPMENTAL NEUROBIOLOGY
Volume 74, Issue 3, Pages 259-268Publisher
WILEY
DOI: 10.1002/dneu.22122
Keywords
olfactory system; odorant receptor; local translation; mouse; axon guidance
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Funding
- ANR [2010-BLAN-1401-01]
- NIH [1RO1DC O12441]
- UMPC
- CNRS
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Rodents contain in their genome more than 1000 functional odorant receptor genes, which are specifically expressed by the olfactory sensory neurons projecting from the olfactory epithelium to the olfactory bulb. Strong evidence for the presence and local translation of odorant receptor mRNAs in the axon of olfactory sensory neurons was obtained, but no function has been assigned to these axonal mRNAs yet. The aim of this review is to discuss the evidence for the presence and local translation of odorant receptor mRNAs in olfactory sensory axons, and to speculate on their possible function in the wiring of the mouse olfactory sensory projections. (c) 2013 Wiley Periodicals, Inc. Develop Neurobiol 74: 259-268, 2014
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