Review
Biochemistry & Molecular Biology
Yousra El Ouaamari, Jasper van den Bos, Barbara Willekens, Nathalie Cools, Inez Wens
Summary: Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis, are characterized by progressive loss of neuronal subtypes. Research on neurotrophic factors (NTFs) as regenerative therapy for these diseases has shown promising results. However, challenges such as delivery methods, blood-brain barrier permeability, and side effects need to be addressed. In addition, combination therapies may be necessary for effective treatment of complex degenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Julia Konovalova, Dmytro Gerasymchuk, Sergio Navarette Arroyo, Sven Kluske, Francesca Mastroianni, Alba Vargas Pereyra, Andrii Domanskyi
Summary: This study demonstrated for the first time the direct regulation of MANF and CDNF expression by specific miRNAs, revealing the mechanism and specificity of miRNAs in regulating these neurotrophic factors. The findings emphasize the complexity and importance of miRNA regulation of target genes, providing a new theoretical basis for further research on neuroprotective treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Jie V. Zhao, Wai-Fung Yeung, Yap-Hang Chan, Dana Vackova, June Y. Y. Leung, Dennis K. M. Ip, Jiaxi Zhao, Wai-Kwan Ho, Hung-fat Tse, Catherine Mary Schooling
Summary: Berberine was found to reduce total cholesterol and high-density lipoprotein cholesterol levels in men, while possibly increasing testosterone levels. Its effects on other CVD risk factors were not significant. Further exploration of alternative pathways and sex-specific effects of berberine would be valuable for potential drug repositioning and healthcare applications.
Review
Clinical Neurology
Maria Grazia Di Benedetto, Catia Scassellati, Nadia Cattane, Marco Andrea Riva, Annamaria Cattaneo
Summary: This article conducted a systematic review on the relationship between childhood trauma and early life stress with psychiatric disorders, supporting the significant role of the neurotrophic factor BDNF in mediating this relationship.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Pharmacology & Pharmacy
Sherly Deborah George, Rajagopalan Archana, Subramani Parasuraman
Summary: The study demonstrated that Caloric Vestibular Stimulation (CVS) can effectively increase motor abilities and reduce behavioral alterations in rats exposed to Chronic Mild Stress (CMS). Additionally, CVS was found to promote regeneration of damaged neural terminals in the hippocampus.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Neurosciences
Olesja Bondarenko, Mart Saarma
Summary: Neurotrophic factors (NTFs) are essential for neuronal development and survival but face challenges in delivery to the brain due to the blood-brain barrier. Nanoparticles (NPs) show promise in stabilizing and transporting NTFs across the BBB, offering a potential solution to systemic delivery.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Medicine, General & Internal
Anna Mosiolek, Jadwiga Mosiolek, Slawomir Jakima, Aleksandra Pieta, Agata Szulc
Summary: Major depressive disorder (MDD) is a multifactorial disease with ongoing research on the role of neurotrophic factors in its pathophysiology. Antidepressant treatment can modify serum levels of neurotrophins, such as BDNF, leading to clinical improvement of MDD. Further research is needed to understand the correlation between different antidepressant drugs and neurotrophic factor serum levels.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Vincenzo Giuseppe Nicoletti, Krisztian Pajer, Damiano Calcagno, Gholam Pajenda, Antal Nogradi
Summary: Mature neurotrophic factors and their propeptides are crucial in regulating neuronal growth, survival, and recovery. Understanding the mechanisms of these factors offers potential for neuroregenerative medicine.
Article
Immunology
Shahab Ghaderi, Masome Rashno, Ali Nesari, Seyed Esmaeil Khoshnam, Alireza Sarkaki, Layasadat Khorsandi, Yaghoob Farbood, Khodabakhsh Rashidi
Summary: The study found that sesamin could significantly improve diabetes-associated behavioral deficits, including reducing anxiety/depression-like behaviors, decreasing locomotor/exploratory activities, and improving passive avoidance learning and memory. These improvements may be attributed, at least partly, to the reduction of blood glucose level, inhibition of neuroinflammation, and potentiation of neurotrophic factors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria S. Gavrish, Mark D. Urazov, Tatiana A. Mishchenko, Victoria D. Turubanova, Ekaterina A. Epifanova, Victoria G. Krut', Alexey A. Babaev, Maria V. Vedunova, Elena Mitroshina
Summary: The role of neurotrophic factors BDNF and GDNF in maintaining brain resistance to hypoxia and promoting recovery of neural networks is being actively studied. This study aimed to evaluate the effects of overexpressing BDNF and GDNF using viral vectors in modeling hypoxia. The results showed increased survival rate of mice under hypoxic conditions, indicating that overexpression of neurotrophic factors may be a potential neuroprotection method.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Limor Rubin, Collin T. Stabler, Adi Schumacher-Klinger, Cezary Marcinkiewicz, Peter Lelkes, Philip Lazarovici
Summary: This review explores the role of neurotrophins in neurogenesis, vasculogenesis, and embryonic development of the respiratory system, as well as their implications for respiratory diseases.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Clinical Neurology
Jongsuk Choi, Jun -Soon Kim, Seung-Jae Hyun, Ki-Jeong Kim, Ho-Joong Kim, Vedran Deletis, Kyung Seok Park
Summary: This study aimed to assess the utility of intraoperative BCR monitoring in posterior lumbar fusion surgery. The results showed a significant correlation between the preservation of BCR and voiding difficulties, suggesting that BCR monitoring may help predict postoperative voiding dysfunction.
CLINICAL NEUROPHYSIOLOGY
(2022)
Review
Chemistry, Medicinal
Konrad Rejdak, Halina Sienkiewicz-Jarosz, Przemyslaw Bienkowski, Anton Alvarez
Summary: In this review, the authors provide an overview of neurotrophic factors (NTFs) and their potential therapeutic use in neurological disorders such as dementia, stroke, and traumatic brain injury (TBI). They also discuss the neuropeptide preparation Cerebrolysin, which resembles the activities of NTFs. The review summarizes the interactions of different NTFs and Cerebrolysin on neuroplasticity, neurogenesis, angiogenesis, inflammation, and their relevance for the treatment of dementia, stroke, and TBI.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Ava Nasrolahi, Fatemeh Javaherforooshzadeh, Mohsen Jafarzadeh-Gharehziaaddin, Javad Mahmoudi, Khadijeh Dizaji Asl, Zahra Shabani
Summary: NTFs are considered as new and promising candidates for treating AD and AD-associated cognitive impairment, with potential to protect and treat neurodegenerative diseases.
MOLECULAR BIOLOGY REPORTS
(2022)
Review
Cell Biology
Rossella Rotondo, Stefania Proietti, Marzia Perluigi, Elvira Padua, Fabrizio Stocchi, Massimo Fini, Vilberto Stocchi, Daniele Volpe, Maria Francesca De Pandis
Summary: The benefits of physical therapy on motor and non-motor symptoms in Parkinson's disease patients are supported by consistent evidence, with neurotrophic factors (NFs) playing a key role in neuroplasticity. However, the lack of standardized exercise training and methodological flaws in clinical trials have limited the evidence for exercise-induced changes in NFs concentration.
AGEING RESEARCH REVIEWS
(2023)