Article
Medicine, General & Internal
Jason Sutin, Rutvi Vyas, Henry A. Feldman, Silvina Ferradal, Chuan-Heng Hsiao, Lucca Zampolli, Lara J. Pierce, Charles A. Nelson, Sarah U. Morton, Susanne Hay, Mohamed El-Dib, Janet S. Soul, Pei-Yi Lin, Patricia E. Grant
Summary: The objective of this study was to evaluate the association between cerebral oxygen metabolism (CMRO2) and neurodevelopmental outcomes at 18 months in neonates with hypoxic ischemic encephalopathy (HIE), and to assess CMRO2 as a potential diagnostic for HIE. The study found that CMRO2 was significantly associated with cognitive and motor outcomes and outperformed conventional clinical evaluations in predicting these outcomes in mild to moderate HIE. This provides a promising, objective, physiologically-based diagnostic for HIE.
Article
Pediatrics
Aisling A. Garvey, Hoda El-Shibiny, Edward Yang, Terrie E. Inder, Mohamed El-Dib
Summary: This study aimed to compare MRI findings on day 4 versus second week in infants with neonatal encephalopathy (NE). The results showed 19% of infants had notable changes in their MRI findings between the early and late scans. Relying solely on early MRI may overestimate injury in some infants and miss injury in others.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Corline E. J. Parmentier, Maarten H. Lequin, Thomas Alderliesten, Henriette F. N. Swanenburg de Veye, Niek E. van der Aa, Jeroen Dudink, Manon J. N. L. Benders, Johanna C. Harteman, Corine Koopman-Esseboom, Floris Groenendaal, Linda S. de Vries
Summary: This study evaluated the evolution of brain injury observed on magnetic resonance imaging (MRI) in neonatal encephalopathy (NE) following perinatal asphyxia. A scoring system was developed to assess brain injury on 3-month MRI and its association with neurodevelopmental outcome. The study found that abnormalities in deep gray matter (DGM) on 3-month MRI, preceded by DGM abnormalities on neonatal MRI, were associated with 18- to 24-month outcome, indicating the potential usefulness of 3-month MRI in evaluating treatment efficacy.
JOURNAL OF PEDIATRICS
(2023)
Editorial Material
Biochemistry & Molecular Biology
GianPietro Sechi, M. Margherita Sechi
Summary: In neonatal hypoxic-ischemic encephalopathy (HIE), therapeutic hypothermia (TH) is the standard care in developed countries, but it may not be beneficial or suitable in developing nations. Moreover, hypothermic neuroprotection is often incomplete, with infants still experiencing death or significant neurological issues. Therefore, there is a need to find innovative neuroprotective compounds for HIE, such as ketone bodies and thiamine, which may provide additional neuroprotection in conjunction with TH and improve treatment strategies in low-middle-income countries.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Neurosciences
Bowen Weng, Chongbing Yan, Yihuan Chen, Xiaohui Gong, Cheng Cai
Summary: Therapeutic hypothermia in neonates with moderate to severe HIE was found to significantly improve neurological outcomes and reduce the incidence of death and disabilities associated with major neuron development.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Pediatrics
Tzu-Yu Liu, Jui-Hsing Chang, Chun-Chih Peng, Chyong-Hsin Hsu, Wai-Tim Jim, Jia-Ying Lin, Chia-Huei Chen, Sung-Tse Li, Hung-Yang Chang, Taiwan Premature Infant Follow-up Network
Summary: The study assessed the predictive validity of the Bayley Scales of Infant and Toddler Development in very-low-birth-weight infants and identified abnormal muscle tone and lower maternal socioeconomic status as factors associated with changes in cognitive outcomes.
FRONTIERS IN PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Kennosuke Tsuda, Jun Shibasaki, Tetsuya Isayama, Akihito Takeuchi, Takeo Mukai, Yuichiro Sugiyama, Tomoaki Ioroi, Akihito Takahashi, Nanae Yutaka, Sachiko Iwata, Makoto Nabetani, Osuke Iwata
Summary: This study investigated the relationship between the severity of encephalopathy and 3-year clinical outcomes in high-survival infants who underwent therapeutic hypothermia. The results showed that while mortality rates were relatively low, the incidence of major disabilities was relatively high, possibly due to Japanese social and ethical norms.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Jonathan Beck, Thierry Debillon, Isabelle Guellec, Antoine Vilotitch, Gauthier Loron, Nathalie Bednarek, Pierre-Yves Ancel, Veronique Pierrat, Anne Ego
Summary: The initiation of therapeutic hypothermia within 6 hours of life is crucial for treating neonatal hypoxic ischemic encephalopathy. This study aimed to identify clinical and healthcare organizational factors associated with delayed therapeutic hypothermia in a French population-based cohort. Delayed therapeutic hypothermia was more common in neonates with moderate HIE and in maternity units with lower annual birth volumes. Early identification of neonates who could benefit from therapeutic hypothermia and access to appropriate care before transfer are important factors in improving outcomes for neonates with HIE.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Medicine, General & Internal
Tingting Zheng, Xini Liu, Xuechun Chen
Summary: This study aims to investigate the efficacy of therapeutic hypothermia for mild neonatal encephalopathy (NE) and provide evidence supporting its use based on recent studies and novel adjunctive therapies. The researchers will conduct a systematic literature search and quality assessment to draw conclusions on the feasibility of therapeutic hypothermia.
Article
Pediatrics
Meaghan M. McGowan, Alexandra C. O'Kane, Gilbert Vezina, Taeun Chang, Nicole Bendush, Penny Glass, Jiaxiang Gai, James Bost, Allen D. Everett, An N. Massaro
Summary: This study found that Tau was a consistent predictive marker for brain injury in neonates with NE, while the combination of IL-6, 8, and 10 within 24 hours was more predictive of severe brain injury. The use of a serial biomarker panel to assess brain injury over the time course of NE disease was supported.
PEDIATRIC RESEARCH
(2021)
Article
Pediatrics
Pierre Elias, Anie Lapointe, Pia Wintermark, Shiran Sara Moore, Daniela Villegas Martinez, Jessica Simoneau, Gabriel Altit
Summary: In a single-center prospective study of neonates with neonatal encephalopathy, we investigated the correlation between left cardiac 3-dimensional echocardiographic parameters and brain injury. Our findings showed that neonates with brain injury had increased left ventricle end-diastolic and stroke volume, as well as greater peak global circumferential strain detected by 3-dimensional echocardiogram on day 2 of life.
JOURNAL OF PEDIATRICS
(2023)
Article
Pediatrics
Licia Lugli, Isotta Guidotti, Marisa Pugliese, Maria Federica Roversi, Luca Bedetti, Elisa Della Casa Muttini, Francesca Cavalleri, Alessandra Todeschini, Maurilio Genovese, Luca Ori, Maria Amato, Francesca Miselli, Laura Lucaccioni, Natascia Bertoncelli, Francesco Candia, Tommaso Maura, Lorenzo Iughetti, Fabrizio Ferrari, Alberto Berardi
Summary: This study evaluated the neurodevelopmental outcomes in surviving asphyxiated neonates who did and did not receive therapeutic hypothermia (TH), showing that TH significantly reduces the occurrence of severe neurodevelopmental impairment. Abnormal p-EEG patterns and general movements were significantly associated with severe neurodevelopmental impairment.
Review
Pediatrics
Neil Marlow, Seetha Shankaran, Elizabeth E. Rogers, Nathalie L. Maitre, Christopher D. Smyser
Summary: Therapeutic hypothermia shows benefits on mortality and neurodevelopmental outcomes in infants with neonatal encephalopathy. Cognitive, educational, and behavioral outcomes are negatively affected by neonatal encephalopathy in children without moderate or severe neuromorbidity.
SEMINARS IN FETAL & NEONATAL MEDICINE
(2021)
Article
Neurosciences
Tushar A. Shah, Haree K. Pallera, Cortney L. Kaszowski, William Thomas Bass, Frank A. Lattanzio
Summary: The study investigated the impact of therapeutic hypothermia on complement effector expression in neonatal hypoxic-ischemic encephalopathy, finding that hypothermia treatment reduced the expression of C1q, C5a, C3, and C9 in neurons and glia, as well as exhibiting variable effects on cytokines, potentially enhancing neuroprotection.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Health Care Sciences & Services
Hanne Lademann, Karl Abshagen, Anna Janning, Jan Dabritz, Dirk Olbertz
Summary: Therapeutic hypothermia is beneficial for neuroprotection in term newborns with perinatal asphyxia, but its effects on preterm infants remain unclear. This pilot study compared the long-term outcomes of late preterm asphyctic infants with and without therapeutic hypothermia to term infants. The study found that preterm infants had better mental outcomes with therapeutic hypothermia, highlighting the importance of further research in this area.
Editorial Material
Clinical Neurology
Sally Jary
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2019)
Review
Clinical Neurology
Betty Hutchon, Deanna Gibbs, Phillip Harniess, Sally Jary, Siew-Lian Crossley, Jane V. Moffat, Neela Basu, Anna P. Basu
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2019)
Article
Pediatrics
Richard Lee-Kelland, Sally Jary, James Tonks, Frances M. Cowan, Marianne Thoresen, Ela Chakkarapani
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2020)
Article
Neurosciences
James Tonks, Grace Cloke, Richard Lee-Kelland, Sally Jary, Marianne Thoresen, Frances M. Cowan, Ela Chakkarapani
Article
Pediatrics
Karen Luyt, Sally L. Jary, Charlotte L. Lea, Grace J. Young, David E. Odd, Helen E. Miller, Grazyna Kmita, Cathy Williams, Peter S. Blair, William Hollingworth, Michelle Morgan, Adam P. Smith-Collins, Steven Walker-Cox, Kristian Aquilina, Ian Pople, Andrew G. Whitelaw
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2020)
Article
Neurosciences
Arthur P. C. Spencer, Hollie Byrne, Richard Lee-Kelland, Sally Jary, Marianne Thoresen, Frances M. Cowan, Ela Chakkarapani, Jonathan C. W. Brooks
Summary: An age-specific probabilistic white matter atlas was created based on the averaged subject-specific fiber bundles from children aged 6-8 years, allowing for more accurate assessment of white matter tracts in this age group compared to using an adult atlas. The age-specific atlas showed better overall performance, with higher volumetric overlap and correlation of diffusion metrics with subject-specific fiber bundles.
BRAIN CONNECTIVITY
(2022)
Article
Clinical Neurology
Cathy Williams, Penny Warnes, Sally Jary, Grace Young, Peter S. Blair, Christopher P. Benton, Helen Miller, Andrew Whitelaw, Ian Pople, Karen Luyt
Summary: Children who have experienced grade 3 or 4 IVHVD have high levels of visual morbidity at age 10 to 11 years. Meeting their unmet visual needs may improve their outcomes.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Clinical Neurology
Arthur P. C. Spencer, Richard Lee-Kelland, Jonathan C. W. Brooks, Sally Jary, James Tonks, Frances M. Cowan, Marianne Thoresen, Ela Chakkarapani
Summary: Children who underwent therapeutic hypothermia showed reduced whole-brain grey and white-matter volumes, with associations between hippocampal and thalamic volumes and functional outcomes.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2022)
Article
Clinical Neurology
Arthur P. C. Spencer, Maarten H. Lequin, Linda S. de Vries, Jonathan C. W. Brooks, Sally Jary, James Tonks, Frances M. Cowan, Marianne Thoresen, Ela Chakkarapani
Summary: The aim of this study was to evaluate mammillary body abnormalities in school-age children without cerebral palsy who underwent therapeutic hypothermia for neonatal hypoxic-ischaemic encephalopathy. The results show that children with mammillary body abnormalities have reduced cognitive scores, smaller hippocampi, and altered MTT microstructure compared to children without these abnormalities.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2023)
Article
Clinical Neurology
Hollie Byrne, Arthur P. C. Spencer, Georgia Geary, Sally Jary, Marianne Thoresen, Frances M. Cowan, Jonathan C. W. Brooks, Elavazhagan Chakkarapani
Summary: Morphological and microstructural changes in the corpus callosum after neonatal hypoxic-ischemic encephalopathy (HIE) are associated with reduced cognitive function in early school-age children.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Neuroimaging
Arthur P. C. Spencer, Jonathan C. W. Brooks, Naoki Masuda, Hollie Byrne, Richard Lee-Kelland, Sally Jary, Marianne Thoresen, Marc Goodfellow, Frances M. Cowan, Ela Chakkarapani
Summary: Therapeutic hypothermia in children treated for neonatal hypoxic-ischaemic encephalopathy reduces severe motor disability but leads to motor deficits and altered white matter connectivity in those without cerebral palsy. Diffusion-weighted imaging showed significant correlations between white matter tracts and motor performance in cases but not controls. Network analysis revealed associations between impaired motor function and brain organization in cases, highlighting the impact of therapeutic hypothermia on brain development.
NEUROIMAGE-CLINICAL
(2021)
Article
Medicine, General & Internal
Marianne Thoresen, Sally Jary, Lars Walloe, Mathias Karlsson, Miriam Martinez-Biarge, Ela Chakkarapani, Frances M. Cowan
Summary: Binary logistic regression using WMxBGT or TIS along with clinical variables provides excellent outcome prediction for infants with hypoxic-ischaemic encephalopathy, outperforming single variable cross-tabulation methods.
Article
Medicine, General & Internal
Julia K. Gundersen, Ela Chakkarapani, Sally Jary, David A. Menassa, Emma Scull-Brown, Adam Frymoyer, Lars Walloe, Marianne Thoresen
Summary: In infants with moderate or severe hypoxic-ischemic encephalopathy (HIE) receiving hypothermia treatment, the cumulative dose of opioids administered for sedation during the first week of life did not show a significant association with neurodevelopmental outcomes at 18-24 months of age. Time to extubation was also found to be independent of sedation dose.
Article
Neuroimaging
Arthur P. C. Spencer, Jonathan C. W. Brooks, Naoki Masuda, Hollie Byrne, Richard Lee-Kelland, Sally Jary, Marianne Thoresen, James Tonks, Marc Goodfellow, Frances M. Cowan, Ela Chakkarapani
Summary: Therapeutic hypothermia for neonatal encephalopathy following birth asphyxia reduces death and cerebral palsy risks, but school-age children treated with this method still show cognitive and motor deficits compared to controls. Diffusion-weighted imaging revealed widespread changes in white matter structure in these children. Network-based statistic analysis identified brain regions associated with visuo-spatial processing and attention as being affected.
NEUROIMAGE-CLINICAL
(2021)
Article
Health Care Sciences & Services
Karen Luyt, Sally Jary, Charlotte Lea, Grace J. Young, David Odd, Helen Miller, Grazyna Kmita, Cathy Williams, Peter S. Blair, Aida Moure Fernandez, William Hollingworth, Michelle Morgan, Adam Smith-Collins, N. Jade Thai, Steven Walker-Cox, Kristian Aquilina, Ian Pople, Andrew Whitelaw
HEALTH TECHNOLOGY ASSESSMENT
(2019)