Journal
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
Volume 56, Issue 7, Pages 612-626Publisher
WILEY
DOI: 10.1111/dmcn.12359
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Funding
- Great Ormond Street Hospital Children's Charity
- Newlife Foundation
- MRC [G0600485] Funding Source: UKRI
- Great Ormond Street Hospital Childrens Charity [V1212] Funding Source: researchfish
- Medical Research Council [G0600485] Funding Source: researchfish
- National Institute for Health Research [NIHR/CS/010/021] Funding Source: researchfish
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Intracranial calcification (ICC) is a common finding on neuroimaging in paediatric neurology practice. In approximately half of all cases the calcification occurs in damaged, neoplastic, or malformed brain. For the large number of other disorders in which ICC occurs, no common pathogenetic mechanism can be suggested. Congenital infection, particularly with cytomegalovirus, accounts for a significant proportion of all cases. However, some genetic diseases, in particular Aicardi-Goutieres syndrome, Band-like calcification, and RNASET2-related disease, may mimic congenital infection; therefore, a full consideration of the radiological and clinical features is necessary before concluding that congenital infection is the cause. In some disorders calcification is a universal finding, in others it is a frequent occurrence, and in some it is only an occasional finding. Characteristic patterns of calcification are seen in a number of conditions, and a systematic approach to the identification and description of radiological findings, taken together in the context of the clinical scenario, allows a diagnosis to be made in many cases. Nonetheless, there remain a number of presumed genetic disorders associated with ICC for which the underlying molecular cause has not yet been identified.
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