Article
Clinical Neurology
Lulin Dai, Wenying Xu, Yunhai Song, Peng Huang, Ningfei Li, Barbara Hollunder, Andreas Horn, Yiwen Wu, Chencheng Zhang, Bomin Sun, Dianyou Li
Summary: This study found that STN-DBS treatment can significantly improve symptoms in patients with GTS, with minimal side effects. STN as a potential target for DBS modulates GTS symptoms through functional connectivity with other relevant brain areas.
JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Piotr Janik, Anna Dunalska, Natalia Szejko, Andrzej Jakubczyk
Summary: Coprolalia and echophenomena repetition known as CTPh are rare in Gilles de la Tourette syndrome (GTS) patients, with a higher occurrence in adolescence and adulthood. As patients age, the severity of tics increases and anxiety disorder is significantly associated with CTPh, indicating that they may be part of the tic spectrum and are age-related symptoms of GTS.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Psychiatry
Ryunosuke Goto, Natsumi Matsuda, Maiko Nonaka, Yu Hamamoto, Yosuke Eriguchi, Mayu Fujiwara, Akane Suzuki, Yukari Yokoyama, Yukiko Kano
Summary: This study provides evidence on the validity and reliability of the GTS-QOL scale in Japanese patients with GTS, making it an effective tool for measuring disease-specific HR-QOL in this population.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neuroimaging
Alexander Muenchau, Lorenza S. Colzato, Azam AghajaniAfjedi, Christian Beste
Summary: This paper proposes an exploration of the characteristics and potential explanations of Tourette syndrome, focusing on neural noise and its adaptation in information processing. Through neurophysiological and imaging approaches, further investigation into the pathophysiology of Tourette syndrome is essential to pave the way for novel interventions targeting neural noise levels and patterns directly in Tourette syndrome.
NEUROIMAGE-CLINICAL
(2021)
Article
Biochemistry & Molecular Biology
Theresa Paulus, Lynn Wernecke, Annik Lundie, Julia Friedrich, Julius Verrel, Tina Rawish, Anne Weissbach, Christian Frings, Christian Beste, Tobias Baeumer, Alexander Muenchau
Summary: Research shows that inhibitory repetitive transcranial magnetic stimulation (rTMS) applied to the left BA40 is not effective in alleviating tic symptoms in GTS patients. The left BA40 does not appear to be a useful target for modulating tic symptoms in GTS.
Article
Clinical Neurology
Justyna Kaczynska, Piotr Janik
Summary: This study evaluated the prevalence, age of onset, and clinical correlates of blocking tics (BTs) in patients with Gilles de la Tourette syndrome (GTS). BTs represent early and common symptoms of GTS, associated with a more severe form of the syndrome.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Petra Heiden, Mauritius Hoevels, Dilruba Bayram, Juan C. Baldermann, Thomas Schueller, Daniel Huys, Veerle Visser-Vandewalle, Pablo Andrade
Summary: This study analyzed the connectivity profiles of different DBS targets for GTS and found significant differences in the connectivity profiles of standard targets. The pvGPi showed the strongest connection to the sensorimotor cortex, while the amGPi showed the strongest connection to the prefrontal cortex. Using probabilistic tractography based on patient data and a normative connectome revealed differences in connectivity profiles.
Article
Genetics & Heredity
Mathis Hildonen, Amanda M. Levy, Christina Dahl, Victoria A. Bjerregaard, Lisbeth Birk Moller, Per Guldberg, Nanette M. Debes, Zeynep Tumer
Summary: This study found that SLC6A4 expression is upregulated in individuals with Gilles de la Tourette syndrome compared to healthy controls. The L-AC/L-AC genotype of the 5-HTTLPR/rs25531/rs25532 three-locus haplotype was associated with higher SLC6A4 mRNA expression levels in GTS individuals.
Article
Plant Sciences
Cheng-Hao Huang, Wen-Ling Liao, Der-Yen Lee, I-Ching Chou, Ming-Yu Wang, Ching-Liang Hsieh
Summary: This study investigated the effects of Yi-Gan-san (YGS), a traditional Chinese medicine formula, on the psychiatric behavior of children and adolescents with Gilles de la Tourette's Syndrome (TS). The results showed that oral administration of YGS for 1 week reduced the intensity of phonic tics, but had no significant effect on the intensity of phonic tics after 2, 3, and 4 weeks. The compliance of oral administration of YGS for 4 weeks was acceptable in children and adolescents with TS.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Behavioral Sciences
Aijun Liu, Yongcheng Jiao, Shaohui Zhang, Haibo Kong
Summary: Bilateral posteroventral GPi DBS can significantly alleviate motor tics and depressive symptoms in GTS patients, but vocal tics and other psychiatric symptoms may worsen without statistical difference during the follow-up period.
BRAIN AND BEHAVIOR
(2022)
Review
Genetics & Heredity
Amanda M. Levy, Peristera Paschou, Zeynep Tumer
Summary: GTS is a childhood-onset neurodevelopmental and psychiatric disorder that is often comorbid with OCD and ADHD. Genetic factors play a significant role in disease etiology, but identifying major susceptibility genes has been challenging due to the complex interplay between multiple genetic factors and environmental influences.
Review
Neurosciences
Adam Takacs, Alexander Muenchau, Dezso Nemeth, Veit Roessner, Christian Beste
Summary: Gilles de la Tourette syndrome (GTS) is characterized by enhanced cognitive functions related to habitual behavior, such as tics, with hyperfunctioning observed in procedural sequence learning and event file binding. The coexistence of these two enhanced functions in GTS suggests their functional connections beyond the disorder, but they are not interchangeable and contribute differently to the cognitive profile of GTS. An integrated theoretical account of hyperbinding and hyperlearning in GTS may help predict the emergence, activation, and persistence of tics in GTS.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
K. R. Mueller-Vahl, N. Szejko, A. Saryyeva, C. Schrader, D. Krueger, A. Horn, A. A. Kuehn, J. K. Krauss
Summary: This study compared the efficacy and safety of deep brain stimulation (DBS) in Gilles de la Tourette syndrome (GTS), finding that the initial effect of pvl GPi DBS was superior to thalamic DBS. While half of the patients discontinued treatment, some individuals continued to benefit from thalamic DBS after years.
Article
Clinical Neurology
Justyna Kaczynska, Piotr Janik
Summary: Tonic tics (TTs) are common in patients with Gilles de la Tourette syndrome (GTS), with a prevalence of 85.2% in adults and 63.9% in children and adolescents. TTs are associated with a greater number of tics, more severe symptoms, and more comorbidities in both age groups.
Article
Pharmacology & Pharmacy
Dana Barchel, Orit Stolar, Tomer Ziv-Baran, Itai Gueta, Matitiahu Berkovitch, Elkana Kohn, Lihi Bar-Lev Schleider
Summary: This study investigates the experience of Tourette's syndrome (TS) patients with medical cannabis. The results suggest that medical cannabis may improve the quality of life and comorbidities of TS patients, although no significant improvement was identified in motor and vocal tics.
CANNABIS AND CANNABINOID RESEARCH
(2022)