Article
Immunology
Haoting Zhan, Linlin Cheng, Xiaoou Wang, Haiqiang Jin, Yongmei Liu, Haolong Li, Dandan Liu, Xinyao Zhang, Wenjie Zheng, Hongjun Hao, Yongzhe Li
Summary: This study found that myelin basic protein (MBP) levels in cerebrospinal fluid (CSF) and serum were significantly higher in Neuro-Behcet's disease (NBD) patients compared to non-inflammatory neurological diseases (NIND). MBP could serve as a marker to distinguish NBD from other diseases and differentiate between acute and chronic progressive NBD. The study also found a positive correlation between MBP index and IgG index, suggesting that MBP index could predict disease relapse. MBP has high diagnostic accuracy for NBD with demyelination and can identify CNS pathogenic processes before clinical symptoms.
CLINICAL IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Natalia Czarniak, Joanna Kaminska, Joanna Matowicka-Karna, Olga Martyna Koper-Lenkiewicz
Summary: Cerebrospinal fluid plays a crucial role in protecting the central nervous system by providing support, absorbing shocks, and transporting nutrients and waste products. This review provides an overview of cerebrospinal fluid history, production, circulation, main components, and the roles of blood-brain barrier and blood-cerebrospinal fluid barrier in maintaining homeostasis. The utility of Albumin Quotient evaluation in the diagnosis of CNS diseases is discussed. The importance of research on cerebrospinal fluid for improving disease management and discovering new treatment options is highlighted.
Article
Oncology
Jan Remsik, Jessica A. Wilcox, N. Esther Babady, Tracy A. McMillen, Behroze A. Vachha, Neil A. Halpern, Vikram Dhawan, Marc Rosenblum, Christine A. Iacobuzio-Donahue, Edward K. Avila, Bianca Santomasso, Adrienne Boire
Summary: Cancer patients with neurologic sequelae of COVID-19 have meningeal inflammatory cytokines without viral neuroinvasion, mainly driven by type II interferon and correlated with the degree of neurological dysfunction. The neuroinflammatory process persists weeks after recovery from acute respiratory infection, leading to long-term neurocognitive dysfunction. Anti-inflammatory treatments may play a role in managing neurological complications of COVID-19 infection.
Article
Medicine, General & Internal
Olga M. Koper-Lenkiewicz, Anna J. Milewska, Joanna Kaminska, Karol Sawicki, Robert Chrzanowski, Justyna Zinczuk, Joanna Reszec, Marzena Tylicka, Ewa Matuszczak, Joanna Matowicka-Karna, Zenon Mariak, Mariusz W. Mucha, Robert Pawlak, Violetta Dymicka-Piekarska
Summary: The study aimed to evaluate the diagnostic usefulness of myelin-associated proteins (Nogo-A, MAG, OMgp) released into extracellular space in patients with brain tumours. CSF Nogo-A and serum MAG were found to be useful in differentiating brain tumour patients from non-tumoural individuals. The decreased CSF Nogo-A concentration was identified as an adverse prognostic factor for patients' survival.
ANNALS OF MEDICINE
(2021)
Article
Medicine, Research & Experimental
Jane L. Zhu, Ricardo T. Paniagua, Henry W. Chen, Stephanie Florez-Pollack, Elaine Kunzler, Noelle Teske, Yevgeniya Byekova Rainwater, Quan-Zhen Li, Gregory A. Hosler, Wenhao Li, Denise M. O. Ramirez, Nancy L. Monson, Heidi T. Jacobe
Summary: This study found a higher frequency of myelin basic protein autoantibodies in patients with morphea, an autoimmune skin disorder. Patients with these antibodies reported higher pain frequencies and demonstrated increased perineural inflammation in their skin tissues.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Clinical Neurology
Christian W. Keller, Joseph A. Lopez, Eva-Maria Wendel, Sudarshini Ramanathan, Catharina C. Gross, Markus Reindl, Russell C. Dale, Heinz Wiendl, Kevin Rostasy, Fabienne Brilot, Jan D. Luenemann
Summary: MOG-antibody associated diseases account for a significant portion of patients with acquired demyelinating disorders, with elevated systemic complement activation observed in both adult and pediatric cases across all clinical syndromes. Complement inhibition should be considered for therapeutic merit in patients with MOGAD.
ANNALS OF NEUROLOGY
(2021)
Article
Cell Biology
Julia Costa, Catherine Hayes, Frederique Lisacek
Summary: Glycosylation is a common post-translational modification of brain proteins, and abnormal glycosylation has been found in central nervous system disorders. A detailed analysis of glycan structures in brain tissues and cerebrospinal fluid has been conducted, creating a dedicated set in the GlyConnect database. The shared molecular composition between cerebrospinal fluid and brain may lead to the discovery of novel glycobiomarkers for neurodegenerative diseases, providing potential therapeutic targets and diagnostic tools.
AGEING RESEARCH REVIEWS
(2023)
Article
Biochemical Research Methods
Katharina Waury, Renske de Wit, Inge M. W. Verberk, Charlotte E. Teunissen, Sanne Abeln
Summary: Cerebrospinal fluid (CSF) is a crucial matrix for neurological disease biomarkers. This study developed a machine learning model that can predict the secretion of brain proteins to CSF based on sequence-based features. The model achieved an accuracy of 0.89 and important prediction features included subcellular localization, signal peptides, and transmembrane regions.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Daria A. Kamaeva, Liudmila P. Smirnova, Svetlana N. Vasilieva, Daria Kazantseva, Alisa R. Vasilieva, Svetlana A. Ivanova
Summary: This article investigates the hydrolytic activity of serum IgG on MBP in bipolar disorder and provides a detailed characterization of its catalytic properties. The study shows that IgG from bipolar patients exhibits significantly higher MBP-hydrolyzing activity compared to healthy individuals. This finding may reveal an additional link between myelin damage and inflammation in bipolar disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Jun-Li Wang, Chao Han, Feng-Lian Yang, Mao-Shui Wang, Yu He
Summary: The study found that in suspected childhood tuberculous meningitis, patients without vomiting or with low serum glucose are more likely to have normal CSF protein levels. Therefore, careful clinical assessment is necessary for interpreting CSF protein levels in children with these characteristics.
ANNALS OF MEDICINE
(2021)
Article
Neurosciences
Madeline Peterson, Molly B. D. Prigge, Erin D. Bigler, Brandon Zielinski, Jace B. King, Nicholas Lange, Andrew Alexander, Janet E. Lainhart, Jared A. Nielsen
Summary: The study found no significant increase in extra-axial cerebrospinal fluid volume in autistic individuals beyond the age of four, compared to controls.
Article
Microbiology
Noha Abdelgawad, Mvuwo (Phophi) Tshavhungwe, Ursula Rohlwink, Helen McIlleron, Mahmoud T. Abdelwahab, Lubbe Wiesner, Sandra Castel, Chanel Steele, Johannes (Nico) Enslin, Nqobile Sindiswa Thango, Paolo Denti, Anthony Figaji
Summary: This analysis provides insights into the pharmacokinetics of rifampicin in children with tuberculous meningitis (TBM) and its penetration into brain tissue. The study characterizes the distribution of rifampicin in cerebrospinal fluid, lumbar and ventricular fluid, and brain extracellular fluid. It confirms rifampicin's ability to reach the brain tissue and provides valuable information for further research and treatment of TBM.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Petr Kelbich, Karel Hrach, Jan Spicka, Petr Vachata, Tomas Radovnicky, Eva Hanuljakova, Jan Krejsek
Summary: The laboratory analysis of basic cerebrospinal fluid parameters is essential in evaluating the central nervous system, with neutrophils and lymphocytes ratios providing insights into infectious or non-infectious CNS involvement. Simultaneously assessing aerobic and anaerobic metabolism using KEB can help specify the type of inflammation in CNS.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Geriatrics & Gerontology
Xianjie Cai, Qingyuan He, Wei Wang, Chunlin Li, Hui Wang, Feng Yin, Tong Li, Dongsheng Kong, Yanxing Jia, Hongfeng Li, Junhao Yan, Xunbin Wei, Qiushi Ren, Yajuan Gao, Shuangfeng Yang, Huaiyu Tong, Yun Peng, Hongbin Han
Summary: In this study, a new method was developed to accelerate the drainage of brain interstitial fluid (ISF) in the extracellular space (ECS). The method involved a minimally invasive surgery that implanted a branch of the external carotid artery in the epidural space, resulting in a pulsation effect on cerebrospinal fluid (CSF). The results showed that the drainage of ISF from the caudate nucleus to the ipsilateral cortex was significantly accelerated, along with increases in the volume fraction of the ECS and molecular diffusion rate. This study provides a new perspective on the treatment of brain diseases through the brain ECS.
Article
Neurosciences
Yu Han, Wenjuan Xiong, Jiaxue Liu, Wei Dai, Yuanyuan Su, Lei Gao, Gengfu Wang, Peiying Li, Xin Zhang
Summary: This study found that Chinese children with ASD have higher serum levels of cytokines, which are associated with severe symptoms. Dysregulation of cytokines influences myelin damage in ASD.
