Review
Medicine, General & Internal
Ramiz H. Kara, Gyusik Park, Shoeb B. Lallani, Hassan N. Kesserwani
Summary: Paroxysmal dyskinesias are rare movement disorders characterized by dystonia, chorea, and athetosis. They usually manifest in early life with variable frequency episodes involving limbs or facial muscles. Recent advancements in genetic analysis have provided insights into the pathophysiology and potential targets for treatment. This case report highlights the role of voltage-gated sodium channels and the implications of cerebellar spreading depolarization in paroxysmal non-kinesigenic dyskinesia.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Genetics & Heredity
Shiroh Miura, Tomofumi Shimojo, Takuya Morikawa, Takashi Kamada, Yusuke Uchiyama, Seiji Kurata, Ryuta Fujioka, Hiroki Shibata
Summary: Paroxysmal kinesigenic dyskinesia (PKD) is characterized by movement attacks triggered by sudden movements, acceleration, or intention to move. A study of two Japanese familial cases revealed possible involvement of variants in the NBEA gene.
JOURNAL OF HUMAN GENETICS
(2021)
Article
Psychology, Clinical
C. M. Gillan, M. M. Vaghi, F. H. Hezemans, S. van Ghesel Grothe, J. Dafflon, A. B. Bruhl, G. Savulich, T. W. Robbins
Summary: Three complementary experiments found no evidence that anxiety impairs goal-directed control in human subjects, even when induced by acute anxiety states from inhalation of carbon dioxide or real-life anxiety-provoking events.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Clinical Neurology
Ruo-Nan Duan, Dan-Dan Zhao, Yi-Ming Liu, Chuan-Zhu Yan
Summary: This study reported a case of PFBC in a Chinese pedigree with a heterozygous deletion of PDGFB, providing evidence of haploinsufficiency in the pathogenesis of PFBC.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Psychiatry
Srinivas Balachander, Sandra Meier, Manuel Matthiesen, Furkhan Ali, Anand Jose Kannampuzha, Mahashweta Bhattacharya, Ravi Kumar Nadella, Vanteemar S. Sreeraj, Dhruva Ithal, Bharath Holla, Janardhanan C. Narayanaswamy, Shyam Sundar Arumugham, Sanjeev Jain, Y. C. Janardhan Reddy, Biju Viswanath
Summary: The study found a high concordance of OCD symptom dimensions within multiplex families, indicating significant heritability of OCD symptom dimensions. Future genetic and neurobiological studies in OCD should consider symptom dimensions as a key parameter in their analyses.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Sini Sulkama, Milla Salonen, Salla Mikkola, Emma Hakanen, Jenni Puurunen, Cesar Araujo, Hannes Lohi
Summary: This study investigated the association between repetitive behavior and various factors such as aggressiveness, hyperactivity/impulsivity, and inattention in pet dogs. The study also revealed a novel association between repetitive behavior and the owner's dog experience. Additionally, certain environmental and lifestyle factors were found to be correlated with repetitive behavior in dogs. Finally, breed differences were identified, indicating a genetic susceptibility to repetitive behavior.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Masanori Isobe, Matilde Vaghi, Naomi A. Fineberg, Annemieke M. Apergis-Schoute, Edward T. Bullmore, Barbara J. Sahakian, Trevor W. Robbins, Samuel R. Chamberlain
Summary: The study demonstrates a link between cognitive inflexibility and putamen morphology in OCD patients and their relatives, indicating a familial marker of OCD. The findings suggest a shared abnormality in basal ganglia structure associated with cognitive rigidity among individuals with OCD and their asymptomatic relatives.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Psychiatry
Srinivas Balachander, Navya Spurthi Thatikonda, Anand Jose Kannampuzha, Mahashweta Bhattacharya, Sweta Sheth, Vinutha Ramesh, Alen Chandy Alexander, Moorthy Muthukumaran, Mino Susan Joseph, Sowmya Selvaraj, Dhruva Ithal, Vanteemar S. Sreeraj, P. John John, Ganesan Venkatasubramanian, Biju Viswanath, Y. C. Janardhan Reddy, Sanjeev Jain
Summary: Patients with a family history of psychosis in OCD are less likely to respond to treatment compared to those with a family history of OCD or sporadic OCD. Further research is needed to understand the influence of genetic vulnerability to psychosis on treatment outcomes in OCD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Ashley M. Shaw, Elizabeth R. Halliday, Niza A. Tonarely, Jill Ehrenreich-May
Summary: The study found a relationship between affect intolerance and internalizing symptoms in youth, with higher levels of affect intolerance predicting more severe symptom reports. Future research should include more samples of depressed youth and utilize experimental or longitudinal methods to validate the results.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Developmental
Omer Linkovski, Tyler M. Moore, Stirling T. Argabright, Monica E. Calkins, Ruben C. Gur, Raquel E. Gur, Ran Barzilay
Summary: Hoarding behavior is common in youth and is associated with poorer mental health and functioning, independent of obsessive-compulsive symptoms. Brief hoarding-behavior assessments in clinical settings may prove useful.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Zhishun Wang, Martine Fontaine, Marilyn Cyr, Moira A. Rynn, Helen Blair Simpson, Rachel Marsh, David Pagliaccio
Summary: This study is the largest to date examining subcortical surface morphometry in OCD. The results show that individuals with OCD exhibit surface expansions on the right nucleus accumbens and inward left amygdala deformations, and these shape alterations are associated with OCD symptom severity. The study also found that these changes are driven by age and health status.
DEPRESSION AND ANXIETY
(2022)
Article
Clinical Neurology
Yuexin Shu, Nannan Liao, Fang Fang, Qiuling Shi, Ning Yan, Yaoyue Hu
Summary: Psychological conditions such as anxiety, insomnia, and OCD are associated with an increased risk of first recurrence of BPPV. However, these psychological conditions do not affect the number of recurrences in patients who have already experienced a relapse.
Article
Psychology, Developmental
Camilla Funch Uhre, Melanie Ritter, Jens Richardt Mollegaard Jepsen, Valdemar Funch Uhre, Nicole Nadine Lonfeldt, Anne Dorothee Mueller, Kerstin Jessica Plessen, Signe Vangkilde, Robert James Blair, Anne Katrine Pagsberg
Summary: This study investigated neurocognitive functioning in children and adolescents with obsessive-compulsive disorder (OCD) and found that they exhibited atypical performance in cognitive flexibility, decision-making, working memory, and processing speed. However, these difficulties did not appear to be the driving factor behind their OCD symptoms. The findings suggest that these neurocognitive difficulties may contribute to lifespan difficulties and interfere with treatment efficacy.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Developmental
Mehdi Zemestani, Omid Isanejad, Zohre Valiei, Eric A. Storch, Meredith E. Coles
Summary: This study evaluated the psychometric properties of the Persian version of the Obsessive-Compulsive Inventory-Child Version (OCI-CV) in clinical and community samples. The OCI-CV demonstrated good convergent and discriminant validity, acceptable sensitivity and specificity for detecting OCD, and good reliability in terms of internal consistency and temporal stability. The findings suggest that the OCI-CV is a valid and reliable measure for assessing obsessive-compulsive symptoms in Iranian youth.
CHILD PSYCHIATRY & HUMAN DEVELOPMENT
(2022)
Article
Psychiatry
Thiago Blanco-Vieira, Marcelo Queiroz Hoexter, Marcelo C. Batistuzzo, Pedro Alvarenga, Natalia Szejko, Afonso Mazine Tiago Fumo, Euripedes C. Miguel, Maria Conceicao do Rosario
Summary: The study found that obsessive-compulsive symptoms (OCS) dimensions are highly prevalent in women, and the presence and severity of maternal OCS are related to children's psychopathology and behavioral problems.
FRONTIERS IN PSYCHIATRY
(2021)
