Article
Multidisciplinary Sciences
Hayelom Kebede Mekonen, Yibrah Berhe, Birhane Alem Berihu, Hale Teka, Abera Hadgu, Letekirstos Gebregziabher, Etenat Halefom Berhe, Tony Magana, Afework Mulugeta
Summary: This study aimed to investigate the burden of major congenital malformations in the Tigray Region, Northern Ethiopia, showing a high prevalence of central nervous system anomalies, particularly neural tube defects, as the most common type of congenital anomalies in newborns in the region, with potential associations with maternal and fetal factors.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Flavio De Maio, Giacomo Grotti, Francesco Mariani, Danilo Buonsenso, Giulia Santarelli, Delia Mercedes Bianco, Brunella Posteraro, Maurizio Sanguinetti, Claudia Rendeli
Summary: It was previously believed that the human bladder is sterile, but recent advances in molecular biology have shown the presence of microorganisms in the urinary tract. Understanding the relationship between urobiota and urinary tract disorders has become a significant research focus. Patients with spina bifida (SB), a condition that can lead to neurogenic bladder and increased susceptibility to urinary tract infections, often undergo clean intermittent catheterization (CIC) for treatment. This study aims to investigate the urobiota composition in SB patients compared to healthy controls and explore the urobiota characteristics in relation to CIC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychology, Developmental
Zoe R. Smith, Grayson N. Holmbeck
Summary: The study examined the factor structure of a medical responsibilities measure and a medical regimen skills scale in families of youth with spina bifida across time. Results showed that both measures had adequate to excellent fit across different age groups and raters, indicating their usefulness in evaluating medical responsibilities and skills in young people with spina bifida.
JOURNAL OF PEDIATRIC PSYCHOLOGY
(2021)
Article
Orthopedics
Wenhao Li, Zhencheng Xiong, Chunke Dong, Jipeng Song, Liubo Zhang, Jun Zhou, Yanlei Wang, Ping Yi, Feng Yang, Xiangsheng Tang, Mingsheng Tan
Summary: Among young people with LBP, SBO is the most common lumbosacral dysplasia, often involving the S1 segment. Most laminae in SBO are in the developmental stage of the spinous process, with abnormal laminar growth direction and laminar stenosis being the most common laminar morphologies in SBO.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Nursing
Eun Kyoung Choi, Jisu Park, Kyua Kim, Eunjeong Bae, Yoonhye Ji, Seung Hyeon Yang, Altantuya Chinbayar, Hyeseon Yun
Summary: This study aimed to explore the experiences of Korean young adults with spina bifida (SB) in transition to adulthood and identify the facilitators or barriers to this transition. Facilitators included understanding and acceptance of SB, acquiring self-management skills, parenting styles encouraging autonomy, parents' emotional support, school teachers' thoughtful consideration, and participation in self-help groups. Barriers included overprotective parenting style, experience of being bullied by peers, damaged self-concept, concealing one's chronic condition from others, and the lack of privacy in school restrooms.
Article
Public, Environmental & Occupational Health
Huan Li, Yan-Hong Huang, Jing Li, Shu Liu, Yan-Ling Chen, Li-Li Li, Cheng-Zhi Jiang, Zong-Jiao Chen, Na Li
Summary: Limited studies have shown a positive association between maternal exposure to PM10 and the risk of spina bifida in offspring. Higher levels of PM10 during the first trimester of pregnancy and the 3 months before pregnancy were found to be significantly associated with an increased risk of spina bifida. Sensitivity analyses supported these findings, suggesting the need for further research with a prospective design and more accurate exposure assessment.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Rehabilitation
Melinda Rocchi, Johan Jarl, Annika Lundkvist Josenby, Ann I. Alriksson-Schmidt
Summary: In Sweden, adults with spina bifida have a lower survival rate compared to the general population, and the causes of death differ between the two groups.
JOURNAL OF REHABILITATION MEDICINE
(2023)
Article
Psychology, Multidisciplinary
Diana M. Ohanian, Tessa K. Kritikos, Olivia E. Clark, Kezia C. Shirkey, Meredith Starnes, Grayson N. Holmbeck
Summary: The study found that youth with spina bifida tend to use primary control coping, and are more likely to use active coping strategies compared to youth with other conditions. Changes in coping styles over the study period were not significant. Factors such as IQ and socioeconomic status were found to be associated with coping styles. Future interventions should focus on promoting adaptive coping behaviors tailored to developmental age and access to resources.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Multidisciplinary Sciences
Melissa A. Bent, Eva M. Ciccodicola, Susan A. Rethlefsen, Tishya A. L. Wren
Summary: Spina bifida is caused by incomplete neural tube closure, leading to muscle weakness and impairments. The severity of muscle weakness depends on the neurological lesion level, with asymmetries in lesion level and body composition affecting gait and function.
Article
Multidisciplinary Sciences
Romain Corroenne, Amy R. Mehollin-Ray, Rebecca M. Johnson, William E. Whitehead, Jimmy Espinoza, Jonathan Castillo, Heidi Castillo, Gunes Orman, Roopali Donepudi, Thierry A. G. M. Huisman, Ahmed A. Nassr, Michael A. Belfort, Magdalena Sanz Cortes, Alireza A. Shamshirsaz
Summary: The study found that in cases who underwent prenatal repair for myelomeningocele, large MMC lesions were associated with an increased risk of clubfeet and reduced chances of intact motor function. This association was observed both at referral and at birth.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Clinical
Tessa K. Kritikos, Colleen Stiles-Shields, Jenna B. Shapiro, Grayson N. Holmbeck
Summary: Young adults with SB recognize benefits associated with their condition, particularly related to personal strengths, interpersonal relationships, and life philosophy. Younger age, majority race, higher education level, and employment are significantly associated with higher benefit-finding scores.
JOURNAL OF HEALTH PSYCHOLOGY
(2022)
Review
Pediatrics
Vera H. H. Koch, MarcosTomasin Lopes, Erika Furusawa, Katharinne Vaz, Ubirajara Barroso
Summary: The worldwide prevalence of neural tube defects (NTDs) is 1.0 per 1000 births. Development of NTDs is caused by genetic and non-genetic factors. Spina bifida (SB) is a main representative of NTDs, and the severity of the spinal cord lesion level determines the level of paralysis, numbness, and bladder/bowel difficulties. Prenatal repair of myelomeningocele can improve motor function and reduce hydrocephalus and hindbrain herniation. Care throughout life and early diagnosis are important for people with SB, who tend to have lower cognitive abilities and IQ. Invasive urological interventions may be necessary when conservative treatment fails. Transition to adult care is challenging, and addressing sexuality and fertility should be done before or during puberty. Bowel and urinary continence decline with age, while skin breakdown increases. Long-term caregiver support should be offered, as survival rates are poor due to various complications.
PEDIATRIC NEPHROLOGY
(2023)
Article
Acoustics
Misun Hwang, Susan J. Back, Jason van Batavia, Luis Octavio Tierradentro-Garcia, Kassa Darge, Stephen A. Zderic
Summary: This retrospective study aimed to evaluate the correlation between lower urinary tract ultrasound parameters and the reference standard of bladder dysfunction in children with spina bifida. The results showed that bladder mass, bladder/body mass ratio, and wall thickness were correlated with ending storage pressures above 15 cm H2O. The optimal cutoff point for bladder weight was found to be 65 g with a pressure cutoff of 30 cm H2O, providing a clinically valuable tool for noninvasive screening.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Review
Obstetrics & Gynecology
Y. Kunpalin, J. Richter, N. Mufti, J. Bosteels, S. Ourselin, P. De Coppi, D. Thompson, A. L. David, J. Deprest
Summary: Multiple intracranial abnormalities were detected by second-trimester ultrasound in fetuses with MMC, but the clinical significance of these findings remains unclear and may not necessarily contraindicate fetal surgery. Long-term follow-up is needed to further investigate the impact of these cranial abnormalities on postnatal outcomes.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Article
Pediatrics
Ashley M. Jenkins, Diane Burns, Rhonda Horick, Brittany Spicer, Lisa M. Vaughn, Jason Woodward
Summary: This study identified and prioritized facilitators and barriers of successful transition to a healthy adult life for adolescents and young adults with spina bifida through concept mapping, engaging diverse stakeholders, including individuals with intellectual, developmental, and physical disabilities. Self-management, self-advocacy, and inclusivity and relationship supports were highlighted as highly feasible and important areas for improvement efforts relevant to this population.
ACADEMIC PEDIATRICS
(2021)