Article
Medicine, Research & Experimental
Mingliang Ren, Xiaoping Wang, Ming Hu, Yi Jiang, Daorong Xu, Haibo Xiang, Jianchun Lin, Bin Yu
Summary: A novel quercetin-containing alpha-CSH/n-HA composite was developed and shown to enhance cell proliferation, migration, and osteogenic differentiation of BMSCs in vitro, as well as potential bone defect repair in vivo. The composite demonstrated increased porosity, leading to improved cell functions and accelerated bone defect repair, highlighting its potential as an artificial bone graft for bone regeneration.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Materials Science, Ceramics
Zepeng Cai, Zhiwen Wu, Yi Wan, Tao Yu, Changren Zhou
Summary: The study prepared micronano calcium phosphate (MNC) with different Ca/P ratio and added it to CPC and CSC, showing significant improvements in mechanical properties and setting time of the cement. MNC promoted hydration reaction, affected crystal growth, and reduced porosity in the cement, delaying degradation.
CERAMICS INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Furqan A. Shah, Martina Jolic, Chiara Micheletti, Omar Omar, Birgitta Norlindh, Lena Emanuelsson, Hakan Engqvist, Thomas Engstrand, Anders Palmquist, Peter Thomsen
Summary: Calcium phosphates (CaP) are important biomaterials for bone regeneration. This study demonstrates how a multi-component CaP formulation can guide bone formation beyond the normal physiological range. The study shows successful bone formation and remodeling in sheep models using this CaP formulation, and the presence of woven bone and vascularized lamellar bone in the pores of the CaP material.
BIOACTIVE MATERIALS
(2023)
Article
Biology
Nicole R. Gould, Katrina M. Williams, Humberto C. Joca, Olivia M. Torre, James S. Lyons, Jenna M. Leser, Manasa P. Srikanth, Marcus Hughes, Ramzi J. Khairallah, Ricardo A. Feldman, Christopher W. Ward, Joseph P. Stains
Summary: The downregulation of sclerostin in osteocytes plays a crucial role in mediating bone formation in response to mechanical cues and parathyroid hormone (PTH). This study reveals a rapid post-translational degradation of sclerostin protein by lysosomes following mechanical load and PTH, showing the importance of lysosomal degradation in regulating bone formation. Impairing this degradation process hampers load-induced bone formation, indicating the significance of lysosomes in osteocyte function.
Article
Materials Science, Ceramics
Jintian Huang, Sujeesh Sebastian, Mattias Collin, Magnus Tagil, Lars Lidgren, Deepak Bushan Raina
Summary: This study evaluated the drug release, biomaterial degradation, and antibacterial effects of tobramycin (TOB) incorporated in a biphasic calcium sulphate/hydroxyapatite (CaS/HA) carrier containing gentamicin (GEN) or vancomycin (VAN). The results showed that the CaS/HA + GEN + TOB combination delayed setting time and had good injectability. TOB was continuously released from CaS/HA for 35 days and showed a sustained antibacterial effect. Adding TOB to CaS/HA containing VAN extended the antimicrobial effect. The study suggests that CaS/HA can be used as a carrier for localized delivery of TOB in the treatment of bone infections.
CERAMICS INTERNATIONAL
(2023)
Article
Engineering, Biomedical
Amir Roshanzadeh, Nomin-Erdene Oyunbaatar, Sarina Ehteshamzadeh Ganjbakhsh, Sangwoo Park, Dong-Su Kim, Pooja P. Kanade, Seongsoo Lee, Dong-Weon Lee, Eung-Sam Kim
Summary: The study investigated the detrimental effects of positively surface charged nanoplastics on neonatal rat ventricular myocytes (NRVMs). It found that the reduction of contraction forces in NRVMs was mainly attributed to significant decreases in mitochondrial membrane potentials and cellular metabolism. This multifaceted assessment provides better understanding of the substantial risks of increasing nanoplastic pollution in the hearts of human infants or adults.
Review
Cell Biology
Lifei Liu, Jianmin Guo, Xi Chen, Xiaoyang Tong, Jiake Xu, Jun Zou
Summary: Exercise training is beneficial for physical and bone health, and the hormone irisin plays a key role in regulating bone metabolism through mechanical forces induced by exercise. Irisin may serve as a novel biomarker for bone metabolism and is influenced by various pathological conditions such as diabetes, obesity, and inflammation. Understanding the regulation of irisin and its impact on skeletal metabolism will be crucial for the treatment and prevention of bone diseases and chronic disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Materials Science, Biomaterials
Runying Guo, Rui Zhang, Sirui Liu, Yanyu Yang, Wenhang Dong, Meiyue Wang, Hongyan Mi, Mengzhe Liu, Jingjing Sun, Xue Zhang, Yimeng Su, Yiming Liu, Di Huang, Rui Li
Summary: A new composite material composed of treated dentin matrix (TDM) and alpha-calcium sulphate hemihydrate (alpha-CSH) was successfully prepared and the optimal composition ratio was explored. The results showed that the TDM/alpha-CSH composite had good physical mixing and structural stability. It exhibited comparable compressive strength to human cancellous bone tissues and excellent biocompatibility with increased expression of osteogenic related genes and proteins. In vivo experiments demonstrated that TDM effectively promoted cell proliferation and osteomalacia. The 50% TDM/alpha-CSH combination displayed optimal osteoconductivity, making it a promising candidate for bone tissue engineering applications.
REGENERATIVE BIOMATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Dorien Van Hede, Bingbing Liang, Sandy Anania, Mojtaba Barzegari, Bruno Verlee, Gregory Nolens, Justine Pirson, Liesbet Geris, France Lambert
Summary: Utilizing a simulation approach to optimize the internal design of calcium phosphate-based scaffolds for bone regeneration showed promising results. The gyroid experimental internal architecture demonstrated high potential for intra-oral bone regeneration applications.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Materials Science, Ceramics
Yessie W. Sari, Annisa Tsalsabila, Noviyan Darmawan, Yuliati Herbani
Summary: This study investigated the effects of surface-modified gold nanoparticles with different amino acids on the formation of hydroxyapatite. The results showed that aspartic acid modification of the gold nanoparticles promoted the crystallization of hydroxyapatite with a smaller crystallite size and a higher Ca/P ratio, which is beneficial for bone substitute applications.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Ib Holzmeister, Jan Weichhold, Juergen Groll, Hala Zreiqat, Uwe Gbureck
Summary: The study investigated the hydraulic reactivity and cement formation of baghdadite (Ca3ZrSi2O9), revealing that the material exhibited reduced particle and crystallite size and partial amorphization after being mechanically activated. Cement formation resulted in high compressive strengths, with a preferred dissolution of calcium and marginal release of zirconium ions. Alkaline conditions were found to be crucial for cement formation.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2021)
Article
Engineering, Biomedical
Chen Zhuang, Guanglin Zhu, Yingjun Wang, Lin Wang, Xuetao Shi, Chuanbin Mao
Summary: Insoluble metal bisphosphonates (BPs) are developed through crystallization on a solid calcium hydroxyapatite (HA)-based substrate, presenting high purity, regular morphologies and excellent biodegradability. These CaBPs can induce osteogenic differentiation of adipose-derived mesenchymal stem cells in vitro and stimulate bone formation effectively in a femur defect rabbit model, showing great potential as biomaterials for tissue regeneration.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Biomedical
Zhangling Nie, Zhiqiao Hu, Xiaodong Guo, Yu Xiao, Xian Liu, Joost D. de Bruijn, Chongyun Bao, Huipin Yuan
Summary: Innate immune responses, specifically M2 macrophages and osteoclastogenesis, play important roles in material-induced bone formation. The study found that M0 macrophages fused to osteoclasts when treated with M-CSF, RANKL, and IL-4, and this osteoclast formation was enhanced with IL-4 treatment. M2 macrophages and osteoclasts produced osteogenic factors that induced osteogenic differentiation of osteogenic precursor cells and led to bone formation.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Multidisciplinary
Ruoxian Deng, Changwei Li, Xiao Wang, Leilei Chang, Shuangfei Ni, Weixin Zhang, Peng Xue, Dayu Pan, Mei Wan, Lianfu Deng, Xu Cao
Summary: The research indicates that myeloid-lineage cells differentiate into subgroups and regulate periosteal bone formation in response to mechanical loading. Macrophages, a subtype of myeloid-lineage cells, play a crucial role in this process by activating TGF-beta 1 to recruit osteoprogenitors.
Article
Engineering, Biomedical
Wei Zhi, Xiaohua Wang, Dong Sun, Taijun Chen, Bo Yuan, Xiangfeng Li, Xuening Chen, Jianxin Wang, Zhao Xie, Xiangdong Zhu, Kai Zhang, Xingdong Zhang
Summary: This study successfully repaired large segmental bone defects in a goat femur model by combining osteoinductive biphasic calcium phosphate (BCP) bioceramic scaffolds with intramedullary nail fixation. The results showed that the BCP scaffold promoted cell proliferation and osteogenic differentiation, and the intramedullary nail fixation maintained stability and structural integrity of the implants. Good integration of the implants with host bone and complete bone substitution in the defect area were observed at 9 and 18 months postoperatively, respectively.
BIOACTIVE MATERIALS
(2022)