Mechanisms of blindness: Animal models provide insight into distinctCRX-associated retinopathies

OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness

(2014) Jerome E. Roger et al.   JOURNAL OF CLINICAL INVESTIGATION

Otx2 ChIP-seq Reveals Unique and Redundant Functions in the Mature Mouse Retina

(2014) Alexander Samuel et al.   PLoS One

Mechanistically Distinct Mouse Models for CRX-Associated Retinopathy

(2014) Nicholas M. Tran et al.   PLoS Genetics

Nonsense-mediated mRNA decay — Mechanisms of substrate mRNA recognition and degradation in mammalian cells

(2013) Christoph Schweingruber et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Loss of Otx2 in the Adult Retina Disrupts Retinal Pigment Epithelium Function, Causing Photoreceptor Degeneration

(2013) M. Housset et al.   JOURNAL OF NEUROSCIENCE

De novoMutations in the Cone-rod Homeobox Gene Associated with Leber Congenital Amaurosis in Chinese Patients

(2013) Xuan Zou et al.   OPHTHALMIC GENETICS

Tropisms of AAV for Subretinal Delivery to the Neonatal Mouse Retina and Its Application for In Vivo Rescue of Developmental Photoreceptor Disorders

(2013) Satoshi Watanabe et al.   PLoS One

Transcription Coactivators p300 and CBP Are Necessary for Photoreceptor-Specific Chromatin Organization and Gene Expression

(2013) Anne K. Hennig et al.   PLoS One

Developing Rods Transplanted into the Degenerating Retina of Crx-Knockout Mice Exhibit Neural Activity Similar to Native Photoreceptors

(2013) Kohei Homma et al.   STEM CELLS

CRX variants in cone–rod dystrophy and mutation overview

(2012) Li Huang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gene Therapy of Inherited Retinopathies: A Long and Successful Road from Viral Vectors to Patients

(2012) Pasqualina Colella et al.   HUMAN GENE THERAPY

Complex effects of nucleotide variants in a mammalian cis-regulatory element

(2012) J. C. Kwasnieski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular analysis of the amphioxus frontal eye unravels the evolutionary origin of the retina and pigment cells of the vertebrate eye

(2012) P. Vopalensky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional Regulation of Rod Photoreceptor Homeostasis Revealed by In Vivo NRL Targetome Analysis

(2012) Hong Hao et al.   PLoS Genetics

OTX2 and CRX rescue overlapping and photoreceptor-specific functions in theDrosophilaeye

(2011) David Terrell et al.   DEVELOPMENTAL DYNAMICS

Crx broadly modulates the pineal transcriptome

(2011) Louise Rovsing et al.   JOURNAL OF NEUROCHEMISTRY

Detection of Variants in 15 Genes in 87 Unrelated Chinese Patients with Leber Congenital Amaurosis

(2011) Lin Li et al.   PLoS One

Active opsin loci adopt intrachromosomal loops that depend on the photoreceptor transcription factor network

(2011) G.-H. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term RNA interference gene therapy in a dominant retinitis pigmentosa mouse model

(2011) L. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRX ChIP-seq reveals the cis-regulatory architecture of mouse photoreceptors

(2010) J. C. Corbo et al.   GENOME RESEARCH

Two novel CRX mutant proteins causing autosomal dominant Leber congenital amaurosis interact differently with NRL

(2010) Lorenzo L. Nichols et al.   HUMAN MUTATION

Visual Acuity in Patients with Leber's Congenital Amaurosis and Early Childhood-Onset Retinitis Pigmentosa

(2010) Saloni Walia et al.   OPHTHALMOLOGY

Functional and Behavioral Restoration of Vision by Gene Therapy in the Guanylate Cyclase-1 (GC1) Knockout Mouse

(2010) Shannon E. Boye et al.   PLoS One

The molecular basis of human retinal and vitreoretinal diseases

(2010) Wolfgang Berger et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Mouse Model Resources for Vision Research

(2010) Jungyeon Won et al.   Journal of Ophthalmology

Transplantation of Human Embryonic Stem Cell-Derived Photoreceptors Restores Some Visual Function in Crx-Deficient Mice

(2009) Deepak A. Lamba et al.   Cell Stem Cell

Gene therapy for red–green colour blindness in adult primates

(2009) Katherine Mancuso et al.   NATURE

Mutations in the DNA-Binding Domain of NR2E3 Affect In Vivo Dimerization and Interaction with CRX

(2009) Raphael Roduit et al.   PLoS One

Cone and cone-rod dystrophy segregating in the same pedigree due to the same novel CRX gene mutation

(2008) V B D Kitiratschky et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Analysis of the Otd-dependent transcriptome supports the evolutionary conservation of CRX/OTX/OTD functions in flies and vertebrates

(2008) Swati S. Ranade et al.   DEVELOPMENTAL BIOLOGY

Dual role of Nr2e3 in photoreceptor development and maintenance

(2008) Andrea L. Webber et al.   EXPERIMENTAL EYE RESEARCH

Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10)

(2008) Lawrence C.S. Tam et al.   HUMAN MOLECULAR GENETICS

Reversal of Blindness in Animal Models of Leber Congenital Amaurosis Using Optimized AAV2-mediated Gene Transfer

(2008) Jeannette Bennicelli et al.   MOLECULAR THERAPY

Safety and Efficacy of Gene Transfer for Leber's Congenital Amaurosis

(2008) Albert M. Maguire et al.   NEW ENGLAND JOURNAL OF MEDICINE

CRX controls retinal expression of the X-linked juvenile retinoschisis (RS1) gene

(2008) Thomas Langmann et al.   NUCLEIC ACIDS RESEARCH

Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

(2008) A. V. Cideciyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leber congenital amaurosis: Genes, proteins and disease mechanisms

(2008) Anneke I. den Hollander et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Regulation of photoreceptor gene expression by Crx-associated transcription factor network

(2007) Anne K. Hennig et al.   BRAIN RESEARCH