Article
Veterinary Sciences
Susan M. Withenshaw, Shaun Cawthraw, Becky Gosling, Kate Newton, Claire E. Oastler, Richard P. Smith, Robert H. Davies
Summary: Salmonellosis is the second most commonly reported zoonosis in the EU, with contaminated meat from broiler chickens as an important source of human infection. Although the prevalence of Salmonella in broiler flocks in Great Britain has decreased since 2010, with known colonisers being isolated at increasing frequencies, further controls on hatchery contamination are required. Investigations on risk factors for Salmonella contamination in broiler hatcheries in GB revealed certain operational practices positively associated with Salmonella detection, highlighting the importance of targeted control measures.
PREVENTIVE VETERINARY MEDICINE
(2021)
Article
Multidisciplinary Sciences
Carl. J. J. Schmidt, Dong Kyun Kim, G. Ken Pendarvis, Behnam Abasht, Fiona. M. M. McCarthy
Summary: Chicken domestication began for divination, cockfighting, and food purposes around 3,500 years ago. Later, industrial scale chicken production selected larger birds with increased egg production. In the mid-20(th) century, intensive selection for growth traits in the broiler industry led to specific cellular and biochemical changes in the modern broiler line compared to the legacy line.
Article
Agriculture, Multidisciplinary
Jin Kai, Zhou Jing, Zuo Qi-sheng, Li Jian-cheng, Jiuzhou Song, Zhang Ya-ni, Chang Guo-bing, Chen Guo-hong, Li Bi-chun
Summary: This study identified a new female-biased gene UBE2I and characterized its functional role in the gonadal development of chicken embryos. By interfering or overexpressing UBE2I, the expression pattern of sex-related genes in chickens was altered. Furthermore, the expression of UBE2I was associated with the level of estradiol and its receptors, suggesting its importance in initiating female-specific development in chickens.
JOURNAL OF INTEGRATIVE AGRICULTURE
(2021)
Review
Biochemistry & Molecular Biology
Zhuo Chen, Hanjie Yu, Xiangqin Chen, Wentian Chen, Wanghua Song, Zheng Li
Summary: TGF-beta superfamily members play important roles in various diseases, and glycosylation modification is involved in the regulation of TGF-beta signaling pathway. There is a complex mutual regulation between glycosylation and TGF-beta signaling, which affects biological processes.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Yuhu Jiao, Guang Wang, Dawei Li, Hongye Li, Jiesheng Liu, Xuesong Yang, Weidong Yang
Summary: Okadaic acid (OA) is a liposoluble shellfish toxin with various toxicities, including embryonic toxicity and neurotoxicity. Exposure to OA in chicken embryos can lead to neural tube defects (NTDs), inhibited neuronal differentiation, and increased cell proliferation. The induction of NTDs by OA may be associated with the Toll-like receptor signaling pathway and oxidative stress in early chick embryos.
Review
Biochemistry & Molecular Biology
Xinyi Wang, Ting Liu, Yifei Huang, Yifeng Dai, Hui Lin
Summary: Fibrosis is a complex abnormal healing process that involves multiple signaling pathways, with the TGF-beta signaling pathway playing a central role. TGF-beta precisely regulates fibrogenesis by controlling gene transcription and translation, and SUMOylation has been identified as a key player in this process, providing potential therapeutic strategies for fibrosis.
Article
Biochemistry & Molecular Biology
Fuensanta Gomez-Bernal, Juan Carlos Quevedo-Abeledo, Maria Garcia-Gonzalez, Yolanda Fernandez-Cladera, Agustin F. Gonzalez-Rivero, Antonia de Vera-Gonzalez, Candelaria Martin-Gonzalez, Miguel A. Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to investigate the relationship between serum levels of transforming growth factor beta 1 (TGF-β1) and disease characteristics, activity, damage, or severity in patients with systemic lupus erythematosus (SLE). The results showed that TGF-β1 serum levels were associated with disease severity and activity, with ocular and cardiovascular manifestations positively correlated, while gastrointestinal and musculoskeletal involvements negatively correlated with circulating TGF-β1 levels.
Review
Cell Biology
Meng-Yan Wang, Wen-Juan Liu, Le-Yi Wu, Gang Wang, Cheng-Lin Zhang, Jie Liu
Summary: This article provides a comprehensive review of the research progress in TGF-beta 2, highlighting its role in various biological processes and its association with diseases related to dysregulation of its signaling.
Review
Biochemistry & Molecular Biology
Jinwook Chung, Md Nazmul Huda, Yoonhwa Shin, Sunhee Han, Salima Akter, Insug Kang, Joohun Ha, Wonchae Choe, Tae Gyu Choi, Sung Soo Kim
Summary: The interaction between reactive oxygen species (ROS) and transforming growth factor-beta (TGF-beta) signaling pathway plays a critical role in tumor development and progression. While ROS can influence TGF-beta signaling, the TGF-beta pathway can regulate ROS production, leading to a complex relationship between the two in cancer cells. Understanding this crosstalk may provide new insights and potential approaches in cancer biology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Manman Ma, Xiaohua Wang, Xiaohui Liu, Yang Han, Yanhui Chu, Yanzhong Guan, Haifeng Liu
Summary: A novel tT beta RII variant, Z-tT beta RII, was designed by fusing the PDGF beta receptor-specific affibody Z(PDGF beta R) to the N-terminus of tT beta RII. Z-tT beta RII exhibited superior specific fibrotic liver-targeting potential and stronger anti-fibrotic effects in vitro and in vivo. It also showed no significant sign of potential side effects in other vital organs in liver fibrotic mice, making it a potential candidate for targeted therapy for liver fibrosis.
ARCHIVES OF PHARMACAL RESEARCH
(2023)
Article
Immunology
Xuanyan Cai, Huiyan Zha, Zhaoxu Yang, Yiwen Du, Xiaoyang Dai, Bo Yang, Jiajia Wang, Qiaojun He, Qinjie Weng
Summary: In this study, the relationship between TGF-beta 1 polymorphisms and susceptibility to chronic liver disease (CLD) was systematically analyzed using 35 eligible studies. The findings indicate that certain TGF-beta 1 gene variations are associated with an increased risk of CLD. Additionally, TGF-beta 1 gene expression is significantly elevated in CLD patients, and a TGF-beta 1 codon 263 variant may affect the secretion of TGF-beta 1 by altering its dimerization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Dieuwke L. Marvin, Vivian M. Spaans, Cor D. De Kroon, Roderick C. Slieker, Maryam Khelil, Peter Ten Dijke, Laila Ritsma, Ekaterina S. Jordanova
Summary: Cervical cancer is the fourth most common cancer in women worldwide, with adenocarcinoma patients having a worse prognosis. The tumor suppressor function of TGF-beta is lost in tumor cells. Analysis of RNA-seq data showed that TGF-beta plays different roles in squamous cell carcinoma and adenocarcinoma. In adenocarcinoma patients, low expression of T beta R2 and SMAD4 was associated with worse survival, while high expression of PAI-1 and alpha v beta 6 was also correlated with worse survival.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Weihua Tian, Bo Zhang, Haian Zhong, Ruixue Nie, Yao Ling, Hao Zhang, Changxin Wu
Summary: The study identified 1,068 circRNA candidates in chicken adipogenesis, with 111 differentially expressed circRNAs detected and enriched in lipid-related pathways. Two DE-circRNAs, Z:35565770|35568133 and Z:54674624|54755962, were identified as potential regulatory circRNAs, with Z:54674624|54755962 potentially acting as a ceRNA to regulate chicken adipogenic differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Beatriz Ballester, Javier Milara, Paula Montero, Julio Cortijo
Summary: The study reveals the overexpression of MUC16 in lung tissue of IPF patients and its collaboration with the TGF-beta 1 pathway to induce fibrotic processes. Repression of MUC16 expression can inhibit fibrotic processes, suggesting that targeting MUC16 may be a potential drug target for human IPF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Savalan Babapoor-Farrokhran, Roozbeh Tarighati Rasekhi, Deanna Gill, Jafar Alzubi, Sumeet K. Mainigi
Summary: Atrial fibrillation is a common clinically significant arrhythmia with four fundamental pathophysiological mechanisms, with TGF-beta playing a key role. Studies have shown that TGF-beta 1 is involved in the development and propagation of atrial fibrillation.
Article
Cell Biology
Michael Schmid, Jacqueline Smith, David W. Burt, Bronwen L. Aken, Parker B. Antin, Alan L. Archibald, Chris Ashwell, Perry J. Blackshear, Clarissa Boschiero, C. Titus Brown, Shane C. Burgess, Hans H. Cheng, William Chow, Derrick J. Coble, Amanda Cooksey, Richard P. M. A. Crooijmans, Joana Damas, Richard V. N. Davis, Dirk-Jan de Koning, Mary E. Delany, Thomas Derrien, Takele T. Desta, Ian C. Dunn, Matthew Dunn, Hans Ellegren, Lel Eoery, Ionas Erb, Marta Farre, Mario Fasold, Damarius Fleming, Paul Flicek, Katie E. Fowler, Laure Fresard, David P. Froman, Valerie Garceau, Paul P. Gardner, Almas A. Gheyas, Darren K. Griffin, Martien A. M. Groenen, Thomas Haaf, Olivier Hanotte, Alan Hart, Julien Haesler, S. Blair Hedges, Jana Hertel, Kerstin Howe, Allen Hubbard, David A. Hume, Pete Kaiser, Darek Kedra, Stephen J. Kemp, Christophe Klopp, Kalmia E. Kniel, Richard Kuo, Sandrine Lagarrigue, Susan J. Lamont, Denis M. Larkin, Raman A. Lawal, Sarah M. Markland, Fiona McCarthy, Heather A. McCormack, Marla C. McPherson, Akira Motegi, Stefan A. Muljo, Andrea Muensterberg, Rishi Nag, Indrajit Nanda, Michael Neuberger, Anne Nitsche, Cedric Notredame, Harry Noyes, Rebecca O'Connor, Elizabeth A. O'Hare, Andrew J. Oler, Sheila C. Ommeh, Helio Pais, Michael Persia, Frederique Pitel, Likit Preeyanon, Pablo Prieto Barja, Elizabeth M. Pritchett, Douglas D. Rhoads, Charmaine M. Robinson, Michael N. Romanov, Max Rothschild, Pierre-Francois Roux, Carl J. Schmidt, Alisa-Sophia Schneider, Matthew G. Schwartz, Steve M. Searle, Michael A. Skinner, Craig A. Smith, Peter F. Stadler, Tammy E. Steeves, Claus Steinlein, Liang Sun, Minoru Takata, Igor Ulitsky, Qing Wang, Ying Wang, Wesley C. Warren, Jonathan M. D. Wood, David Wragg, Huaijun Zhou
CYTOGENETIC AND GENOME RESEARCH
(2015)
Editorial Material
Anatomy & Morphology
Parker B. Antin, Rudolf Jaenisch
DEVELOPMENTAL DYNAMICS
(2016)
Letter
Multidisciplinary Sciences
Alyssa Ward, Thomas O. Baldwin, Parker B. Antin
Editorial Material
Biochemistry & Molecular Biology
Nirav Merchant, Eric Lyons, Stephen Goff, Matthew Vaughn, Doreen Ware, David Micklos, Parker Antin
Editorial Material
Anatomy & Morphology
Parker Antin
DEVELOPMENTAL DYNAMICS
(2013)
Editorial Material
Anatomy & Morphology
Parker B. Antin
DEVELOPMENTAL DYNAMICS
(2013)
Article
Cell Biology
Alejandro Lencinas, Danny C. Chhun, Kelvin P. Dan, Kristen D. Ross, Elizabeth A. Hoover, Parker B. Antin, Raymond B. Runyan
DISEASE MODELS & MECHANISMS
(2013)
Article
Biochemistry & Molecular Biology
Alexander S. Bobbs, Aleksi V. Saarela, Tatiana A. Yatskievych, Parker B. Antin
JOURNAL OF BIOLOGICAL CHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Parker B. Antin, Tatiana A. Yatskievych, Sean Davey, Diana K. Darnell
NUCLEIC ACIDS RESEARCH
(2014)
Article
Multidisciplinary Sciences
Elizabeth A. Robb, Parker B. Antin, Mary E. Delany
Article
Multidisciplinary Sciences
Pricila K. Moly, James R. Cooley, Sebastian L. Zeltzer, Tatiana A. Yatskievych, Parker B. Antin
Article
Evolutionary Biology
Elizabeth A. O'Hare, Parker B. Antin, Mary E. Delany
JOURNAL OF HEREDITY
(2019)
Review
Cell Biology
Jing Yang, Parker Antin, Geert Berx, Cedric Blanpain, Thomas Brabletz, Marianne Bronner, Kyra Campbell, Amparo Cano, Jordi Casanova, Gerhard Christofori, Shoukat Dedhar, Rik Derynck, Heide L. Ford, Jonas Fuxe, Antonio Garcia de Herreros, Gregory J. Goodall, Anna-Katerina Hadjantonakis, Ruby J. Y. Huang, Chaya Kalcheim, Raghu Kalluri, Yibin Kang, Yeesim Khew-Goodall, Herbert Levine, Jinsong Liu, Gregory D. Longmore, Sendurai A. Mani, Joan Massague, Roberto Mayor, David McClay, Keith E. Mostov, Donald F. Newgreen, M. Angela Nieto, Alain Puisieux, Raymond Runyan, Pierre Savagner, Ben Stanger, Marc P. Stemmler, Yoshiko Takahashi, Masatoshi Takeichi, Eric Theveneau, Jean Paul Thiery, Erik W. Thompson, Robert A. Weinberg, Elizabeth D. Williams, Jianhua Xing, Binhua P. Zhou, Guojun Sheng
NATURE REVIEWS MOLECULAR CELL BIOLOGY
(2020)
Article
Ecology
Marco Malatesta, Giulia Mori, Domenico Acquotti, Barbara Campanini, Alessio Peracchi, Parker B. Antin, Riccardo Percudani
NATURE ECOLOGY & EVOLUTION
(2020)