Folate, Homocysteine and the Cardiac Neural Crest

Review of Interventions for the Prevention and Control of Folate and Vitamin B12 Deficiencies

(2015) José F. Cordero et al.   FOOD AND NUTRITION BULLETIN

Gene–Nutrient Interactions: Importance of Folic Acid and Vitamin B12 During Early Embryogenesis

(2015) Richard H. Finnell et al.   FOOD AND NUTRITION BULLETIN

Cardiac developmental toxicity

(2012) Gretchen J. Mahler et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Characterization of Gene-Environment Interactions for Colorectal Cancer Susceptibility Loci

(2012) C. M. Hutter et al.   CANCER RESEARCH

Coordinating Tissue Interactions: Notch Signaling in Cardiac Development and Disease

(2012) José Luis de la Pompa et al.   DEVELOPMENTAL CELL

Atrioventricular valve development: New perspectives on an old theme

(2012) Annemarieke de Vlaming et al.   DIFFERENTIATION

The neural crest in cardiac congenital anomalies

(2012) Anna Keyte et al.   DIFFERENTIATION

Role of DNMT3B in the regulation of early neural and neural crest specifiers

(2012) Kristen Martins-Taylor et al.   Epigenetics

Three-dimensional and molecular analysis of the arterial pole of the developing human heart

(2012) Aleksander Sizarov et al.   JOURNAL OF ANATOMY

How insights from cardiovascular developmental biology have impacted the care of infants and children with congenital heart disease

(2012) Alvin J. Chin et al.   MECHANISMS OF DEVELOPMENT

Novel synthesis and preclinical evaluation of folic acid derivatives labeled with 18F-[FDG] for PET imaging of folate receptor-positive tumors

(2012) I. Al Jammaz et al.   NUCLEAR MEDICINE AND BIOLOGY

Genome-wide DNA demethylation in mammals

(2012) Lionel A Sanz et al.   GENOME BIOLOGY

Epigenetics and Cardiovascular Development

(2011) Ching-Pin Chang et al.   Annual Review of Physiology

Origin and development of the atrioventricular myocardial lineage: Insight into the development of accessory pathways

(2011) Wim T. J. Aanhaanen et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Maternal DNA hypomethylation and congenital heart defects

(2011) Shimul Chowdhury et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Congenital heart defects and maternal genetic, metabolic, and lifestyle factors

(2011) Charlotte A. Hobbs et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Extracellular matrix and heart development

(2011) Marie Lockhart et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Altered signal transduction inFolr1−/−mouse embryo fibroblasts

(2011) Dennis R. Warner et al.   CELL BIOLOGY INTERNATIONAL

Vitamin supply in pregnancy for prevention of congenital birth defects

(2011) Andrew E Czeizel et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Economic burden of neural tube defects and impact of prevention with folic acid: a literature review

(2011) Yunni Yi et al.   EUROPEAN JOURNAL OF PEDIATRICS

Lipid rafts: signaling and sorting platforms of cells and their roles in cancer

(2011) Simon Staubach et al.   Expert Review of Proteomics

Ingression, migration and early differentiation of cardiac progenitors

(2011) Esther Camp   Frontiers in Bioscience-Landmark

An evolving web of signaling networks regulated by Cripto-1

(2011) Tadahiro Nagaoka et al.   GROWTH FACTORS

Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects

(2011) Huibo Chang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Factors contributing to the success of folic acid public health campaigns

(2011) D. Rofail et al.   JOURNAL OF PUBLIC HEALTH

Birth Prevalence of Congenital Heart Disease Worldwide

(2011) Denise van der Linde et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiac regeneration: different cells same goal

(2011) Phil Barnett et al.   MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING

Maternal Genome-Wide DNA Methylation Patterns and Congenital Heart Defects

(2011) Shimul Chowdhury et al.   PLoS One

No Effect of Folic Acid Supplementation on Global DNA Methylation in Men and Women with Moderately Elevated Homocysteine

(2011) Audrey Y. Jung et al.   PLoS One

NMDA receptor subunit composition controls synaptogenesis and synapse stabilization

(2011) A. C. Gambrill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal nutritional status, C1 metabolism and offspring DNA methylation: a review of current evidence in human subjects

(2011) Paula Dominguez-Salas et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Fetal Neural Tube Stem Cells from Pax3 Mutant Mice Proliferate, Differentiate, and Form Synaptic Connections When Stimulated with Folic Acid

(2011) Shunsuke Ichi et al.   STEM CELLS AND DEVELOPMENT

Translational Research on the Mitral Valve: from Developmental Mechanisms to New Therapies

(2011) Daniel P. Judge et al.   Journal of Cardiovascular Translational Research

Does global hypomethylation contribute to susceptibility to neural tube defects?

(2010) Richard H Finnell et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects

(2010) Li Wang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate

(2010) Maria Serrano et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Developmental basis of adult cardiovascular diseases

(2010) Roger R. Markwald et al.   Annals of the New York Academy of Sciences

Laying the groundwork for growth: Cell-cell and cell-ECM interactions in cardiovascular development

(2010) Stephanie L. K. Bowers et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Circulating Folate, Vitamin B12, Homocysteine, Vitamin B12 Transport Proteins, and Risk of Prostate Cancer: a Case-Control Study, Systematic Review, and Meta-analysis

(2010) S. M. Collin et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Transcriptional regulation of heart valve development and disease

(2010) Elaine E. Wirrig et al.   CARDIOVASCULAR PATHOLOGY

Mouse Models of Congenital Heart Defects

(2010) Margaret L. Kirby et al.   Circulation-Cardiovascular Imaging

The molecular genetics of congenital heart disease: a review of recent developments

(2010) Michael Wolf et al.   CURRENT OPINION IN CARDIOLOGY

Folate protection from congenital heart defects linked with canonical Wnt signaling and epigenetics

(2010) Kersti K Linask et al.   CURRENT OPINION IN PEDIATRICS

High-affinity folate receptor in cardiac neural crest migration: A gene knockdown model using siRNA

(2010) Thomas H. Rosenquist et al.   DEVELOPMENTAL DYNAMICS

Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation

(2010) Yunlong Liu et al.   Epigenetics

Congenital heart defects and biomarkers of methylation in children: a case-control study

(2010) Sylvia A. Obermann-Borst et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Folic acid in early pregnancy: a public health success story

(2010) Sarah G. Običan et al.   FASEB JOURNAL

Functional interactions between the LRP6 WNT co-receptor and folate supplementation

(2010) Jason D. Gray et al.   HUMAN MOLECULAR GENETICS

Folic Acid Supplementation Stimulates Notch Signaling and Cell Proliferation in Embryonic Neural Stem Cells

(2010) Huan Liu et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves

(2010) Rajan Jain et al.   JOURNAL OF CLINICAL INVESTIGATION

Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects

(2010) Henk J. Blom et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Novel folate binding protein-1 interactions in embryonic orofacial tissue

(2010) M. Michele Pisano et al.   LIFE SCIENCES

Maternal Global Methylation Status and Risk of Congenital Heart Diseases

(2010) Lydi M. J. W. van Driel et al.   OBSTETRICS AND GYNECOLOGY

Maternal Folate-Related Gene Environment Interactions and Congenital Heart Defects

(2010) Charlotte A. Hobbs et al.   OBSTETRICS AND GYNECOLOGY

ALDH1L1 inhibits cell motility via dephosphorylation of cofilin by PP1 and PP2A

(2010) N V Oleinik et al.   ONCOGENE

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Teratogenicity and underlying mechanisms of homocysteine in animal models: A review

(2010) Nina H. van Mil et al.   REPRODUCTIVE TOXICOLOGY

Epicardium and Myocardium Originate From a Common Cardiogenic Precursor Pool

(2010) Bram van Wijk et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Factors controlling cardiac neural crest cell migration

(2010) Margaret L. Kirby et al.   Cell Adhesion & Migration

Isolation and Culture of Avian Embryonic Valvular Progenitor Cells

(2010) Gretchen Mahler et al.   Jove-Journal of Visualized Experiments

Folic Acid Supplementation Cardiovascular Disease: The State of the Art

(2009) Lydia A. Bazzano   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Molecular mechanisms of homocysteine toxicity

(2009) A. A. Boldyrev   BIOCHEMISTRY-MOSCOW

Contributions of hyperhomocysteinemia to atherosclerosis: Causal relationship and potential mechanisms

(2009) Ji Zhou et al.   BIOFACTORS

Computational modeling of epithelial–mesenchymal transformations

(2009) Adrian Neagu et al.   BIOSYSTEMS

Understanding the causes and prevention of neural tube defects: Insights from thesplotchmouse model

(2009) Nicholas D.E. Greene et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Regulation of folate receptor 1 gene expression in the visceral endoderm

(2009) J. Michael Salbaum et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Mutational spectrum at GATA1 provides insights into mutagenesis and leukemogenesis in Down syndrome

(2009) D. C. Cabelof et al.   BLOOD

118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects

(2009) Gary M Shaw et al.   BMC Medical Genetics

Origin of Cardiac Fibroblasts and the Role of Periostin

(2009) Paige Snider et al.   CIRCULATION RESEARCH

Folate Supplementation Limits the Aggressiveness of Glioma via the Remethylation of DNA Repeats Element and Genes Governing Apoptosis and Proliferation

(2009) E. Hervouet et al.   CLINICAL CANCER RESEARCH

Importance of gene-environment interactions in the etiology of selected birth defects

(2009) H Zhu et al.   CLINICAL GENETICS

The role of secondary heart field in cardiac development

(2009) Laura A. Dyer et al.   DEVELOPMENTAL BIOLOGY

Folate rescues lithium-, homocysteine- and Wnt3A-induced vertebrate cardiac anomalies

(2009) M. Han et al.   Disease Models & Mechanisms

Folate receptor α regulates cell proliferation in mouse gonadotroph αT3-1 cells

(2009) Congjun Yao et al.   EXPERIMENTAL CELL RESEARCH

Genetic or nutritional disorders in homocysteine or folate metabolism increase protein N-homocysteinylation in mice

(2009) Hieronim Jakubowski et al.   FASEB JOURNAL

Preparation and characterization of folate-poly(ethylene glycol)-grafted-trimethylchitosan for intracellular transport of protein through folate receptor-mediated endocytosis

(2009) Yu Zheng et al.   JOURNAL OF BIOTECHNOLOGY

Enhancement of Notch receptor maturation and signaling sensitivity by Cripto-1

(2009) Kazuhide Watanabe et al.   JOURNAL OF CELL BIOLOGY

Contribution of extracellular matrix to the mechanical properties of the heart

(2009) Gregory M. Fomovsky et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The extracellular matrix: At the center of it all

(2009) Stephanie L.K. Bowers et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

High-resolution 1H NMR spectroscopic investigation of a chick embryo model of neural tube development

(2009) Muireann Coen et al.   MAGNETIC RESONANCE IN CHEMISTRY

Human DNA methylomes at base resolution show widespread epigenomic differences

(2009) Ryan Lister et al.   NATURE

A bHLH Code for Cardiac Morphogenesis

(2009) Simon J. Conway et al.   PEDIATRIC CARDIOLOGY

Transcriptional Regulation of Heart Valve Progenitor Cells

(2009) Santanu Chakraborty et al.   PEDIATRIC CARDIOLOGY

Role of Pulse Oximetry in Examining Newborns for Congenital Heart Disease: A Scientific Statement from the AHA and AAP

(2009) W. T. Mahle et al.   PEDIATRICS

Developmental toxicity of ethanol in chick heart in ovo and in micromass culture can be prevented by addition of vitamin C and folic acid

(2009) Samreen Memon et al.   REPRODUCTIVE TOXICOLOGY

The N-methyl-d-aspartate receptor in heart development: A gene knockdown model using siRNA

(2009) Octavian V. Lie et al.   REPRODUCTIVE TOXICOLOGY

The many facets of the matricelluar protein periostin during cardiac development, remodeling, and pathophysiology

(2009) Russell A. Norris et al.   Journal of Cell Communication and Signaling

Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease

(2008) An L. Moens et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Inhibition of methylation and changes in gene expression in relation to neural tube defects

(2008) Ivon J. M. van der Linden et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Embryonic development in the reduced folate carrier knockout mouse is modulated by maternal folate supplementation

(2008) Janee Gelineau-van Waes et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Oxidative stress during diabetic pregnancy disrupts cardiac neural crest migration and causes outflow tract defects

(2008) Sarah C. Morgan et al.   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Dick Smithells, folic acid, and the prevention of neural tube defects

(2008) Christopher Schorah   BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY

Microarray analysis of E9.5 reduced folate carrier (RFC1; Slc19a1) knockout embryos reveals altered expression of genes in the cubilin-megalin multiligand endocytic receptor complex

(2008) Janee Gelineau-van Waes et al.   BMC GENOMICS

Notch Signaling in Cardiac Development

(2008) Kyle Niessen et al.   CIRCULATION RESEARCH

Variants of Folate Metabolism Genes and the Risk of Conotruncal Cardiac Defects

(2008) Elizabeth Goldmuntz et al.   Circulation-Cardiovascular Genetics

Periostin as a Heterofunctional Regulator of Cardiac Development and Disease

(2008) Simon Conway et al.   CURRENT GENOMICS

Homocysteine enhances cardiac neural crest cell attachment in vitro by increasing intracellular calcium levels

(2008) David J. Heidenreich et al.   DEVELOPMENTAL DYNAMICS

Myocardial tissue engineering: the extracellular matrix☆

(2008) Payam Akhyari et al.   EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY

Gene-environment interactions in the causation of neural tube defects: folate deficiency increases susceptibility conferred by loss of Pax3 function

(2008) K. A. Burren et al.   HUMAN MOLECULAR GENETICS

Ethanol exposure induces differential microRNA and target gene expression and teratogenic effects which can be suppressed by folic acid supplementation

(2008) L.-L. Wang et al.   HUMAN REPRODUCTION

Effects of Folate on Notch Signaling and Cell Proliferation in Neural Stem Cells of Neonatal Rats In Vitro

(2008) Xumei ZHANG et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Autoantibodies to folate receptor during pregnancy and neural tube defect risk

(2008) Robert M. Cabrera et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE

Polymorphisms in genes related to folate and cobalamin metabolism and the associations with complex birth defects

(2008) R. Brouns et al.   PRENATAL DIAGNOSIS