Journal
DEVELOPMENTAL DYNAMICS
Volume 240, Issue 6, Pages 1344-1353Publisher
WILEY
DOI: 10.1002/dvdy.22596
Keywords
FGF8; diastemal tooth; tooth development; ex vivo culture
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Funding
- NIH [DE12329, DE15123]
- Natural Science Foundation of China [30572043, 30771132]
- Ministry of Science and Technology of China [2010CB944800]
- China Scholarship Council [2008627069]
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Regression of vestigial tooth buds results in the formation of the toothless diastema, a unique feature of the mouse dentition. Revitalization of the diastemal vestigial tooth bud provides an excellent model for studying tooth regeneration and replacement. It has been previously shown that suppression of fibroblast growth factor (FGF) signaling in the diastema results in vestigial tooth bud regression. In this study, we report that application of exogenous FGF8 to the mouse embryonic diastemal region rescues diastemal tooth development. However, this rescue of diastemal tooth development occurs only in an isolated diastemal regions and not in the mandibular quadrant, which includes the incisor and molar germs. FGF8 promotes cell proliferation and inhibits apoptosis in diastemal tooth epithelium, and revitalizes the tooth developmental program, as evidenced by the expression of genes critical for normal tooth development. Our results also support the idea that the adjacent tooth germs contribute to the suppression of diastemal vestigial tooth buds by means of multiple signals. Developmental Dynamics 240:1344-1353, 2011. (C) 2011 Wiley-Liss, Inc.
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