Journal
DEVELOPMENTAL DYNAMICS
Volume 239, Issue 8, Pages 2246-2255Publisher
WILEY
DOI: 10.1002/dvdy.22357
Keywords
Lmx1b; limb development; microarray; Nail-Patella syndrome
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Funding
- Muscular Dystrophy Association [91733]
- Canadian Institute for Health Research [MOP-77556]
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During limb development, the dorsal limb mesenchyme expression of the transcription factor LMX1B is required for dorsoventral limb patterning. In mice, Lmx1b mutations result in the mirror-image duplication of ventral limb structures and loss of dorsal limb structures. Heterozygous LMX1B mutations in humans cause the Nail-Patella Syndrome characterized by limb, kidney, and eye developmental defects. We used DNA microarrays to compare the mRNAs in E13.5 mouse Lmx1b mutant and wild-type limbs. We report 14 genes that require Lmx1b for their normal expression in the dorsal limb or the restriction of their expression to the ventral limb. Developmental Dynamics 239:2246-2255, 2010. (C) 2010 Wiley-Liss, Inc.
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