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Cell Biology
Laura Moniot-Perron, Benoit Moindrot, Line Manceau, Joanne Edouard, Yan Jaszczyszyn, Pascale Gilardi-Hebenstreit, Celine Hernandez, Sebastien Bloyer, Daan Noordermeer
Summary: Hox genes encode transcription factors that determine segmental identities along the body axis. The BX-C cluster in Drosophila contains the three most posterior Hox genes, which show collinear activation involving changes in histone modifications, chromatin structure, and regulatory elements. This study focuses on the Abd-B gene and reveals the importance of the Fab-7 boundary in maintaining insulation between different chromatin domains. Interestingly, a non-canonical inversion of collinear chromatin dynamics is observed at Abd-B, resulting in differential activation of alternative promoters and fine-tuning of transcriptional output.
Article
Developmental Biology
Bryan Johnson, Judith Leatherman
Summary: In the Drosophila testis niche, the tumor suppressor gene Merlin and the gene Expanded have partially redundant functions in regulating cyst lineage cell proliferation, as well as impacting and integrating multiple signaling pathways. Merlin's ability to dynamically change its activity via phosphorylation in response to neighboring germ cell division provides a mechanism for the dynamic regulation of signaling pathways that control stem cells.
DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Torsten U. Banisch, Maija Slaidina, Selena Gupta, Megan Ho, Lilach Gilboa, Ruth Lehmann
Summary: This research has identified a mechanism that connects hormonal triggers for somatic tissue morphogenesis with PGC differentiation. Two hormone peaks allow PGCs to promote differentiation by derepressing a differentiation gene.
DEVELOPMENTAL CELL
(2021)
Article
Cell Biology
Pieter Martino, Raghava Sunkara, Nicholas Heitman, Martina Rangl, Alexia Brown, Nivedita Saxena, Laura Grisanti, Donald Kohan, Masashi Yanagisawa, Michael Rendl
Summary: The researchers found that endothelin produced by hair follicle progenitors binds to endothelin receptors on dermal sheath cells, triggering their contraction and hair follicle regression. This study reveals that the endothelin signaling pathway plays a crucial role in regulating dermal sheath contraction.
NATURE CELL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kevin Y. L. Ho, Rohan J. Khadilkar, Rosalyn L. Carr, Guy Tanentzapf
Summary: In the Drosophila hematopoietic organ, gap junctions form a network that coordinates fate decisions between blood progenitors, maintaining hematopoietic homeostasis.
Article
Multidisciplinary Sciences
Philippe J. Batut, Xin Yang Bing, Zachary Sisco, Joao Raimundo, Michal Levo, Michael S. Levine
Summary: Past studies have provided contradictory claims about the role of genome organization in gene activity regulation. This study demonstrates that the Drosophila genome is organized by two independent classes of regulatory sequences, tethering elements and insulators. These two levels of genome organization operate independently to ensure precise transcriptional dynamics and reliable complex patterning processes.
Article
Developmental Biology
Nastaran Mues, Kenneth Hammer, Judith Leatherman
Summary: Regulation of stem cell division is crucial for determining the abundance of differentiating progeny in stem cell-supported tissues. In this study, the Drosophila testis niche was used to investigate the regulation of stem cell division. It was found that the epidermal growth factor receptor (Egfr) and receptor tyrosine kinase Pvr play important roles in the cyst lineage cells of the testis, with some shared functions and some receptor-specific functions.
CELLS & DEVELOPMENT
(2023)
Article
Cell Biology
Tingting Li, Xiaoyan Yang, Zhigang Feng, Wang Nie, Zhiyu Fang, Yan Zou
Summary: The study demonstrates that CATP-8/P5A ATPase regulates neuronal migration in Caenorhabditis elegans by controlling EGL-20/Wnt biogenesis, suggesting a conserved role in neural development in both worms and human cells. This highlights the significance of P5A ATPase in translocating Wnt proteins to the ER for proper processing and secretion.
Article
Developmental Biology
Luis Clarembaux-Badell, Pablo Baladron-de-Juan, Hugo Gabilondo, Irene Rubio-Ferrera, Irene Millan, Carlos Estella, Felix S. Valverde-Ortega, Ignacio Monedero Cobeta, Stefan Thor, Jonathan Benito-Sipos
Summary: A striking feature of the nervous system is the appearance of different neural cell subtypes at different axial levels. In fruit flies, this segmental diversity is regulated by programmed cell death (PCD) and the Hox homeotic genes. This study shows that the transcriptional cofactor Dachshund supports Hox-mediated PCD in specific segments, even with weak Hox expression.
DEVELOPMENTAL NEUROBIOLOGY
(2022)
Article
Cell Biology
Alexandra D. Buffry, Sebastian Kittelmann, Alistair P. McGregor
Summary: Hox genes determine the regional identity of animal bodies during embryogenesis and play a role in post-embryonic fine-scale morphology. In Drosophila melanogaster, the Ultrabithorax (Ubx) gene regulates bristle and trichome patterning on the femurs of the second and third leg pairs. The repression of trichomes in the proximal posterior region of the T2 femur by Ubx is mediated by the activation of microRNA-92a and microRNA-92b. Additionally, a novel enhancer of Ubx that recapitulates its temporal and regional activity in T2 and T3 legs has been identified, along with transcription factors and co-factors that regulate trichome patterning.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Leonard Clinton D'Souza, Nithin Kuriakose, Shamprasad Varija Raghu, Shama Prasada Kabekkodu, Anurag Sharma
Summary: This study demonstrates the crucial role of the hematopoietic niche in benzene-induced hematopoietic injury using a Drosophila model, revealing the mechanism of aberrant hemocyte production induced by benzene.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Rafael Senos Demarco, Brian J. Stack, Alexander M. Tang, Justin Voog, Sharsti L. Sandall, Tony D. Southall, Andrea H. Brand, D. Leanne Jones
Summary: The text discusses the role of Escargot in regulating the maintenance of somatic cyst stem cells in the Drosophila testis by attenuating the activity of the pro-differentiation insulin receptor pathway. The study shows that Escargot positively regulates the expression of an antagonist of insulin signaling and is required to suppress stem cell loss in response to starvation. Understanding how Escargot regulates cell-fate decisions during homeostasis and nutrient availability decline may provide insight into the metabolic regulation of stem cell behavior in other tissues and organisms.
Article
Biology
Leah J. Greenspan, Margaret de Cuevas, Kathy H. Le, Jennifer M. Viveiros, Erika L. Matunis
Summary: Adult stem cells in the Drosophila testis are regulated by signals from somatic hub cells, including the Epidermal growth factor receptor (EGFR) signaling pathway. After the removal of somatic cyst stem cells (CySCs), the hub cells proliferate and undergo transdifferentiation into new CySCs. EGFR signaling is normally inhibited in hub cells but is activated after CySC ablation to drive stem cell regeneration.
Review
Cell Biology
Narendra Pratap Singh, Robb Krumlauf
Summary: Gene duplication and divergence play a significant role in the generation of morphological diversity and emergence of novel features in vertebrates. Although genome sequencing has improved our understanding of gene and regulatory element evolution, progress in studying protein function conservation and divergence has been slow. Some studies have explored the functional evolution of related proteins, but understanding of protein function variation within gene families remains limited.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Diego Sainz de la Maza, Silvana Hof-Michel, Lee Phillimore, Christian Boekel, Marc Amoyel
Summary: This study reveals that the Drosophila testis niche supports germline stem cells and somatic cyst stem cells. While cell-cycle progression is required for cyst stem cell self-renewal, the E2f1/Dp transcription factor coordinates cell cycle progression with stem cell identity by regulating the metabolic state of the cells.
Correction
Biochemistry & Molecular Biology
Sebastian Sorge, Nati Ha, Maria Polychronidou, Jana Friedrich, Daniela Bezdan, Petra Kaspar, Martin H. Schaefer, Stephan Ossowski, Stefan R. Henz, Juliane Mundorf, Jenny Raetzer, Fani Papagiannouli, Ingrid Lohmann
Article
Developmental Biology
Lisa Schardt, Janina-Jacqueline Ander, Ingrid Lohmann, Fani Papagiannouli
MECHANISMS OF DEVELOPMENT
(2015)
Review
Biochemistry & Molecular Biology
Fani Papagiannouli, Ingrid Lohmann
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2015)
Review
Biochemical Research Methods
Fani Papagiannouli, Ingrid Lohmann
BIOTECHNOLOGY JOURNAL
(2012)
Article
Cell Biology
Fani Papagiannouli, Bernard M. Mechler
Correction
Cell Biology
Fani Papagiannouli, Lisa Schardt, Janin Grajcarek, Nati Ha, Ingrid Lohmann
DEVELOPMENTAL CELL
(2014)
Article
Biochemistry & Molecular Biology
Sebastian Sorge, Nati Ha, Maria Polychronidou, Jana Friedrich, Daniela Bezdan, Petra Kaspar, Martin H. Schaefer, Stephan Ossowski, Stefan R. Henz, Juliane Mundorf, Jenny Raetzer, Fani Papagiannouli, Ingrid Lohmann
Article
Biochemistry & Molecular Biology
Fani Papagiannouli, Bernard M. Mechler
Article
Developmental Biology
Fani Papagiannouli
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY
(2013)
Article
Cell Biology
Srividya Tamirisa, Fani Papagiannouli, Eugen Rempel, Olga Ermakova, Nils Trost, Jun Zhou, Juliane Mundorf, Samantha Brunel, Naima Ruhland, Michael Boutros, Jan U. Lohmann, Ingrid Lohmann
Article
Genetics & Heredity
Zongzhao Zhai, Nati Ha, Fani Papagiannouli, Anne Hamacher-Brady, Nathan Brady, Sebastian Sorge, Daniela Bezdan, Ingrid Lohmann
Article
Cell & Tissue Engineering
Fani Papagiannouli, Cameron Wynn Berry, Margaret T. Fuller
Review
Biochemistry & Molecular Biology
Fani Papagiannouli
Summary: Cellular trafficking through the endosomal-lysosomal system plays a crucial role in the transport of cargo proteins, receptors, and lipids. The cooperation between endosomal-lysosomal machineries and polarity and signaling cues is essential for cell homeostasis and response to environmental cues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
A Brandt, F Papagiannouli, N Wagner, M Wilsch-Bräuninger, M Braun, EE Furlong, S Loserth, C Wenzl, F Pilot, N Vogt, T Lecuit, G Krohne, J Grosshans