Journal
DEVELOPMENTAL CELL
Volume 23, Issue 6, Pages 1084-1091Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2012.10.002
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Funding
- NIH [GM33289]
- Gerald J. Lieberman fellowship
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Single-molecule analysis is a powerful modern form of biochemistry, in which individual kinetic steps of a catalytic cycle of an enzyme can be explored in exquisite detail. Both single-molecule fluorescence and single-molecule force techniques have been widely used to characterize a number of protein systems. We focus here on molecular motors as a paradigm. We describe two areas where we expect to see exciting developments in the near future: first, characterizing the coupling of force production to chemical and mechanical changes in motors, and second, understanding how multiple motors work together in the environment of the cell.
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