Review
Chemistry, Inorganic & Nuclear
Anne Vessieres, Yong Wang, Michael J. McGlinchey, Gerard Jaouen
Summary: Organometallic quinone methides (OM-QMs) exhibit unique chemical and biological properties when incorporated into specific substrates like ferrocifens, leading to disruption of cancer cell metabolism and cytotoxicity. Among these, ferrocifens show the highest toxicity within the iron, ruthenium, osmium triad, and the complexes can be utilized as imaging probes.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Inorganic & Nuclear
Riccardo Pettinari, Fabio Marchetti, Alessia Tombesi, Corrado Di Nicola, Claudio Pettinari, Chuanpan Guo, Zhihong Zhang, Agustin Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
Summary: Two new pyrazole ligands with a pyridine moiety were synthesized and fully characterized, and their coordination modes in metal complexes were analyzed. Cytotoxicity studies showed similar activity of these ligands and complexes in cisplatin-sensitive and cisplatin-resistant ovarian carcinoma cells.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Multidisciplinary
Srividya Swaminathan, Jebiti Haribabu, Naveen Kumar Kalagatur, Maroli Nikhil, Nithya Balakrishnan, Nattamai S. P. Bhuvanesh, Krishna Kadirvelu, Ponmalai Kolandaivel, Ramasamy Karvembu
Summary: The synthesis of fourteen new Ru-II-arene complexes were characterized and found to exhibit high toxicity towards IMR-32 cancer cells, with two complexes showing the highest activity and the ability to induce apoptosis and cell cycle arrest. These complexes also demonstrated good binding affinity with receptors commonly overexpressed in cancer cells.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Inorganic & Nuclear
Subhadeep Paul, Subhadarsini Sahoo, Somarupa Sahoo, Chelliah Jayabaskaran, Akhil R. Chakravarty
Summary: In this study, ruthenium(II) polypyridyl complexes were used as photosensitizers with enhanced absorption in the visible region, and their application in photodynamic therapy was investigated. Among them, a bichromophoric compound (complex 3) exhibited high photosensitivity and photocytotoxicity, demonstrating promising potential for cancer cell treatment.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Stephen Mensah, Joseph D. Rosenthal, Mamta Dagar, Tyson Brown, Jonathan J. Mills, Christopher G. Hamaker, Gregory M. Ferrence, Michael I. Webb
Summary: The evolution of high virulence bacterial strains has led to the development of novel therapeutic agents. Metal-based therapeutics, with their structural variability and unique modes of action, show great promise. This study focused on the preparation and evaluation of ruthenium(ii)-arene complexes containing Schiff base ligands with an attached ferrocene, and identified a complex with prominent activity against clinically relevant bacterial strains.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Inorganic & Nuclear
Raphael T. Ryan, Dmytro Havrylyuk, Kimberly C. Stevens, L. Henry Moore, Sean Parkin, Jessica S. Blackburn, David K. Heidary, John P. Selegue, Edith C. Glazer
Summary: The beta-diketone scaffold, a commonly used synthetic intermediate, showed promising structure-dependent cytotoxicity in constructing Ru(II) complexes, suggesting the potential for future drug development.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Isabelle Holzer, Oksana Desiatkina, Nicoleta Anghel, Serena K. K. Johns, Ghalia Boubaker, Andrew Hemphill, Julien Furrer, Emilia Paunescu
Summary: Eight novel carbohydrate-tethered trithiolato dinuclear ruthenium(II)-arene complexes were synthesized and evaluated for their activity against transgenic T. gondii tachyzoites. Seven conjugates strongly inhibited parasite proliferation while maintaining HFF viability. Two galactose-based conjugates (23 and 26) exhibited low IC50 values and reduced toxicity compared to the non-modified complexes.
Article
Chemistry, Medicinal
Jiangkun Yan, Kairui Yue, Xuejing Fan, Ximing Xu, Jing Wang, Mengting Qin, Qianer Zhang, Xiaohan Hou, Xiaoyang Li, Yong Wang
Summary: This paper develops a series of ferrocene-based hydroxamic acids as novel HDAC6 inhibitors. The two ansa-ferrocenyl complexes show the most potent inhibition activity at the nanomolar level. Compound II-5 displays the highest inhibitory activity on HDAC6 and selective towards other HDAC isoforms. It induces cellular apoptosis in cancer cells and demonstrates optimal human plasma stability, making it a suitable lead for further evaluation and development in treating HDAC6-associated disorders and diseases.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Yong Wang, Pascal Pigeon, Wei Li, Jiangkun Yan, Patrick M. Dansette, Mohamed Othman, Michael J. McGlinchey, Gerard Jaouen
Summary: Ferrociphenols, compounds characterized by a biologically active redox motif, have anticancer properties. This study synthesized a variety of ferrociphenols with nitrogen-containing substituents and investigated their structure-activity relationships. Oxidative metabolism experiments and ROS-related bioactivity measurements were conducted to explore the cytotoxicity of imidoferrociphenols. Additionally, dimerization phenomenon observed in the crystal structure of a ferrociphenol may affect its antitumor activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Denise Lovison, Dario Alessi, Lorenzo Allegri, Federica Baldan, Maurizio Ballico, Giuseppe Damante, Marilisa Galasso, Daniele Guardavaccaro, Silvia Ruggieri, Andrea Melchior, Daniele Veclani, Chiara Nardon, Walter Baratta
Summary: The paper describes a chiral ruthenium complex with high cytotoxic activity against various cell lines, particularly showing strong inhibition against the anaplastic thyroid cancer cell line 8505 C.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Atousa Goudarzi, Mitra Ghassemzadeh, Maryam Saeidifar, Kioumars Aghapoor, Farshid Mohsenzadeh, Bernhard Neumueller
Summary: The synthesis of a new Pd(II) complex and its characterization were reported. The complex exhibited potent anticancer activity against MCF-7 breast cancer cells, and showed good antimicrobial activity against both Gram-positive and Gram-negative bacteria.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Tomiris Nabiyeva, Basile Roufosse, Matylda Odachowski, Judith Baumgartner, Christoph Marschner, Akalesh Kumar Verma, Burgert Blom
Summary: A series of osmium arene complexes involving sigma-germyl, germanate, sigma-stannyl, and stannate ligands were synthesized, characterized, and tested for potential anticancer activities. Comprehensive analyses using various techniques were conducted, along with cytotoxicity and apoptosis assays against malignant cancer cell lines. The study revealed that some of the complexes exhibited anti-cancer effects on malignant cancer cells.
Article
Chemistry, Inorganic & Nuclear
Oksana Desiatkina, Serena K. Johns, Nicoleta Anghel, Ghalia Boubaker, Andrew Hemphill, Julien Furrer, Emilia Paunescu
Summary: The study focused on the synthesis and evaluation of new dinuclear ruthenium(II)-arene compounds linked to antimicrobial compounds, revealing strong inhibitory effects on parasite proliferation while showing relatively small impact on host cell viability.
Article
Chemistry, Multidisciplinary
Bruno Therrien
Summary: This article discusses the author's contributions to the development and popularity of arene ruthenium assemblies, which have been mainly driven by applications in the biological field. The author has focused on using arene ruthenium building blocks as tools to construct added-value objects for nearly 15 years.
Article
Chemistry, Inorganic & Nuclear
Juan Sanz Garcia, Marie Gaschard, Isabelle Navizet, Mehdi Sahihi, Siden Top, Yong Wang, Pascal Pigeon, Anne Vessieres, Michele Salmain, Gerard Jaouen
Summary: The family of ferrocifens, derived from the anti-oestrogen tamoxifen, exhibit a broad antitumor activity by generating reactive oxygen species and electrophilic quinone methides. In addition to their known targets, cathepsin B was unexpectedly identified as a new target for ferrocifens.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Mingyang Liu, Xuemei Yang, Paul J. Dyson
Summary: This study proposes a method to generate aryl chlorides by chloro-group transfer from chlorophenol pollutants, which can simultaneously degrade toxic chlorophenol pollutants, providing a new approach in environmental pollutant detoxication.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Physical
Gabriela Gastelu, David Savary, Martin Hulla, Daniel Ortiz, Jorge G. Uranga, Paul J. Dyson
Summary: The article introduces an alternative reaction pathway for the O-formylation of alcohols and bio-alcohols, which produces industrially relevant formate esters. The reaction is catalyzed by formic acid, which can be produced from CO2 captured in the reaction. The in situ produced formic acid improves the reaction rate, and each catalyst can be recycled for reuse.
Article
Biochemistry & Molecular Biology
Taryn M. Golding, Reinner O. Omondi, Supratim Biswas, Suparna Chakraborty, Sharon Prince, Gregory S. Smith
Summary: The success of small metal-containing molecules as pharmaceutical agents has led to investigations into the pharmacological activity of supramolecular coordination complexes (SCCs), which have shown promising anticancer activity. The present study evaluated the anticancer activity of quinoline-containing binuclear complexes and metallarectangles in breast cancer cell lines. The results demonstrated that some of these complexes exhibited superior or comparable activity to the clinical chemotherapeutic drugs cisplatin in different breast cancer cell lines. Additionally, the compounds showed increased selectivity towards breast cancer cells over non-tumorigenic cells and displayed favorable binding to DNA and albumin.
Article
Chemistry, Inorganic & Nuclear
Tara K. Davids, Wade F. Petersen, Gregory S. Smith
Summary: A trinuclear bis-cyclometalated iridium(III) polypyridyl complex was synthesized and evaluated as a photoredox catalyst for visible light-mediated thiol-ene coupling reactions. The complex exhibited a blue-shifted emission spectrum and showed promising catalytic activity in photoredox reactions. Compared to a trinuclear ruthenium congener, the trinuclear iridium polypyridyl complex exhibited the highest NMR yields in hydrothiolation coupling reactions.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Editorial Material
Chemistry, Organic
Xiao-Feng Wu, Paul J. Dyson, Bruce A. Arndtsen
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Stephen de Doncker, Eva Fischer-Fodor, Catalin Ioan Vlad, Patriciu Achimas-Cadariu, Gregory S. Smith, Siyabonga Ngubane
Summary: Two diphenyl formamidine ligands, four dirhodium(II,II) complexes, and three axially modified low-valent dirhodium(II,II) metallodendrimers were synthesized and evaluated for their anticancer activity against ovarian cancer cell lines. The dirhodium(II,II) complexes exhibited moderate cytotoxicity, with acetate and methyl-substituted formamidinate compounds showing increased cytotoxicity compared to cisplatin in the cisplatin resistant cell line. Methyl- and fluoro-substituted formamidinate complexes also demonstrated comparable or increased cytotoxic activity in another cell line. The low-valent metallodendrimers exhibited some activity, but generally showed decreased cytotoxicity compared to the precursor complexes, except for one case where an acetate-derived metallodendrimer showed higher cytotoxicity than dirhodium(II,II) tetraacetate.
Article
Chemistry, Inorganic & Nuclear
Lorenzo Pietracci, Riccardo Pettinari, Alessia Tombesi, Fabio Marchetti, Claudio Pettinari, Agustiïn Galindo, Farzaneh Fadaei-Tirani, Mouna Hadiji, Paul J. Dyson
Summary: This study investigates the coordination mechanisms of pyrazolone ligands containing a pyridine ring with the (Ru(II)) fragment through experimental and theoretical calculations. The ligands were found to coordinate in an unusual N,O-chelating fashion with Ru(II), and various complexes were synthesized. The study provides important insights into the properties of the ligands and complexes.
Article
Chemistry, Inorganic & Nuclear
Alfonso Annunziata, Maria Elena Cucciolito, Maddalena Di Ronza, Giarita Ferraro, Mouna Hadiji, Antonello Merlino, Daniel Ortiz, Rosario Scopelliti, Farzaneh Fadaei Tirani, Paul J. Dyson, Francesco Ruffo
Summary: This article reports a series of Ruthenium(II) complexes with a three-legged piano-stool structure based on an arene ring and an N-heterocyclic carbene(NHC)-carbene ligand with a peracetylated glucose moiety. The complexes undergo hydrolysis in water and show reactivity towards model nucleophiles and biological macromolecules. However, they exhibit low anti-tumor activity against human ovarian carcinoma cells and cisplatin-resistant cells.
Article
Chemistry, Multidisciplinary
Shunlin Zhang, Yuxin Xie, Rosie J. J. Somerville, Farzaneh Fadaei Tirani, Rosario Scopelliti, Zhaofu Fei, Dunru Zhu, Paul J. J. Dyson
Summary: This study reports a new family of proton conductors based on MIL-101 and protic ionic liquid polymers (PILPs) containing different anions. The PILP@MIL-101 composites maintain the nanoporous cavities and water stability of MIL-101, while providing much-improved proton transport. The PILP@MIL-101 composite with HSO4- anions shows superprotonic conductivity (6.3 x 10(-2) S cm(-1)) at 85 degrees C and 98% relative humidity.
Article
Chemistry, Multidisciplinary
Haodan Guo, Yanyan Fang, Yan Lei, Jinpeng Wu, Minghua Li, Xiangrong Li, Hong Bo Cheng, Yuan Lin, Paul J. Dyson
Summary: This study demonstrates the use of a self-assembled ionic insulating layer to improve the performance of wide-bandgap perovskite solar cells. The layer effectively suppresses halide phase separation, reducing open-circuit voltage loss and improving device stability.
Article
Multidisciplinary Sciences
Mingyang Liu, Paul J. Dyson
Summary: Efficient valorization of lignin, a sustainable and renewable source, is essential for reducing dependence on fossil-derived feedstocks. This study presents a highly efficient strategy for extracting aromatic monomers and generating functionalized diaryl ethers from lignin using oxidative cross-coupling reactions.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Gabriela Gastelu, Pritha Saha, Paul J. Dyson, Martin Hulla, Jorge G. Uranga
Summary: Autocatalytic reactions play a key role in the beginning of life and carbon capture and utilization, providing inspiration for the development of advanced systems for the synthesis of value-added chemicals.
Article
Chemistry, Multidisciplinary
Yue Hu, Xinmin Li, Mingyang Liu, Stephan Bartling, Henrik Lund, Paul J. Dyson, Matthias Beller, Rajenahally V. Jagadeesh
Summary: Catalytic hydrodeoxygenation is a crucial technology for converting biomass-based feedstocks into essential chemicals and fuels. This study reports the preparation and application of Ni nanoparticles supported on ZSM-5 as an efficient hydrodeoxygenation catalyst. The Ni-based nanoparticles exhibit selective hydrodeoxygenation of various functional substrates, showcasing their versatility.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Patrick Doerflinger, Yong Ding, Valentin Schmid, Melina Armer, Roland C. Turnell-Ritson, Bin Ding, Paul J. Dyson, Mohammad Khaja Nazeeruddin, Vladimir Dyakonov
Summary: This study investigates the effect of a stabilizing additive on the charge carrier mobility and lifetime in triple cation perovskite thin films under thermal stress. The results reveal different conductivity behaviors in two temperature regions and identify two dominant scattering mechanisms. The stabilizing additive limits temperature-activated mobile ions and retards degradation of the perovskite film, leading to improved performance and stability.
Article
Chemistry, Inorganic & Nuclear
Sarah A. P. Pereira, Jan Romano-deGea, Ana Isabel Barbosa, Sofia A. Costa A. Lima, Paul J. J. Dyson, M. Lucia M. F. S. Saraiva
Summary: The study demonstrates that ruthenium-based compounds, especially [Ru(& eta;(6)-toluene)(PPh3)(2)Cl]Cl, show high selectivity and cytotoxicity against breast cancer cells. This compound has potential as a promising candidate for breast cancer treatment.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Guojun Hu, Ziyue Deng, Yanwei Wang, Dan Yuan, Yong Zhang, Yingming Yao
Summary: A series of rare-earth metal complexes were synthesized and used as efficient initiators for the polymerization of trimethylene carbonate (TMC) and (L)-lactide ((L)-LA).
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Van Ha Nguyen, John H. K. Yip
Summary: In this study, eight PtII-azulene complexes were synthesized to investigate the effect of metalation on the electronic structures, spectroscopy, and luminescence of organic chromophores. The results showed that the attachment of Pt substituents to azulene affected the HOMOs, LUMOs, and luminescence properties. The study provides insights into the role of metalation in modifying the properties of organic chromophores.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Moon Kedia, Virender Singh, Bhaskaran Shankar, Malaichamy Sathiyendiran
Summary: This study synthesized two types of neutral binuclear metallocycles using a one-pot solvothermal method and characterized their structures. The analysis revealed that these complexes adopt a binuclear heteroleptic cyclic architecture and belong to phosphine oxide donor (P=O)-based supramolecular coordination cyclic complexes.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Radhey S. Srivastava
Summary: This study demonstrates the effectiveness of zero-valent elements as reductants for the deoxydehydration reaction of polyols catalyzed by ONO-pincer ligated molybdenum dioxo. The insolubility and easy separability of the reductants and their oxidized products during the reaction are emphasized. Additionally, the choice of ligand has an impact on the catalytic performance of the reaction.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Hao Zhou, Yajun Sun, Li Deng, Weiran Yang, Yuehui Li
Summary: Efficient Ru-catalyzed hydrogenation of aldehydes was achieved using carbazole-derived phosphine ligands, with the crucial role of N-H moiety in promoting the catalytic reaction. The method was successfully applied in the Co/Ru-catalyzed hydroformylation process, resulting in the production of long-chain alcohols with excellent yields.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Theodor Danescu, Alexandru Lupan, Radu Silaghi-Dumitrescu, R. Bruce King
Summary: The structures and energies of complexes containing (Me2C2N2P)2Ru2(CO)n and (Me2C2N2P)2Fe2(CO)n have been studied. Low-energy structures are characterized by the presence of bridging diazaphospholyl rings, while higher-energy structures involve different ligand structures.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Savannah C. Kapper, Aamani Ponnekanti, Jonas Schaab, Tian-yi Li, Christine L. Chung, Gael Ung, Peter I. Djurovich, Mark E. Thompson
Summary: Organometallic iridium complexes with two cyclometalated ligands and one bis-oxazoline derived ancillary ligand were studied. These complexes have emission spanning across the visible and near-ultraviolet region, with moderate to high photoluminescence quantum yields. The (ppy)2Ir(BOX-CN) complexes were resolved into Delta- and Lambda-diastereomers based on solubility differences.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Zahra Karimi Sangari, Hossein Naeimi
Summary: In this research, a nanostructured CoCuFe2O4 catalyst was prepared using a brief and useful synthetic strategy. This catalyst was used for synthesizing 1,2,4,5-tetrasubstituted imidazole derivatives under ultrasonic irradiation. The approach offers advantages such as high efficiency, short reaction times, simplicity of the reaction medium, accelerated reaction rates, and easier separation and purification of products.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Rukhsana Gul, Wajid Munir, Ebraheem Abdu Musad Saleh, Shaukat Shujah, Muhammad Sirajuddin, Saira Tabassum, Khalil Ur Rehman, Dilfaraz Khan, Sameerah I. Al-Saeedi, Ehab A. Abdelrahman
Summary: Two new Schiff base ligands were synthesized and used to form copper, nickel, and cobalt complexes. The synthesized compounds were characterized and screened for various biological activities. The metal complexes showed better activities in antibacterial, antifungal, antidiabetic, and antioxidant assays.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Review
Chemistry, Inorganic & Nuclear
Ahsan Nazir, Pengwei Huo, Ameena Tur Rasool
Summary: This review explores the potential of g-C3N4-based S-scheme heterojunctions in addressing environmental issues. It summarizes the mechanism and preparation techniques of S-scheme heterojunctions based on g-C3N4, and presents recent studies on their applications in pollutant removal, CO2 reduction, hydrogen production, and bacterial disinfection. The review concludes with an outlook on future challenges for g-C3N4-based S-scheme heterojunctions.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Francois Mazars, Koffi Senam Etse, Guillermo Zaragoza, Lionel Delaude
Summary: The activity of three Pd-PEPPSI catalyst precursors with N-heterocyclic carbene (NHC) ligands derived from caffeine and theophylline in Mizoroki-Heck reactions was tested. The results showed that the catalysts achieved high conversions and yields, especially in the presence of electron-withdrawing substituents.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
Article
Chemistry, Inorganic & Nuclear
Bo-Han Wu, Xue Zhou, Lin Liu, Zheng-Bo Han
Summary: Researching carbon dioxide removal from flue gas and natural gas is crucial. Metal-organic frameworks (MOFs) are commonly used in adsorption due to their high surface area, porosity, and chemical properties. An ultra-microporous MOF CPM-20(Co) with mixed ligand was synthesized using inexpensive ligands. The material exhibited high selectivities and low regenerative energy, making it a promising option for CO2 separation in industries.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2024)
