Article
Environmental Sciences
Xiangyang Li, Yue Zhang, Leqiang Gao, Xiaodi Yang, Guiqing Zhou, Yujian Sang, Jinglong Xue, Zhixiong Shi, Zhiwei Sun, Xianqing Zhou
Summary: Previous studies have shown that BDE-209 can cause reproductive and developmental toxicity, but the exact mechanism is still unknown. This study found that BDE-209 damaged the testis and epididymis, induced spermatogenic cell apoptosis, and reduced sperm quantity and quality. Furthermore, BDE-209 affected histone methylation and inhibited meiosis initiation and cell cycle progression, resulting in long-term male reproductive toxicity.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Andrology
Manish Kuchakulla, Manish Narasimman, Kajal Khodamoradi, Zahra Khosravizadeh, Ranjith Ramasamy
Summary: Spermatogenesis is a complex process involving multiple regulatory elements and steps, essential for maintaining and promoting male fertility. Reduced sperm DNA integrity can negatively impact fertility, with sources of DNA damage including replication errors and fragmentation due to various causes like apoptosis and oxidative stress. Research also covers DNA repair mechanisms in spermatozoon.
Article
Cell Biology
Sandrine Floriot, Laura Bellutti, Johan Castille, Pauline Moison, Sebastien Messiaen, Bruno Passet, Laurent Boulanger, Abdelhak Boukadiri, Sophie Tourpin, Christian Beauvallet, Marthe Vilotte, Julie Riviere, Christine Pechoux, Maud Bertaud, Jean-Luc Vilotte, Gabriel Livera
Summary: This study reveals the essential role of centrosome cohesion in male gametogenesis. Mutant mice lacking the Cep250 gene exhibit male infertility due to a reduction in the spermatogonial pool and the blockade of meiotic divisions. The findings provide new insights into the function of centrosome cohesion in male germline development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Le P. Ngo, Simran Kaushal, A. Isaac Chaim, Patrizia Mazzucato, Catherine Ricciardi, D. Leona Samson, D. Zachary Nagel, P. Bevin Engelward
Summary: By utilizing the CometChip, researchers uncovered significant variability in DNA repair efficiency among individuals, indicating its potential utility in future epidemiological and clinical studies.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Martina Fiumara, Samuele Ferrari, Attya Omer-Javed, Stefano Beretta, Luisa Albano, Daniele Canarutto, Angelica Varesi, Chiara Gaddoni, Chiara Brombin, Federica Cugnata, Erika Zonari, Matteo Maria Naldini, Matteo Barcella, Bernhard Gentner, Ivan Merelli, Luigi Naldini
Summary: Base and prime editors have shown potential for precise genetic engineering, but their cellular responses and genotoxicity are not well understood. This study compared the efficiency, toxicity, and genotoxicity between base and prime editors and Cas9 in human hematopoietic cells. The findings suggest that these editors can induce harmful effects and genotoxicity, raising concerns for their clinical applications.
NATURE BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Huishi Toh, Alexander Smolentsev, Ryan Sadjadi, Dennis Clegg, Jingqi Yan, Ron Stewart, James A. Thomson, Peng Jiang
Summary: Diabetic retinopathy is a common complication of long-term diabetes that can lead to vision loss. The early understanding and prevention of this condition are limited, with no effective methods until later stages. The study used a Nile rat model to examine the transcriptomic changes in retinal vascular development, aiming to better understand the early pathogenesis of diabetic retinopathy.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Huishi Toh, Alexander Smolentsev, Ryan Sadjadi, Dennis Clegg, Jingqi Yan, Ron Stewart, James A. Thomson, Peng Jiang
Summary: This study aims to understand the early pathogenesis of diabetic retinopathy by analyzing whole retinal vascular transcriptomic changes in a Nile rat model. The study identified the complex associations between acellular capillary density and factors like blood glucose, diet, and sex. A random forest regression model based on gene expression patterns was developed to predict acellular capillary density. Additionally, potential drugs that can attenuate early diabetic retinopathy were also identified.
SCIENTIFIC REPORTS
(2023)
Review
Endocrinology & Metabolism
Yan Wang, Mengrong Su, Yujie Chen, Xinyu Huang, Lian Ruan, Qizhuang Lv, Li Li
Summary: This study provides a systematic review of the role and mechanism of DNA damage repair in germ cell development. It summarizes the causes, detection methods, and repair methods of DNA damage, as well as the mechanism of DNA damage repair. It also discusses the causes of abnormal DNA damage repair in germ cells, the effects of germ cell damage, and the applications of DNA damage repair in reproductive diseases and related surgical treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Environmental Sciences
Ericka Marel Quezada-Maldonado, Yesennia Sanchez-Perez, Yolanda I. Chirino, Claudia M. Garcia-Cuellar
Summary: This study analyzed the types of DNA damage and alterations in DNA repair pathways induced by PM exposure, showing that PM mainly causes oxidative stress and DNA damage through the formation of DNA adducts and DSBs, as well as deregulates the protein expression in DNA repair pathways. However, there are still limitations in the knowledge about the effects of PM on DNA repair pathways, and further research is needed to deepen our understanding.
ENVIRONMENTAL POLLUTION
(2021)
Article
Engineering, Environmental
Hongrui Guo, Yujuan Ouyang, Jiaqi Wang, Hengmin Cui, Huidan Deng, Xinyue Zhong, Zhijie Jian, Huan Liu, Jing Fang, Zhicai Zuo, Xun Wang, Ling Zhao, Yi Geng, Ping Ouyang, Huaqiao Tang
Summary: Copper is essential but over-exposure can lead to adverse health effects. CuSO4 was found to induce spermatogenesis disorder through oxidative stress-mediated DNA damage and apoptosis, impairing male reproductive function.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Inga R. Grin, Daria V. Petrova, Anton V. Endutkin, Chunquan Ma, Bing Yu, Haiying Li, Dmitry O. Zharkov
Summary: Base excision DNA repair is an important pathway in safeguarding the genome of plants, and understanding their repair mechanisms is crucial for developing new crop varieties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
S. Ahmad, M. L. Tan, Shahrul Hamid
Summary: Cardiovascular disease is a leading global cause of death, influenced by factors such as genetics, high-fat intake, smoking, hypertension, diabetes, and lifestyle. The disease is caused by the sudden production of reactive oxygen species, resulting in DNA damage and cell death. Various forms of DNA damage have been associated with cardiovascular disease. Therefore, reducing reactive oxygen species is crucial, and nutraceuticals and their bioactive compounds play a role in mitigating DNA damage.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Nutrition & Dietetics
Jingqian Su, Qiaofen Su, Shan Hu, Xinglin Ruan, Songying Ouyang
Summary: Aging is a cellular state characterized by a permanent cessation of cell division and evasion of apoptosis. DNA damage, metabolic dysfunction, telomere damage, and mitochondrial dysfunction are the main factors associated with senescence. Ginseng, a traditional Chinese medicine, has active components that have antioxidant, anti-apoptotic, neuroprotective, and age-delaying effects. This review focuses on the anti-aging mechanisms of the active ingredients of ginseng and expands the scope of ideas for further research on natural products and aging.
Article
Multidisciplinary Sciences
Yu Jiang, Fei Huang, Lu Chen, Jia-Hui Gu, Yun-Wen Wu, Meng-Yan Jia, Zhen Lin, Yong Zhou, Yan-Chu Li, Chao Yu, Ming-Han Tong, Li Shen, Heng-Yu Fan, Qian-Qian Sha
Summary: The R-loop, a three-strand nucleic acid structure, plays important regulatory roles in the meiosis process, particularly in transcriptional regulation and DNA repair. The study of R-loop in mice revealed its predominant distribution at promoter-related regions, its association with high transcription activity, and its crucial role in fertility and DSB repair. These findings highlight the significance of R-loop in spermatogenesis.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Genetics & Heredity
Bo Liu, Zhen Li
Summary: In this review, the expression pattern and specific molecular mechanisms of PA1 protein in various biological processes are systematically summarized. Additionally, new perspectives on the role of PA1 for future studies are proposed.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Kristopher R. Schwab, Sanjeevkumar R. Patel, Gregory R. Dressler
MOLECULAR AND CELLULAR BIOLOGY
(2011)
Article
Multidisciplinary Sciences
Jeremy A. Daniel, Margarida Almeida Santos, Zhibin Wang, Chongzhi Zang, Kristopher R. Schwab, Mila Jankovic, Darius Filsuf, Hua-Tang Chen, Anna Gazumyan, Arito Yamane, Young-Wook Cho, Hong-Wei Sun, Kai Ge, Weiqun Peng, Michel C. Nussenzweig, Rafael Casellas, Gregory R. Dressler, Keji Zhao, Andre Nussenzweig
Article
Multidisciplinary Sciences
Andrew J. Kump, Manoj Panta, Kristopher R. Schwab, Mark H. Inlow, Shaad M. Ahmad
Summary: The Forkhead domain transcription factors mediate various cardiogenic processes, with the Drosophila Fox gene jumeau (jumu) controlling different categories of cardiac progenitor cell division, such as regulating Polo kinase activity and working together with Myb. Nebbish (neb), a gene activated by jumu, was found to be required for only two categories of jumu-regulated cardiac progenitor cell division, highlighting the central role of Fox TFs in cardiogenesis.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Manoj Panta, Andrew J. Kump, John M. Dalloul, Kristopher R. Schwab, Shaad M. Ahmad
Article
Developmental Biology
Ni Song, Kristopher R. Schwab, Larry T. Patterson, Terry Yamaguchi, Xinhua Lin, Steven S. Potter, Richard A. Lang
Article
Biology
Kristopher R. Schwab, Larry T. Patterson, Heather A. Hartman, Ni Song, Richard A. Lang, Xinhua Lin, S. Steven Potter
Article
Developmental Biology
Kristopher Schwab, Heather A. Hartman, Hung-Chi Liang, Bruce J. Aronow, Larty T. Patterson, S. Steven Potter
DEVELOPMENTAL BIOLOGY
(2006)
Article
Urology & Nephrology
K Schwab, DP Witte, BJ Aronow, P Devarajan, SS Potter, LT Patterson
AMERICAN JOURNAL OF NEPHROLOGY
(2004)
Article
Urology & Nephrology
K Schwab, LT Patterson, BJ Aronow, R Luckas, HC Liang, SS Potter
KIDNEY INTERNATIONAL
(2003)
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)