Review
Cell Biology
Yifang Yan, Qiang Wang
Summary: BMP signaling plays a crucial role in dorsoventral axis patterning across diverse vertebrates, with its regulation being strongly conserved during evolution. Despite variations in BMP signaling, the embryonic dorsoventral axis displays robust stability, shaped by multiple factors working together.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Afshan Sohail, Andrew J. Bendall
Summary: The articulated jaws of vertebrates arise from the first pharyngeal arch, and Dlx genes play a crucial role in jaw development, but Dlx5 alone is not sufficient to activate mandibular marker genes.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Jay B. Lusk, Ellora Hui Zhen Chua, Prameet Kaur, Isabelle Chiao Han Sung, Wen Kin Lim, Vanessa Yuk Man Lam, Nathan Harmston, Nicholas S. Tolwinski
Summary: Proper embryonic development requires directional axes for patterning cells into embryonic structures. In Drosophila, the expression of transcription factors and the Toll and TGF beta signaling pathways play crucial roles in determining the anterior to posterior and dorsal to ventral patterning of the early embryo. In this study, we identified a novel loss of function mutation in the Raf kinase gene, which leads to the loss of ventral cell fates and reveals a novel role for Raf in embryonic patterning independent of the MAPK cascade.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Yu-Bing Wang, Ning-Ning Song, Lei Zhang, Pengcheng Ma, Jia-Yin Chen, Ying Huang, Ling Hu, Bingyu Mao, Yu-Qiang Ding
Summary: Rnf220 plays a crucial role in the early development of the hindbrain in mice, regulating the patterning and development of different cell types. It is expressed in specific regions of the hindbrain during embryonic stages and affects the development of progenitor cells and post-mitotic cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Axelle Wilmerding, Lauranne Bouteille, Lucrezia Rinaldi, Nathalie Caruso, Yacine Graba, Marie-Claire Delfini
Summary: The study revealed that HOXB8 acts as a tumor suppressor in an in vivo model, counteracting ERK-induced tumorigenesis by reversing the oncogenic transcriptome induced by ERK signaling. The research also identified new downstream targets of ERK oncogenic activation, providing potential insights for therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Li Sun, Yun Qi Wei, Kang Hao Wu, Jing Ying Yan, Jie Na Xu, Yun Rong Wu, Gui Xin Li, Ji Ming Xu, Nicholas P. Harberd, Zhong Jie Ding, Shao Jian Zheng
Summary: The YABBY transcription factor INNER NO OUTER (INO) in Arabidopsis regulates iron accumulation in seeds by repressing the expression of NRAMP1, a transporter that contributes to seed loading. Reduced expression of INO leads to higher iron accumulation in seeds, while overexpression results in oxidative damage and cell death in developing seeds. This study highlights the important role of INO in safeguarding reproduction by controlling iron loading into developing seeds.
Article
Developmental Biology
Makoto Abe, Timothy C. Cox, Anthony B. Firulli, Stanley M. Kanai, Jacob Dahlka, Kim-Chew Lim, James Douglas Engel, David E. Clouthier
Summary: Neural crest cells in the mandibular and maxillary prominences initially respond to signals from both regions, with GATA3 playing a crucial role in separating the upper and lower jaw domains during development by influencing BMP4 and FGF8 gene regulatory networks.
Article
Biology
Vanessa Barone, Maria Byrne, Deirdre C. Lyons
Summary: Cell size asymmetries are consistently produced during sea star cleavage, but they are not necessary for dorsal-ventral axis formation in sea star embryos.
Review
Multidisciplinary Sciences
Lucie Riglet, Stefano Gatti, Edwige Moyroud
Summary: Plant epidermis is a multifunctional surface that interacts with external factors, relying on minuscule structures and cuticle elaborations. Understanding the formation and functions of these elements require a multidisciplinary approach, utilizing modern tools and advanced microscopy techniques.
Article
Biochemistry & Molecular Biology
Ivy K. N. Chiang, Matthew S. Graus, Nils Kirschnick, Tara Davidson, Winnie Luu, Richard Harwood, Keyi Jiang, Bitong Li, Yew Yan Wong, Mehdi Moustaqil, Emmanuelle Lesieur, Renae Skoczylas, Valerie Kouskoff, Jan Kazenwadel, Luis Arriola-Martinez, Emma Sierecki, Yann Gambin, Kari Alitalo, Friedmann Kiefer, Natasha L. Harvey, Mathias Francois
Summary: SOX7, a BEC-specific transcription factor, modulates the expression level of angiocrine signals in blood vascular endothelial cells (BECs) to pattern lymphatic vessels. It directly represses the transcription of Vegfc, a major lymphangiogenic growth factor, and interacts with HEY1 to regulate Notch pathway. Our finding reveals the importance of SOX7 in modulating downstream signaling events crucial for lymphatic patterning.
Article
Multidisciplinary Sciences
Jessica Cristina Marin-Llera, Jesus Chimal-Monroy
Summary: During embryonic development, a variety of genetic programs are activated and regulated by morphogens, which lead to the generation of diverse somatic cells. The soaked bead assay is an experimental tool that can study the role of specific molecules in development, providing information on the control of cell induction, cell fate, and pattern formation.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Biochemistry & Molecular Biology
Hye Jeong Cho, A. Reum Han, Cheol Choi
Summary: This study found that the use of paper-bagging can enhance the skin color of apples and also change the skin patterning of the fruits. The results showed that the expression of MdMYB10, a transcription factor that regulates anthocyanin biosynthesis, was higher in bag removal fruits, and the methylation level in the MdMYB10 promoter region was reduced. These findings suggest that bag removal treatment can induce a change in apple skin patterning by altering DNA methylation of MdMYB10.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Ana Guerra, Jorge Belinha, Naside Mangir, Sheila MacNeil, Renato Natal Jorge
Summary: Angiogenesis, the formation of new blood vessels from pre-existing ones, is mainly influenced by vascular endothelial growth factor (VEGF) and can be mimicked by a meshless-based model proposed in this study. Both the experimental assay and simulation results showed that treatments with VEGF increased the total vessel number and length. The model accurately simulates capillary network patterns for lower VEGF concentrations, but may show some discrepancies for higher concentrations due to changes in blood vessel width.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Plant Sciences
Mao Li, Viktoriya Coneva, Kelly R. Robbins, David Clark, Dan Chitwood, Margaret Frank
Summary: The study explores complex color patterning in the popular ornamental plant coleus, using a quantitative color analysis framework to reveal color features associated with aesthetic value. This comprehensive exploration provides insights and tools for exploring the color pallet of the plant kingdom.
Article
Biochemistry & Molecular Biology
Tao Lin, Yuechan Chen, Yanling Zhang, Yaoyao Li, Lingyu Gao, Zhiwei Zhang
Summary: The study investigated the transcription regulation of KLF7 in chicken adipose tissue, with findings showing that the 5'-flanking sequence of KLF7 has significant promoter activity. GATA2 enhanced promoter activity, while GATA3 inhibited it, indicating that GATA2 and GATA3 play important roles in regulating KLF7 expression.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Hematology
Freyr Johannsson, Niels A. Arnason, Ragna Landroe, Sveinn Gudmundsson, Olafur E. Sigurjonsson, Ottar Rolfsson
Article
Biochemical Research Methods
Lea F. Buchweitz, James T. Yurkovich, Christoph Blessing, Veronika Kohler, Fabian Schwarzkopf, Zachary A. King, Laurence Yang, Freyr Johannsson, Olafur E. Sigurjonsson, Ottar Rolfsson, Julian Heinrich, Andreas Draeger
BMC BIOINFORMATICS
(2020)
Article
Multidisciplinary Sciences
Christian Christensen, Sandra Mjoll Jonsdottir-Buch, Olafur Eysteinn Sigurjonsson
Article
Oncology
Catalin Constantinescu, Sergiu Pasca, Tiberiu Tat, Patric Teodorescu, Catalin Vlad, Sabina Iluta, Delia Dima, Dana Tomescu, Ecaterina Scarlatescu, Alina Tanase, Olafur Eysteinn Sigurjonsson, Anca Colita, Hermann Einsele, Ciprian Tomuleasa
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Review
Biotechnology & Applied Microbiology
Thora Sigmarsdottir, Sarah McGarrity, Ottar Rolfsson, James T. Yurkovich, Olafur E. Sigurjonsson
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Alina-Andreea Zimta, Olafur Eysteinn Sigurjonsson, Diana Gulei, Ciprian Tomuleasa
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Medicine, General & Internal
Catalin Constantinescu, Sergiu Pasca, Alina-Andreea Zimta, Tiberiu Tat, Ioana Rus, Patric Teodorescu, Sabina Iluta, Alina Tanase, Anca Colita, Olafur Sigurjonsson, Hermann Einsele, Ciprian Tomuleasa
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Medicine, General & Internal
Minodora Desmirean, Sebastian Rauch, Ancuta Jurj, Sergiu Pasca, Sabina Iluta, Patric Teodorescu, Cristian Berce, Alina-Andreea Zimta, Cristina Turcas, Adrian-Bogdan Tigu, Cristian Moldovan, Irene Paris, Jakob Steinheber, Cedric Richlitzki, Catalin Constantinescu, Olafur Eysteinn Sigurjonsson, Delia Dima, Bobe Petrushev, Ciprian Tomuleasa
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Oncology
Dalma Deak, Nicolae Gorcea-Andronic, Valentina Sas, Patric Teodorescu, Catalin Constantinescu, Sabina Iluta, Sergiu Pasca, Ionut Hotea, Cristina Turcas, Vlad Moisoiu, Alina-Andreea Zimta, Simona Galdean, Jakob Steinheber, Ioana Rus, Sebastian Rauch, Cedric Richlitzki, Raluca Munteanu, Ancuta Jurj, Bobe Petrushev, Cristina Selicean, Mirela Marian, Olga Soritau, Alexandra Andries, Andrei Roman, Delia Dima, Alina Tanase, Olafur Sigurjonsson, Ciprian Tomuleasa
Summary: Acute leukemias, especially ALL, can lead to low survival rates due to CNS involvement, primarily caused by specific adhesion molecules expressed by a subset of leukemic cells, allowing them to interact and adhere to endothelial cells.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Thora Bjorg Sigmarsdottir, Sarah McGarrity, James T. Yurkovich, Ottar Rolfsson, Olafur Eysteinn Sigurjonsson
Summary: Since their discovery in 1976, MSCs have gained interest as a possible tool to enhance therapeutics in regenerative medicine. However, the lack of understanding about metabolic function and differences among cell lineages hinders the full realization of MSCs' therapeutic potential. By reconstructing the MSC metabolic network and creating new genome-scale metabolic models, researchers aim to explore metabolic function and enhance understanding of these cell phenotypes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Microbiology
Niels Arni Arnason, Freyr Johannsson, Ragna Landro, Bjorn Hardarsson, Sveinn Gudmundsson, Aina-Mari Lian, Janne Reseland, Ottar Rolfsson, Olafur E. Sigurjonsson
Summary: This study investigated the effect of pathogen inactivation on the release of proteins in stored platelets. The results showed that the majority of proteins increased in concentration during storage, but some proteins had significantly different concentrations between the pathogen inactivated group and the control group. Additionally, a subset of proteins displayed a decrease in concentration related to pathogen inactivation. The study found that pathogen inactivation had limited effect on protein concentration in stored platelets.
Article
Biotechnology & Applied Microbiology
Thora Bjorg Sigmarsdottir, Sarah McGarrity, Adrian Lopez Garcia de Lomana, Aristotelis Kotronoulas, Snaevar Sigurdsson, James T. Yurkovich, Ottar Rolfsson, Olafur Eysteinn Sigurjonsson
Summary: This study aimed to characterize the metabolic shifts that occur during osteogenesis by profiling extracellular metabolites and classifying the process into three metabolic stages. The identified metabolic stages provide a framework for further investigations to identify biomarkers of osteogenic differentiation and optimize MSC differentiation for clinical applications.
BIOENGINEERING-BASEL
(2021)
Article
Nanoscience & Nanotechnology
Adrianna Milewska, Olafur E. Sigurjonsson, Kristjan Leosson
Summary: This study utilizes noninvasive surface-enhanced Raman scattering (SERS) to investigate the long-term differentiation of MSCs on biocompatible gold nanoisland SERS substrates, showing that this technique is sufficient to study the bone formation process of these cells, potentially enabling continuous label-free screening of live cells.
ACS APPLIED BIO MATERIALS
(2021)
Article
Hematology
Marta Mikaelsdottir, Brynjar Vidarsson, Gudmundur Runarsson, Una Bjarnadottir, Pall T. Onundarson, Olafur E. Sigurjonsson, Anna M. Halldorsdottir
Summary: Therapeutic phlebotomy is the standard treatment for hereditary hemochromatosis, with little data available on the storage properties of platelet concentrates from HH donors. A study comparing platelets from healthy individuals and HH patients found no significant difference in quality over 7-day storage, indicating that platelets from HH individuals are comparable to healthy donors. Further extensive studies are needed for definitive conclusions.
Article
Biotechnology & Applied Microbiology
Sandra M. Jonsdottir-Buch, Kristbjorg Gunnarsdottir, Olafur E. Sigurjonsson
BIOENGINEERING-BASEL
(2020)
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)