Article
Genetics & Heredity
M. Kathleen Pitirri, Emily L. Durham, Natalie A. Romano, Jacob I. Santos, Abigail P. Coupe, Hao Zheng, Danny Z. Chen, Kazuhiko Kawasaki, Ethylin Wang Jabs, Joan T. Richtsmeier, Meng Wu, Susan M. Motch Perrine
Summary: The Fgfr2c C342Y mutation in the Crouzon syndrome mouse model leads to abnormal development of the lower jaw and craniofacial anomalies. Meckel's cartilage may play a role in mandibular bone formation, suggesting a functional relationship between the two. Mandibular dysmorphogenesis could be attributed to abnormalities in Meckel's cartilage affecting the development of the mandible.
FRONTIERS IN GENETICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jian Zhang, Chensheng Lin, Yingnan Song, Jiang Chen
Summary: The study found that different parts of Meckel's cartilage activate different combinations of BMP signaling pathways. In mouse models lacking Bmp4, the formation of chondrogenic rostral process and median mandibular symphysis were impaired, leading to abnormalities in Meckel's cartilage, mandibular intramembranous bone, and tongue muscle. The loss of central hard tissues in these mutant mice mimicked the typical sign of the median mandible Tessier 30 cleft in humans.
Article
Dentistry, Oral Surgery & Medicine
C. Tsutsumi-Arai, Y. Arai, A. Tran, M. Salinas, Y. Nakai, S. Orikasa, W. Ono, N. Ono
Summary: The mandibular condylar cartilage (MCC) plays a crucial role in the vertical growth of the mandibular ramus. In this study, researchers investigated the role of parathyroid hormone-related protein (PTHrP) in MCC chondrogenesis. They found that PTHrP released from cells in the superficial layer directly promotes proliferation of chondrocyte precursor cells and prevents their premature differentiation. This study uncovers a unique mechanism by which PTHrP regulates MCC chondrogenesis.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Materials Science, Biomaterials
Mahmoud Farahat, Emilio S. Hara, Risa Anada, Gulsan A. S. Kazi, Nahid M. Akhter, Takuya Matsumoto
Summary: Meckel's cartilage in the mandible shows different developmental fates in different portions. The stiffness of the environment affects its degeneration and mineralization. The expression of YAP, a mechanosensing protein, is dependent on the developmental stage of the tissue. The degradation of cartilage is associated with the enhanced expression of integrin-beta 1 and cartilage matrix-degrading enzymes MMP-1 and MMP-13, which can be blocked by YAP inhibitor and integrin-beta 1 antibody.
Article
Multidisciplinary Sciences
Aida Karagah, Reza Tabrizi, Fatemeh Pourahmadali, Ahad Alizadeh, Maryam Tofangchiha, Romeo Patini
Summary: This study assessed the correlation between radiomorphometric indices of the mandible and mandibular angle fractures in an Iranian population. The findings showed that patients with a large gonial angle, short ramus height, minimum ramus width, and impacted third molar are more susceptible to mandibular angle fractures.
Article
Health Care Sciences & Services
Giovanni Badiali, Mirko Bevini, Ottavia Lunari, Elisa Lovero, Federica Ruggiero, Federico Bolognesi, Liliana Feraboli, Alberto Bianchi, Claudio Marchetti
Summary: This study utilized patient-specific osteosynthesis implants (PSIs) and virtual surgical planning to successfully conduct orthognathic surgery, with postoperative analysis showing accurate reproduction of planned maxillo-mandibular positioning and flexibility in vertical correction.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
Hide Sakashita, Yasuhiko Bando, Arata Nagasaka, Koji Sakiyama, Go Onozawa, Fuyoko Taira, Yudai Ogasawara, Yuji Owada, Hideaki Sakashita, Osamu Amano
Summary: This study found that E-FABP-positive septoclasts participated in the disappearance of Meckel's cartilage, indicating their crucial role in the resorption of the uncalcified cartilage matrix.
HISTOCHEMISTRY AND CELL BIOLOGY
(2022)
Article
Orthopedics
Y. He, M. Zhang, J. Song, M. L. Warman
Summary: The study showed that cell-depleted areas within MCC cartilage are not repopulated by new cells in adult mice after diphtheria toxin-mediated chondrocyte killing.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Physiology
Ana Prates Soares, Heilwig Fischer, Sabrin Aydin, Claudius Steffen, Katharina Schmidt-Bleek, Carsten Rendenbach
Summary: The mandible is responsible for shaping the lower face, masticatory movements, and articulation of phonemes. Pathologies that damage the mandible severely impact patients. Mandibular reconstruction techniques using flaps, notably free vascularized fibula flaps, need to consider the unique clinical traits and differences of the mandible to achieve successful outcomes.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Jing Gao, Lulu Jiang, Baohong Zhao
Summary: This paper provides a comprehensive review of the current research status on mandibular flexure, exploring its physiological mechanisms, influencing factors, and implications for clinical diagnosis and treatment. It offers crucial clinical recommendations, including precise control over mouth opening during impression-taking, prioritizing materials with high elastic modulus or bone-tissue-like properties, and customizing framework design based on individual variations.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Anatomy & Morphology
Yoshihito Shimazu, Yuji Taya, Yuuichi Soeno, Tomoo Kudo, Kaori Sato, Mamoru Takeda
Summary: Our study aimed to investigate the interaction between the initiation site of Meckel's cartilage (MC) resorption and the development of incisor tooth germs. Through histology-based 3D reconstruction and immunohistochemical staining, we found that MC resorption starts on E16.0 and is closely related to the cervical loop of the incisor tooth germ. The proximity of incisor tooth germ tissue determines the disappearance of MC during tooth development.
JOURNAL OF ANATOMY
(2023)
Article
Multidisciplinary Sciences
Xiaojie Ma, Zhuo Wang, Jinbo Wan, Jiamin Xu, Haoran Wang, Yifeng Bian, Linzhong Wan, Yifei Du, Yuli Wang, Hua Yuan
Summary: This study analyzed the morphology of paired fibula and mandible in order to choose the optimal fibular segments for mandibular reconstruction in the Chinese population. The results showed that the distal and middle segments of the fibula were suitable for reconstructing the anterior area of the mandible, while the proximal segment of the fibula was more compatible with the premolar and molar areas of the mandible.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
M. Garcia, J. A. Cabrera, A. Bataller, S. Postigo, J. J. Castillo
Summary: The study focuses on developing a 3D multibody model to reproduce jaw movement and design devices that allow for a greater aperture range based on the kinematic behavior of the patient's jaw.
BIO-DESIGN AND MANUFACTURING
(2021)
Article
Multidisciplinary Sciences
Marketa Kaucka, Alberto Joven Araus, Marketa Tesarova, Joshua D. Currie, Johan Bostrom, Michaela Kavkova, Julian Petersen, Zeyu Yao, Anass Bouchnita, Andreas Hellander, Tomas Zikmund, Ahmed Elewa, Phillip T. Newton, Ji-Feng Fei, Andrei S. Chagin, Kaj Fried, Elly M. Tanaka, Jozef Kaiser, Andras Simon, Igor Adameyko
Summary: The study analyzes limb development and regeneration in amphibians, and reveals that regeneration is based on cartilage expansion and ossification follows after the final size of regenerating cartilage is reached, leading to bulkier bones. The process of ossification starts from the cortical bone and proceeds inwards in both regenerative and developmental processes, showing the diversity of schemes for the synchrony of cortical and endochondral ossification among vertebrates.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Saori Shibuya, Mitsushiro Nakatomi, Kaori Kometani-Gunjigake, Kayoko Nakao-Kuroishi, Kae Matsuyama, Shinji Kataoka, Takashi Toyono, Yuji Seta, Tatsuo Kawamoto
Summary: Optimal Msx1 gene is crucial for mandibular tip development, and its deficiency leads to rare abnormalities in the median cleft of the lower lip and cleft chin. The study found that the expression of Msx1 gene is reduced in the mandibular tip, resulting in incomplete fusion of the mandibular processes and failure to restore during development. In addition, the absence of the Msx1 gene also causes division of Meckel's cartilage and surrounding soft tissues. The results suggest that the Msx1 gene is indispensable for proper mandibular tip development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)