Article
Nanoscience & Nanotechnology
Chia-Chen Hsu, Andrea Serio, Sahana Gopal, Amy Gelmi, Ciro Chiappini, Ravi A. Desai, Molly M. Stevens
Summary: Surface topography, such as microgrooves, can alter the behavior and differentiation patterns of stem cells by enhancing alignment, modifying nuclear geometry, increasing cellular stiffness, and inducing epigenetic changes. In this study, microgrooves were found to promote neuronal differentiation of neural stem cells by downregulating Notch signaling and modifying the epigenetic landscape.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Medicine, Research & Experimental
Ludovica Cotellessa, Federica Marelli, Paolo Duminuco, Michela Adamo, Georgios E. . Papadakis, Lucia Bartoloni, Naoko Sato, Mariarosaria Lang-Muritano, Amineh Troendle, Waljit S. . Dhillo, Annamaria Morelli, Giulia Guarnieri, Nelly Pitteloud, Luca Persani, Marco Bonomi, Paolo Giacobini, Valeria Vezzoli
Summary: Fertility in vertebrate species is controlled by GnRH neurons, which arise outside the central nervous system and migrate into the forebrain during development. Genetic disorders associated with infertility, such as CHH and Kallmann syndrome, are characterized by defects in GnRH neuron migration. The study found that Jag1/Notch signaling is involved in the development of GnRH neurons, and JAG1 insufficiency may contribute to the pathogenesis of CHH in humans.
Article
Physics, Fluids & Plasmas
Chandrashekar Kuyyamudi, Shakti N. Menon, Sitabhra Sinha
Summary: Cells in developing embryos differentiate reliably despite fluctuations in morphogen concentrations and molecular processes, by utilizing cell-cell interactions and the asymmetry in gene response to global morphogen signals. This bimodal response ensures consistent developmental outcomes and reduces uncertainty in boundary locations between distinct fates.
Article
Biochemical Research Methods
Joana Sales-Dias, Andreia Ferreira, Marcia Lamy, Giacomo Domenici, Sandra M. S. Monteiro, Antonio Pires, Ana R. Lemos, Khrystyna Kucheryava, Ligia S. Nobre, Pedro M. F. Sousa, Tiago M. Bandeiras, Gabriela Silva, Ana Barbas
Summary: Development of specific functional blocking anti-DLL1 antibodies with potential activity against ER+ breast cancer cells was reported, suggesting the potential for identifying anti-DLL1 antibodies candidates against breast cancer using this strategy.
Article
Materials Science, Multidisciplinary
Yong-Keun Ahn, Yong-Kwon Jeong, Chan-Hee Han, Nong-Moon Hwang
Summary: By heating sheet samples at different positions to induce different stresses and evolve {100} texture, the magnetic flux density (B50) was increased by 8.7% and the eddy current loss (W15/50) was decreased by 12.4%.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2021)
Article
Developmental Biology
Yusuke Okubo, Fumiaki Ohtake, Katsuhide Igarashi, Yukuto Yasuhiko, Yoko Hirabayashi, Yumiko Saga, Jun Kanno
Summary: The study reveals that Delta like 1 intracellular domain (D1ICD) plays a role in regulating cell proliferation, neurogenesis, and gliogenesis in the developing dorsal root ganglia (DRG) by modulating its production. D1ICD acts as an integral component of lateral inhibition mechanism by inhibiting Notch activity, and also promotes neurogenesis through the MAP kinase pathway.
Article
Chemistry, Physical
Bao-ying Wang, Xia Yu, Jaber Karimpoor Majd
Summary: This paper introduces a novel market participation model and forecasting method with wind turbine, photovoltaic, fuel cell, and a new hybrid energy storage system, aiming to minimize cost and improve market reliability. By using multi artificial neural networks and stochastic modeling, the forecasting accuracy and market participation accuracy are both improved.
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
(2021)
Article
Virology
Emmanuel C. Ijezie, John M. O'Dowd, Man Kuan, Alexandra R. Faeth, Elizabeth A. Fortunato
Summary: HCMV infection is the leading cause of virus-induced neurologic birth defects, but the mechanism is still unclear. This study used HCMV-infected induced pluripotent stem cells (iPSCs) to generate in vitro brain organoids and found that infected organoids had fewer neural rosettes and structural deficits. Further experiments showed that HCMV-induced downregulation of NID1 impaired neural rosette formation and integrity.
JOURNAL OF VIROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Tetsuo Yasugi, Makoto Sato
Summary: Notch signalling is a conserved pathway that regulates cell fate through cell-cell communication. A key feature of Notch signalling is lateral inhibition, where neighboring cells acquire different cell fates. The dynamics of Notch in various developmental processes have been studied using mathematical and computational approaches, which provide valuable insights into the mechanisms of Notch signalling.
Article
Obstetrics & Gynecology
Jennifer McEachron, Agha Wajdan Baqir, Nancy Zhou, Absia Jabbar, Raavi Gupta, Daniel Levitan, Yi-Chun Lee
Summary: Over 20% of USC patients were found to express WT1, which was associated with increased chemosensitivity. However, while WT1 expression was correlated with a trend towards improved PFS, the association was not significant.
GYNECOLOGIC ONCOLOGY REPORTS
(2022)
Article
Multidisciplinary Sciences
Do Hee Kwon, Jae Berm Park, Joo Sang Lee, Sung Joo Kim, Bongkum Choi, Ki-Young Lee
Summary: This study investigated the in vivo functions of hDlk1-expressing MSCs in humanized NSG mice, showing that hDlk1(+)hMSCs can effectively promote the development of human T cells and induce antigen-specific T cell response. The diverse and functionally active human T cells developed in humanized NSG mice suggest potential advantages for developing therapeutics targeting infectious diseases in the future.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Dennis Piontek, Luca Bugliaro, Marius Schmidl, Daniel K. Zhou, Christiane Voigt
Summary: A new volcanic ash cloud detection algorithm VACOS based on artificial neural networks and geostationary sensor data has been developed, showing promising results in monitoring volcanic ash clouds during both day and night time.
Article
Pediatrics
Xiaojiao Zhang, Lili Liu, Wei Bai, Ying Han, Xinlin Hou
Summary: Asphyxiated neonates showed significantly increased diversity and richness of microbiota on the first day of life, primarily consisting of pathogenic flora. The presence of Lachnospiraceae and Clostridia in asphyxiated neonates on day 1 may be related to neural development at 6 months.
FRONTIERS IN PEDIATRICS
(2021)
Article
Multidisciplinary Sciences
Corinna Gaertner, Annika Messmer, Petra Dietmann, Michael Kuehl, Susanne J. Kuehl
Summary: Bop1 protein is expressed in the developing anterior tissue of Xenopus laevis and is necessary for proper development of cranial cartilage, brain, and eyes. Knockdown of Bop1 affects retinal lamination and expression of specific marker genes, indicating a novel function of Bop1 independent of ribosomal biogenesis.
Article
Anatomy & Morphology
Chih-Liang Tien, Saeid Mohammadparast, Chenbei Chang
Summary: HP1β regulates the transition from precursor to more differentiated cell types during neural and neural crest development in Xenopus by repressing the pluripotency-associated transcription regulator pou5f3.2/oct25.
DEVELOPMENTAL DYNAMICS
(2021)
Review
Developmental Biology
Cheng Shi, Pengfei Jiao, Zhiyi Chen, Lan Ma, Siyue Yao
Summary: This review discusses the molecular etiology of congenital craniofacial abnormalities, with a focus on the role and mechanism of noncoding RNAs in regulating craniofacial development. Aberrant expression of noncoding RNAs has been implicated in the pathogenesis of craniofacial abnormalities, providing potential therapeutic targets.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Hideru Togashi, Steven Ray Davis, Makoto Sato
Summary: Tile patterns, regulated by cell adhesion molecules, are regular arrangements of cells that play important functional roles in multicellular organisms. The physical constraints and cell adhesion regulate both cell shape and tissue morphogenesis.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Armen Khanbabei, Lina Segura, Cynthia Petrossian, Aaron Lemus, Ithan Cano, Courtney Frazier, Armen Halajyan, Donnie Ca, Mariano Loza-Coll
Summary: This article investigates the genetic regulatory mechanisms of Drosophila intestinal stem cells. The study found that most target genes co-regulated by Esg and STAT show a consistent gene expression pattern. However, manipulating these validated targets in vivo rarely replicated the effects of manipulating Esg and STAT, suggesting the presence of complex genetic interactions among the downstream targets of these two master regulator genes.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Bayley J. Waters, Zoe R. Birman, Matthew R. Wagner, Julia Lemanski, Barak Blum
Summary: Researchers found that conditional deletion of Robo2 in adult mice led to a significant loss of islet architecture without affecting beta cell identity or function, suggesting that Robo2 plays a role in actively maintaining adult islet architecture. Understanding the factors required for islet architecture maintenance is crucial for developing future diabetes therapies.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Rhiannon Clements, Tyler Smith, Luke Cowart, Jennifer Zhumi, Alan Sherrod, Aidan Cahill, Ginger L. Hunter
Summary: Cell protrusions play a crucial role in regulating cell activities during development. By studying the regulation mechanism in fruit fly sensory bristle patterning, it was found that Myosin XV is essential for the dynamics of signaling filopodia and promotes long-range Notch signaling.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Margaret Keating, Ryan Hagle, Daniel Osorio-Mendez, Anjelica Rodriguez-Parks, Sarah I. Almutawa, Junsu Kang
Summary: Knock-in reporter (KI) animals are essential for studying gene expression in biomedical research. This study developed a new strategy using minicircle technology and a minimal promoter to enhance knock-in events and establish stable KI transgenic reporter lines. The study also highlighted the importance of selecting the proper KI line due to potential inappropriate influence of genome editing on reporter gene expression.
DEVELOPMENTAL BIOLOGY
(2024)
Article
Developmental Biology
Christian Altbuerger, Meta Rath, Daniel Armbruster, Wolfgang Driever
Summary: This study reveals that Neurog1 and Olig2 transcription factors have differential requirements for the development of dopaminergic neurons, and they integrate local patterning signals and Notch neurogenic selection signaling to specify the progenitor population and initiate neurogenesis and differentiation.
DEVELOPMENTAL BIOLOGY
(2024)